BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0087.p (813 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZT7.1 D8IZT7_HERSS Exported extracellular alpha-helical protein 1134 0.0 B3R7Q4.1 B3R7Q4_CUPTR Putative uncharacterized protein 803 0.0 B2JG49.1 B2JG49_BURP8 Alpha-2-macroglobulin domain protein 802 0.0 Q0K5I8.1 Q0K5I8_CUPNH Large extracellular alpha-helicalprotein 788 0.0 Q46VU1.1 Q46VU1_CUPPJ Alpha-2-macroglobulin, N-terminal 781 0.0 >D8IZT7.1 D8IZT7_HERSS Exported extracellular alpha-helical protein Length = 1938 Score = 1134 bits (2933), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/781 (70%), Positives = 639/781 (81%), Gaps = 15/781 (1%) Query: 1 VIAWLTRLNRYHERWGDTSGKTPDTRAIGLLAKEPGVKTLNLPALSDAKDGERPFEVVGI 60 VIAWLTRLN+YHE+WGD K DTR++ LLAKEPG K L+LPA DAK+GE PFEV+GI Sbjct: 407 VIAWLTRLNKYHEKWGDP--KKVDTRSVSLLAKEPGAKKLDLPAQKDAKEGEWPFEVIGI 464 Query: 61 PLKDPGFYVVELESQKLGASLLGKPAPMYVRTSTLVTNLSVHVKLGRENNAVWVTRLDTA 120 PLKDPGFYVVELESQKLGASLLGKP PMYVRTS LVTNLSVHVKLGR N AVWVTRLD A Sbjct: 465 PLKDPGFYVVELESQKLGASLLGKPQPMYVRTSALVTNLSVHVKLGRANGAVWVTRLDDA 524 Query: 121 KPVADADVRISNCKGDEIWRGKTNAIGVATIAKPLEDVCA-MGQNQDGA--INGLFVSAR 177 KPVADA++R+SNC G +IW+GKTNA GVA + LED CA G + D A INGLFVSAR Sbjct: 525 KPVADAEIRVSNCDGAQIWQGKTNASGVAMMPA-LEDACANRGYSPDNADKINGLFVSAR 583 Query: 178 KTDEQGRADMAFALTSWNDGIESWRFNLLTDRSASSSARAHTIFDRTLFRAGETVSMKHE 237 KTDE+GR DMAFALTSWN+GIESWRFNL TD S++ RA T+FDRTLFRAGETVSMKH Sbjct: 584 KTDEKGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRTLFRAGETVSMKHV 643 Query: 238 FRLESMNGFALAGKDKLPTRVRIIHQGSGQEFQFALNWRNQKNAETVFSIPKEAKLGSYE 297 R E++ GF L K+ LPTRVRI H GSGQ++QF L WR K+AET F +PK+AKLGSYE Sbjct: 644 IRTETLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWRGNKSAETTFVLPKQAKLGSYE 703 Query: 298 VLLDRGA--AKAGSETNGDGDGDGEEGGYAPGTYSSGSFRVEEFRLPLMQGRITPVTGKG 355 V+LD+G A A +E D EGGY GTY +GSFRVEEFRLPLMQGRITP G Sbjct: 704 VVLDQGKVDANASAEPTEQSDDGDYEGGYGRGTYVTGSFRVEEFRLPLMQGRITPPKG-- 