BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0010.0009.p (460 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A1WES6.1 A1WES6_VEREI Heavy metal sensor signal transduction his... 786 0.0 D8IWG4.1 D8IWG4_HERSS Two component heavy metal sensor histidine... 613 e-173 E6UX86.1 E6UX86_VARPD Heavy metal sensor signal transduction his... 475 e-132 Q1IEQ7.1 Q1IEQ7_PSEE4 Putative heavy metal sensor histidine kinase 434 e-119 F2K594.1 F2K594_PSEBR Putative two-component system, sensor kinase 429 e-118 >A1WES6.1 A1WES6_VEREI Heavy metal sensor signal transduction histidine kinase Length = 458 Score = 786 bits (2031), Expect = 0.0, Method: Compositional matrix adjust. Identities = 375/454 (82%), Positives = 411/454 (90%) Query: 1 MRHSIIARLVMMFAAAALVIFSLIGGVLYAVVKNELLRHERDGLVTTFNDIEYMVSRVGT 60 M++SIIARLV+MFAAAAL+IFSLIG VLYAVV NELL HER+ LVTTF DIEYMVSR GT Sbjct: 1 MKNSIIARLVIMFAAAALIIFSLIGSVLYAVVDNELLHHERNSLVTTFKDIEYMVSRAGT 60 Query: 61 VERWARVQTKLDTLTPADGKVRFWVFSDDPQFSYGKDLAELHDFDYDPNNIGRLRIKGKE 120 ERWA VQ KLDTLTPADGKVRFW+FSDDP+F YGKDLAELH+F PNN+GR+ IKGK+ Sbjct: 61 TERWAHVQVKLDTLTPADGKVRFWIFSDDPRFGYGKDLAELHEFANHPNNLGRMSIKGKK 120 Query: 121 FPMHTLTKVLPAYLDRPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGYWIA 180 +P+HTLT++LPAYLDRPAIRLT+GVD YFETLRTFV AM GLSLAG+ LVIL GYWIA Sbjct: 121 YPLHTLTRILPAYLDRPAIRLTVGVDAASYFETLRTFVAAMTGLSLAGVLLVILCGYWIA 180 Query: 181 RAGLQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLEAFN 240 R GLQPLKKMSDKAQTLSP+TLSERLT+SALPDELSDLAQAFNGALDRMENAYKQLEAFN Sbjct: 181 RTGLQPLKKMSDKAQTLSPKTLSERLTLSALPDELSDLAQAFNGALDRMENAYKQLEAFN 240 Query: 241 ADVAHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLARCDQ 300 ADVAHELRTPLANLIGETQVALSRERSAPEFE VLQSNLEE+DRLRSIINDMLFLARCDQ Sbjct: 241 ADVAHELRTPLANLIGETQVALSRERSAPEFESVLQSNLEEMDRLRSIINDMLFLARCDQ 300 Query: 301 GEAATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTNLLQ 360 GEAAT LV+ IADEVQKT++FFEFVLDE M VE+ GD A ++IET+LFRRALTNLLQ Sbjct: 301 GEAATGLVHALIADEVQKTMDFFEFVLDETGMRVEISGDTHATALIETSLFRRALTNLLQ 360 Query: 361 NAIQHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRDFDGVH 420 NAIQHSPAGA I V+IDA+ VQ+AVSNPGEP+EQ HLPRLFDRFYRVD+ARRD +G+H Sbjct: 361 NAIQHSPAGACIEVAIDAKNHGVQIAVSNPGEPVEQGHLPRLFDRFYRVDTARRDINGIH 420 Query: 421 GHGLGLAIVKAIALMHGGTAFASSRGGKTTIGFT 454 GHGLGLAIVKAIALMHGG+ FA+S GG TTIGFT Sbjct: 421 GHGLGLAIVKAIALMHGGSVFAASTGGVTTIGFT 454 >D8IWG4.1 D8IWG4_HERSS Two component heavy metal