BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0007.0042.p (428 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value B4CVI8.1 B4CVI8_9BACT Multi-sensor signal transduction histidine... 335 9e-90 A9GRS8.1 A9GRS8_SORC5 Two-component hybrid sensor and regulator ... 236 8e-60 A4G3M4.1 A4G3M4_HERAR Putative two-component histidine kinase se... 222 8e-56 Q8F425.1 Q8F425_LEPIN Sensor histidine kinase and response regul... 219 9e-55 Q72RN6.1 Q72RN6_LEPIC Histidine kinase response regulator hybrid... 219 9e-55 >B4CVI8.1 B4CVI8_9BACT Multi-sensor signal transduction histidine kinase Length = 891 Score = 335 bits (859), Expect = 9e-90, Method: Compositional matrix adjust. Identities = 184/434 (42%), Positives = 254/434 (58%), Gaps = 68/434 (15%) Query: 13 FQLLFESVPGLFLVLLPDFTIIAVSDAYLQATLTKREHIVGRPLFQVFPDNPDDPAADGV 72 F+ LF+S+PGL++VL PDF I+AVSDA+L+AT+T+RE ++G F VFPDNP+DP A G Sbjct: 484 FRALFDSLPGLYVVLTPDFGIVAVSDAFLKATMTEREGLLGHKFFDVFPDNPNDPNATGE 543 Query: 73 ANLRSSLKRVLATQAPHAMAMQKYDVRCPGGDGFETRYWSPSNFPVFGKDGAIRYIMHRA 132 NLR+SL RVL + MA+QKYD+R P G FE RYWSP N PV G D I Y++HR Sbjct: 544 TNLRASLNRVLKSHRSETMAIQKYDIRRPDGT-FEERYWSPVNSPVLGADRRIEYLIHRV 602 Query: 133 EDITSYVQLKKERQELGRRSDRPQESCNAQEFEVPALNGDMVAGFRHLHALNRALKLEIL 192 ED+T +V+ K+E Q E+ Sbjct: 603 EDVTDFVKQKRE---------------AGQNVEI-------------------------- 621 Query: 193 ARNQLEDANQELTR---QLQLNIEKLEASNKELESFSYSXAAD----------------- 232 +N+L++ E+ R ++Q +L A+N ELE+FSYS + D Sbjct: 622 -KNRLDNMEAEVFRSSQRVQAANNQLRAANSELEAFSYSVSHDLRAPLRHIDGFADLLGN 680 Query: 233 ----QLDEEGLRKLQVIRNNIRNMGRLIDELLEFSRLSRKELNYGHLNMSAMAKACFDDA 288 LD++G R L+ I ++ + MG LID+LL FSR+ R E+ ++N++A+ + Sbjct: 681 HAGSTLDDKGKRYLKTISDSAKRMGALIDDLLVFSRIGRAEMKRTNVNLNALVDEVIQEL 740 Query: 289 ASAVTSPATL-RLGDLPAAEGDITLIKQVWFNLLANALKFSARREQILIDVSAESVDGIL 347 ++ + + +LPAA+ D L++QV NLLANA+K++ ++ +I+V Sbjct: 741 RIETSARNVVWKRQELPAADADPALLRQVLVNLLANAVKYTRPKDPAVIEVGYVKKGDED 800 Query: 348 TYTVRDNGAGFDMRYYNKLFGVFQRLHRASEFEGTGVGLAIVHRIVTRHGGRVWAEGAVG 407 VRDNG GFDM Y KLFGVFQRLHRA EFEGTG+GLA V RI+ RHGGRVWAE +G Sbjct: 801 ALYVRDNGVGFDMTYVGKLFGVFQRLHRAEEFEGTGIGLANVQRIIVRHGGRVWAESQLG 860 Query: 408 EGAAFHFTLPAATG 421 EGA F+FTLP A+G Sbjct: 861 EGATFYFTLPIASG 874 >A9GRS8.1 A9GRS8_SORC5 Two-component hybrid sensor and regulator EC=2.7.3.