761 Query: 356 KGDALVAPKEVPLDVQLNYINGGGASGQTVRVTSLMRAKPVSFPAYEGYSFDAGNSGGED 415 A VA KE+PLD+QLNYINGG A+ Q V+V+SL+R++ ++ Y+G+SFDA S +D Sbjct: 762 ---AQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNIAGYDGFSFDAPRS--DD 816 Query: 416 GAGNDDQKIVADKLPVTLDKNGAGRTTVKSLPVLKTPRELLTEMTYNDPNGEIQTVSNVT 475 + DDQKIVADKL +TLDKNGAGR T+ LP L+ P+ELLTEMTY+DPNGE+QT+SNVT Sbjct: 817 DSNADDQKIVADKLAITLDKNGAGRATISKLPALQRPQELLTEMTYSDPNGEVQTISNVT 876 Query: 476 TLWPSAVVIGIKGGDWVSVKKKLALTMVALNAAGQPQADVPVEISGESKQTNSHRKRMVG 535 LWPSAVV+G++ G+WVSVKKKL LT V LN AGQPQA VPVEI G +++TNSHRKRMVG Sbjct: 877 PLWPSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQPQAGVPVEIRGIARKTNSHRKRMVG 936 Query: 536 GFYAYENTRSSQNLGTLCSGKTDKHGVLICEVSLTEAGNVELTASGKDANGNASFAKTSV 595 GFYAYEN S Q+LG LCSGK+D+HG+ C+ L+EAGNVEL AS KD NGNA+ A++SV Sbjct: 937 GFYAYENDESKQDLGKLCSGKSDQHGMFTCDTELSEAGNVELIASAKDGNGNAAAARSSV 996 Query: 596 WVTRQGELWFDGENQDRIDILPEKKTYQPGETARFQVRMPFRYATALVAVEREGIIDTQV 655 WVT +GE+WFDGENQDRIDILPEKK YQPGETA FQVRMPFR ATALVAVEREG+IDT+V Sbjct: 997 WVTGRGEVWFDGENQDRIDILPEKKNYQPGETANFQVRMPFRSATALVAVEREGVIDTRV 1056 Query: 656 VQLNGQDPTISLPVKGGFAPNVYVSVLAVRGRMREVPWYSFFTWGWKEPINWWHEFKEYQ 715 VQL+GQDPTIS+P+K + PNVYVSVLAVRGRMREVPWYSFF WGWKEPINWWHEF+EYQ Sbjct: 1057 VQLSGQDPTISVPMKAEYGPNVYVSVLAVRGRMREVPWYSFFIWGWKEPINWWHEFREYQ 1116 Query: 716 APGTMVDLAKPAYKFGIAEIAVGSGAHVLKVAVAADKASYPIRSVAKVNVQVTQPDGKPX 775 PG +VDL+KPA+KFGIAE+ VG H L+VAV+ DK +YPIR++AKV VQV P+GKP Sbjct: 1117 GPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVAVSTDKPTYPIRAIAKVQVQVKLPNGKPA 1176 Query: 776 A 776 A Sbjct: 1177 A 1177 >B3R7Q4.1 B3R7Q4_CUPTR Putative uncharacterized protein Length = 2023 Score = 803 bits (2073), Expect = 0.0, Method: Compositional matrix adjust. Identities = 423/829 (51%), Positives = 550/829 (66%), Gaps = 72/829 (8%) Query: 1 VIAWLTRLNRYHERW-------GDTSGKTP------------DTRAIGLLAKEPGVKTLN 41 V+ WL + R HE +G++P +TR++ LL + PGV+ L Sbjct: 439 VMQWLGLVRRLHEASYTRGELDAVLAGRSPYRVSNPRNAVSIETRSVSLLERAPGVQKLA 498 Query: 42 LPALSDAKDGERPFEVVGIPLKDPGFYVVELESQKLGASLLGKPAPMYVRTSTLVTNLSV 101 +P S D RPFEVVGIPL +PGF+VVE+ S LG +LLGK APMYVRT+ LVTNL V Sbjct: 499 VPKPSG--DAPRPFEVVGIPLPEPGFHVVEIASPMLGEALLGKRAPMYVRTAALVTNLGV 556 Query: 102 HVKLGR---------ENNAVWVTRLDTAKPVADADVRISNCKGDEIWRGKTNAIGVATIA 152 H KLGR + WVT LD KPV+DA V + +C G + G+T+A GVA A Sbjct: 557 HFKLGRGSGNEDDGSRSGLAWVTALDDGKPVSDAAVAVRDCSGRLLGEGRTDASGVARFA 616 Query: 153 KPLEDVCAMGQNQDGAINGLFVSAR----KTDEQGRADMAFALTSWNDGIESWRFNLLTD 208 + L +Q+G ++G FVSAR +G+ADMAF ++ WN GIESWRFN+ TD Sbjct: 617 R-LAAAPESACDQNG-LSGYFVSARIAATHPQARGKADMAFVMSDWNRGIESWRFNVPTD 674 Query: 209 RSASSSARAHTIFDRTLFRAGETVSMKHEFRLESMNGFALAGKDK-LPTRVRIIHQGSGQ 267 SA+ + RAHTIFDRTL RAGETVSMKH R E+ GFAL + LPTRV I H+GSGQ Sbjct: 675 TSATPTVRAHTIFDRTLLRAGETVSMKHLIRAETAQGFALPPASRPLPTRVTIRHEGSGQ 734 Query: 268 EFQFALNWRNQ----KNAETVFSIPKEAKLGSYEVLLDRGAAKAGSETNGDGDGDGEEGG 323 ++ L WR ++AE+ F +P A+LG Y V L+ GDG +EGG Sbjct: 735 SYELPLQWRQTATGGRSAESTFQVPAAARLGVYTVELE----------TQKGDGAKDEGG 784 Query: 324 YAPGTYSSGSFRVEEFRLPLMQGRITPVTGKGKGDALVAPKEVPLDVQLNYINGGGASGQ 383 +Y+SGSFRVE FRLP++ G + GK +VAP E+P+ V+++Y++GGGA+G Sbjct: 785 VR--SYTSGSFRVEAFRLPVLAGTLQVA---GKAGPVVAPAELPVGVEIHYLSGGGAAGL 839 Query: 384 TVRVTSLMRAKPVSFPAYEGYSFDAG----NSGGED--------GAGNDDQKIVADKLPV 431 VRV++L+R K VSFP Y+G+SF SGG++ GA +D QK+VADKLP+ Sbjct: 840 PVRVSALLRDKYVSFPGYDGFSFTPPRAQRESGGDEEMDEDQQGGASDDRQKLVADKLPL 899 Query: 432 TLDKNGAGRTTVKSLPVLKTPRELLTEMTYNDPNGEIQTVSNVTTLWPSAVVIGIKGGDW 491 TLDKNG G T+ LP + PR+L+ E + DPNGEIQT+ +WP+AVV GI+ DW Sbjct: 900 TLDKNGNGSVTLTKLPKTEAPRDLVLEAGFADPNGEIQTLRQTVPVWPAAVVAGIRTDDW 959 Query: 492 VSVKKKLALTMVALNAAGQPQADVPVEISGESKQTNSHRKRMVGGFYAYENTRSSQNLGT 551 VSVK+KLA+ V L+ G+P AD PV+I+ ++ T S RKR+VGGFY Y+N +++LGT Sbjct: 960 VSVKQKLAVQGVVLDVNGKPVADAPVKINARARITTSARKRVVGGFYRYDNRTETRDLGT 1019 Query: 552 