BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0118.p (229 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8ITH2.1 D8ITH2_HERSS 3-hydroxyacyl-CoA dehydrogenase protein EC... 308 5e-82 B5WSW7.1 B5WSW7_9BURK 3-hydroxybutyryl-CoA dehydrogenase EC=1.1.... 291 4e-77 A2WF96.1 A2WF96_9BURK 3-hydroxyacyl-CoA dehydrogenase 291 5e-77 D5WMV7.1 D5WMV7_BURSC 3-hydroxybutyryl-CoA dehydrogenase EC=1.1.... 288 5e-76 Q397D0.1 Q397D0_BURS3 3-hydroxyacyl-CoA dehydrogenase EC=1.1.1.35 286 1e-75 >D8ITH2.1 D8ITH2_HERSS 3-hydroxyacyl-CoA dehydrogenase protein EC=1.1.1.35 Length = 512 Score = 308 bits (788), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 152/226 (67%), Positives = 176/226 (77%), Gaps = 2/226 (0%) Query: 1 VGMHFFNPVPLMALVEIISGLASDAAVAECVYDTALAWGKNPVHTKSTPGFIVNRVARPY 60 VGMHFFNPVP+MALVEIISGLASDAA+A+C++DTALAWGK PV +STPGFIVNR+ARPY Sbjct: 147 VGMHFFNPVPMMALVEIISGLASDAALAQCLHDTALAWGKTPVMARSTPGFIVNRLARPY 206 Query: 61 YAEALRILNEQAAGPATIDAILREAGGFRMGPFELMDLIGHDVNFAVTQSVFHAYFTDPR 120 YAE LR+L+E A PATIDA++REAGGFRMGPFELMDLIGHDVNFAVTQSVFHAYF DPR Sbjct: 207 YAEGLRMLHEGGAQPATIDAVMREAGGFRMGPFELMDLIGHDVNFAVTQSVFHAYFNDPR 266 Query: 121 FTPSLIQQELVNAGFLGRKSGRGFYRYGADAVAPTPATEAAVEHASQMVQLSGTGPLAEA 180 FTPSLIQQELV+AG+LGRKSGRGFYRYG A AP P TE + QL G PL E Sbjct: 267 FTPSLIQQELVHAGYLGRKSGRGFYRYGEAAGAPRPETERDYPKPTATPQLYGDHPLVEM 326 Query: 181 LAARLGNVSVERSSTPGADDAVLQCGSARAYLTDGRSATRRAADNR 226 + R + P D +++ +A +TDGRSAT RA +++ Sbjct: 327 IHTRYPGQVQRHPARP--DQLLMKVNAACLCITDGRSATLRAWEHQ 370 >B5WSW7.1 B5WSW7_9BURK 3-hydroxybutyryl-CoA dehydrogenase EC=1.1.1.157 Length = 519 Score = 291 bits (745), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 148/230 (64%), Positives = 171/230 (74%), Gaps = 4/230 (1%) Query: 1 VGMHFFNPVPLMALVEIISGLASDAAVAECVYDTALAWGKNPVHTKSTPGFIVNRVARPY 60 VGMHFFNP P+MALVE++SGLA+ A VA CVY+TA AWGK PV+ +STPGFIVNRVARP+ Sbjct: 142 VGMHFFNPAPVMALVEVVSGLATSADVATCVYETAAAWGKTPVYARSTPGFIVNRVARPF 201 Query: 61 YAEALRILNEQAAGPATIDAILREAGGFRMGPFELMDLIGHDVNFAVTQSVFHAYFTDPR 120 YAE LR+LNEQAA A+ID ++REAGGFRMGPFELMDLIGHDVNFAVT+SVF A+F DPR Sbjct: 202 YAEGLRLLNEQAADAASIDEVMREAGGFRMGPFELMDLIGHDVNFAVTESVFRAFFNDPR 261 Query: 121 FTPSLIQQELVNAGFLGRKSGRGFYRYGADAVAPTPATEAAVEHASQMVQLSGTGPLAEA 180 FTPSLIQQELVNAGFLGRKSGRGFY YGA+A P P A + ++V+L + E Sbjct: 262 FTPSLIQQELVNAGFLGRKSGRGFYEYGANATRPNPRI-ARPADSPRVVKLFPQSGVIER 320 Query: 181 LAARL---GNVSVERSSTPGADDAVLQCGSARAYLTDGRSATRRAADNRH 227 L RL G V+ T D V Q A LTDGR+AT+ A D H Sbjct: 321 LQQRLRDAGLVTTTMPETERFDGVVAQIDDAVLRLTDGRTATQCAYDTDH 370 >A2WF96.1 A2WF96_9BURK 3-hydroxyacyl-CoA dehydrogenase Length = 518 Score = 291 bits (745), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 147/222 (66%), Positives = 168/222 (75%), Gaps = 2/222 (0%) Query: 2 