BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0218.p (578 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IT60.1 D8IT60_HERSS Chloride channel protein 857 0.0 D5NID7.1 D5NID7_9BURK Cl-channel voltage-gated family protein 748 0.0 Q13Y48.1 Q13Y48_BURXL Putative chloride channel family protein, ... 740 0.0 B2T517.1 B2T517_BURPP Chloride channel core 731 0.0 B2JHU9.1 B2JHU9_BURP8 Chloride channel core 722 0.0 >D8IT60.1 D8IT60_HERSS Chloride channel protein Length = 555 Score = 857 bits (2215), Expect = 0.0, Method: Compositional matrix adjust. Identities = 439/555 (79%), Positives = 498/555 (89%) Query: 24 MLLWAAVVGFVGALATIGFRECIDAVQYLLTGHSGSFVEIAKGLSWQMRVLLPTCGGVVA 83 MLLW A+ GFVGALATI FRECI +Q +TGH GSFV+IAKGL W RVLLPTCGGVVA Sbjct: 1 MLLWGALAGFVGALATIAFRECIALLQIWMTGHDGSFVDIAKGLPWYTRVLLPTCGGVVA 60 Query: 84 GLILIWAKRMPAGATSDYMEAVAIGDGRIPIRHTLLRSLSSLATVGSGGSIGREGPMVQL 143 GL L+WAKR PAG DYMEAVAIGDG IP+R+TLLRS+SSLA++ SGGSIGREGPMVQL Sbjct: 61 GLFLVWAKRTPAGNGGDYMEAVAIGDGAIPVRNTLLRSISSLASIASGGSIGREGPMVQL 120 Query: 144 AALCASLVGRFAHFPSSRMRLLVACGAAAGITSAYNAPIAGAFFVTEIVLGALVMESFGP 203 +ALCASLVG+F+HFPSSR+RLLVACGAAAGITSAYNAPIAGAFF+TEIVLG+LVMESFGP Sbjct: 121 SALCASLVGKFSHFPSSRLRLLVACGAAAGITSAYNAPIAGAFFITEIVLGSLVMESFGP 180 Query: 204 VVVASVVANITMRELPGYKPAYEMPYFPEVAGVEIILFVVLGVIAGLLAPQFLRLLELSK 263 VVVASVVANITMRELPGY+ AYEMPYFPE+ G E++LF+VLGV+AG+LAPQFLR+LEL K Sbjct: 181 VVVASVVANITMRELPGYRAAYEMPYFPEIGGWEVMLFLVLGVLAGVLAPQFLRVLELGK 240 Query: 264 TAFRKTRLPLPLRLGLGGLLVGLLSVRVPEVWGNGYSVVNSLLHTDWLWSTVLIVMIYKI 323 F K RLPLP+RLG+GGLLVGL+SV+VPEVWGNGYS+VNSLLHT W+W VL+V++ K+ Sbjct: 241 HGFGKLRLPLPVRLGVGGLLVGLISVQVPEVWGNGYSLVNSLLHTSWVWQAVLMVLVVKV 300 Query: 324 VATALTTGSGAVGGIFTPTLFVGAAIGFLFGDMAHALWPHAISQPFAYAMVGMGAFLAAA 383 +AT++T GSGAVGGIFTPTLFVGAA+G+LFGD A AL P ISQPFAYAMVGMGAFLAAA Sbjct: 301 LATSITVGSGAVGGIFTPTLFVGAAVGYLFGDAAQALLPVHISQPFAYAMVGMGAFLAAA 360 Query: 384 