BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0009.0007.p (1000 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J017.1 D8J017_HERSS Diguanylate cyclase/phosphodiesterase A pr... 1388 0.0 D0J3M4.1 D0J3M4_COMT2 Diguanylate cyclase/phosphodiesterase 939 0.0 D8DBJ0.1 D8DBJ0_COMTE Diguanylate cyclase/phosphodiesterase 936 0.0 B7WZH4.1 B7WZH4_COMTE Diguanylate cyclase/phosphodiesterase with... 925 0.0 D4X6Y3.1 D4X6Y3_9BURK Diguanylate cyclase/phosphodiesterase with... 896 0.0 >D8J017.1 D8J017_HERSS Diguanylate cyclase/phosphodiesterase A protein Length = 1002 Score = 1388 bits (3593), Expect = 0.0, Method: Compositional matrix adjust. Identities = 650/973 (66%), Positives = 789/973 (81%) Query: 22 ELQQCRSSLEEKEALLAAFSRSMAILELAPDGTILSANDNFLTLMAYRHSDIVGHHHRML 81 E+ R S E++ALLAA RSMAILE + DGT+L AN+NFL ++ YR +D+VG HHRML Sbjct: 10 EVDHQRLSGSERDALLAALWRSMAILEFSADGTVLEANENFLAMLGYRRADVVGQHHRML 69 Query: 82 CNPTHAGSPEYAEFWRRLHQGEVVSGTLQRMRSDGSRLWLEATCNPVFDAEGRLLRVVSI 141 C+P + + Y +FW L +GE+++GTLQR G+ +WLEA C+P+ DA+G+LL+V+S+ Sbjct: 70 CDPAYVQTDAYQQFWEHLRKGELIAGTLQRRHVGGATVWLEALCSPILDAQGQLLKVISV 129 Query: 142 AADITAHIDDSQEKHSVLRALNRSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHR 201 AADI+AHIDDS+ +S+L ALNRSLGV+E S +G+I+ ANGNYLKTM YL E+++G+ H Sbjct: 130 AADISAHIDDSRHSNSILSALNRSLGVVELSPEGVILAANGNYLKTMEYLAEDLLGQPHS 189 Query: 202 FLCEPDYVDSQEYENFWRDVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKII 261 LCE DY S+EY FWRDV+ GRFFSGRF R R GR +WWEATY+P+ D G+ ++I Sbjct: 190 ILCEADYAASEEYTCFWRDVSLGRFFSGRFPRRTRSGRTIWWEATYSPLLDAHGKAERVI 249 Query: 262 SIGSDVSYRMVREQRDREYQHLLSLGINETDNAVFITNDANHIVFHNTGFSRMLGFTAEE 321 IG+DV+YR+ RE+ DRE+ HLLSLGINETDNAV IT+D N IVFHNTGF+RMLGF +++ Sbjct: 250 CIGTDVTYRVTREKSDREHLHLLSLGINETDNAVLITDDQNRIVFHNTGFTRMLGFESQQ 309 Query: 322 VIGRRPRELFEGQTAILKLIEDCYAVIAEGRSFHGEEMMVDKQGHPLWVSTVVNPILDGD 381 VIGR P ELF + +K +E C+ + +GRS+H EE++ D Q P+W+S VVNPILDG Sbjct: 310 VIGRLPGELFASRPTFVKSLERCHGELVQGRSYHTEELIHDMQEQPVWISAVVNPILDGA 369 Query: 382 GKLINAVCILTDITNTKMHEVLQYKTLNAMVREASLQEVLTMVCVELERIAPDIVASILR 441 GKLI+AVC++TDITNTK+HEVLQY+ LNAM R++SL E + ++C E+ER+AP+++AS+LR Sbjct: 370 GKLIHAVCVMTDITNTKVHEVLQYRVLNAMARDSSLSEQMNLLCEEVERVAPEVIASVLR 429 Query: 442 VDENGLLHPVAGPSLPDAYNRAIEGVAIGPCVGSCGTAAFRAEPVEVVDIATDPLWSDYR 501 VDE+G L +A PSLP+AY++AI+G+ +GP VG CG+AA+ + V DI TDP W+DY+ Sbjct: 430 VDEHGCLRTLAAPSLPEAYSKAIDGLHVGPMVGCCGSAAYTGQTVISEDIQTDPHWNDYK 489 Query: 502 DLLLPTGLESCWSTPIKSADGRVIGTFAFYYHGKRRPDPFHHRLVDVSLHLCALALEREE 561 L LP GL +CWSTPIKSA G+VIGTF FYY +P FHH LV+ LHLCALA+ERE+ Sbjct: 490 HLALPHGLRACWSTPIKSASGQVIGTFGFYYRHPGQPSAFHHLLVEAGLHLCALAIERED 