- Length = 1171 Score = 236 bits (601), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 147/437 (33%), Positives = 228/437 (52%), Gaps = 40/437 (9%) Query: 12 DFQLLFESVPGLFLVLLPDFTIIAVSDAYLQATLTKREHIVGRPLFQVFPDNPDDPAADG 71 DF+ +FE +PG ++V+ PDFT++A SDA+L+A +RE +GR +F VFPDNPDDP A G Sbjct: 39 DFRAIFEGIPGNYVVIRPDFTVVAASDAFLRAANIRREEFLGRHIFDVFPDNPDDPHATG 98 Query: 72 VANLRSSLKRVLATQAPHAMAMQKYDVRCP--GGDGFETRYWSPSNFPVFGKDGAIRYIM 129 NLR+S++RV+ +AP +MA+QKYD+ P G GFE RYWSP N P+ G DG + YI+ Sbjct: 99 TRNLRASIERVIQMRAPDSMAVQKYDIPRPEAEGGGFEERYWSPLNSPLLGPDGRVAYII 158 Query: 130 HRAEDITSYVQLKKERQELGRRSDRPQESCNAQEFEVPALNGDMVAGFRHLHALNRALKL 189 HR ED+T +VQLK+ E RR++ + E EV F + R Sbjct: 159 HRVEDVTEFVQLKQRGIEQCRRTEELKTRAERVEAEV----------FLRAQEIQR---- 204 Query: 190 EILARNQLEDANQELTRQLQLNIEKLEASNKELESF----------SYSXAADQLDEEGL 239 A QL AN++L+R +L + EL + + A L + Sbjct: 205 ---ANEQLRVANEQLSRLDELKTRFFSNVSHELRTPLTLMLCPIDELLTSAPGGLTDRQR 261 Query: 240 RKLQVIRNNIRNMGRLIDELLEFSRL--SRKELNYGHLNMSAMAKACFDDAASAVTSPAT 297 +++ R N R + +L++ LL+F+R+ +R +++Y L++SA+ +AV Sbjct: 262 ELVELARRNARRLLKLVNTLLDFARIEAARMQVSYEALDLSALTAEVVSAFRAAVERAGL 321 Query: 298 LRLGDLPAAEGDITLIKQVW----FNLLANALKFSARREQILIDVSAESVDGILTYTVRD 353 + D P + + +++W NL++NA KF+ E I ++ + VRD Sbjct: 322 RLVVDCPPLPERVYVDREMWEKIVLNLVSNAFKFTLEGE---IGIALRWAGDHVLLEVRD 378 Query: 354 NGAGFDMRYYNKLFGVFQRLHRA--SEFEGTGVGLAIVHRIVTRHGGRVWAEGAVGEGAA 411 G G ++F F R+ A EG+G+GLA+V +V H G V A VG G+ Sbjct: 379 TGTGIPADELPRIFDRFHRIQGAHGRSHEGSGIGLALVRELVRFHMGEVHATSEVGRGST 438 Query: 412 FHFTLPAATGDQTHEQL 428 F +PA + E++ Sbjct: 439 FTVRIPAGSAHVPAERI 455 Score = 68.9 bits (167), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 71/251 (28%), Positives = 115/251 (45%), Gaps = 31/251 (12%) Query: 188 KLEILARNQLEDANQELTR-----------QLQLNIEKLEASNKELESFSYSXAADQLDE 236 L+I R ++EDA + R +L+ + + + + L S+ DQ Sbjct: 755 SLDITERKRVEDALADADRRKDEFLAMLGHELRNPMAPICVAVELLRRRSHGGPPDQ--- 811 Query: 237 EGLRKLQVIRNNIRNMGRLIDELLEFSRLSRK--ELNYGHLNM-SAMAKACFDDAASAVT 293 ++VI R + RL+D+LL+ SR++R EL +++ +A+A+A Sbjct: 812 ----HIEVIARQTRTLMRLVDDLLDVSRITRGKIELRKERIDVKAAVARAVESTREQIEA 867 Query: 294 