TNAPLMAILMIFEMTLSYQVVLPLMLSCVVAYVIARSLDGNSMYEITLKRHRDAAERIRL 443 + APLMAILMIFEMTLSYQVVLPLMLSCVVAYV+ARS+DG SMYEITLKRHRD ER+RL Sbjct: 361 SYAPLMAILMIFEMTLSYQVVLPLMLSCVVAYVVARSVDGRSMYEITLKRHRDNEERLRL 420 Query: 444 RGTHMSELIKPAETVLQKDAPFSEVTRIFLQYPVKYIYITDQENRYLGVVALQDVTSLLL 503 RGTHMSELI+PAETVL ++A E++ +FL+YPVKY+YI D RYLGVVALQD+TS LL Sbjct: 421 RGTHMSELIRPAETVLHEEASLEEISALFLKYPVKYVYIVDGRQRYLGVVALQDITSWLL 480 Query: 504 DKDDIATKCAGDFMRTHFLHEVTPDMSLGEALQLFLDHQGERLPVISSAEDPRLLGVVFK 563 DK + A + A DF+R HFLHEVTPDMSLGEALQLFLDHQGERLPVI+SA+DP+LLGVVFK Sbjct: 481 DKKEAAGRVARDFLRPHFLHEVTPDMSLGEALQLFLDHQGERLPVIASADDPQLLGVVFK 540 Query: 564 TSLLDAYFRLDRSGE 578 TSLLDAYFRLDR+G Sbjct: 541 TSLLDAYFRLDRAGN 555 >D5NID7.1 D5NID7_9BURK Cl-channel voltage-gated family protein Length = 577 Score = 748 bits (1932), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/575 (65%), Positives = 460/575 (80%), Gaps = 2/575 (0%) Query: 1 MRNALLKYRFRLQTWLRMSESHAMLLWAAVVGFVGALATIGFRECIDAVQYLLTGHSGSF 60 M + LLK R R Q R+SE+H ML+W+ VVG GA ATI FRE I +Q+ + G +GSF Sbjct: 1 MLSFLLKLRTRAQDLFRLSEAHTMLVWSVVVGVAGAFATIAFREGIALLQFAVVGKAGSF 60 Query: 61 VEIAKGLSWQMRVLLPTCGGVVAGLILIWAKRMP-AGATSDYMEAVAIGDGRIPIRHTLL 119 VE+A+ L W +R+ LP GG++AG L+ A+R G DYMEAVAIGDG +P++ +L Sbjct: 61 VEMARSLPWTVRIWLPAAGGLIAGFFLLIARRYEDKGNHVDYMEAVAIGDGVVPVKLSLW 120 Query: 120 RSLSSLATVGSGGSIGREGPMVQLAALCASLVGRFAHFPSSRMRLLVACGAAAGITSAYN 179 RS+SSL T+ SGGSIGREGPMVQLAAL ASL+GR+ HF SR+RLLVACGAAAGITSAY+ Sbjct: 121 RSVSSLFTISSGGSIGREGPMVQLAALAASLIGRWVHFDPSRLRLLVACGAAAGITSAYS 180 Query: 180 APIAGAFFVTEIVLGALVMESFGPVVVASVVANITMRELPGYKPAYEMPYFPEVAGVEII 239 APIAGAFFVTEIVLG++ MESFGPVVV++VVANITMRE GY+P YEMP FP VAG+E++ Sbjct: 181 APIAGAFFVTEIVLGSIAMESFGPVVVSAVVANITMREFAGYRPPYEMPVFPPVAGLEVL 240 Query: 240 LFVVLGVIAGLLAPQFLRLLELSKTAFRKTRLPLPLRLGLGGLLVGLLSVRVPEVWGNGY 299 LFV LG++ G APQFLRLL++SK +FRK +PLP+RL LGGL+VG+LSVR PEVWGNGY Sbjct: 241 LFVALGLLCGAAAPQFLRLLDVSKKSFRKLPVPLPVRLALGGLVVGILSVRTPEVWGNGY 