549 Query: 562 ARSRIHRLAFYDSLTGLPNRSLLLVSANQAIANAARTQIPLAVLFIDLDRFKQINDSLGH 621 AR+RIH+LAFYDSLTGLPNRSLLLV A QAIA A R +AV+FIDLDRFKQ+NDSLGH Sbjct: 550 ARARIHQLAFYDSLTGLPNRSLLLVQAGQAIAAAERNCSTVAVMFIDLDRFKQVNDSLGH 609 Query: 622 QAGDELLCTVASRLQTEARKSDIVGRLSGDEFVIVLAQCDLNRVTDVVKRIQTSLSMPCH 681 QAGDELL TVA+RLQ++AR+SDIVGRLSGDEFV+VL Q D +T+VVKRIQ L+MPCH Sbjct: 610 QAGDELLRTVATRLQSQARRSDIVGRLSGDEFVVVLTQYDTQHLTEVVKRIQERLAMPCH 669 Query: 682 IAGVTLTPSASIGISLFPDNGETIEILLHRADMAMYQTKANNRDRFSFFSDEMNTQAQER 741 I G L PSASIG+++FPDNG IE LLHRAD+AMYQ KA NR RFSFFS+EMN+ AQER Sbjct: 670 INGTPLNPSASIGVAIFPDNGNDIETLLHRADIAMYQAKAVNRGRFSFFSEEMNSMAQER 729 Query: 742 LALEGALRDALRGGDFELHYQPQINFHTGLLHGVEALARWHHDQLGQISPARFIPIAEEC 801 LALE ALRDALRGGD EL++QPQI H LHGVEALARWHH QLGQISP RFIPIAEEC Sbjct: 730 LALESALRDALRGGDLELNFQPQIKLHDQSLHGVEALARWHHPQLGQISPGRFIPIAEEC 789 Query: 802 GLIGELGKWALEEACFQLHDWRRRGINVPSVSVNLSSTNFHDLELPQFIAGLLQRFALAP 861 GLIGELGKWALEEACFQL DWRRRGI VPS+SVNLS+TNFHDL+LPQF+ GLL+R+AL P Sbjct: 790 GLIGELGKWALEEACFQLSDWRRRGIQVPSISVNLSATNFHDLDLPQFVTGLLRRYALEP 849 Query: 862 GDLTLEITETVMMDTNPSTTRTIREVHAQGVKLAMDDFGTGYSSLGYLRNLPVCELKLDQ 921 DLTLEITETV+MDTNPST++TI VHA G+ LAMDDFGTGYSSLGYLR LPV ELKLDQ Sbjct: 850 SDLTLEITETVLMDTNPSTSQTIAAVHALGIPLAMDDFGTGYSSLGYLRKLPVSELKLDQ 909 Query: 922 SFVRDMDRDQTVLALTNAVIRIGESLDLIVVAEGVEDKRQYDLLKQQGCDVAQGYLFSRP 981 SFVRDM +D V ALTNAVIRIGESL L VVAEGVED QY LL QGCDVAQGYLFSRP Sbjct: 910 SFVRDMAKDPAVSALTNAVIRIGESLKLTVVAEGVEDAEQYALLISQGCDVAQGYLFSRP 969 Query: 982 MLATVFEHWLKNF 994 M A E+W+++ Sbjct: 970 MSADALENWVRDL 982 >D0J3M4.1 D0J3M4_COMT2 Diguanylate cyclase/phosphodiesterase Length = 868 Score = 939 bits (2426), Expect = 0.0, Method: Compositional matrix adjust. Identities = 469/835 (56%), Positives = 590/835 (70%), Gaps = 3/835 (0%) Query: 159 LRALNRSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHRFLCEPDYVDSQEYENFW 218 L+AL+R + + EF DG + AN NYL+ MG+ E+ +G+ HR C DS Y W Sbjct: 18 LQALDRVMAMAEFGLDGALHRANDNYLQLMGFTREQSLGRPHRSFCSARLADSARYREIW 77 Query: 219 RDVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISIGSDVSYRMVREQRDR 278 + G +SG +R+ DG W EATY+PV D +G + I+ I +DV+ R REQ + Sbjct: 78 THLCAGNAYSGVVERLRSDGSSCWLEATYSPVMDAQGRVMHILKIATDVTQRRAREQAQQ 137 Query: 279 EYQHLLSLGINETDNAVFITNDANHIVFHNTGFSRMLGFTAEEVIGRRPRELFEGQTAIL 338 E+ LSL + +D AV I++ ++ IV N GF+RM G+ EEV GR P L Q A Sbjct: 138 EHLRRLSLVADASDTAVVISDGSSRIVHVNGGFTRMFGWRTEEVAGRMPIALLAPQ-ASE 196 Query: 339 KLIEDCYAVIAEGRSFHGEEMMVDKQGHPLWVSTVVNPILDGDGKLINAVCILTDITNTK 398 ++ A + G+ EE++V K G W + NPILD DG+ V +LTDIT +K Sbjct: 197 