BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0056.p (352 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZA6.1 D8IZA6_HERSS 4-hydroxythreonine-4-phosphate dehydrogena... 544 e-153 A4G255.1 PDXA_HERAR 4-hydroxythreonine-4-phosphate dehydrogenase... 511 e-143 F1VWK9.1 F1VWK9_9BURK 4-hydroxythreonine-4-phosphate dehydrogenase 497 e-138 A6SV12.1 PDXA_JANMA 4-hydroxythreonine-4-phosphate dehydrogenase... 489 e-136 C3XBE4.1 C3XBE4_OXAFO 4-hydroxythreonine-4-phosphate dehydrogena... 438 e-121 >D8IZA6.1 D8IZA6_HERSS 4-hydroxythreonine-4-phosphate dehydrogenase EC=1.1.1.262 Length = 340 Score = 544 bits (1402), Expect = e-153, Method: Compositional matrix adjust. Identities = 270/336 (80%), Positives = 297/336 (88%) Query: 15 RPTLAITCGEPAGIGPEISVKAAWQLRAEVRSVLLGDAAFLAQTAQALDPAIALSALSLQ 74 RP LA+TCGEPAGIGPEIS++AAW+LR EVR +LLGDAA LAQ+A +D + ++A+S+Q Sbjct: 3 RPILALTCGEPAGIGPEISLRAAWELRHEVRCILLGDAALLAQSAYEIDAQMRVAAISIQ 62 Query: 75 AFRNSGLPNFPQDRLIVIDCPTSEPVVPGVLDARNGRAVLQTLDVAVEWALQGQFDAIVT 134 A+RNSGLP+FP D L VIDCP +EPV PGVLDARNGRAVLQTLD+AV+ AL G F AIVT Sbjct: 63 AWRNSGLPHFPTDCLTVIDCPVAEPVRPGVLDARNGRAVLQTLDLAVQGALSGAFAAIVT 122 Query: 135 APLQKSTINDAGVPFTGHTEYLAERTATPQVVMMLAGGDAPHLRVALATTHLALKDVSAA 194 APLQKSTINDAGV FTGHTEYLAE T TPQVVMMLAGG +PHLRVALATTHLALKDV AA Sbjct: 123 APLQKSTINDAGVAFTGHTEYLAEVTHTPQVVMMLAGGQSPHLRVALATTHLALKDVPAA 182 Query: 195 ITFDGLSRTLDIIHADLRDKFGIAQPRILVTGLNPHAGENGYLGREEIDVISPALAAAKA 254 IT D L+RTLDI+HADLR KFGIA+PRILVTGLNPHAGENGYLGREEI+VISPAL AA+A Sbjct: 183 ITADSLARTLDILHADLRSKFGIARPRILVTGLNPHAGENGYLGREEIEVISPALEAARA 242 Query: 255 RGIDVAGPYPADTLFQHKYLEHADCVLAMYHDQGLPVLKFASFGQGINITLGLPIIRTSV 314 RGID GPYPADTLFQ KYLE ADCVLAMYHDQGLPVLKFASFG GINITLGLP+IRTSV Sbjct: 243 RGIDARGPYPADTLFQPKYLEDADCVLAMYHDQGLPVLKFASFGHGINITLGLPLIRTSV 302 Query: 315 DHGTALDLAAQGLGRADHGSMIEAIRTAALMARAKN 350 DHGTALDLAA GLG ADHGSM+ A+R AA MAR + Sbjct: 303 DHGTALDLAAAGLGHADHGSMLVAVRAAADMARRQK 338 >A4G255.1 PDXA_HERAR 4-hydroxythreonine-4-phosphate dehydrogenase EC=1.1.1.262 Length = 344 Score = 511 bits (1315), Expect = e-143, Method: Compositional matrix adjust. Identities = 253/328 (77%), Positives = 288/328 (87%), Gaps = 1/328 (0%) Query: 14 RRPTLAITCGEPAGIGPEISVKAAWQLRAEVRSVLLGDAAFLAQTAQALDPAIALSALSL 73 +RPT+AITCGEPAGIGPEIS++AAW+LRA+V+S+L+GDAAFLA A A++P I LSALS Sbjct: 3 KRPTIAITCGEPAGIGPEISIRAAWELRADVKSILIGDAAFLAMIAGAINPDIHLSALSW 62 Query: 74 QAFRNSGLPNFPQDRLIVIDCPTSEPVVPGVLDARNGRAVLQTLDVAVEWALQGQFDAIV 133 QA RNSGLP FP+D++ VIDCP + VVPG LDA+NGR VLQTLD+A++ A+Q FDAIV Sbjct: 