sensor histidine kinase protein Length = 467 Score = 613 bits (1580), Expect = e-173, Method: Compositional matrix adjust. Identities = 298/459 (64%), Positives = 365/459 (79%), Gaps = 4/459 (0%) Query: 1 MRHSIIARLVMMFAAAALVIFSLIGGVLYAVVKNELLRHERDGLVTTFNDIEYMVSRVGT 60 +R SI ARLV M AA+AL+IF+L G VLY V+K ELLRHERDGLVTT NDI Y + R G Sbjct: 8 LRQSITARLVWMSAASALLIFALTGMVLYTVLKGELLRHERDGLVTTLNDISYQIGRAGN 67 Query: 61 VERWARVQTKLDTLTPADGKVRFWVFSDDPQFSYGKDLAELHDFDY---DPNNIGRLRIK 117 ERW RVQ KL TL+ AD V FW+ S D +F+YG DL+ L + N++GRL + Sbjct: 68 TERWGRVQAKLATLSQADQHVSFWISSSDARFTYG-DLSRLAPQAIRADEGNSVGRLHLP 126 Query: 118 GKEFPMHTLTKVLPAYLDRPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGY 177 G+ +P+H +T+ LPA+ +RPA+ +T+GVD EPYFE RTF++A SL GI L ++ Y Sbjct: 127 GRRYPLHIMTRTLPAFEERPAVDVTVGVDGEPYFEMRRTFLLATSVFSLLGIVLAVISSY 186 Query: 178 WIARAGLQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLE 237 WIARAGL PL++MSD+AQ+ SP+ LS R+ V A+P ELS LA AFNGALDR+E+AY QLE Sbjct: 187 WIARAGLAPLRQMSDRAQSFSPRKLSARMPVEAMPQELSVLALAFNGALDRIEDAYTQLE 246 Query: 238 AFNADVAHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLAR 297 AFNADVAHELRTPLANLIGETQVAL+RERSA EF+ VLQSNLEELDR+RSI+NDMLFLAR Sbjct: 247 AFNADVAHELRTPLANLIGETQVALARERSAGEFKDVLQSNLEELDRIRSIVNDMLFLAR 306 Query: 298 CDQGEAATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTN 357 DQGEAAT+ V +ADEVQKT++FFEFVLD+ M +EV GD +A +M+ETALF+RALTN Sbjct: 307 SDQGEAATARVPARVADEVQKTVDFFEFVLDDSGMRIEVAGDTEATAMMETALFKRALTN 366 Query: 358 LLQNAIQHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRDFD 417 L+QNAIQHSP GA + + I Q++ V+VAVSNPG+PI++ HLPRLFDRFYRVDSAR+D + Sbjct: 367 LIQNAIQHSPEGALLRIDIACQEETVRVAVSNPGKPIDEHHLPRLFDRFYRVDSARQDIN 426 Query: 418 GVHGHGLGLAIVKAIALMHGGTAFASSRGGKTTIGFTVG 456 G HGHGLGLAIVKA+A MHGG AFASS+ G +IGFT+ Sbjct: 427 GSHGHGLGLAIVKAVARMHGGRAFASSKEGVNSIGFTIA 465 >E6UX86.1 E6UX86_VARPD Heavy metal sensor signal transduction histidine kinase Length = 464 Score = 475 bits (1222), Expect = e-132, Method: Compositional matrix adjust. Identities = 270/459 (58%), Positives = 342/459 (74%), Gaps = 6/459 (1%) Query: 1 MRHSIIARLVMMFAAAALVIFSLIGGVLYAVVKNELLRHERDGLVTTFNDIEYMVSRVGT 60 ++ SI RLV MFAAAAL F+LIG L+ V+ EL RH+ + L TT ++Y + +GT Sbjct: 4 VKGSITVRLVAMFAAAALATFALIGAALHGVLVRELERHQYEELDTTLKSLQYWIGAIGT 63 Query: 61 VERWARVQTKLDTLTPADGKVRFWVFSDDPQFSYGKDLAELHDFDYDPNNIGR---LRIK 117 +RW+RVQT++D LTP DG VRFWV SDDP+F YGK LAEL + N GR + + Sbjct: 64 