300 Query: 300 SVVNSLLHTDWLWSTVLIVMIYKIVATALTTGSGAVGGIFTPTLFVGAAIGFLFGDMAHA 359 SVVNS+LH+ W W+ +++V+++K+VATA T+GSGAVGG+FTPTLFVGA +G LFG HA Sbjct: 301 SVVNSILHSPWTWTALVLVLVFKLVATAATSGSGAVGGVFTPTLFVGAVVGSLFGQGMHA 360 Query: 360 LWPHAISQPFAYAMVGMGAFLAAATNAPLMAILMIFEMTLSYQVVLPLMLSCVVAYVIAR 419 LWPH S PFAYAMVGMGAFLA AT APLMAILMIFEMTLSYQVVLPLMLSCVVAY ++R Sbjct: 361 LWPHGTSAPFAYAMVGMGAFLAGATQAPLMAILMIFEMTLSYQVVLPLMLSCVVAYFVSR 420 Query: 420 SLDGNSMYEITLKRHRDAAERIRLRGTHMSELIKPAETVLQKDAPFSEVTRIFLQYPVKY 479 ++ SMYEITL+R+ ER RLR T M ELI+PAETV+ +A ++TR+FL+YPVKY Sbjct: 421 AIGKTSMYEITLRRNHQEQERSRLRATQMRELIRPAETVVPPNATVHDMTRVFLEYPVKY 480 Query: 480 IYITDQENRYLGVVALQDVTSLLLDKDDIATKCAGDFMRTHFLHEVTPDMSLGEALQLFL 539 +Y+ ++ +LGVVAL+D+TS LLD D +TK A D+++ HF +TPDM LG ALQ FL Sbjct: 481 LYVANESGAFLGVVALKDITSDLLDGRDTSTKTAADYLQPHF-DVLTPDMPLGVALQHFL 539 Query: 540 DHQGERLPVISSAEDPRLLGVVFKTSLLDAYFRLD 574 QGERLPV+ SA P L GVV+KTSLLDAYFR++ Sbjct: 540 AFQGERLPVVESAAHPTLAGVVYKTSLLDAYFRMN 574 >Q13Y48.1 Q13Y48_BURXL Putative chloride channel family protein, clcB-like protein Length = 591 Score = 740 bits (1911), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/571 (64%), Positives = 455/571 (79%), Gaps = 2/571 (0%) Query: 5 LLKYRFRLQTWLRMSESHAMLLWAAVVGFVGALATIGFRECIDAVQYLLTGHSGSFVEIA 64 LLK R R Q R+SE+H ML+W+ VVG GA ATI FRE I +Q + G +GSFVE+A Sbjct: 19 LLKLRTRAQDLFRLSEAHTMLVWSVVVGVAGAFATIAFREGIALLQTAVVGKAGSFVEMA 78 Query: 65 KGLSWQMRVLLPTCGGVVAGLILIWAKRMPAGATS-DYMEAVAIGDGRIPIRHTLLRSLS 123 + L W +R+ LP GG++AG L+ A+R + DYMEAVAIGDG +P++ + RS+S Sbjct: 79 RSLPWTVRIWLPAAGGLIAGFFLLIARRHEDKSNHVDYMEAVAIGDGVVPVKLSFWRSVS 138 Query: 124 SLATVGSGGSIGREGPMVQLAALCASLVGRFAHFPSSRMRLLVACGAAAGITSAYNAPIA 183 SL T+ SGGSIGREGPMVQLAAL ASL+GR+ HF +R+RLLVACGAAAGITSAY+APIA Sbjct: 139 SLFTISSGGSIGREGPMVQLAALAASLIGRWVHFDPARLRLLVACGAAAGITSAYSAPIA 198 Query: 184 GAFFVTEIVLGALVMESFGPVVVASVVANITMRELPGYKPAYEMPYFPEVAGVEIILFVV 