AFVDHYRAELRAGQPVGREEIVVGKHGQRYWAKVISNPILDADGRWQYTVSMLTDITRSK 256 Query: 399 MHEVLQYKTLNAMVREASLQEVLTMVCVELERIAPDIVASILRVDENGLLHPVAGPSLPD 458 MHE LQ++ L AM RE L EVL MVC E+ERIAP++ ASIL VD GLLHP+AGPSLP Sbjct: 257 MHEALQHRVLEAMARERPLVEVLEMVCQEVERIAPEVTASILEVDAQGLLHPLAGPSLPH 316 Query: 459 AYNRAIEGVAIGPCVGSCGTAAFRAEPVEVVDIATDPLWSDYRDLLLPTGLESCWSTPIK 518 +Y+ ++GVAIGP VGSCGTAA+R PV V DIA DPLW+D++ L+LP G ++CWSTPI Sbjct: 317 SYSALLDGVAIGPNVGSCGTAAWRNAPVLVDDIAHDPLWTDFKHLILPLGFKACWSTPIC 376 Query: 519 SADGRVIGTFAFYYHGKRRPDP--FHHRLVDVSLHLCALALEREEARSRIHRLAFYDSLT 576 ++ G+ IGTFAFYY + D FH +LVD +HLCALALERE +R+RI +LAFYD LT Sbjct: 377 NSGGKPIGTFAFYYREQLTGDASAFHQQLVDACIHLCALALERELSRARIRQLAFYDGLT 436 Query: 577 GLPNRSLLLVSANQAIANAARTQIPLAVLFIDLDRFKQINDSLGHQAGDELLCTVASRLQ 636 GLPNRSLL A+QAIA+AA LAVLFIDLDRFKQ+NDSLGH GDELL VA+RLQ Sbjct: 437 GLPNRSLLQAKADQAIASAAGNDEQLAVLFIDLDRFKQVNDSLGHPVGDELLRNVATRLQ 496 Query: 637 TEARKSDIVGRLSGDEFVIVLAQCDLNRVTDVVKRIQTSLSMPCHIAGVTLTPSASIGIS 696 R SDI GRLSGDEFV VL QCD V + ++R+Q L+ P +IA +L+ SAS+GI+ Sbjct: 497 RVLRSSDIAGRLSGDEFVAVLPQCDAEHVANTIERLQELLAEPLNIADTSLSISASVGIA 556 Query: 697 LFPDNGETIEILLHRADMAMYQTKANNRDRFSFFSDEMNTQAQERLALEGALRDALRGGD 756 +FP +G +E L+HRADMAMYQ K+ R RF FFS EMN AQERLALE ALR AL+ G Sbjct: 557 MFPMDGRDMETLVHRADMAMYQAKSKGRGRFCFFSSEMNRLAQERLALETALRKALKSGG 616 Query: 757 FELHYQPQINFHTGLLHGVEALARWHHDQLGQISPARFIPIAEECGLIGELGKWALEEAC 816 LHYQPQI TG L+GVEALARW H +LG+ISPARFIP+AEECGLI +LG WALEEAC Sbjct: 617 LRLHYQPQIEMATGRLYGVEALARWTHAELGEISPARFIPLAEECGLIADLGSWALEEAC 676 Query: 817 FQLHDWRRRGINVPSVSVNLSSTNFHDLELPQFIAGLLQRFALAPGDLTLEITETVMMDT 876 QL WR +G+ VP+VSVNLS ++FH+L+LP+ IA L R L P DLTLE+TE++++DT Sbjct: 677 RQLSQWRAKGMEVPAVSVNLSPSSFHNLDLPRMIADTLDRNDLVPQDLTLELTESILLDT 736 Query: 877 NPSTTRTIREVHAQGVKLAMDDFGTGYSSLGYLRNLPVCELKLDQSFVRDMDRDQTVLAL 936 NPST +TI EVHA GV+L+MDDFGTGYSSL YLR LPV ELKLD+SFV D++ D+ AL Sbjct: 737 NPSTMKTINEVHAHGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLEHDEAARAL 796 Query: 937 TNAVIRIGESLDLIVVAEGVEDKRQYDLLKQQGCDVAQGYLFSRPMLATVFEHWL 991 ++A++ IG+SL L VVAEGVE Q +L +QG VAQG+LF+RP+ FEHWL Sbjct: 797 SSAILGIGKSLHLTVVAEGVETPTQSVMLCEQGYPVAQGFLFARPLAPKEFEHWL 851 Score = 127 bits (319), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 77/250 (30%), Positives = 121/250 (48%), Gaps = 8/250 (3%) Query: 31 EEKEALLAAFSRSMAILELAPDGTILSANDNFLTLMAYRHSDIVGHHHRMLCNPTHAGSP 90 E + A L A R MA+ E DG + ANDN+L LM + +G HR C+ A S Sbjct: 12 ELQLAQLQALDRVMAMAEFGLDGALHRANDNYLQLMGFTREQSLGRPHRSFCSARLADSA 71 Query: 91 EYAEFWRRLHQGEVVSGTLQRMRSDGSRLWLEATCNPVFDAEGRLLRVVSIAADITAHID 150 Y E W L G SG ++R+RSDGS WLEAT +PV DA+GR++ ++ IA D+T Sbjct: 