BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0187.p (390 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J0G6.1 D8J0G6_HERSS 3-hydroxy-3-methylglutaryl-coenzyme A redu... 600 e-169 F1W2S0.1 F1W2S0_9BURK Hydroxymethylglutaryl-CoA reductase 581 e-164 B1K6G7.1 B1K6G7_BURCC Hydroxymethylglutaryl-CoA reductase, degra... 574 e-162 A0AXW8.1 A0AXW8_BURCH Hydroxymethylglutaryl-CoA reductase, degra... 573 e-161 A2W0V8.1 A2W0V8_9BURK Hydroxymethylglutaryl-CoA reductase 570 e-160 >D8J0G6.1 D8J0G6_HERSS 3-hydroxy-3-methylglutaryl-coenzyme A reductase protein EC=1.1.1.88 Length = 436 Score = 600 bits (1548), Expect = e-169, Method: Compositional matrix adjust. Identities = 304/425 (71%), Positives = 337/425 (79%), Gaps = 38/425 (8%) Query: 2 TVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQIP 61 T DSRLP FR+ P QRL ++ + A L E ALL P ALPL A+GMIENV+G+FQ+P Sbjct: 10 TPDSRLPGFRTYTPAQRLAEVGRLAQLDQAEQALLGQPGALPLGTADGMIENVVGSFQLP 69 Query: 62 MGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIGV 121 +GVAGYFQLNG+DVLVPMAVEEPSVVAAASFMAKL+R CGGF TSSS PLMRAQ+Q+ G+ Sbjct: 70 LGVAGYFQLNGRDVLVPMAVEEPSVVAAASFMAKLVRTCGGFQTSSSLPLMRAQIQLTGI 129 Query: 122 SDPYGARVL--------------------------------------AGAMVIVHLIVDV 143 SDP+GAR+ GAMV+ HLIVDV Sbjct: 130 SDPHGARLAILKERQAIIDIANSRDQLLQQLGGGCRDIEVQVFPDTRRGAMVVTHLIVDV 189 Query: 144 RDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYDG 203 RDAMGANTVNTMAEAVA HIE++TGGKVRLRILSNLADLRLARA V+VS + L+TA Y G Sbjct: 190 RDAMGANTVNTMAEAVASHIERVTGGKVRLRILSNLADLRLARARVKVSADVLSTAQYRG 249 Query: 204 ADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGHY 263 +VIN IVDAY AAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACR+G Y Sbjct: 250 EEVINGIVDAYELAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRHGRY 309 Query: 264 TSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAVG 323 TSL+ WEI DG LVGTLEIPMPVGLVGGATKTHP AR+ALK++ V+SAQ LAE+AVAVG Sbjct: 310 TSLTHWEIAADGDLVGTLEIPMPVGLVGGATKTHPAARVALKILGVQSAQALAEVAVAVG 369 Query: 324 LAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVKL 383 LAQNMAALRALATEGIQRGHMALHARNI LAAGA A EMDW+VQQMVA DVRVD+A L Sbjct: 370 LAQNMAALRALATEGIQRGHMALHARNIALAAGAEASEMDWLVQQMVARHDVRVDYAKAL 429 Query: 384 LAQRR 388 LA+RR Sbjct: 430 LAERR 434 >F1W2S0.1 F1W2S0_9BURK Hydroxymethylglutaryl-CoA reductase Length = 426 Score = 581 bits (1498), Expect = e-164, Method: Compositional matrix adjust. Identities = 291/424 (68%), Positives = 337/424 (79%), Gaps = 38/424 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 MT+DSRLP FR+L+P RL+ I A LT +E AL+A P +LPLEVANGM+ENVIG F++ Sbjct: 1 MTIDSRLPNFRALDPAARLDHIVAVAGLTPEERALIAEPGSLPLEVANGMVENVIGKFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 P VAGYFQ+NG+DVLVPM VEEPSVVAAASFMAK+IR+ GGF TSS+ PLMRAQVQV+ Sbjct: 61 