BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0012.0056.p (509 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J165.1 D8J165_HERSS D-galactarate dehydratase protein EC=4.2.1.42 779 0.0 Q0K2L8.1 Q0K2L8_CUPNH Probable D-galactarate dehydratase EC=4.2.... 652 0.0 Q128M4.1 Q128M4_POLSJ Galactarate dehydratase EC=4.2.1.42 652 0.0 Q46UY6.1 Q46UY6_CUPPJ Galactarate dehydratase EC=4.2.1.42 649 0.0 Q1LE30.1 Q1LE30_RALME Galactarate dehydratase EC=4.2.1.42 649 0.0 >D8J165.1 D8J165_HERSS D-galactarate dehydratase protein EC=4.2.1.42 Length = 522 Score = 779 bits (2012), Expect = 0.0, Method: Compositional matrix adjust. Identities = 381/431 (88%), Positives = 405/431 (93%), Gaps = 2/431 (0%) Query: 5 TATQASNTNIPRYILMHENDNVAIVVNDRGLPAGTVFPDGLTLISQVPQGHKIALRDIPQ 64 T T AS + PRYI+M++ DNVAIVVND GLPAGTVFPDGLTL+ +VPQGHKIALRD+ Q Sbjct: 3 TDTSASQASAPRYIMMNDTDNVAIVVNDGGLPAGTVFPDGLTLVDRVPQGHKIALRDLKQ 62 Query: 65 GAAIIRYDVAIGYAARDIARGSWIEESVVTLPPARELDNLPIATRKAPALASVPLEGYTF 124 G AI+RYDVAIGYA RDI +G WIEES+V +PPARELDNLPIAT+K PA PLEGYTF Sbjct: 63 GEAIVRYDVAIGYAVRDIPKGGWIEESLVQMPPARELDNLPIATKK-PA-PQPPLEGYTF 120 Query: 125 EGYRNADGSVGTRNLLAITTTVQCVAGVVEHAVRRIRQELLPKYPNVEDVVALEHTYGCG 184 EGYRNADGSVGTRNLLAITTTVQCVAGVVEHAV+RIR ELLPKYPNVEDVVALEHTYGCG Sbjct: 121 EGYRNADGSVGTRNLLAITTTVQCVAGVVEHAVKRIRAELLPKYPNVEDVVALEHTYGCG 180 Query: 185 VAIDAPNADIPIRTLRNISLNPNFGGQAMVVSLGCEKLQPNRLLPESIIPIHKEGEAYVV 244 VAIDAPNA IPIRTLRNISLNPNFGGQAMVVSLGCEKLQPNRLLPE++IPIHK+GE YVV Sbjct: 181 VAIDAPNAGIPIRTLRNISLNPNFGGQAMVVSLGCEKLQPNRLLPENMIPIHKQGEPYVV 240 Query: 245 CLQDAEHVGFNSMIDSILKMAEARLQELDKRRRVTCPASDLVVGVQCGGSDAFSGVTANP 304 CLQDAEHVGFNSMIDSI+ MAEARL EL+KRRR TCPASDLVVGVQCGGSDAFSGVTANP Sbjct: 241 CLQDAEHVGFNSMIDSIMNMAEARLTELNKRRRETCPASDLVVGVQCGGSDAFSGVTANP 300 Query: 305 AVGFATDLLVRAGAAVMFSEVTEVRDGIDQLTSRAVNEEVAQAMIREMDWYDKYLQKGGV 364 AVGFATDLLVRAGA+VMFSEVTEVRDGIDQLTSRAVNEEVAQAMIREMDWYD YL++GGV Sbjct: 301 AVGFATDLLVRAGASVMFSEVTEVRDGIDQLTSRAVNEEVAQAMIREMDWYDNYLKQGGV 360 Query: 365 DRSANTTPGNKKGGLANIVEKAMGSIVKSGSSPISGVLAPGDKLKQKGLIYAATPASDFV 424 DRSANTTPGNKKGGLANIVEKAMGSIVKSGSSPISGVL+PGDKL+QKGLIYAATPASDF+ Sbjct: 361 DRSANTTPGNKKGGLANIVEKAMGSIVKSGSSPISGVLSPGDKLQQKGLIYAATPASDFI 420 Query: 425 CGTLQLAAGMN 435 CGTLQLAAGMN Sbjct: 421 CGTLQLAAGMN 431 >Q0K2L8.1 Q0K2L8_CUPNH Probable D-galactarate dehydratase EC=4.2.1.42 