72 RYREIWTHLCAGNAYSGVVERLRSDGSSCWLEATYSPVMDAQGRVMHILKIATDVTQRRA 131 Query: 151 DSQEKHSVLRALN-----RSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHRFLCE 205 Q + LR L+ V+ IV NG + + G+ EE+ G+ L Sbjct: 132 REQAQQEHLRRLSLVADASDTAVVISDGSSRIVHVNGGFTRMFGWRTEEVAGRMPIALLA 191 Query: 206 PDYVDSQEYENFWR-DVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISIG 264 P S+ + + +R ++ G+ + + G+ W + P+ D +G +S+ Sbjct: 192 PQA--SEAFVDHYRAELRAGQPVGREEIVVGKHGQRYWAKVISNPILDADGRWQYTVSML 249 Query: 265 SDVSYRMVRE 274 +D++ + E Sbjct: 250 TDITRSKMHE 259 >D8DBJ0.1 D8DBJ0_COMTE Diguanylate cyclase/phosphodiesterase Length = 860 Score = 936 bits (2419), Expect = 0.0, Method: Compositional matrix adjust. Identities = 469/835 (56%), Positives = 589/835 (70%), Gaps = 3/835 (0%) Query: 159 LRALNRSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHRFLCEPDYVDSQEYENFW 218 L+AL+R + + EF DG + AN NYL+ MG+ E+ +G+ HR C DS Y W Sbjct: 10 LQALDRVMAMAEFGLDGSLHRANDNYLQLMGFTREQSLGRPHRSFCSARLADSARYREIW 69 Query: 219 RDVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISIGSDVSYRMVREQRDR 278 + G +SG +R+ DG W EATY+PV D +G I I+ I +DV+ R REQ + Sbjct: 70 THLCAGNAYSGVVERLRSDGSSCWLEATYSPVMDAQGRVIHILKIATDVTQRRAREQAQQ 129 Query: 279 EYQHLLSLGINETDNAVFITNDANHIVFHNTGFSRMLGFTAEEVIGRRPRELFEGQTAIL 338 E+ LSL + +D AV I++ ++ IV N GF+RM G+ EEV G P L Q A Sbjct: 130 EHLRRLSLVADASDTAVVISDGSSRIVHVNGGFTRMFGWRTEEVAGLMPIALLAPQ-ASE 188 Query: 339 KLIEDCYAVIAEGRSFHGEEMMVDKQGHPLWVSTVVNPILDGDGKLINAVCILTDITNTK 398 ++ A + G+ EE++V K G W + NPILD DG+ V +LTDIT +K Sbjct: 189 AFVDHYRAELRAGQPVGREEIVVGKHGQRYWAKVISNPILDADGRWQYTVSMLTDITRSK 248 Query: 399 MHEVLQYKTLNAMVREASLQEVLTMVCVELERIAPDIVASILRVDENGLLHPVAGPSLPD 458 MHE LQ++ L AM RE L EVL MVC E+ERIAP++ ASIL VD GLLHP+AGPSLP Sbjct: 249 MHEALQHRVLEAMARERPLVEVLEMVCQEVERIAPEVTASILEVDAQGLLHPLAGPSLPH 308 Query: 459 AYNRAIEGVAIGPCVGSCGTAAFRAEPVEVVDIATDPLWSDYRDLLLPTGLESCWSTPIK 518 +Y+ ++GVAIGP VGSCGTAA+R PV V DIA DPLW+D++ L+LP G ++CWSTPI Sbjct: 309 SYSALLDGVAIGPNVGSCGTAAWRNAPVLVDDIAHDPLWTDFKHLILPLGFKACWSTPIC 368 Query: 519 SADGRVIGTFAFYYHGKRRPDP--FHHRLVDVSLHLCALALEREEARSRIHRLAFYDSLT 576 ++ G+ IGTFAFYY + D FH +LVD +HLCALALERE +R+RI +LAFYD LT Sbjct: 369 NSGGKPIGTFAFYYREQLTGDASAFHQQLVDACIHLCALALERELSRARIRQLAFYDGLT 428 Query: 577 GLPNRSLLLVSANQAIANAARTQIPLAVLFIDLDRFKQINDSLGHQAGDELLCTVASRLQ 636 GLPNRSLL A+QAIA+AA LAVLFIDLDRFKQ+NDSLGH GDELL VA+RLQ Sbjct: 429 GLPNRSLLQAKADQAIASAAGNDEQLAVLFIDLDRFKQVNDSLGHPVGDELLRNVATRLQ 488 Query: 637 TEARKSDIVGRLSGDEFVIVLAQCDLNRVTDVVKRIQTSLSMPCHIAGVTLTPSASIGIS 696 R SDI GRLSGDEFV VL QCD V + ++R+Q L+ P +IA +L+ SAS+GI+ Sbjct: 489 