BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0086.p (402 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZT7.1 D8IZT7_HERSS Exported extracellular alpha-helical protein 513 e-143 Q0K5I8.1 Q0K5I8_CUPNH Large extracellular alpha-helicalprotein 352 5e-95 B3R7Q4.1 B3R7Q4_CUPTR Putative uncharacterized protein 348 1e-93 Q1LHH3.1 Q1LHH3_RALME Large extracellular alpha-helicalprotein 345 7e-93 Q46VU1.1 Q46VU1_CUPPJ Alpha-2-macroglobulin, N-terminal 336 3e-90 >D8IZT7.1 D8IZT7_HERSS Exported extracellular alpha-helical protein Length = 1938 Score = 513 bits (1321), Expect = e-143, Method: Compositional matrix adjust. Identities = 253/377 (67%), Positives = 297/377 (78%), Gaps = 4/377 (1%) Query: 5 LALLLSPAIDAGAAGVAGFSPQGEVAQIRQARATFSEPIIKFGDPKAAAPFDVNCAVAGT 64 ++LL A +A V FSPQGEV +IRQ RA FSE ++KFGDPKAA+PFD +CAVAGT Sbjct: 14 MSLLPVKPAQAASATVQSFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADCAVAGT 73 Query: 65 SRWADGKNWVYDFERDLPPGTRCSFTLKPGVKAVSGAALSGKSVFQFSTGGPAVVRHMP- 123 +RWAD +NWVYDFERDLPPGTRCSFTL+ K+V+G ++ GK+ FQFSTGGPAV R P Sbjct: 74 ARWADDRNWVYDFERDLPPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPY 133 Query: 124 SGEEIEEEQAFILFQNGAANQDTVRDHLYCEAEGVHERIPVKFVADATRKQLLQEFAKKI 183 SG +I E+QAFILFQNG A + +VR HLYCEAEG++ERIP K V +A RK LLQ+FAK + Sbjct: 134 SGAQIAEDQAFILFQNGPATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQFAKGV 193 Query: 184 DPATVTIVQCQQRLPNDATVRLTWDKGIATPN--GIATTIPQTFKFKVRKEFTASLSCER 241 DPA+VTIVQCQQRLPN+A V+L WD+GIA N + T+ PQ F F+VR EF ASLSC+R Sbjct: 194 DPASVTIVQCQQRLPNEAHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQR 253 Query: 242 ENANAACSPIRPVTMSFSSPVPRKLAEAVELKSSNGKLKPFFEKGNVDDTVYGLTFKPPF 301 ENANAACSPI PVT+SFS+PVPRKLAE V + ++ GK+KP E G+ D+ V L FKPPF Sbjct: 254 ENANAACSPILPVTLSFSAPVPRKLAEQVVMNATTGKIKPTLE-GDKDEAVRELRFKPPF 312 Query: 302 AENGEFTINLPSGFKDESGRALGNASAFPLKSRTAGYPPLAKFPAAPFGIIELNADATLP 361 E +FTI+LPSGFKDE GR L NA AFPLKS A +PPLAKFPAAPFGIIELNAD TLP Sbjct: 313 PEKSDFTISLPSGFKDEDGRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNADPTLP 372 Query: 362 VTLRRVEANLLARGVLG 378 VTLRRVEA L RG G Sbjct: 373 VTLRRVEAGLQVRGKDG 389 >Q0K5I8.1 Q0K5I8_CUPNH Large extracellular alpha-helicalprotein Length = 2023 Score = 352 bits (904), Expect = 5e-95, Method: Compositional matrix adjust. Identities = 186/376 (49%), Positives = 241/376 (64%), Gaps = 19/376 (5%) Query: 20 VAGFSPQGEVAQIRQARATFSEPIIKFGDPKAAAPFDVNCAVAGT---SRWADGKNWVYD 76 V FSP+G V Q+RQ F E ++ GD +A AP V+C AGT +RW D KNWVYD Sbjct: 45 VTRFSPEGTVGQVRQVAIRFDEAMVPMGDVQATAPAAVSCTGAGTGGQARWIDAKNWVYD 104 Query: 77 FERDLPPGTRCSFTLKPGVKAVSGAALSGKSVFQFSTGGPAVVRHMPSGEEIEEEQAFIL 136 F DLPPG RC+ ++ G+++V+G A +GK ++F TGGP VV P+G EIEE+Q F L Sbjct: 105 FASDLPPGVRCTVRMRTGLRSVAGTAYAGKPEYRFETGGPTVVSSRPAGGEIEEDQVFAL 