Length = 521 Score = 652 bits (1682), Expect = 0.0, Method: Compositional matrix adjust. Identities = 319/431 (74%), Positives = 357/431 (82%), Gaps = 3/431 (0%) Query: 5 TATQASNTNIPRYILMHENDNVAIVVNDRGLPAGTVFPDGLTLISQVPQGHKIALRDIPQ 64 T T P YI MH NDNVAIV ND GLPAG FP GL L VPQGHK+AL D+ + Sbjct: 4 TPTAGGQAARPLYITMHANDNVAIVANDGGLPAGMEFPCGLVLAEGVPQGHKVALTDLRE 63 Query: 65 GAAIIRYDVAIGYAARDIARGSWIEESVVTLPPARELDNLPIATRKAPALASVPLEGYTF 124 G A+IRY+V IGYA +D+ RGSW+ E V+ +P A EL +LP+ TR AP L PLEGYTF Sbjct: 64 GDAVIRYNVVIGYALKDLPRGSWVNERVIRMPAAPELHDLPVGTRVAPLL---PLEGYTF 120 Query: 125 EGYRNADGSVGTRNLLAITTTVQCVAGVVEHAVRRIRQELLPKYPNVEDVVALEHTYGCG 184 EGYRNADGSVGTRN+L ITTTVQCV GVVE AVRRI++ELLPKYPNV+DVV LEHTYGCG Sbjct: 121 EGYRNADGSVGTRNILGITTTVQCVEGVVEFAVRRIKEELLPKYPNVDDVVGLEHTYGCG 180 Query: 185 VAIDAPNADIPIRTLRNISLNPNFGGQAMVVSLGCEKLQPNRLLPESIIPIHKEGEAYVV 244 VAIDAP+A IPIRT+RNI+LNPNFGG+ M+VSLGCEKLQP RL+ IPI +EGE VV Sbjct: 181 VAIDAPDAGIPIRTIRNIALNPNFGGEVMIVSLGCEKLQPARLIGAGTIPIQQEGEPDVV 240 Query: 245 CLQDAEHVGFNSMIDSILKMAEARLQELDKRRRVTCPASDLVVGVQCGGSDAFSGVTANP 304 CLQD +HVGF SMIDSI+ AE L L+ RRR TCPASDLVVGVQCGGSDAFSGVTANP Sbjct: 241 CLQDEQHVGFASMIDSIMATAEKHLARLNARRRETCPASDLVVGVQCGGSDAFSGVTANP 300 Query: 305 AVGFATDLLVRAGAAVMFSEVTEVRDGIDQLTSRAVNEEVAQAMIREMDWYDKYLQKGGV 364 AVGFATDLLVRAGA VMFSEVTEVRDGIDQLT+RA EVA+A++R+M WYD+YL++G V Sbjct: 301 AVGFATDLLVRAGATVMFSEVTEVRDGIDQLTARAATPEVAEALVRQMAWYDRYLEQGKV 360 Query: 365 DRSANTTPGNKKGGLANIVEKAMGSIVKSGSSPISGVLAPGDKLKQKGLIYAATPASDFV 424 DRSANTTPGNKKGGL+NIVEKAMGSIVKSG+ PI GV PG+K+ QKGLIYAATPA DFV Sbjct: 361 DRSANTTPGNKKGGLSNIVEKAMGSIVKSGTGPIHGVTGPGEKVTQKGLIYAATPAGDFV 420 Query: 425 CGTLQLAAGMN 435 CGTLQLAAGMN Sbjct: 421 CGTLQLAAGMN 431 >Q128M4.1 Q128M4_POLSJ Galactarate dehydratase EC=4.2.1.42 Length = 548 Score = 652 bits (1681), Expect = 0.0, Method: Compositional matrix adjust. Identities = 323/432 (74%), Positives = 360/432 (83%), Gaps = 13/432 (3%) Query: 15 PRYILMHENDNVAIVVNDRGLPAGTVFPDGLTLISQVPQGHKIALRDIPQGAAIIRYDVA 74 P YI MH++DNVAIV ND GLPAGTVF GL L QVPQGHK+AL D+P+G A++RY+V Sbjct: 28 PLYITMHDHDNVAIVANDGGLPAGTVFDSGLRLCEQVPQGHKVALVDLPKGTAVLRYNVP 87 Query: 75 IGYAARDIARGSWIEESVVTLPPARELDNLPIATRKAPALASVPLEGYTFEGYRNADGSV 134 IGYA +DI GSW+ E ++ +P ARELDNLPIAT + P L PLEGYTFEGYRN DGSV Sbjct: 88 IGYALKDIPAGSWVHERLLEMPSARELDNLPIATVRPPVLP--PLEGYTFEGYRNPDGSV 