63 QAVRNSGLPAFPRDQITVIDCPLAAHVVPGRLDAQNGRYVLQTLDIAIDGAMQHWFDAIV 122 Query: 134 TAPLQKSTINDAGVPFTGHTEYLAERTATPQVVMMLAGGDAPH-LRVALATTHLALKDVS 192 TAPLQKSTINDAGVPFTGHTEYLA++TAT QVVMMLA LRVALATTHLALKDV+ Sbjct: 123 TAPLQKSTINDAGVPFTGHTEYLADKTATKQVVMMLATNATLQPLRVALATTHLALKDVA 182 Query: 193 AAITFDGLSRTLDIIHADLRDKFGIAQPRILVTGLNPHAGENGYLGREEIDVISPALAAA 252 AAITFD L+ +DI+HADL+ KFGIA+PRILVTGLNPHAGE GYLGREEIDVI+P L AA Sbjct: 183 AAITFDSLAGIIDILHADLQQKFGIAKPRILVTGLNPHAGEGGYLGREEIDVITPVLQAA 242 Query: 253 KARGIDVAGPYPADTLFQHKYLEHADCVLAMYHDQGLPVLKFASFGQGINITLGLPIIRT 312 +A+G DV GPYPADTLFQ K L ADCVLAMYHDQGLPVLK+ASFG G+NITLGLPIIRT Sbjct: 243 QAKGYDVRGPYPADTLFQQKLLAGADCVLAMYHDQGLPVLKYASFGLGVNITLGLPIIRT 302 Query: 313 SVDHGTALDLAAQGLGRADHGSMIEAIR 340 SVDHGTALDLAA GLG+ADHGSM+EAIR Sbjct: 303 SVDHGTALDLAAAGLGQADHGSMLEAIR 330 >F1VWK9.1 F1VWK9_9BURK 4-hydroxythreonine-4-phosphate dehydrogenase Length = 345 Score = 497 bits (1280), Expect = e-138, Method: Compositional matrix adjust. Identities = 244/332 (73%), Positives = 280/332 (84%) Query: 15 RPTLAITCGEPAGIGPEISVKAAWQLRAEVRSVLLGDAAFLAQTAQALDPAIALSALSLQ 74 RPT+AITCGEPAGIGPEI+++AAW+LR EV VL+GDA FLA A+ +DP+I+L+A+S+Q Sbjct: 10 RPTIAITCGEPAGIGPEIALRAAWELRDEVNCVLIGDAPFLAILAEQIDPSISLAAISVQ 69 Query: 75 AFRNSGLPNFPQDRLIVIDCPTSEPVVPGVLDARNGRAVLQTLDVAVEWALQGQFDAIVT 134 RN GLP FP RL+V+D P + V+PG LD RNGR+VLQ LD+A+E L G F A+VT Sbjct: 70 GVRNDGLPRFPPHRLVVLDSPLAAHVIPGQLDKRNGRSVLQMLDMAIEGTLAGWFAAMVT 129 Query: 135 APLQKSTINDAGVPFTGHTEYLAERTATPQVVMMLAGGDAPHLRVALATTHLALKDVSAA 194 APLQKSTINDAGVPFTGHTEYLAE+T TP VVMMLA LRVALAT HLALK+V AA Sbjct: 130 APLQKSTINDAGVPFTGHTEYLAEKTGTPHVVMMLAASGEHPLRVALATIHLALKEVPAA 189 Query: 195 ITFDGLSRTLDIIHADLRDKFGIAQPRILVTGLNPHAGENGYLGREEIDVISPALAAAKA 254 ITFD L RTLDI+ +L+++FG+A+PRILV GLNPHAGE GYLG EEID+I PAL AA+A Sbjct: 190 ITFDSLGRTLDILQRELQERFGLAKPRILVAGLNPHAGEGGYLGHEEIDIIIPALQAARA 249 Query: 255 RGIDVAGPYPADTLFQHKYLEHADCVLAMYHDQGLPVLKFASFGQGINITLGLPIIRTSV 314 RGI VAGPYPADTLFQ KYL+ ADCVLAMYHDQGLPVLKFASFG GINITLGLP+IRTSV Sbjct: 250 RGISVAGPYPADTLFQPKYLKDADCVLAMYHDQGLPVLKFASFGHGINITLGLPLIRTSV 309 Query: 315 DHGTALDLAAQGLGRADHGSMIEAIRTAALMA 346 DHGTALDLAA G+G ADHGSM+EAIRTA MA Sbjct: 310 DHGTALDLAALGVGHADHGSMVEAIRTAVQMA 341 >A6SV12.1 PDXA_JANMA 4-hydroxythreonine-4-phosphate dehydrogenase EC=1.1.1.262 Length = 343 Score = 489 bits (1260), Expect = e-136, Method: Compositional matrix adjust. Identities = 248/325 (76%), Positives = 285/325 (87%), Gaps = 1/325 (0%) Query: 14 RRPTLAITCGEPAGIGPEISVKAAWQLRAEVRSVLLGDAAFLAQTAQALDPAIALSALSL 