LCSGKTDKHGVLICEVSLTEAGNVELTASGKDANGNASFAKTSVWVTRQGELWFDGENQD 611 +C +TD G C+V+L +AG +EL A+ +D +G + A T+VWVTRQGELWF GEN D Sbjct: 1020 VCETRTDAQGRARCDVTLEQAGQIELVANARDKDGRTAQAATTVWVTRQGELWFGGENHD 1079 Query: 612 RIDILPEKKTYQPGETARFQVRMPFRYATALVAVEREGIIDTQVVQLNGQDPTISLPVKG 671 RID+LPEKK+Y PG+TA FQVRMPFR+ATALVAVEREGI TQVV+L+G DPT+ + VK Sbjct: 1080 RIDLLPEKKSYAPGDTAVFQVRMPFRHATALVAVEREGIYQTQVVELHGSDPTVRVQVKP 1139 Query: 672 GFAPNVYVSVLAVRGRMREVPWYSFFTWGWKEPINWWHEF----KEYQAPGTMVDLAKPA 727 + PNVYVSVLA+RGR+ EVPWYSFFTWGW++P WW F +EY AP +VDL+KPA Sbjct: 1140 EWGPNVYVSVLALRGRLHEVPWYSFFTWGWRQPGEWWRAFRSEGREYAAPTALVDLSKPA 1199 Query: 728 YKFGIAEIAVGSGAHVLKVAVAADKASYPIRSVAKVNVQVTQPDGKPXA 776 ++ G+AEI VG+ H L VAV DKASYP+R A+V +QV PDGKP A Sbjct: 1200 FRLGLAEIRVGNAGHRLDVAVTPDKASYPVRGKARVAIQVRLPDGKPAA 1248 >B2JG49.1 B2JG49_BURP8 Alpha-2-macroglobulin domain protein Length = 2020 Score = 802 bits (2071), Expect = 0.0, Method: Compositional matrix adjust. Identities = 406/777 (52%), Positives = 527/777 (67%), Gaps = 29/777 (3%) Query: 24 DTRAIGLLAKEPGVKTLNLPALSDAKDGERPFEVVGIPLKDPGFYVVELESQKLGASLLG 83 D R++ LLA +P V+TL LP RPFEVVG+P+ PGFYV+EL S LGASLLG Sbjct: 473 DVRSLSLLAGQPNVETLALPKADPT--ALRPFEVVGVPVTKPGFYVIELASPALGASLLG 530 Query: 84 KPAPMYVRTSTLVTNLSVHVKLGRENNAVWVTRLDTAKPVADADVRISNCKGDEIWRGKT 143 K APMYVRT+ LVTNL VH K GREN+ VWVT LD +PV +ADVR+S+C GDE+ GKT Sbjct: 531 KHAPMYVRTAVLVTNLGVHFKQGRENSVVWVTTLDKGQPVPNADVRMSDCNGDELASGKT 590 Query: 144 NAIGVATIAKPLEDVCAMGQNQDGAINGLFVSARKTDEQGRADMAFALTSWNDGIESWRF 203 +A GV T+ +PL + + +D + GLFVSAR D + DMAF + WN GIE+WRF Sbjct: 591 DAHGVLTVNQPL---TSRHECKDDSFEGLFVSARIDDPKTGHDMAFVRSDWNRGIEAWRF 647 Query: 204 NLLTDRSASSSARAHTIFDRTLFRAGETVSMKHEFRLESMNGFALAGKDKLPTRVRIIHQ 263 N+ TD S S RAHT+FDRTL RAGETVSMKH R+E+M G A PTR+ I H Sbjct: 648 NVPTDTSIEQSVRAHTVFDRTLLRAGETVSMKHMIRVETMQGLAF--PTTYPTRLTIRHL 705 Query: 264 GSGQEFQFALNWRNQKNAETVFSIPKEAKLGSYEVLLDRGAAKAGSET---NGDGDGDGE 320 GSGQ + L W A++ F+IP AKLG Y V LD