145 Query: 135 GTRNLLAITTTVQCVAGVVEHAVRRIRQELLPKYPNVEDVVALEHTYGCGVAIDAPNADI 194 G+RN+LAITTTVQCVAGVVE AV+RI+ ELLP++PNV+DVV LEHTYGCGVAIDAP+A I Sbjct: 146 GSRNILAITTTVQCVAGVVEFAVKRIKDELLPRFPNVDDVVGLEHTYGCGVAIDAPDAII 205 Query: 195 PIRTLRNISLNPNFGGQAMVVSLGCEKLQPNRLLPESIIPI-----------HKEGEAYV 243 PIRTLRNI+LNPNFGG+ MVVSLGCEKLQP RLLP I I E E V Sbjct: 206 PIRTLRNITLNPNFGGEVMVVSLGCEKLQPERLLPPGTIQIVDERNVADVGISAEAELDV 265 Query: 244 VCLQDAEHVGFNSMIDSILKMAEARLQELDKRRRVTCPASDLVVGVQCGGSDAFSGVTAN 303 VCLQ HVGF SMIDSI++ A L+ LD RRR T PAS+LVVGVQCGGSDAFSGVTAN Sbjct: 266 VCLQSEHHVGFMSMIDSIMETALLHLERLDARRRETVPASELVVGVQCGGSDAFSGVTAN 325 Query: 304 PAVGFATDLLVRAGAAVMFSEVTEVRDGIDQLTSRAVNEEVAQAMIREMDWYDKYLQKGG 363 PAVGFATDLLVRAGA VMFSE TEVRDGIDQLTSRA EVA+AMIREM WYD YLQKG Sbjct: 326 PAVGFATDLLVRAGATVMFSETTEVRDGIDQLTSRASTPEVAEAMIREMAWYDAYLQKGR 385 Query: 364 VDRSANTTPGNKKGGLANIVEKAMGSIVKSGSSPISGVLAPGDKLKQKGLIYAATPASDF 423 VDRSANTTPGNKKGGL+NIVEKAMGSIVKSG++PISGVL+PG+K++QKGLIYAATPASDF Sbjct: 386 VDRSANTTPGNKKGGLSNIVEKAMGSIVKSGTAPISGVLSPGEKVRQKGLIYAATPASDF 445 Query: 424 VCGTLQLAAGMN 435 +CGTLQLAAGMN Sbjct: 446 ICGTLQLAAGMN 457 >Q46UY6.1 Q46UY6_CUPPJ Galactarate dehydratase EC=4.2.1.42 Length = 524 Score = 649 bits (1673), Expect = 0.0, Method: Compositional matrix adjust. Identities = 320/424 (75%), Positives = 358/424 (84%), Gaps = 5/424 (1%) Query: 15 PRYILMHENDNVAIVVNDRGLPAGTVFPDGLTLISQVPQGHKIALRDIPQGAAIIRYDVA 74 P YI +H DNVAIV ND GLPAG FP GL L VPQGHK+AL D+ QG A++RY+V Sbjct: 12 PLYIRIHPEDNVAIVANDGGLPAGAAFPCGLVLQEAVPQGHKVALSDLKQGDAVVRYNVV 71 Query: 75 IGYAARDIARGSWIEESVVTLPPARELDNLPIATRKAPALASVPLEGYTFEGYRNADGSV 134 IGYA +D+ RGSW+ E V+ +P A L +LPI TR L PLEGYTFEG+RN DGSV Sbjct: 72 IGYALKDLPRGSWVNERVIEMPVAPGLTDLPIGTRVPAPLP--PLEGYTFEGFRNPDGSV 129 Query: 135 GTRNLLAITTTVQCVAGVVEHAVRRIRQELLPKYPNVEDVVALEHTYGCGVAIDAPNADI 194 GTRN+LAITTTVQCV+GVVEHAVRRIR+ELLP+YPNV+DVV LEHTYGCGVAIDAP+A I Sbjct: 130 GTRNILAITTTVQCVSGVVEHAVRRIREELLPRYPNVDDVVGLEHTYGCGVAIDAPDAVI 189 Query: 195 PIRTLRNISLNPNFGGQAMVVSLGCEKLQPNRLLPESIIPIHK---EGEAYVVCLQDAEH 251 PIRTLRNI+LNPNFGG AM+VSLGCEKLQP+RL+P IPI E + VVCLQD +H Sbjct: 190 PIRTLRNIALNPNFGGTAMMVSLGCEKLQPDRLMPAGTIPIQTGAGEVQVGVVCLQDEQH 249 Query: 252 VGFNSMIDSILKMAEARLQELDKRRRVTCPASDLVVGVQCGGSDAFSGVTANPAVGFATD 311 VGF SMI SI+ MAE L+ L+ RRR TCP SDLVVGVQCGGSDAFSGVTANPAVGFATD Sbjct: 250 