RVLRSSDIAGRLSGDEFVAVLPQCDAEHVANTIERLQELLAEPLNIADTSLSISASVGIA 548 Query: 697 LFPDNGETIEILLHRADMAMYQTKANNRDRFSFFSDEMNTQAQERLALEGALRDALRGGD 756 +FP +G +E L+HRADMAMYQ K+ R RF FFS EMN AQERLALE ALR AL+ G Sbjct: 549 MFPMDGRDMETLVHRADMAMYQAKSKGRGRFCFFSSEMNRLAQERLALETALRKALKSGG 608 Query: 757 FELHYQPQINFHTGLLHGVEALARWHHDQLGQISPARFIPIAEECGLIGELGKWALEEAC 816 LHYQPQI TG L+GVEALARW H +LG+ISPARFIP+AEECGLI +LG WALEEAC Sbjct: 609 LRLHYQPQIEMATGRLYGVEALARWTHAELGEISPARFIPLAEECGLIADLGSWALEEAC 668 Query: 817 FQLHDWRRRGINVPSVSVNLSSTNFHDLELPQFIAGLLQRFALAPGDLTLEITETVMMDT 876 QL WR +G+ VP+VSVNLS ++FH+L+LP+ IA L R L P DLTLE+TE++++DT Sbjct: 669 RQLSQWRAKGMEVPAVSVNLSPSSFHNLDLPRMIADTLDRNDLVPQDLTLELTESILLDT 728 Query: 877 NPSTTRTIREVHAQGVKLAMDDFGTGYSSLGYLRNLPVCELKLDQSFVRDMDRDQTVLAL 936 NPST +TI EVHA GV+L+MDDFGTGYSSL YLR LPV ELKLD+SFV D++ D+ AL Sbjct: 729 NPSTMKTINEVHAHGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLEHDEAARAL 788 Query: 937 TNAVIRIGESLDLIVVAEGVEDKRQYDLLKQQGCDVAQGYLFSRPMLATVFEHWL 991 ++A++ IG+SL L VVAEGVE Q +L +QG VAQG+LF+RP+ FEHWL Sbjct: 789 SSAILGIGKSLHLTVVAEGVETPTQSVMLCEQGYPVAQGFLFARPLTPKEFEHWL 843 Score = 125 bits (315), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 77/250 (30%), Positives = 121/250 (48%), Gaps = 8/250 (3%) Query: 31 EEKEALLAAFSRSMAILELAPDGTILSANDNFLTLMAYRHSDIVGHHHRMLCNPTHAGSP 90 E + A L A R MA+ E DG++ ANDN+L LM + +G HR C+ A S Sbjct: 4 ELQLAQLQALDRVMAMAEFGLDGSLHRANDNYLQLMGFTREQSLGRPHRSFCSARLADSA 63 Query: 91 EYAEFWRRLHQGEVVSGTLQRMRSDGSRLWLEATCNPVFDAEGRLLRVVSIAADITAHID 150 Y E W L G SG ++R+RSDGS WLEAT +PV DA+GR++ ++ IA D+T Sbjct: 64 RYREIWTHLCAGNAYSGVVERLRSDGSSCWLEATYSPVMDAQGRVIHILKIATDVTQRRA 123 Query: 151 DSQEKHSVLRALN-----RSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHRFLCE 205 Q + LR L+ V+ IV NG + + G+ EE+ G L Sbjct: 124 REQAQQEHLRRLSLVADASDTAVVISDGSSRIVHVNGGFTRMFGWRTEEVAGLMPIALLA 183 Query: 206 PDYVDSQEYENFWR-DVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISIG 264 P S+ + + +R ++ G+ + + G+ W + P+ D +G +S+ Sbjct: 184 PQA--SEAFVDHYRAELRAGQPVGREEIVVGKHGQRYWAKVISNPILDADGRWQYTVSML 241 Query: 265 SDVSYRMVRE 274 +D++ + E Sbjct: 242 TDITRSKMHE 251 >B7WZH4.1 B7WZH4_COMTE Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) Length = 868 Score = 925 bits (2391), Expect = 0.0, Method: Compositional matrix adjust. Identities = 462/838 (55%), Positives = 584/838 (69%), Gaps = 9/838 (1%) Query: 159 LRALNRSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHRFLCEPDYVDSQEYENFW 218 L+AL+R + + EF DG++ AN NYL+ MG E+ +G+ HR C S Y W Sbjct: 18 LQALDRVMAMAEFGLDGVLCRANDNYLQLMGLTREQCLGRAHRSFCSAQLAGSARYREIW 77 Query: 219 RDVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISIGSDVSYRMVREQRDR 278 + G +SG +R+ DG W EATY+PV D +G I+ I +DV+ R EQ + Sbjct: 78 AHLCAGNAYSGVVERLRSDGSSCWLEATYSPVMDAQGRVAHILKIATDVTQRRALEQAQQ 137 Query: 279 EYQHLLSLGINETDNAVFITNDANHIVFHNTGFSRMLGFTAEEVIGRRPRELFEGQTAIL 338 E+ LSL + +D AV I++ + IV N GF+RM G+ EEV GR P L Q + Sbjct: 138 EHLRRLSLVADASDTAVVISDGNSRIVHVNGGFTRMFGWRTEEVAGRTPIALLAPQVSE- 196 Query: 339 KLIEDCYAVIAEGRSFHGEEMMVDKQGHPLWVSTVVNPILDGDGKLINAVCILTDITNTK 398 ++ + + G+ EE++V K G W + NPILD G V +LTDIT +K Sbjct: 197 TFVDRYRSDLRAGQPVGREEIVVGKHGQRYWAKVISNPILDAGGCWQYTVSMLTDITRSK 256 Query: 399 MHEVLQYKTLNAMVREASLQEVLTMVCVELERIAPDIVASILRVDENGLLHPVAGPSLPD 458 MHE LQ++ L AM RE L EVL MVC+E+ERIAP++ ASIL VD GLLHP+AGPSLP Sbjct: 257 MHEALQHRVLEAMARERPLVEVLEMVCLEVERIAPEVTASILEVDAQGLLHPLAGPSLPQ 316 Query: 459 AYNRAIEGVAIGPCVGSCGTAAFRAEPVEVVDIATDPLWSDYRDLLLPTGLESCWSTPIK 518 +Y+ ++G+A+GP VGSCGTAA+ PV+V DI DPLW+D+R L+LP G ++CWSTPI Sbjct: 317 SYSALLDGLAVGPKVGSCGTAAWLNAPVQVDDIGQDPLWADFRHLILPLGFKACWSTPIC 376 Query: 519 SADGRVIGTFAFYYHGKRRP-----DPFHHRLVDVSLHLCALALEREEARSRIHRLAFYD 573 +++G+ IGTFAFYY R P FH +LVD +HLCALALERE +R+RI +LAFYD Sbjct: 377 NSEGKPIGTFAFYY---REPLTGGASAFHQQLVDACIHLCALALERELSRARIRQLAFYD 433 Query: 574 SLTGLPNRSLLLVSANQAIANAARTQIPLAVLFIDLDRFKQINDSLGHQAGDELLCTVAS 633 LTGLPNRSLL A+QAIA+AA LAVLFIDLDRFKQ+NDSLGH GDELL +VA+ Sbjct: 434 GLTGLPNRSLLQAKADQAIASAATHDAQLAVLFIDLDRFKQVNDSLGHPVGDELLRSVAA 493 Query: 634 RLQTEARKSDIVGRLSGDEFVIVLAQCDLNRVTDVVKRIQTSLSMPCHIAGVTLTPSASI 693 RLQ R SDI GRLSGDEFV VL CD V + ++R+Q L+ P +IA +L SASI Sbjct: 494 RLQRVLRSSDIAGRLSGDEFVAVLPHCDAEYVANTIERLQELLAEPLNIADTSLAISASI 553 Query: 694 GISLFPDNGETIEILLHRADMAMYQTKANNRDRFSFFSDEMNTQAQERLALEGALRDALR 753 GI++FP +G +E L+HRADMAMYQ K+ R RF FFS EMN AQERLALE ALR AL+ Sbjct: 554 GIAMFPSDGRDMETLVHRADMAMYQAKSKGRGRFCFFSSEMNRLAQERLALETALRKALK 613 Query: 754 GGDFELHYQPQINFHTGLLHGVEALARWHHDQLGQISPARFIPIAEECGLIGELGKWALE 813 G LHYQPQI TG L+GVEALARW H +LG+ISPARFIP+AEECGLI +LG WALE Sbjct: 614 SGGLRLHYQPQIEMATGRLYGVEALARWSHAELGEISPARFIPLAEECGLIADLGSWALE 673 Query: 814 EACFQLHDWRRRGINVPSVSVNLSSTNFHDLELPQFIAGLLQRFALAPGDLTLEITETVM 873 EAC QL WR +G+ VP+VSVNLS ++FH+L+LP+ IA L R L P DLTLE+TE+++ Sbjct: 674 EACRQLSQWRAKGLEVPAVSVNLSPSSFHNLDLPRMIADTLDRNDLVPQDLTLELTESIL 733 Query: 874 MDTNPSTTRTIREVHAQGVKLAMDDFGTGYSSLGYLRNLPVCELKLDQSFVRDMDRDQTV 933 +DTNPST +TI EVHA GV+L+MDDFGTGYSSL YLR LPV ELKLD+SFV D++ D+ Sbjct: 734 LDTNPSTMKTINEVHAHGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLEHDEAA 793 Query: 934 LALTNAVIRIGESLDLIVVAEGVEDKRQYDLLKQQGCDVAQGYLFSRPMLATVFEHWL 991 AL++A++ IG+SL L VVAEGVE Q +L +QG VAQG+LF+RP+ FEHWL Sbjct: 794 RALSSAILGIGKSLHLTVVAEGVETPTQSVMLCEQGYPVAQGFLFARPLAPQEFEHWL 851 Score = 128 bits (321), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 79/251 (31%), Positives = 122/251 (48%), Gaps = 10/251 (3%) Query: 31 EEKEALLAAFSRSMAILELAPDGTILSANDNFLTLMAYRHSDIVGHHHRMLCNPTHAGSP 90 E + A L A R MA+ E DG + ANDN+L LM +G HR C+ AGS Sbjct: 12 ELQLARLQALDRVMAMAEFGLDGVLCRANDNYLQLMGLTREQCLGRAHRSFCSAQLAGSA 71 Query: 91 EYAEFWRRLHQGEVVSGTLQRMRSDGSRLWLEATCNPVFDAEGRLLRVVSIAADITAH-- 148 Y E W L G SG ++R+RSDGS WLEAT +PV DA+GR+ ++ IA D+T Sbjct: 72 RYREIWAHLCAGNAYSGVVERLRSDGSSCWLEATYSPVMDAQGRVAHILKIATDVTQRRA 131 Query: 149 IDDSQEKHSVLRALN-----RSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHRFL 203 ++ +Q++H LR L+ V+ + IV NG + + G+ EE+ G+ L Sbjct: 132 LEQAQQEH--LRRLSLVADASDTAVVISDGNSRIVHVNGGFTRMFGWRTEEVAGRTPIAL 189 Query: 204 CEPDYVDSQEYENFWRDVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISI 263 P V + + D+ G+ + + G+ W + P+ D G +S+ Sbjct: 190 LAPQ-VSETFVDRYRSDLRAGQPVGREEIVVGKHGQRYWAKVISNPILDAGGCWQYTVSM 248 Query: 264 GSDVSYRMVRE 274 +D++ + E Sbjct: 249 LTDITRSKMHE 259 >D4X6Y3.1 D4X6Y3_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor Length = 870 Score = 896 bits (2315), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/839 (54%), Positives = 576/839 (68%), Gaps = 10/839 (1%) Query: 159 LRALNRSLGVIEFSADGIIVGANGNYLKTMGYLPEEIVGKHHRFLCEPDYVDSQEY---- 214 L +++R+L + +F ADG ++ N N+L +GY EE + H LC D +D + Sbjct: 37 LASMDRALLLFDFDADGALLKVNANFLAAVGYTREEALSLRHDMLC--DSMDEGKGIASG 94 Query: 215 ENFWRDVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISIGSDVSYRMVRE 274 E W + +G FSG + +DG +W EATY P+ D +G+ IS S VS + + + Sbjct: 95 ERIWTRLRRGEHFSGTCRYRMKDGSSLWIEATYLPLGDKDGK----ISRVSVVSRKSIAD 150 Query: 275 QRDREYQHLLSLGINETDNAVFITNDANHIVFHNTGFSRMLGFTAEEVIGRRPRELFEGQ 334 +E LL LGINET NAV ++ IV+ N GF RMLGF + + + EL G Sbjct: 151 AERQEEVRLLLLGINETGNAVAVSGCDGRIVYVNDGFQRMLGFARGDALNQELGELLAGG 210 Query: 335 TAILKLIEDCYAVIAEGRSFHGEEMMVDKQGHPLWVSTVVNPILDGDGKLINAVCILTDI 394 E+ IA FH + ++ D+ G PLWVS + N + D G L+N V +LTDI Sbjct: 211 RPDGGTREELDRRIACREGFHKDVLVYDRYGKPLWVSVMANSVFDERGTLVNIVDVLTDI 270 Query: 395 TNTKMHEVLQYKTLNAMVREASLQEVLTMVCVELERIAPDIVASILRVDENGLLHPVAGP 454 T TK+HEVLQ + L AMV EAS+ EV+ MVC E+ER+AP++ AS+LRVD++G L P+A P Sbjct: 271 TPTKVHEVLQRRVLQAMVNEASVVEVMNMVCREVERLAPEVAASVLRVDDSGTLRPLAAP 330 Query: 455 SLPDAYNRAIEGVAIGPCVGSCGTAAFRAEPVEVVDIATDPLWSDYRDLLLPTGLESCWS 514 S+PDAY+ A+EG+ IGP VG+CGTAAF PV V DIATDPLW DYR L LP +++CWS Sbjct: 331 SMPDAYSEALEGMKIGPNVGACGTAAFLGRPVIVPDIATDPLWDDYRHLPLPEDIKACWS 390 Query: 515 TPIKSADGRVIGTFAFYYHGKRRPDPFHHRLVDVSLHLCALALEREEARSRIHRLAFYDS 