GMHFFNPVPLMALVEIISGLASDAAVAECVYDTALAWGKNPVHTKSTPGFIVNRVARPYY 61 G+HFFNP PLMALVE++SGLA+ AVA+ +Y TA+AWGK PV KSTPGFIVNRVARPYY Sbjct: 152 GLHFFNPAPLMALVEVVSGLATAPAVAQMLYATAVAWGKRPVMVKSTPGFIVNRVARPYY 211 Query: 62 AEALRILNEQAAGPATIDAILREAGGFRMGPFELMDLIGHDVNFAVTQSVFHAYFTDPRF 121 AEALR LNEQ PA+IDA++REAGGFRMGPFELMDLIGHDVNFAVT+SVF AYF DPR+ Sbjct: 212 AEALRALNEQGGTPASIDAVMREAGGFRMGPFELMDLIGHDVNFAVTESVFRAYFNDPRY 271 Query: 122 TPSLIQQELVNAGFLGRKSGRGFYRYGADAVAPTPATEAAVEHASQMVQLSGTGPLAEAL 181 TPSLIQQELVNAGFLGRKSGRGFY Y DA P P E + + +V + GP A AL Sbjct: 272 TPSLIQQELVNAGFLGRKSGRGFYSYADDATPPAPDVEPPCDAPADVVLFAQDGP-AAAL 330 Query: 182 AARLGN-VSVERSSTPGADDAVLQCGSARAYLTDGRSATRRA 222 ARL ++ R + DD + G A LTDGR+AT RA Sbjct: 331 HARLAQRIAGARHADAHRDDLLASAGRASIALTDGRTATVRA 372 >D5WMV7.1 D5WMV7_BURSC 3-hydroxybutyryl-CoA dehydrogenase EC=1.1.1.157 Length = 519 Score = 288 bits (736), Expect = 5e-76, Method: Compositional matrix adjust. Identities = 146/230 (63%), Positives = 169/230 (73%), Gaps = 4/230 (1%) Query: 1 VGMHFFNPVPLMALVEIISGLASDAAVAECVYDTALAWGKNPVHTKSTPGFIVNRVARPY 60 VGMHFFNP P+MALVE++SGLA+ A VA CVY+TA AWGK PV+ +STPGFIVNRVARP+ Sbjct: 142 VGMHFFNPAPVMALVEVVSGLATSADVATCVYETAAAWGKTPVYARSTPGFIVNRVARPF 201 Query: 61 YAEALRILNEQAAGPATIDAILREAGGFRMGPFELMDLIGHDVNFAVTQSVFHAYFTDPR 120 YAE LR+LNEQAA +ID ++REAGGFRMGPFELMDLIGHDVNFAVT+SVF AYF DPR Sbjct: 202 YAEGLRLLNEQAASAESIDEVIREAGGFRMGPFELMDLIGHDVNFAVTESVFRAYFNDPR 261 Query: 121 FTPSLIQQELVNAGFLGRKSGRGFYRYGADAVAPTPATEAAVEHASQMVQLSGTGPLAEA 180 FTPSLIQQELVNAGFLGRKSGRGFY YG +A P+P A + ++V+L + Sbjct: 262 FTPSLIQQELVNAGFLGRKSGRGFYEYGPNATRPSPWL-APPTDSPRVVKLFPQSGVIAR 320 Query: 181 LAARL---GNVSVERSSTPGADDAVLQCGSARAYLTDGRSATRRAADNRH 227 L RL G V+ T D V Q A LTDGR+AT+ A D H Sbjct: 321 LQRRLLDAGLVTATMPETECIDGVVAQIDDALLRLTDGRTATQCAHDTDH 370 >Q397D0.1 Q397D0_BURS3 3-hydroxyacyl-CoA dehydrogenase EC=1.1.1.35 Length = 518 Score = 286 bits (733), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 146/223 (65%), Positives = 165/223 (73%), Gaps = 2/223 (0%) Query: 2 GMHFFNPVPLMALVEIISGLASDAAVAECVYDTALAWGKNPVHTKSTPGFIVNRVARPYY 61 G+HFFNP PLMALVE++SGLA+ VA+ +Y TA AWGK PV KSTPGFIVNRVARPYY Sbjct: 152 GLHFFNPAPLMALVEVVSGLATAPEVAQVLYATAAAWGKRPVMAKSTPGFIVNRVARPYY 211 Query: 62 AEALRILNEQAAGPATIDAILREAGGFRMGPFELMDLIGHDVNFAVTQSVFHAYFTDPRF 121 AEALR+LNEQ PA+IDA++REAGGFRMGPFELMDLIGHDVNFAVT+SVF AYF DPR+ Sbjct: 212 AEALRVLNEQGGAPASIDAVMREAGGFRMGPFELMDLIGHDVNFAVTESVFRAYFNDPRY 271 Query: 122 TPSLIQQELVNAGFLGRKSGRGFYRYGADAVAPTPATEAAVEHASQMVQLSGTGPLAEAL 181 TPSLIQQELVNAGFLGRKSGRGFY Y A P P EA + + + GP A AL Sbjct: 272 TPSLIQQELVNAGFLGRKSGRGFYSYADGATPPAPELEAPRDAPADVALFVEDGP-AAAL 330 Query: 182 AARLGN-VSVERSSTPGADDAVLQCGSARAYLTDGRSATRRAA 223 AR + R + ADD + G A LTDGR+AT RAA Sbjct: 331 HARFAERIPGARQAGAHADDLLATAGRASIALTDGRTATARAA 373