164 Query: 137 FQNGAANQDTVRDHLYCEAEGVHERIPVKFVADATRKQLLQ----EFAKKIDPATVTIVQ 192 NGAA +VR+H +C+A+G+ ERIPV+ +A R +L E K P V ++ Sbjct: 165 RFNGAATAASVREHAWCQAQGLGERIPVRLLAGKERDAVLDAIHWERIAKQAPDAVHLLA 224 Query: 193 CQQRLPNDATVRLTWDKGIATPNGIATTIPQTFKFKVRKEFTASLSCERENANAACSPIR 252 CQQRLP A V+L GIATP+G+AT + F + VR+ FTAS SCERE+A + C+P+R Sbjct: 225 CQQRLPAAARVQLVLGAGIATPSGVATRDERRFDYTVREPFTASFSCEREHAQSPCTPLR 284 Query: 253 PVTMSFSSPVPRKLAEAVELKSSNGKLKPFFEKGNV-DDTVYGLTFKPPFAENGEFTINL 311 P+++SFSSPVPRKLAE+V LK+ +G P F+ D +V LTF PFAE +FTI + Sbjct: 285 PMSVSFSSPVPRKLAESVVLKTPSGPRAPQFDPDLAPDASVSALTFAAPFAEKAQFTIEV 344 Query: 312 PSGFKDESGRALGNASAFPLKSRTAGYPPLAKFPAAPFGIIELNADA-----------TL 360 P KD+SGR L NA FPLK TA PPLAKF AAPFG++E + L Sbjct: 345 PRNLKDDSGRTLANADLFPLKVATASMPPLAKFAAAPFGVVERFGELPRGKAPADYPPLL 404 Query: 361 PVTLRRVEANLLARGV 376 PVTLR VEA+L RGV Sbjct: 405 PVTLRNVEADLAVRGV 420 >B3R7Q4.1 B3R7Q4_CUPTR Putative uncharacterized protein Length = 2023 Score = 348 bits (892), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 185/380 (48%), Positives = 246/380 (64%), Gaps = 21/380 (5%) Query: 17 AAGVAGFSPQGEVAQIRQARATFSEPIIKFGDPKAAAPFDVNCAVAGTS---RWADGKNW 73 AA V+ FSP+G V Q+RQ F E ++ GD +AAAP V+C A TS RW D +NW Sbjct: 43 AAQVSRFSPEGTVGQVRQVAIRFDEAMVPMGDVQAAAPAAVSCTGASTSGQARWIDARNW 102 Query: 74 VYDFERDLPPGTRCSFTLKPGVKAVSGAALSGKSVFQFSTGGPAVVRHMPSGEEIEEEQA 133 VYDF DLPPG RC+ ++ G+++ +G A +GK+ ++F TGGP VV PSG EIEE+Q Sbjct: 103 VYDFASDLPPGVRCTVRMRAGLRSEAGTAYAGKAEYRFETGGPTVVSSRPSGGEIEEDQV 162 Query: 134 FILFQNGAANQDTVRDHLYCEAEGVHERIPVKFVADATRKQLLQ-----EFAKKIDPATV 188 F L NGA +VR+H +C+A+G+ ERIPV+ +A R+ +L+ AK + P V Sbjct: 163 FALRFNGATTAASVREHAWCQAQGLGERIPVRLLAGKEREAVLEAIRWDRLAKPM-PDAV 221 Query: 189 TIVQCQQRLPNDATVRLTWDKGIATPNGIATTIPQTFKFKVRKEFTASLSCERENANAAC 248 ++ CQQRLP A V+L GIATP+G+AT + F + VR+ FTAS SCERE+A + C Sbjct: 222 HLLACQQRLPAAARVQLVLGAGIATPSGVATREERRFDYTVREPFTASFSCEREHAQSPC 281 Query: 249 SPIRPVTMSFSSPVPRKLAEAVELKSSNGKLKPFFEKGNV-DDTVYGLTFKPPFAENGEF 307 +P+RP+T++FS+PVPRKLAE+V LK+ +G P F+ D +V LTF PFAE +F Sbjct: 282 TPLRPMTVTFSAPVPRKLAESVVLKTPSGPRAPQFDPDLAPDASVSALTFAAPFAEKAQF 341 Query: 308 TINLPSGFKDESGRALGNASAFPLKSRTAGYPPLAKFPAAPFGIIELNADA--------- 358 TI +P +D+SGR L NA FPLK TA PPLAKF AAPFG++E + Sbjct: 342 TIEVPRKLQDDSGRPLANADLFPLKVATAAMPPLAKFAAAPFGVVERFGELPRGKSAQDY 401 Query: 359 --TLPVTLRRVEANLLARGV 376 LPVTLR VEA+L RGV Sbjct: 402 PPLLPVTLRNVEADLSVRGV 421 >Q1LHH3.1 Q1LHH3_RALME Large extracellular alpha-helicalprotein Length = 1993 Score = 345 bits (885), Expect = 7e-93, Method: Compositional matrix adjust. Identities = 179/385 (46%), Positives = 243/385 (63%), Gaps = 21/385 (5%) Query: 6 ALLLSPAIDAGAAGVAGFSPQGEVAQIRQARATFSEPIIKFGDPKAAAPFDVNC---AVA 62 A+L +P A AA + FSP+G V Q+RQ F E ++ GD KAA P V+C +V Sbjct: 20 AVLWAPM--ASAAQITRFSPEGVVPQVRQVAIRFDEAMVPMGDLKAAPPAAVSCTGGSVG 77 Query: 63 GTSRWADGKNWVYDFERDLPPGTRCSFTLKPGVKAVSGAALSGKSVFQFSTGGPAVVRHM 122 G+ RW + NWVYDFERDLPPG RCS + G+K+V+G +GK ++F TGGP V+ Sbjct: 78 GSGRWVNATNWVYDFERDLPPGVRCSVRMSAGLKSVAGKTYAGKPEYRFETGGPFVISAR 137 Query: 123 PSGEEIEEEQAFILFQNGAANQDTVRDHLYCEAEGVHERIPVKFVADATRKQLLQEF--- 179 PSG +IEE+Q F+L NGAA ++R+H +C+AEG+ ERIPV+ + R +++ Sbjct: 138 PSGGQIEEDQVFVLRFNGAATAGSIREHAWCQAEGLGERIPVRLLTGKERDGVIEAVRWN 197 Query: 180 -AKKIDPATVTIVQCQQRLPNDATVRLTWDKGIATPNGIATTIPQTFKFKVRKEFTASLS 238 K +P V ++ CQQRLP A ++L D GI+TP+G+ATT P+ F ++VR+ F A + Sbjct: 198 DIVKQNPEAVHLLACQQRLPAGARMQLVLDAGISTPSGLATTAPRRFDYQVREPFAAGFT 257 Query: 239 CERENANAACSPIRPVTMSFSSPVPRKLAEAVELKSSNGKLKPFFEKGNVDDT-VYGLTF 297 CERE A A C+P+RP+ ++F++PVPRKLAE + LK+ +G P F+ + D V +TF Sbjct: 258 CERERAEAPCTPLRPLVVTFTAPVPRKLAEHIVLKTPSGPRAPKFDSDDARDAPVSSVTF 317 Query: 298 KPPFAENGEFTINLPSGFKDESGRALGNASAFPLKSRTAGYPPLAKFPAAPFGIIELNAD 357 PF E TI P KDESGR+L NA FP+K TA PPLAKF AAPFG++E AD Sbjct: 318 PGPFPEKASLTIEAPKDLKDESGRSLSNADLFPIKLTTAALPPLAKFAAAPFGVVERFAD 377 Query: 358 A-----------TLPVTLRRVEANL 371 LPVTLR VEA+L Sbjct: 378 VPRGKSPADYPPLLPVTLRNVEADL 402 >Q46VU1.1 Q46VU1_CUPPJ Alpha-2-macroglobulin, N-terminal Length = 2016 Score = 336 bits (862), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 185/379 (48%), Positives = 237/379 (62%), Gaps = 19/379 (5%) Query: 17 AAGVAGFSPQGEVAQIRQARATFSEPIIKFGDPKAAAPFDVNC---AVAGTSRWADGKNW 73 AA V FSP+G V Q+RQ F E ++ GD +AAAP + C A AG RW D NW Sbjct: 38 AAQVTRFSPEGTVPQVRQVAIRFDEAMVPMGDVQAAAPAAIACTGAATAGHGRWVDASNW 97 Query: 74 VYDFERDLPPGTRCSFTLKPGVKAVSGAALSGKSVFQFSTGGPAVVRHMPSGEEIEEEQA 133 V+DFERDLPPG RCS + +++ +G A +GK ++F TGGP VV PSG EIEE+Q Sbjct: 98 VFDFERDLPPGVRCSVRMSASLRSAAGKAYAGKPEYRFETGGPTVVASRPSGGEIEEDQI 157 Query: 134 FILFQNGAANQDTVRDHLYCEAEGVHERIPVKFVADATRKQLLQE-FAKKI---DPATVT 189 F L NGAA +VRDH +C+AEG+ ERIPV+ + R +L + K+I P + Sbjct: 158 FALRFNGAATAASVRDHAWCQAEGLGERIPVRLLTGKERDGVLDAIYWKRIAKDAPDAIH 217 Query: 190 IVQCQQRLPNDATVRLTWDKGIATPNGIATTIPQTFKFKVRKEFTASLSCERENANAACS 249 ++ CQQRLP A ++L GIATP+G+AT + F + VR+ FTAS SCERE+A + C+ Sbjct: 218 LLACQQRLPAGARMQLVLGAGIATPSGLATRDERRFDYTVREPFTASFSCEREHAQSPCT 277 Query: 250 PIRPVTMSFSSPVPRKLAEAVELKSSNGKLKPFFEKGNV-DDTVYGLTFKPPFAENGEFT 308 P+RP+T+SFS+P+ R+LAE V LK+ +G P FE D V LTF PFAE FT Sbjct: 278 PLRPMTVSFSAPISRRLAEHVVLKTPSGPRAPQFEVDLAPDANVTSLTFAAPFAEKANFT 337 Query: 309 INLPSGFKDESGRALGNASAFPLKSRTAGYPPLAKFPAAPFGIIELNADA---------- 358 I +P KD+SGR L NA FPLK TA PPLAKF AAPFG++E + Sbjct: 338 IEIPRDLKDDSGRTLANADLFPLKVSTASMPPLAKFAAAPFGVVERFGELPKGKAPADYP 397 Query: 359 -TLPVTLRRVEANLLARGV 376 LPVTLR VEA+L RGV Sbjct: 398 PLLPVTLRNVEADLQVRGV 416