G A A S+ + D + + Sbjct: 706 GSGQTWHMPLTWAADHTADSTFAIPAAAKLGEYSVSLDDGDAIAASDATSIQANDDNEDD 765 Query: 321 EGGYAPGTYSSGSFRVEEFRLPLMQGRITPVTGKGKGDALVAPKEVPLDVQLNYINGGGA 380 A +YSSGSFRVEEFRLP+ +G I K LVA E + +Q++Y++GGGA Sbjct: 766 SADSARHSYSSGSFRVEEFRLPVFKGTI--AVRDEKNHPLVAASEAHVALQIDYMSGGGA 823 Query: 381 SGQTVRVTSLM-RAKPVSFPAYEGYSF------------DAGNSGGEDGAGNDDQKIVAD 427 SG V+V++LM R P Y +SF A + E A +D K++AD Sbjct: 824 SGLPVQVSALMKRTTPAFAGTYPAFSFAPYRKRNDTRSSSADDEDSEQAADDDTSKLIAD 883 Query: 428 KLPVTLDKNGAGRTTVKSLPVLKTPRELLTEMTYNDPNGEIQTVSNVTTLWPSAVVIGIK 487 K VTL++NGAG T+KS+P + P+ L E T+ DPNGE+QT+S TLWP+AVV G+K Sbjct: 884 KEAVTLERNGAGSLTLKSVPSVDAPKRLALEATFADPNGEVQTISGSATLWPAAVVAGVK 943 Query: 488 GGDWVSVKKKLALTMVALNAAGQPQADVPVEISGESKQTNSHRKRMVGGFYAYENTRSSQ 547 G WVSV K + + +A++ G+P+A VP+E+ G ++ T + RKRMVGGFYAY+N ++ Sbjct: 944 SGQWVSVGKTVPVKALAVDLQGKPRAGVPLEVRGIARITITSRKRMVGGFYAYDNHTETK 1003 Query: 548 NLGTLCSGKTDKHGVLICEVSLTEAGNVELTASGKDANGNASFAKTSVWVTRQGELWFDG 607 +LGTLCSGK+D G+L C+ L EAGNV+L + KD +G+AS A TSVWVTR+ +LWF G Sbjct: 1004 DLGTLCSGKSDDRGLLTCDAKLKEAGNVDLVVTAKDGDGHASTAATSVWVTREEDLWFGG 1063 Query: 608 ENQDRIDILPEKKTYQPGETARFQVRMPFRYATALVAVEREGIIDTQVVQLNGQDPTISL 667 EN DRID+LPEK Y+PGE+ARFQVRMPFR+ATALVAVEREGI++T VV+L+G+DPT+ L Sbjct: 1064 ENTDRIDVLPEKSAYEPGESARFQVRMPFRFATALVAVEREGIVETHVVKLDGKDPTVEL 1123 Query: 668 PVKGGFAPNVYVSVLAVRGRMREVPWYSFFTWGWKEPINW----WHEFKEYQAPGTMVDL 723 V + PNVYVSVLA+RGR+R+VPWYSFFTWGWK P+ W W+E + Y+AP +VDL Sbjct: 1124 KVNEAWGPNVYVSVLALRGRIRDVPWYSFFTWGWKAPLEWARAFWYEGRYYEAPTPLVDL 1183 Query: 724 AKPAYKFGIAEIAVGSGAHVLKVAVAADKASYPIRSVAKVNVQVTQPDGKPXAAASR 780 +KPA+++G+AEI VG+ AH L V V D SY +R A + ++V P GKP A ++ Sbjct: 1184 SKPAFRYGLAEIKVGTAAHKLAVTVTPDAKSYTVRGNAHMKLRVQMPGGKPAPAGTQ 1240 >Q0K5I8.1 Q0K5I8_CUPNH Large extracellular alpha-helicalprotein Length = 2023 Score = 788 bits (2035), Expect = 0.0, Method: Compositional matrix adjust. Identities = 410/791 (51%), Positives = 531/791 (67%), Gaps = 60/791 (7%) Query: 24 DTRAIGLLAKEPGVKTLNLPALSDAKDGERPFEVVGIPLKDPGFYVVELESQKLGASLLG 83 +TR++ LL + PGV+ L +P S D RPFEVVGIPL +PGF+VVE+ S LG SLLG Sbjct: 480 ETRSVSLLERAPGVQKLAVPKPSG--DAPRPFEVVGIPLPEPGFHVVEIASPMLGESLLG 537 Query: 84 KPAPMYVRTSTLVTNLSVHVKLGR---------ENNAVWVTRLDTAKPVADADVRISNCK 134 K APMYVRT+ LVTNL VH KLGR + WVT LD KPVADA V + +C Sbjct: 538 KRAPMYVRTAALVTNLGVHFKLGRSAGNEDDGSRSGLAWVTALDDGKPVADAAVAVRDCS 597 Query: 135 GDEIWRGKTNAIGV---ATIAKPLEDVCAMGQNQDGAINGLFVSAR----KTDEQGRADM 187 G + G+T+A GV A +A E C Q+G ++G FVSAR +G+ADM Sbjct: 598 GRLLGEGRTDASGVVRFARLAAAPEGAC----EQNG-LSGYFVSARIGVGHPQARGKADM 652 Query: 188 AFALTSWNDGIESWRFNLLTDRSASSSARAHTIFDRTLFRAGETVSMKHEFRLESMNGFA 247 AF ++ WN GIESWRFN+ TD + + RAHTIFDRTL RAGETVSMKH R E+ GFA Sbjct: 653 AFVMSDWNRGIESWRFNVPTDTGTAPTVRAHTIFDRTLLRAGETVSMKHVIRAETAQGFA 712 Query: 248 LAGKDK-LPTRVRIIHQGSGQEFQFALNWRNQ----KNAETVFSIPKEAKLGSYEVLLDR 302 L + LPTRV I H+GSGQ ++ L WR ++AE+ F +P AKLG Y V L+ Sbjct: 713 LPPASRPLPTRVVIRHEGSGQTYELPLQWRQTATGGRSAESSFQVPAAAKLGVYSVELET 772 Query: 303 GAAKAGSETNGDGDGDGEEGGYAPGTYSSGSFRVEEFRLPLMQGRITPVTGKGKGDALVA 362 + G++ NG G Y+SGSFRVE FRLP++ G + GK +VA Sbjct: 773 QKGE-GAQDNGGARG-----------YTSGSFRVEAFRLPVLAGTLQVA---GKAGPMVA 817 Query: 363 PKEVPLDVQLNYINGGGASGQTVRVTSLMRAKPVSFPAYEGYSFDAGNSGGEDGAGN--- 419 P E+P+ V+++Y++GGGA+G VRV++L+R K VSFP Y+ +SF+ + E +G+ Sbjct: 818 PAELPVGVEIHYLSGGGAAGLPVRVSALLRDKYVSFPGYDEFSFNPPRAQRESASGDEEM 877 Query: 420 ----------DDQKIVADKLPVTLDKNGAGRTTVKSLPVLKTPRELLTEMTYNDPNGEIQ 469 D QK+VADKLPVTLDKNG G T++ LP ++ PR+LL E + DPNGEIQ Sbjct: 878 DEDEQGDASADSQKLVADKLPVTLDKNGNGTVTLRKLPKIEAPRDLLLEAGFADPNGEIQ 937 Query: 470 TVSNVTTLWPSAVVIGIKGGDWVSVKKKLALTMVALNAAGQPQADVPVEISGESKQTNSH 529 T+ +WP+AVV GI+ WVSVK+KLA+ V L+ G+P AD PV+I+ ++ T S Sbjct: 938 TLRQTVPVWPAAVVAGIRTDGWVSVKQKLAVHGVVLDVNGKPVADAPVKINARARITTSA 997 Query: 530 RKRMVGGFYAYENTRSSQNLGTLCSGKTDKHGVLICEVSLTEAGNVELTASGKDANGNAS 589 RKR+VGGFY Y+N +++LGT+C +TD G C+V+L +AG +EL AS +D +G + Sbjct: 998 RKRVVGGFYRYDNRSETRDLGTVCETRTDAQGRARCDVALEQAGQIELVASARDKDGRTA 1057 Query: 590 FAKTSVWVTRQGELWFDGENQDRIDILPEKKTYQPGETARFQVRMPFRYATALVAVEREG 649 A ++VWVTRQGELWF GEN DRID+LPEKK+Y PG+TA FQVRMPFR+ATALVAVEREG Sbjct: 1058 QAASTVWVTRQGELWFGGENHDRIDLLPEKKSYAPGDTAVFQVRMPFRHATALVAVEREG 1117 Query: 650 IIDTQVVQLNGQDPTISLPVKGGFAPNVYVSVLAVRGRMREVPWYSFFTWGWKEPINWWH 709 I TQVV+L+G DPT+ + VK + PNVYVSVLA+RGR+ EVPWYSFFTWGW++P WW Sbjct: 1118 IYQTQVVELHGSDPTVRVQVKPEWGPNVYVSVLALRGRLHEVPWYSFFTWGWRQPGEWWR 1177 Query: 710 EF----KEYQAPGTMVDLAKPAYKFGIAEIAVGSGAHVLKVAVAADKASYPIRSVAKVNV 765 F +EY AP +VDL+KPA++ G+AEI VG+ H L V V DKASYP+R A+V + Sbjct: 1178 AFRSEGREYAAPTALVDLSKPAFRLGLAEIRVGNAGHRLDVTVTPDKASYPVRGKARVAI 1237 Query: 766 QVTQPDGKPXA 776 QV P+GKP A Sbjct: 1238 QVKLPEGKPAA 1248 >Q46VU1.1 Q46VU1_CUPPJ Alpha-2-macroglobulin, N-terminal Length = 2016 Score = 781 bits (2016), Expect = 0.0, Method: Compositional matrix adjust. Identities = 412/828 (49%), Positives = 546/828 (65%), Gaps = 72/828 (8%) Query: 1 VIAWLTRLNRYHE-RWGDT------SGKTP------------DTRAIGLLAKEPGVKTLN 41 V+ WL + R HE W +G++P +TR++ LL + GV+ L+ Sbjct: 434 VLRWLGLVRRMHEASWTRAELDAVLAGRSPYGVNNPRNAPSIETRSVSLLERAQGVQKLS 493 Query: 42 LPALSDAKDGERPFEVVGIPLKDPGFYVVELESQKLGASLLGKPAPMYVRTSTLVTNLSV 101 +P S D RPFEVVGIPL +PGF+VVE+ S LG +LLGK APMYVRT+ LVTNL V Sbjct: 494 VPKPSG--DAPRPFEVVGIPLPEPGFHVVEIASPMLGEALLGKRAPMYVRTAALVTNLGV 551 Query: 102 HVKLGRENN------AVWVTRLDTAKPVADADVRISNCKGDEIWRGKTNAIGVATIAKPL 155 H KL R + WVT LD KPV DA V + +C G + G+T+A GV AK L Sbjct: 552 HFKLARGDGDGSMSGLAWVTALDDGKPVRDAAVAVRDCSGRLLGEGRTDASGVVRFAK-L 610 Query: 156 EDVCAMGQNQDG-AINGLFVSAR----KTDEQGRADMAFALTSWNDGIESWRFNLLTDRS 210 +DV G+ DG + G FVSAR + +G+ADMAF ++ WN GIE+WRFN+ TD S Sbjct: 611 DDV--RGRTCDGNGLMGYFVSARIAATHPEARGKADMAFVMSDWNRGIETWRFNVPTDAS 668 Query: 211 ASSSARAHTIFDRTLFRAGETVSMKHEFRLESMNGFALAGKD-KLPTRVRIIHQGSGQEF 269 A+ + RAHT+FDRTL