73 +RPT+AIT GEPAGIGPEIS++AAW+LRA+V+S+L+GDAAFLA TA A++PAI LSALSL Sbjct: 3 KRPTIAITSGEPAGIGPEISIRAAWELRADVKSILIGDAAFLAMTAAAINPAIRLSALSL 62 Query: 74 QAFRNSGLPNFPQDRLIVIDCPTSEPVVPGVLDARNGRAVLQTLDVAVEWALQGQFDAIV 133 QA RNSG+P+F +D++ VIDCP + VVPG LDA+NGR VLQTLD+ +E A QG FDAIV Sbjct: 63 QAVRNSGVPDFSRDQIAVIDCPLAAHVVPGKLDAQNGRYVLQTLDIGIEGAQQGWFDAIV 122 Query: 134 TAPLQKSTINDAGVPFTGHTEYLAERTATPQVVMMLAGGDAPH-LRVALATTHLALKDVS 192 TAPLQKSTINDAGVPFTGHTEYLA++T T QVVMMLA P LRV LATTHLALKDV+ Sbjct: 123 TAPLQKSTINDAGVPFTGHTEYLADKTNTAQVVMMLATNATPQPLRVGLATTHLALKDVA 182 Query: 193 AAITFDGLSRTLDIIHADLRDKFGIAQPRILVTGLNPHAGENGYLGREEIDVISPALAAA 252 AAIT D L+ LDI+ ADL++KFGIA+PRILV GLNPHAGE GYLGREEI+VI+P L AA Sbjct: 183 AAITIDSLAGILDILLADLQNKFGIAKPRILVAGLNPHAGEGGYLGREEIEVITPVLQAA 242 Query: 253 KARGIDVAGPYPADTLFQHKYLEHADCVLAMYHDQGLPVLKFASFGQGINITLGLPIIRT 312 +A+G DV GPYPADTLFQ KYLE ADCVLAMYHDQGLPVLK+ASFG G+NITLGLP+IRT Sbjct: 243 QAKGFDVRGPYPADTLFQQKYLEDADCVLAMYHDQGLPVLKYASFGLGVNITLGLPLIRT 302 Query: 313 SVDHGTALDLAAQGLGRADHGSMIE 337 SVDHGTALDLAA GLG+ADHGSM+E Sbjct: 303 SVDHGTALDLAAAGLGQADHGSMLE 327 >C3XBE4.1 C3XBE4_OXAFO 4-hydroxythreonine-4-phosphate dehydrogenase EC=1.1.1.262 Length = 351 Score = 438 bits (1127), Expect = e-121, Method: Compositional matrix adjust. Identities = 222/342 (64%), Positives = 262/342 (76%), Gaps = 11/342 (3%) Query: 14 RRPTLAITCGEPAGIGPEISVKAAWQLRAEVRSVLLGDAAFLAQTAQALDPAIALSALS- 72 R P +AIT GEPAGIGPEIS++ AW+ R V VL+GD A+L + AQ +DP I L + Sbjct: 3 RTPVIAITTGEPAGIGPEISIRGAWECRKTVLPVLIGDYAYLEELAQKIDPVIVLKRIDR 62 Query: 73 LQAFRNSGLPNFPQDRLIVIDCPTSEPVVPGVLDARNGRAVLQTLDVAVEWALQGQFDAI 132 + A R +F D + V+DCP + V PG L+ NG VL +LD+A+E AL+ FDAI Sbjct: 63 IHAERLESSHHF--DGIYVVDCPLEQTVTPGKLNPANGITVLNSLDIAIEGALKRNFDAI 120 Query: 133 VTAPLQKSTINDAGVPFTGHTEYLAERTATPQVVMMLAGGDAPH--------LRVALATT 184 VTAP+QKSTINDAG+PFTGHTEYLAE+TAT QVVMMLAG P LRVALATT Sbjct: 121 VTAPVQKSTINDAGIPFTGHTEYLAEKTATRQVVMMLAGPTKPMGNDIPGFALRVALATT 180 Query: 185 HLALKDVSAAITFDGLSRTLDIIHADLRDKFGIAQPRILVTGLNPHAGENGYLGREEIDV 244 HL +K+VS AIT L L II DL++KFGIA P+ILVTGLNPHAGENGYLG EEIDV Sbjct: 181 HLPIKNVSGAITIGSLMEILSIIDNDLKNKFGIASPKILVTGLNPHAGENGYLGMEEIDV 240 Query: 245 ISPALAAAKARGIDVAGPYPADTLFQHKYLEHADCVLAMYHDQGLPVLKFASFGQGINIT 304 ISPAL A+ GI GP+PADTLFQ ++L++ADC+LAMYHDQGLPVLK+A+FGQG+NIT Sbjct: 241 ISPALEKARKAGIHACGPFPADTLFQPRFLQNADCILAMYHDQGLPVLKYATFGQGVNIT 300 Query: 305 LGLPIIRTSVDHGTALDLAAQGLGRADHGSMIEAIRTAALMA 346 LGLP+IRTSVDHGTALD+A +GLG ADHGSMIEAI TAALMA Sbjct: 301 LGLPLIRTSVDHGTALDIAEKGLGLADHGSMIEAINTAALMA 342