243 GAFFVTEIVLG++ MESFGPVVV++VVANITMRE GY+P YEMP FP VAG+E++LFV Sbjct: 199 GAFFVTEIVLGSIAMESFGPVVVSAVVANITMREFAGYRPPYEMPVFPPVAGLEVLLFVA 258 Query: 244 LGVIAGLLAPQFLRLLELSKTAFRKTRLPLPLRLGLGGLLVGLLSVRVPEVWGNGYSVVN 303 LG++ G APQFLRLL++SK +FRK +PLP+RL LGGL+VG+LSV PEVWGNGYSVVN Sbjct: 259 LGLLCGAAAPQFLRLLDVSKKSFRKLPVPLPVRLALGGLVVGILSVWTPEVWGNGYSVVN 318 Query: 304 SLLHTDWLWSTVLIVMIYKIVATALTTGSGAVGGIFTPTLFVGAAIGFLFGDMAHALWPH 363 S+LH+ W W+ +++V+++K+VATA T+GSGAVGG+FTPTLFVGA +G LFG HALWPH Sbjct: 319 SILHSPWTWTALVLVLVFKLVATAATSGSGAVGGVFTPTLFVGAVVGSLFGQGMHALWPH 378 Query: 364 AISQPFAYAMVGMGAFLAAATNAPLMAILMIFEMTLSYQVVLPLMLSCVVAYVIARSLDG 423 S PFAYAMVGMGAFLA AT APLMAILMIFEMTLSYQVVLPLMLSCVVAY ++R++ Sbjct: 379 GTSAPFAYAMVGMGAFLAGATQAPLMAILMIFEMTLSYQVVLPLMLSCVVAYFVSRAIGK 438 Query: 424 NSMYEITLKRHRDAAERIRLRGTHMSELIKPAETVLQKDAPFSEVTRIFLQYPVKYIYIT 483 SMYEITL+R+ + ER RLR T M ELI+PAETV++ +A E+TR+FL+YPVKY+Y+ Sbjct: 439 TSMYEITLRRNHEEQERSRLRATQMRELIRPAETVVRPNATVHEMTRVFLEYPVKYLYVA 498 Query: 484 DQENRYLGVVALQDVTSLLLDKDDIATKCAGDFMRTHFLHEVTPDMSLGEALQLFLDHQG 543 + +LGVVAL+D+TS LLD D A K A D+++ HF +TPDM LG ALQ FL QG Sbjct: 499 SESGAFLGVVALKDITSDLLDGRDTAAKTAADYLQPHF-DVLTPDMPLGVALQHFLAFQG 557 Query: 544 ERLPVISSAEDPRLLGVVFKTSLLDAYFRLD 574 ERLPV+ SA P L GVV+KTSLLDAYFR++ Sbjct: 558 ERLPVVESAAHPTLAGVVYKTSLLDAYFRMN 588 >B2T517.1 B2T517_BURPP Chloride channel core Length = 591 Score = 731 bits (1887), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/571 (64%), Positives = 455/571 (79%), Gaps = 2/571 (0%) Query: 5 LLKYRFRLQTWLRMSESHAMLLWAAVVGFVGALATIGFRECIDAVQYLLTGHSGSFVEIA 64 LLK R R Q R+S++H ML+W+ VVG GA ATI FRE I +Q+ + G SGSFVE+A Sbjct: 19 LLKLRTRAQNLFRLSDAHTMLIWSVVVGVAGAFATIAFREAIALLQFAIVGKSGSFVEMA 78 Query: 65 KGLSWQMRVLLPTCGGVVAGLILIWAKRMPAGATS-DYMEAVAIGDGRIPIRHTLLRSLS 123 +GL W +R+ LP GG++AG +L+ A+R DYMEAVAIGDG +P++ ++ RS+S Sbjct: 79 RGLPWTVRIWLPAAGGLIAGFLLLIARRYEDKCNHIDYMEAVAIGDGVVPVKLSMWRSVS 