PYSVAGYFQINGRDVLVPMVVEEPSVVAAASFMAKIIRESGGFQTSSTGPLMRAQVQVME 120 Query: 121 VSDPYGAR--VLA------------------------------------GAMVIVHLIVD 142 ++DP+GAR VL+ G MVIVHLIVD Sbjct: 121 LADPFGARHAVLSHKQELITLANSRDKVLIGLGGGCKDIEVHVFADTARGPMVIVHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAEAVAG IE ITGGKVRLRILSNLADLRLARA V++ PE L +ADY Sbjct: 181 VRDAMGANTVNTMAEAVAGRIEAITGGKVRLRILSNLADLRLARARVQIRPELLKSADYT 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 VIN I+DAYTFAA+DPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACR+G Sbjct: 241 ADQVINGIIDAYTFAAIDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRDGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSL+TWE+ G LVGT+E+PMPVGLVGGATKTHP+ARL+LK+M ++SAQELAEIAVAV Sbjct: 301 YTSLTTWEVSATGDLVGTIEMPMPVGLVGGATKTHPMARLSLKIMQLRSAQELAEIAVAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+ ALRAL+TEGIQRGHMALHARNI + AGA+ ++D + ++MVAA DVR DFA + Sbjct: 361 GLAQNLGALRALSTEGIQRGHMALHARNIAIVAGATGADVDRIAREMVAAGDVRADFAAE 420 Query: 383 LLAQ 386 LL + Sbjct: 421 LLGK 424 >B1K6G7.1 B1K6G7_BURCC Hydroxymethylglutaryl-CoA reductase, degradative Length = 428 Score = 574 bits (1480), Expect = e-162, Method: Compositional matrix adjust. Identities = 295/427 (69%), Positives = 331/427 (77%), Gaps = 38/427 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 M +DS LP FRSL P+QRL +++ L E ALLA P ALPL+ ANGMIENVIGTF++ Sbjct: 1 MPIDSALPNFRSLTPEQRLSHLSRIVGLDDAEHALLAQPGALPLDTANGMIENVIGTFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 PM VAGYF++N +DV+VPMAVEEPS+VAAAS+MAKL R GGF TSSS PLMRAQVQVIG Sbjct: 61 PMAVAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVIG 120 Query: 121 VSDPYGARV-----------LA---------------------------GAMVIVHLIVD 142 V DPYGAR+ LA GAM++ HLIVD Sbjct: 121 VDDPYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAE VA IE ITGG+VRLRILSNLADLRLARA VR S L T DY Sbjct: 181 VRDAMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYA 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 G VI+R++DAY FAA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R+G Sbjct: 241 GEAVIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSL+TWE +G LVGT+E+PMPVGLVGGATKTHPLARLALK+M+V SAQEL EIAVAV Sbjct: 301 YTSLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+ ALRALATEGIQRGHMALHARNI +AAGA+ ++D + QQMVAAKDVR DFAV+ Sbjct: 361 GLAQNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQQMVAAKDVRTDFAVE 420 Query: 383 LLAQRRG 389 LLA R G Sbjct: 421 LLAGRSG 427 >A0AXW8.1 A0AXW8_BURCH Hydroxymethylglutaryl-CoA reductase, degradative Length = 428 Score = 573 bits (1477), Expect = e-161, Method: Compositional matrix adjust. Identities = 294/427 (68%), Positives = 331/427 (77%), Gaps = 38/427 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 M +DS LP FRSL P+QRL +++ L E ALLA P ALPL+ ANGMIENVIGTF++ Sbjct: 1 