574 +PIKS+DGRVIGTF FY+ +R PD FHHRLVDV ++LCALALEREEAR+RI +LAFYD Sbjct: 391 SPIKSSDGRVIGTFGFYFRERRLPDDFHHRLVDVCVYLCALALEREEARARIRQLAFYDE 450 Query: 575 LTGLPNRSLLLVSANQAIANAARTQIPLAVLFIDLDRFKQINDSLGHQAGDELLCTVASR 634 LTGLPNR+LLL A Q+IA A + +AVLF+DLDRFKQ+ND+LGH GD LL VA R Sbjct: 451 LTGLPNRNLLLAQAEQSIARAEPERKRVAVLFLDLDRFKQVNDTLGHPIGDALLRDVAQR 510 Query: 635 LQTEARKSDIVGRLSGDEFVIVLAQCDLNRVTDVVKRIQTSLSMPCHIAGVTLTPSASIG 694 L AR +DIVGRLSGDEFV+++ + R+T + I +L+ P + GVTL PS SIG Sbjct: 511 LCRLARATDIVGRLSGDEFVMLMPDFEHGRLTAAAEHILVALAQPFSVGGVTLNPSVSIG 570 Query: 695 ISLFPDNGETIEILLHRADMAMYQTKANNRDRFSFFSDEMNTQAQERLALEGALRDALRG 754 IS+FP+NG ++ LL ADMAMYQ K R+R SFFS EMN QAQERLALE ALRDAL Sbjct: 571 ISVFPENGRDMDTLLRHADMAMYQAKTAGRNRISFFSAEMNRQAQERLALEAALRDALEA 630 Query: 755 GDFELHYQPQINFHTGLLHGVEALARWHHDQLGQISPARFIPIAEECGLIGELGKWALEE 814 LHYQPQ+ G L+GVEALARW H LG ISP RF+P+AEECGLIG+LG WAL E Sbjct: 631 KALRLHYQPQVGLKNGSLYGVEALARWRHPTLGDISPVRFVPLAEECGLIGDLGDWALRE 690 Query: 815 ACFQLHDWRRRGINVPSVSVNLSSTNFHDLELPQFIAGLLQRFALAPGDLTLEITETVMM 874 AC QL WR G+ VPSVSVNLS+TNFH+L LP+ IA L F LAP DL LEITE V++ Sbjct: 691 ACSQLAIWRSNGLRVPSVSVNLSATNFHNLNLPRMIAATLAEFGLAPADLMLEITEGVVL 750 Query: 875 DTNPSTTRTIREVHAQGVKLAMDDFGTGYSSLGYLRNLPVCELKLDQSFVRDMDRDQTVL 934 D T RTI E+H GV+L+MDDFGTGYSSLG+LR L V ELKLD+SFV+ ++ D Sbjct: 751 DATAGTLRTIAELHRLGVRLSMDDFGTGYSSLGHLRRLIVDELKLDRSFVQGLESDDAAR 810 Query: 935 ALTNAVIRIGESLDLIVVAEGVEDKRQYDLLKQQGCDVAQGYLFSRPMLATVFEHWLKN 993 ALT+AVIRIGESL L VVAEGVE++ Q L +QGC QG+LFS P+ A E WL+ Sbjct: 811 ALTSAVIRIGESLSLPVVAEGVENEEQRRFLIEQGCAAGQGFLFSPPLPAGELEEWLRG 869 Score = 98.6 bits (244), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 69/258 (26%), Positives = 112/258 (43%), Gaps = 6/258 (2%) Query: 37 LAAFSRSMAILELAPDGTILSANDNFLTLMAYRHSDIVGHHHRMLCNPTHAGS--PEYAE 94 LA+ R++ + + DG +L N NFL + Y + + H MLC+ G Sbjct: 37 LASMDRALLLFDFDADGALLKVNANFLAAVGYTREEALSLRHDMLCDSMDEGKGIASGER 96 Query: 95 FWRRLHQGEVVSGTLQRMRSDGSRLWLEATCNPVFDAEGRLLRVVSIAADITAHIDDSQE 154 W RL +GE SGT + DGS LW+EAT P+ D +G++ RV ++ A + +E Sbjct: 97 IWTRLRRGEHFSGTCRYRMKDGSSLWIEATYLPLGDKDGKISRVSVVSRKSIADAERQEE 156 Query: 155 KHSVLRALNRSLGVIEFSA-DGIIVGANGNYLKTMGYLPEEIVGKHHRFLCEPDYVDSQE 213 +L +N + + S DG IV N + + +G+ + + + L D Sbjct: 157 VRLLLLGINETGNAVAVSGCDGRIVYVNDGFQRMLGFARGDALNQELGELLAGGRPDGGT 216 Query: 214 YENFWRDVNQGRFFSGRFKRIARDGRPVWWEATYTPVFDLEGEPIKIISIGSDVSYRMVR 273 E R + F R G+P+W VFD G + I+ + +D++ V Sbjct: 217 REELDRRIACREGFHKDVLVYDRYGKPLWVSVMANSVFDERGTLVNIVDVLTDITPTKVH 276 Query: 274 EQRDREYQHLLSLGINET 291 E R +L +NE Sbjct: 277 EVLQR---RVLQAMVNEA 291