138 Query: 124 SLATVGSGGSIGREGPMVQLAALCASLVGRFAHFPSSRMRLLVACGAAAGITSAYNAPIA 183 SL T+ SGGSIGREGPMVQLAAL SL+GR+ HF R+RLLVACGAAAGITSAY+APIA Sbjct: 139 SLFTISSGGSIGREGPMVQLAALAGSLIGRWVHFDPPRLRLLVACGAAAGITSAYSAPIA 198 Query: 184 GAFFVTEIVLGALVMESFGPVVVASVVANITMRELPGYKPAYEMPYFPEVAGVEIILFVV 243 GAFFVTEIVLG++ MESFGPVVV++VVANITMRE GYKP YEMP FP VAG+E++LFV Sbjct: 199 GAFFVTEIVLGSIAMESFGPVVVSAVVANITMREFAGYKPPYEMPVFPPVAGLEVLLFVA 258 Query: 244 LGVIAGLLAPQFLRLLELSKTAFRKTRLPLPLRLGLGGLLVGLLSVRVPEVWGNGYSVVN 303 LG + G APQFLRLL+LSK +FRK +PLP+RL LGGL+VG+LSV PEVWGNGYSVVN Sbjct: 259 LGALCGAAAPQFLRLLDLSKQSFRKLPVPLPVRLALGGLVVGILSVWTPEVWGNGYSVVN 318 Query: 304 SLLHTDWLWSTVLIVMIYKIVATALTTGSGAVGGIFTPTLFVGAAIGFLFGDMAHALWPH 363 ++LH+ W W+ +++V+++KIVATA T GSGAVGG+FTPTLFVGA +G LFG HALWPH Sbjct: 319 AILHSPWTWTALVLVLVFKIVATAATAGSGAVGGVFTPTLFVGAVVGSLFGQGMHALWPH 378 Query: 364 AISQPFAYAMVGMGAFLAAATNAPLMAILMIFEMTLSYQVVLPLMLSCVVAYVIARSLDG 423 S PFAYAMVGMGAFLA AT APLMAILMIFEMTLSYQVVLPLMLSCVVAY ++R++ Sbjct: 379 GTSAPFAYAMVGMGAFLAGATQAPLMAILMIFEMTLSYQVVLPLMLSCVVAYFVSRAIGK 438 Query: 424 NSMYEITLKRHRDAAERIRLRGTHMSELIKPAETVLQKDAPFSEVTRIFLQYPVKYIYIT 483 NSMYEITL+R+ + ER RLR T M ELI+PAETV+ +A ++TR+FL+YPVKY+Y+ Sbjct: 439 NSMYEITLRRNHEEQERSRLRATQMRELIRPAETVVPPNATVHDMTRVFLEYPVKYLYVA 498 Query: 484 DQENRYLGVVALQDVTSLLLDKDDIATKCAGDFMRTHFLHEVTPDMSLGEALQLFLDHQG 543 ++ +LGVVAL+D+TS LLD D + K A ++++ HF +TPDM LG ALQ FL QG Sbjct: 499 NESGAFLGVVALKDITSDLLDGSDTSAKTAANYLQPHF-DVLTPDMPLGVALQHFLAFQG 557 Query: 544 ERLPVISSAEDPRLLGVVFKTSLLDAYFRLD 574 ERLPV+ SA P L GVV+KTSLLDAYFR++ Sbjct: 558 ERLPVVESAAHPTLAGVVYKTSLLDAYFRMN 588 >B2JHU9.1 B2JHU9_BURP8 Chloride channel core Length = 577 Score = 722 bits (1864), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/575 (63%), Positives = 452/575 (78%), Gaps = 2/575 (0%) Query: 1 MRNALLKYRFRLQTWLRMSESHAMLLWAAVVGFVGALATIGFRECIDAVQYLLTGHSGSF 60 M + LL+ R R R+S++H ML+W+ +VG GA