SPATLRLGDLPAAE----GDITLIKQVWFNLLANALKFSARREQILIDVSAESVDGILTY 349 +RL LPAA GD ++Q+ NLL NA K++ I V+ E G + Sbjct: 868 RRHQIRL-VLPAAAVQVLGDDVRLEQILVNLLTNACKYTDPGGH--IGVTVEQRGGQVEL 924 Query: 350 TVRDNGAGFDMRYYNKLFGVFQRLHRASEFE--GTGVGLAIVHRIVTRHGGRVWAEG-AV 406 VRD+G G +F +F + R+ + G G+GL IV +V HGG + A Sbjct: 925 RVRDDGIGISREVLPHVFELFHQADRSLDRAPGGLGIGLTIVRDLVALHGGSIEATSPGP 984 Query: 407 GEGAAFHFTLP 417 G+G+ F LP Sbjct: 985 GQGSEFIVRLP 995 >A4G3M4.1 A4G3M4_HERAR Putative two-component histidine kinase sensor protein Length = 463 Score = 222 bits (566), Expect = 8e-56, Method: Compositional matrix adjust. Identities = 107/233 (45%), Positives = 156/233 (66%), Gaps = 21/233 (9%) Query: 206 RQLQLNIEKLEASNKELESFSYSXA---------------------ADQLDEEGLRKLQV 244 R+++ N +LE +NKELESFSYS + AD+LD+EG R L V Sbjct: 226 RKIEKNAAQLELTNKELESFSYSVSHDLRSPLRAIDGYSRMFEEDFADRLDDEGRRLLSV 285 Query: 245 IRNNIRNMGRLIDELLEFSRLSRKELNYGHLNMSAMAKACFDDAASAVTSPATLRLGDLP 304 IR + + MG+LID+LL FSR+ RK ++ ++M+A+ + + ++ + L+ +LP Sbjct: 286 IRVSSKKMGQLIDDLLAFSRMGRKPVDSAKVDMNALVDEVWTEVCASSKTVLPLKKTNLP 345 Query: 305 AAEGDITLIKQVWFNLLANALKFSARREQILIDVSAESVDGILTYTVRDNGAGFDMRYYN 364 A GD L++QVW NLLANA+K+S+++E+ +++++A+ + + YTVRDNG GFDMR+YN Sbjct: 346 AVWGDQALLRQVWMNLLANAVKYSSKKEEQIVEITAKQSEHEVVYTVRDNGVGFDMRFYN 405 Query: 365 KLFGVFQRLHRASEFEGTGVGLAIVHRIVTRHGGRVWAEGAVGEGAAFHFTLP 417 KLFGVFQRLH +EF GTGVGLAI R++ RHGGR+WAE E F+F+LP Sbjct: 406 KLFGVFQRLHTENEFPGTGVGLAIAQRVIVRHGGRIWAESKPDEYTIFNFSLP 458 >Q8F425.1 Q8F425_LEPIN Sensor histidine kinase and response regulator of a two component complex Length = 832 Score = 219 bits (557), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 138/429 (32%), Positives = 227/429 (52%), Gaps = 22/429 (5%) Query: 6 SDKEITDFQLLFESVPGLFLVLLPDFTIIAVSDAYLQATLTKREHIVGRPLFQVFPDNPD 65 +D + +++L+FES+PGL+L+L PD I AVSD+YL+AT TKR+ I+GR +F VFPDNP Sbjct: 5 TDLKHNEYRLIFESLPGLYLILFPDLRIAAVSDSYLKATNTKRDEILGRGIFDVFPDNPS 64 Query: 66 DPAADGVANLRSSLKRVLATQAPHAMAMQKYDVRCP--GGDGFETRYWSPSNFPVFGKDG 123 DP ADGV NL SSL VL + P+ MA+QKYDVR P G GFE +YWSP N P+ + Sbjct: 65 DPNADGVGNLYSSLLLVLKEKIPNTMAVQKYDVRRPESEGGGFEEKYWSPMNSPILNEKR 124 Query: 124 AIRYIMHRAEDITSYVQLKKERQELGRRSDRPQESCNAQEFEVPALNGDMVAGFRHLHAL 183 + YI+HR E++T +VQLK + +E + ++ + + E E+ ++ + L L Sbjct: 125 EVIYIVHRVEEVTEFVQLKNKGKEQNKITEELKNLTVSMETEIYQRAQEIQKNNKELIRL 184 Query: 184 NRALKLEILARNQLEDANQELTRQLQLNIEKLEASNKELE---SFSYSXAADQLDEEGLR 240 N L ++++ Q L QL + + EL + L ++G+ Sbjct: 185 NEELTQR---EREIQEVYQRLFNMDQLKSQFFANVSHELRTPLTLILGPTRALLKDQGIT 241 Query: 241 K-----LQVIRNNIRNMGRLIDELLEFSRLS--RKELNYGHLNMSAMAK---ACFDDAAS 290 L+ I N + + +++LL+ S+L + L Y + N+S + + + FD Sbjct: 242 STQRTFLETIERNSYTLLKHVNDLLDLSKLDSGKMTLKYSNANLSEVIRYIASHFDSITK 301 Query: 291 AVTSPATLRLGDLPAAEGDITLIKQVWFNLLANALKFSARREQILIDVSAESVDGILTYT 350 L + + + D++ ++++ NL++NA KF +IL ++ E + + Sbjct: 302 ERNIDFVLMIPENFPIQMDVSKVERIILNLISNAFKFVPDSGKILCELKTEGT--MASIY 359 Query: 351 VRDNGAGFDMRYYNKLFGVFQRLHR--ASEFEGTGVGLAIVHRIVTRHGGRVWAEGAVGE 408 + DNG G + +++F F+++ + F GTG+GLAIV V H G + + Sbjct: 360 IADNGPGIPIHLRDQIFEKFRQIEEGDSRSFGGTGLGLAIVKEFVDLHLGSIGVFDSFLG 419 Query: 409 GAAFHFTLP 417 GA F +P Sbjct: 420 GALFKVQIP 428 Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 95/238 (39%), Positives = 135/238 (56%), Gaps = 22/238 (9%) Query: 208 LQLNIEKLEASNKELESFSYSXAAD---------------------QLDEEGLRKLQVIR 246 L+ IE LE +N ++ESFSYS + D ++D E LR L+++ Sbjct: 593 LKKTIETLENANADMESFSYSVSHDLRAPILVIEGFLQIILEDFSEKMDPEALRSLKIVH 652 Query: 247 NNIRNMGRLIDELLEFSRLSRKELNYGHLNMSAMAKACFDDAASAVTSPATL-RLGDLPA 305 N+ M LI +LL F ++S+ +L + M M + L ++ +LP Sbjct: 653 KNVVYMNHLIQDLLSFHKVSKIDLPIRLIEMDKMVQDVIATVLQNYPKKNYLFQVDELPN 712 Query: 306 AEGDITLIKQVWFNLLANALKFSARREQILIDVSAESVDGILTYTVRDNGAGFDMRYYNK 365 A + +KQVW NL++NA+K+S+ RE I + E +DG Y + DNG GF+ Y NK Sbjct: 713 ALANGAALKQVWMNLISNAVKYSSTRETPFIKIGFEEMDGFNNYFIEDNGVGFNKAYSNK 772 Query: 366 LFGVFQRLHRASEFEGTGVGLAIVHRIVTRHGGRVWAEGAVGEGAAFHFTLPAATGDQ 423 LF VFQRLH EFEGTGVGLAIV +IV RHGG+V+AEG V +G+ F FTLP + ++ Sbjct: 773 LFKVFQRLHTQEEFEGTGVGLAIVSKIVQRHGGQVFAEGEVNKGSKFSFTLPKLSRNE 830 >Q72RN6.1 Q72RN6_LEPIC Histidine kinase response regulator hybrid protein Length = 832 Score = 219 bits (557), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 138/429 (32%), Positives = 227/429 (52%), Gaps = 22/429 (5%) Query: 6 SDKEITDFQLLFESVPGLFLVLLPDFTIIAVSDAYLQATLTKREHIVGRPLFQVFPDNPD 65 +D + +++L+FES+PGL+L+L PD I AVSD+YL+AT TKR+ I+GR +F VFPDNP Sbjct: 5 