R GETVSMKH R E+ GFAL ++ KLP V I H+GSGQ + Sbjct: 669 ATQTVRAHTVFDRTLLRVGETVSMKHFIRSETAQGFALPPENRKLPETVVIRHEGSGQTY 728 Query: 270 QFALNWRNQ----KNAETVFSIPKEAKLGSYEVLLDRGAAKAGSETNGDGDGDGEEGGYA 325 + L WRN ++AE+ F +P AKLG Y V L +G GDG + + Sbjct: 729 ELPLQWRNTATGGRSAESSFQVPPAAKLGVYNVAL-----------QAEGSGDGSDS--S 775 Query: 326 PGTYSSGSFRVEEFRLPLMQGRITPVTGKGKGDALVAPKEVPLDVQLNYINGGGASGQTV 385 TYSSGSFRVE FRLP++ G + GKG A+VAP E+P+ V+++Y++GGGA+G V Sbjct: 776 ARTYSSGSFRVEAFRLPVLTGTLQ--ASGGKGGAVVAPAELPVGVEVHYVSGGGAAGLPV 833 Query: 386 RVTSLMRAKPVSFPAYEGYSFDAGNSGGEDGAGNDD-------------QKIVADKLPVT 432 RV++L+R K ++FP Y+ YSF E+ +G+++ QK++ADKLP+T Sbjct: 834 RVSALLRDKWINFPGYDEYSFSPPRPTRENASGDEEMSDVDEGQARDGAQKLIADKLPLT 893 Query: 433 LDKNGAGRTTVKSLPVLKTPRELLTEMTYNDPNGEIQTVSNVTTLWPSAVVIGIKGGDWV 492 LDKNG G T++ +P + PR+L+ E + DPNGE+QT+ +WPSAVV GI+ WV Sbjct: 894 LDKNGNGSVTLRKMPKIDAPRDLVLEAGFADPNGEVQTLRQTVPVWPSAVVAGIRTEGWV 953 Query: 493 SVKKKLALTMVALNAAGQPQADVPVEISGESKQTNSHRKRMVGGFYAYENTRSSQNLGTL 552 SVK+KLA+ + L+ G+P AD PV+ + ++ T S RKR+VGGFY Y+N S++LGT+ Sbjct: 954 SVKQKLAVHGLVLDTQGKPVADAPVKFNARARITTSTRKRVVGGFYRYDNRSESRDLGTV 1013 Query: 553 CSGKTDKHGVLICEVSLTEAGNVELTASGKDANGNASFAKTSVWVTRQGELWFDGENQDR 612 C +TD G C+V+L +AG VEL A +D +G ++ A ++VWVTRQGELWF GEN DR Sbjct: 1014 CETRTDVQGRARCDVTLDQAGQVELVAIARDKDGRSAQAASTVWVTRQGELWFGGENHDR 1073 Query: 613 IDILPEKKTYQPGETARFQVRMPFRYATALVAVEREGIIDTQVVQLNGQDPTISLPVKGG 672 ID+LPEKK Y PG+TA FQVRMPFR ATALVAVEREG+++TQVV+LNG DPT+ + VK Sbjct: 1074 IDVLPEKKQYAPGDTAVFQVRMPFRQATALVAVEREGVLETQVVELNGSDPTVRVKVKPE 1133 Query: 673 FAPNVYVSVLAVRGRMREVPWYSFFTWGWKEPINWWHEF----KEYQAPGTMVDLAKPAY 728 + PNVYVSV+ +RGR+ EVPWYSFFTWGW++P WW F KEY AP +VDL++PA+ Sbjct: 1134 WGPNVYVSVMTIRGRLHEVPWYSFFTWGWRQPGEWWRAFRSEGKEYAAPTALVDLSRPAF 1193 Query: 729 KFGIAEIAVGSGAHVLKVAVAADKASYPIRSVAKVNVQVTQPDGKPXA 776 + G+AEI VG+ AH L V V DKASY +R A+V +QV PDGKP A Sbjct: 1194 RLGLAEIRVGNEAHRLDVTVTPDKASYSVRGKARVALQVKLPDGKPAA 1241