ATI FRE I +Q + TG GS Sbjct: 1 MLSFLLRLRTRAAHLFRLSDAHTMLVWSVIVGIAGAFATIAFREGISLLQRVFTGQDGSL 60 Query: 61 VEIAKGLSWQMRVLLPTCGGVVAGLILIWAKR-MPAGATSDYMEAVAIGDGRIPIRHTLL 119 VE+A+ L MR+ LP GG++AG++L+ A+R + +DYMEAV IGDG +P+R +L Sbjct: 61 VEMARRLPLAMRIGLPAFGGLIAGMLLLLAQRGVDRKLHTDYMEAVVIGDGVVPVRVSLW 120 Query: 120 RSLSSLATVGSGGSIGREGPMVQLAALCASLVGRFAHFPSSRMRLLVACGAAAGITSAYN 179 RS SSL T+ SGGSIGREGPMVQLAAL ASL+GR HF R+RLLVACGAAAGITSAY+ Sbjct: 121 RSASSLFTISSGGSIGREGPMVQLAALGASLIGRVVHFDPPRLRLLVACGAAAGITSAYS 180 Query: 180 APIAGAFFVTEIVLGALVMESFGPVVVASVVANITMRELPGYKPAYEMPYFPEVAGVEII 239 APIAGAFFVTEIVLG++ MESFGPVVV+SVV+NI MRE GYKP YEMP FP VAG+E++ Sbjct: 181 APIAGAFFVTEIVLGSIAMESFGPVVVSSVVSNIVMREFAGYKPPYEMPVFPPVAGLEVL 240 Query: 240 LFVVLGVIAGLLAPQFLRLLELSKTAFRKTRLPLPLRLGLGGLLVGLLSVRVPEVWGNGY 299 LFV LG++ G APQFLRL++ SK+AF + +PLP RL LGGL+VG+LSV PEVWGNGY Sbjct: 241 LFVALGLLCGAAAPQFLRLIDASKSAFGRLPVPLPFRLALGGLVVGILSVWTPEVWGNGY 300 Query: 300 SVVNSLLHTDWLWSTVLIVMIYKIVATALTTGSGAVGGIFTPTLFVGAAIGFLFGDMAHA 359 SVVNS+LH+ W W+ +L+V+ +K++ATA T GSGAVGG+FTPTLFVGA IG LFG + Sbjct: 301 SVVNSILHSPWTWTALLVVLAFKLIATAATVGSGAVGGVFTPTLFVGAVIGSLFGLGMNG 360 Query: 360 LWPHAISQPFAYAMVGMGAFLAAATNAPLMAILMIFEMTLSYQVVLPLMLSCVVAYVIAR 419 LWPHA S PFAYAMVGMGAFLA AT APLMAILMIFEMTLSYQVVLPLMLSCVVAY AR Sbjct: 361 LWPHATSAPFAYAMVGMGAFLAGATQAPLMAILMIFEMTLSYQVVLPLMLSCVVAYFAAR 420 Query: 420 SLDGNSMYEITLKRHRDAAERIRLRGTHMSELIKPAETVLQKDAPFSEVTRIFLQYPVKY 479 ++ SMY+ITL R+R+ ER+RLR T M ELI+P +TV+Q +A ++TR+FL+YPVKY Sbjct: 421 AIGKTSMYDITLHRNREEQERMRLRATQMRELIRPPQTVVQPNATVHDMTRVFLEYPVKY 480 Query: 480 IYITDQENRYLGVVALQDVTSLLLDKDDIATKCAGDFMRTHFLHEVTPDMSLGEALQLFL 539 +Y+TD+ + +LGVVAL+D+TS LLD+ D +TK A D+++ HF +TPDM LG ALQ F+ Sbjct: 481 LYVTDESDAFLGVVALKDITSDLLDRRDTSTKTAADYLQPHF-DVLTPDMPLGVALQHFM 539 Query: 540 DHQGERLPVISSAEDPRLLGVVFKTSLLDAYFRLD 574 QGERLPV+ S P L GVV+KTSLLDAYFR++ Sbjct: 540 AFQGERLPVVESRARPTLAGVVYKTSLLDAYFRMN 574