MPIDSALPNFRSLTPEQRLSHLSRAVGLDDAEHALLAQPGALPLDTANGMIENVIGTFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 PM VAGYF++N +DV+VPMAVEEPS+VAAAS+MAKL R GGF TSSS PLMRAQVQVIG Sbjct: 61 PMAVAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVIG 120 Query: 121 VSDPYGARV-----------LA---------------------------GAMVIVHLIVD 142 V DPYGAR+ LA GAM++ HLIVD Sbjct: 121 VDDPYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAE VA IE ITGG+VRLRILSNLADLRLARA VR S L T DY Sbjct: 181 VRDAMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYA 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 G VI+R++DAY FAA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R+G Sbjct: 241 GEAVIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSL+TWE +G LVGT+E+PMPVGLVGGATKTHPLARLALK+M+V SAQEL EIAVAV Sbjct: 301 YTSLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQELGEIAVAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+ ALRALATEGIQRGHMALHARNI +AAGA+ ++D + Q+MVAAKDVR DFAV+ Sbjct: 361 GLAQNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQRMVAAKDVRADFAVE 420 Query: 383 LLAQRRG 389 LLA R G Sbjct: 421 LLAGRSG 427 >A2W0V8.1 A2W0V8_9BURK Hydroxymethylglutaryl-CoA reductase Length = 428 Score = 570 bits (1468), Expect = e-160, Method: Compositional matrix adjust. Identities = 292/427 (68%), Positives = 330/427 (77%), Gaps = 38/427 (8%) Query: 1 MTVDSRLPQFRSLNPQQRLEQIAQRANLTADEVALLANPAALPLEVANGMIENVIGTFQI 60 M +DS LP FRSL P+QRL +++ L E ALLA P ALPL+ ANGMIENVIGTF++ Sbjct: 1 MPIDSALPNFRSLTPEQRLSYLSRAVGLDDAEHALLARPGALPLDTANGMIENVIGTFEL 60 Query: 61 PMGVAGYFQLNGKDVLVPMAVEEPSVVAAASFMAKLIRDCGGFHTSSSAPLMRAQVQVIG 120 PM VAGYF++N +DV+VPMAVEEPS+VAAAS+MAKL R GGF TSSS PLMRAQVQV+G Sbjct: 61 PMAVAGYFRINDRDVIVPMAVEEPSIVAAASYMAKLSRAAGGFRTSSSGPLMRAQVQVVG 120 Query: 121 VSDPYGARV-----------LA---------------------------GAMVIVHLIVD 142 V DPYGAR+ LA GAM++ HLIVD Sbjct: 121 VDDPYGARLAILRHAAELIALANSRDKVLVGLGGGCRDIEVHVFPDTPRGAMIVAHLIVD 180 Query: 143 VRDAMGANTVNTMAEAVAGHIEQITGGKVRLRILSNLADLRLARAHVRVSPEALTTADYD 202 VRDAMGANTVNTMAE VA IE ITGG+VRLRILSNLADLRLARA VR S L T DY Sbjct: 181 VRDAMGANTVNTMAETVATRIEAITGGQVRLRILSNLADLRLARAEVRYSAATLATDDYA 240 Query: 203 GADVINRIVDAYTFAAVDPYRAATHNKGIMNGIDPVIVATGNDWRAVEAGAHAYACRNGH 262 G VI+R++DAY FAA DPYRAATHNKGIMNGIDPV+VATGNDWRAVEAGAHAYA R+G Sbjct: 241 GEAVIDRVIDAYVFAATDPYRAATHNKGIMNGIDPVVVATGNDWRAVEAGAHAYASRSGR 300 Query: 263 YTSLSTWEIGNDGHLVGTLEIPMPVGLVGGATKTHPLARLALKMMDVKSAQELAEIAVAV 322 YTSL+TWE +G LVGT+E+PMPVGLVGGATKTHPLARLALK+M+V SAQ L EIAVAV Sbjct: 301 YTSLTTWEKAANGDLVGTIEMPMPVGLVGGATKTHPLARLALKIMNVTSAQALGEIAVAV 360 Query: 323 GLAQNMAALRALATEGIQRGHMALHARNIGLAAGASAEEMDWVVQQMVAAKDVRVDFAVK 382 GLAQN+ ALRALATEGIQRGHMALHARNI +AAGA+ ++D + Q+MVAAKDVR DFAV+ Sbjct: 361 GLAQNLGALRALATEGIQRGHMALHARNIAVAAGATGADIDRIAQRMVAAKDVRTDFAVE 420 Query: 383 LLAQRRG 389 LLA R G Sbjct: 421 LLAGRSG 427