VGFASMIASIMTMAETHLERLNARRRETCPVSDLVVGVQCGGSDAFSGVTANPAVGFATD 309 Query: 312 LLVRAGAAVMFSEVTEVRDGIDQLTSRAVNEEVAQAMIREMDWYDKYLQKGGVDRSANTT 371 LLVRAGAAVMFSEVTEVRDGIDQLT+RA EVA AMIREM WYD+YL++G VDRSANTT Sbjct: 310 LLVRAGAAVMFSEVTEVRDGIDQLTARAATPEVADAMIREMAWYDRYLERGRVDRSANTT 369 Query: 372 PGNKKGGLANIVEKAMGSIVKSGSSPISGVLAPGDKLKQKGLIYAATPASDFVCGTLQLA 431 PGNKKGGL+NIVEKAMGSI+KSG +PISGVL+PG+KLKQKGLIYAATPASDF+CGTLQLA Sbjct: 370 PGNKKGGLSNIVEKAMGSIIKSGRAPISGVLSPGEKLKQKGLIYAATPASDFICGTLQLA 429 Query: 432 AGMN 435 AGMN Sbjct: 430 AGMN 433 >Q1LE30.1 Q1LE30_RALME Galactarate dehydratase EC=4.2.1.42 Length = 530 Score = 649 bits (1673), Expect = 0.0, Method: Compositional matrix adjust. Identities = 318/438 (72%), Positives = 366/438 (83%), Gaps = 5/438 (1%) Query: 1 MSAETATQASNTNIPRYILMHENDNVAIVVNDRGLPAGTVFPDGLTLISQVPQGHKIALR 60 +S + A + P YI +H NDNVAIV ND GLPAG+VFP GLTL+ +VPQGHK+AL Sbjct: 4 LSVQNAQGQAAERAPLYIRIHANDNVAIVANDGGLPAGSVFPCGLTLVERVPQGHKVALV 63 Query: 61 DIPQGAAIIRYDVAIGYAARDIARGSWIEESVVTLPPARELDNLPIATRKAPALASVPLE 120 D+ +G A+ RY+V IGYA +D+ RG+W+ E V+ +P A L +LPI TR L PLE Sbjct: 64 DLKKGDAVTRYNVTIGYALQDLPRGAWVNERVIEMPTAPGLTDLPIGTRVPEPLP--PLE 121 Query: 121 GYTFEGYRNADGSVGTRNLLAITTTVQCVAGVVEHAVRRIRQELLPKYPNVEDVVALEHT 180 GYTFEG+RN DGSVGTRN+LAITTTVQCV+GVVEHAV RI+ ELLP+YPNV+DV+ LEHT Sbjct: 122 GYTFEGFRNPDGSVGTRNILAITTTVQCVSGVVEHAVHRIKTELLPRYPNVDDVIGLEHT 181 Query: 181 YGCGVAIDAPNADIPIRTLRNISLNPNFGGQAMVVSLGCEKLQPNRLLPESIIPIHK--- 237 YGCGVAIDAP+A +PIRTLRNI+LNPNFGG AM+VSLGCEKLQP RL+P IPI Sbjct: 182 YGCGVAIDAPDAIVPIRTLRNIALNPNFGGTAMMVSLGCEKLQPERLMPPGTIPIQTGAG 241 Query: 238 EGEAYVVCLQDAEHVGFNSMIDSILKMAEARLQELDKRRRVTCPASDLVVGVQCGGSDAF 297 E + VVCLQD +HVGF SMIDSI+ MAE LQ L+ R+R T P S+LVVGVQCGGSDAF Sbjct: 242 EVQVGVVCLQDDKHVGFASMIDSIMAMAETHLQTLNARKRETVPVSELVVGVQCGGSDAF 301 Query: 298 SGVTANPAVGFATDLLVRAGAAVMFSEVTEVRDGIDQLTSRAVNEEVAQAMIREMDWYDK 357 SGVTANPAVGFATDLLVRAGA VMFSEVTEVRDGIDQLT+RA EVA+AMIREMDWYD+ Sbjct: 302 SGVTANPAVGFATDLLVRAGATVMFSEVTEVRDGIDQLTARAATPEVAEAMIREMDWYDR 361 Query: 358 YLQKGGVDRSANTTPGNKKGGLANIVEKAMGSIVKSGSSPISGVLAPGDKLKQKGLIYAA 417 YL +G VDRSANTTPGNKKGGL+NIVEKAMGSIVKSGS+PISGV++PG+K+KQKGLIYAA Sbjct: 362 YLDRGRVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSAPISGVVSPGEKVKQKGLIYAA 421 Query: 418 TPASDFVCGTLQLAAGMN 435 TPASDF+CGTLQLAAGMN Sbjct: 422 TPASDFICGTLQLAAGMN 439