ADRWSRVQTRMDALTPEDGSVRFWVLSDDPRFQYGKGLAELDGLTREAN--GRSSSILLP 121 Query: 118 GKEFPMHTLTKVLPAYLDRPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGY 177 G+E P TL+ +P + RPA+RL +G ++EPY T +TF+ A++ L L G+ +V+L GY Sbjct: 122 GQERPFRTLSVHIPPFEGRPAVRLIVGRNSEPYERTRKTFLSALLMLGLGGVLVVVLAGY 181 Query: 178 WIARAGLQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLE 237 WIAR GL+PL+++S +AQ L P+TLS+RL +ALP ELS LA+AFNGAL R+E AY QLE Sbjct: 182 WIARVGLRPLERLSGEAQALRPKTLSQRLQTTALPVELSALAEAFNGALSRLEEAYGQLE 241 Query: 238 AFNADVAHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLAR 297 AFNADVAHELRTPLANLIG TQVALSR+RSA +FE VLQ+NLE+L+RLRSI+NDMLFLAR Sbjct: 242 AFNADVAHELRTPLANLIGSTQVALSRQRSAGDFEEVLQANLEDLERLRSIVNDMLFLAR 301 Query: 298 CDQGEAATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTN 357 D+GE AT LV T +A EV+KTI+FFEFVLDE + V + GDV A++ +E+ALFRRA++N Sbjct: 302 ADRGEVATGLVLTPVALEVRKTIDFFEFVLDESRTQVGIAGDVQAEARLESALFRRAMSN 361 Query: 358 LLQNAIQHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRD-F 416 LLQNAI+HS GA+ITV++ +AVSNPG I++ HL LFDRFYRVD+AR D Sbjct: 362 LLQNAIEHSTPGAQITVTLREGPAATWIAVSNPGAAIDEAHLQHLFDRFYRVDAARNDGG 421 Query: 417 DGVHGHGLGLAIVKAIALMHGGTAFASSRGGKTTIGFTV 455 HGHGLGLAIVKA+A MHGG ASS GG T F+V Sbjct: 422 GEHHGHGLGLAIVKAVASMHGGQVSASSEGGVNTFAFSV 460 >Q1IEQ7.1 Q1IEQ7_PSEE4 Putative heavy metal sensor histidine kinase Length = 471 Score = 434 bits (1115), Expect = e-119, Method: Compositional matrix adjust. Identities = 224/453 (49%), Positives = 293/453 (64%), Gaps = 3/453 (0%) Query: 3 HSIIARLVMMFAAAALVIFSLIGGVLYAVVKNELLRHERDGLVTTFNDIEYMVSRVGTVE 62 +SI RL +F AL +F LIG LY V L L F+ +E ++R GT E Sbjct: 10 NSIALRLSALFTLVALAVFVLIGSALYRQVDRSLDLLPAAELDARFSVLESTLNRFGTPE 69 Query: 63 RWARVQTKLDTLTPADGKVRFWVFSDDPQFSYGKDLAELHDFDYDPNNIGRLRIKGKEFP 122 WA+V KL+ L+ D ++RFWV S DP F YG ++ F + LR+ +P Sbjct: 70 HWAKVNNKLNLLSEEDRRIRFWVVSSDPAFEYGHPTEQVRAFAEGAPGMRDLRLASSPYP 129 Query: 123 MHTLTKVLPAYLDRPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGYWIARA 182 L LPA +RP +R IG+DTE +++ + ++A++GL+ G+ L L GYW+AR Sbjct: 130 YKVLVSELPALGERPPLRFLIGIDTETFWQAQHSLLVAIVGLAAFGVLLASLLGYWVARI 189 Query: 183 GLQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLEAFNAD 242 GL+PL+ +SD+AQ L+P L RL LP EL+ A AFN ALDR+ AY QLEAFNAD Sbjct: 190 GLKPLQALSDEAQALAPPRLDGRLPTRDLPPELAQFAGAFNAALDRVTQAYSQLEAFNAD 249 Query: 243 VAHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLARCDQGE 302 VAHELR+PL NLIG+TQVAL+R