TDLKHNEYRLIFESLPGLYLILFPDLRIAAVSDSYLKATNTKRDEILGRGIFDVFPDNPS 64 Query: 66 DPAADGVANLRSSLKRVLATQAPHAMAMQKYDVRCP--GGDGFETRYWSPSNFPVFGKDG 123 DP ADGV NL SSL VL + P+ MA+QKYDVR P G GFE +YWSP N P+ + Sbjct: 65 DPNADGVGNLYSSLLLVLKEKIPNTMAVQKYDVRRPESEGGGFEEKYWSPMNSPILNEKR 124 Query: 124 AIRYIMHRAEDITSYVQLKKERQELGRRSDRPQESCNAQEFEVPALNGDMVAGFRHLHAL 183 + YI+HR E++T +VQLK + +E + ++ + + E E+ ++ + L L Sbjct: 125 EVIYIVHRVEEVTEFVQLKNKGKEQNKITEELKNLTVSMETEIYQRAQEIQKNNKELIRL 184 Query: 184 NRALKLEILARNQLEDANQELTRQLQLNIEKLEASNKELE---SFSYSXAADQLDEEGLR 240 N L ++++ Q L QL + + EL + L ++G+ Sbjct: 185 NEELTQR---EREIQEVYQRLFNMDQLKSQFFANVSHELRTPLTLILGPTRALLKDQGIT 241 Query: 241 K-----LQVIRNNIRNMGRLIDELLEFSRLS--RKELNYGHLNMSAMAK---ACFDDAAS 290 L+ I N + + +++LL+ S+L + L Y + N+S + + + FD Sbjct: 242 STQRTFLETIERNSYTLLKHVNDLLDLSKLDSGKMTLKYSNANLSEVIRYIASHFDSITK 301 Query: 291 AVTSPATLRLGDLPAAEGDITLIKQVWFNLLANALKFSARREQILIDVSAESVDGILTYT 350 L + + + D++ ++++ NL++NA KF +IL ++ E + + Sbjct: 302 ERNIDFVLMIPENFPIQMDVSKVERIILNLISNAFKFVPDSGKILCELKTEGT--MASIY 359 Query: 351 VRDNGAGFDMRYYNKLFGVFQRLHR--ASEFEGTGVGLAIVHRIVTRHGGRVWAEGAVGE 408 + DNG G + +++F F+++ + F GTG+GLAIV V H G + + Sbjct: 360 IADNGPGIPIHLRDQIFEKFRQIEEGDSRSFGGTGLGLAIVKEFVDLHLGSIGVFDSFLG 419 Query: 409 GAAFHFTLP 417 GA F +P Sbjct: 420 GALFKVQIP 428 Score = 177 bits (450), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 95/238 (39%), Positives = 135/238 (56%), Gaps = 22/238 (9%) Query: 208 LQLNIEKLEASNKELESFSYSXAAD---------------------QLDEEGLRKLQVIR 246 L+ IE LE +N ++ESFSYS + D ++D E LR L+++ Sbjct: 593 LKKTIETLENANADMESFSYSVSHDLRAPILVIEGFLQIILEDFSEKMDPEALRSLKIVH 652 Query: 247 NNIRNMGRLIDELLEFSRLSRKELNYGHLNMSAMAKACFDDAASAVTSPATL-RLGDLPA 305 N+ M LI +LL F ++S+ +L + M M + L ++ +LP Sbjct: 653 KNVVYMNHLIQDLLSFHKVSKIDLPIRLIEMDKMVQDVIATVLQNYPKKNYLFQVDELPN 712 Query: 306 AEGDITLIKQVWFNLLANALKFSARREQILIDVSAESVDGILTYTVRDNGAGFDMRYYNK 365 A + +KQVW NL++NA+K+S+ RE I + E +DG Y + DNG GF+ Y NK Sbjct: 713 ALANGAALKQVWMNLISNAVKYSSTRETPFIKIGFEEMDGFNNYFIEDNGVGFNKAYSNK 772 Query: 366 LFGVFQRLHRASEFEGTGVGLAIVHRIVTRHGGRVWAEGAVGEGAAFHFTLPAATGDQ 423 LF VFQRLH EFEGTGVGLAIV +IV RHGG+V+AEG V +G+ F FTLP + ++ Sbjct: 773 LFKVFQRLHTQEEFEGTGVGLAIVSKIVQRHGGQVFAEGEVNKGSKFSFTLPKLSRNE 830