RSA + VLQSNLEEL+RLRSIINDMLFLA DQG Sbjct: 250 VAHELRSPLTNLIGQTQVALTRGRSAEHYFEVLQSNLEELERLRSIINDMLFLASADQGS 309 Query: 303 AATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTNLLQNA 362 ATSL ++A+EV T+++ +++L++ Q+SV V G DA++ E A RRAL NLL NA Sbjct: 310 KATSLTSASLAEEVATTLDYLDYILEDAQVSVSVSG--DAQACFEKAQLRRALINLLNNA 367 Query: 363 IQHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRDFDGVHGH 422 +QH+ I V I+A ++ V +AVSNPG I + HLP LF+RFYRVD+AR + G H Sbjct: 368 VQHTAPHQVIQVRIEAGEEQVSIAVSNPGPAIAEEHLPMLFERFYRVDAARSN-SGGGNH 426 Query: 423 GLGLAIVKAIALMHGGTAFASSRGGKTTIGFTV 455 GLGLAIVKAIA+MHGGT F S G T G + Sbjct: 427 GLGLAIVKAIAVMHGGTVFVRSEAGANTFGINL 459 >F2K594.1 F2K594_PSEBR Putative two-component system, sensor kinase Length = 455 Score = 429 bits (1103), Expect = e-118, Method: Compositional matrix adjust. Identities = 223/450 (49%), Positives = 289/450 (64%), Gaps = 4/450 (0%) Query: 4 SIIARLVMMFAAAALVIFSLIGGVLYAVVKNELLRHERDGLVTTFNDIEYMVSRVGTVER 63 SI RL MF A ++F LIGG LY V L L ++ +E V R GT E Sbjct: 6 SIALRLSGMFTLVAALVFLLIGGALYQQVAKGLGLLPEAELDARYSVLESTVGRYGTPEH 65 Query: 64 WARVQTKLDTLTPADGKVRFWVFSDDPQFSYGKDLAELHDFDYDPNNIGRLRIKGKEFPM 123 W ++ KL L D ++ FW+ SDDP+F YG A++ F L + + +PM Sbjct: 66 WVKINNKLRLLGEEDKRIHFWIVSDDPRFEYGNPDAQIRAFAQGALGKRDLTLPQRHYPM 125 Query: 124 HTLTKVLPAYLDRPAIRLTIGVDTEPYFETLRTFVIAMIGLSLAGIFLVILFGYWIARAG 183 L PA RP +R IG+DTE +++T ++A++ L++ G+FL L GYW+AR G Sbjct: 126 KVLVSQFPAKDQRPPLRFMIGIDTETFYQTQHRLLVALVSLAIVGVFLASLLGYWVARIG 185 Query: 184 LQPLKKMSDKAQTLSPQTLSERLTVSALPDELSDLAQAFNGALDRMENAYKQLEAFNADV 243 L+PL K+SD+A+ L+P LS RL +S LP ELS +FN LDR+E AY +LE+FNADV Sbjct: 186 LKPLIKLSDEARRLAPPRLSGRLQLSPLPPELSQFVSSFNATLDRVEQAYSRLESFNADV 245 Query: 244 AHELRTPLANLIGETQVALSRERSAPEFEIVLQSNLEELDRLRSIINDMLFLARCDQGEA 303 AHELR+PL NLIG+TQVAL+R RSA + VLQSNLEEL+RLRSIINDMLFLA DQG Sbjct: 246 AHELRSPLTNLIGQTQVALTRGRSAEHYFEVLQSNLEELERLRSIINDMLFLASADQGSK 305 Query: 304 ATSLVYTAIADEVQKTIEFFEFVLDEMQMSVEVVGDVDAKSMIETALFRRALTNLLQNAI 363 AT L T++A EV T+++ +F+L++ Q+ V V G DA++ IE A RRAL NLL NA+ Sbjct: 306 ATKLTSTSLASEVATTLDYLDFILEDAQVQVRVSG--DAQANIEIAHLRRALINLLSNAV 363 Query: 364 QHSPAGARITVSIDAQQQDVQVAVSNPGEPIEQRHLPRLFDRFYRVDSARRDFDGVHGHG 423 QH+ G I V I+A + +AV+NPGEPI HLPRLF+RFYRVD++R + HG Sbjct: 364 QHTAPGQVIDVRIEALGDQITLAVTNPGEPIAGEHLPRLFERFYRVDASRSNSGA--NHG 421 Query: 424 LGLAIVKAIALMHGGTAFASSRGGKTTIGF 453 LGLAIVKAIALMHGG F S G T G Sbjct: 422 LGLAIVKAIALMHGGDVFVRSDQGANTFGI 451