BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0061.p (452 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZV6.1 D8IZV6_HERSS 23S rRNA (Uracil-5-)-methyltransferase pro... 785 0.0 A4G4J6.1 A4G4J6_HERAR 23S rRNA (Uracil-5-)-methyltransferase rum... 727 0.0 A6SZX6.1 A6SZX6_JANMA SAM-dependent methyltransferases related t... 717 0.0 F1VVJ8.1 F1VVJ8_9BURK 23S rRNA (Uracil-5-)-methyltransferase 657 0.0 Q0K956.1 RUMA_CUPNH 23S rRNA (uracil-5-)-methyltransferase RumA ... 641 0.0 >D8IZV6.1 D8IZV6_HERSS 23S rRNA (Uracil-5-)-methyltransferase protein EC=2.1.1.35 Length = 453 Score = 785 bits (2027), Expect = 0.0, Method: Compositional matrix adjust. Identities = 372/453 (82%), Positives = 407/453 (89%), Gaps = 1/453 (0%) Query: 1 MQQNII-NIKALDMDGRGVGHVANEDGTQGKVIFVEGALPGEQVSFQSYRRKPKWEAATM 59 MQQ+II IK+LDMDGRGVGH+ NEDGTQGKVIFVEGALPGE+VSFQSYR+KPKWEA M Sbjct: 1 MQQDIIIEIKSLDMDGRGVGHLENEDGTQGKVIFVEGALPGERVSFQSYRKKPKWEAGVM 60 Query: 60 TALHRESSLRVKPQCDYFGLCGGCAMQHLEPSAQVAMKQRVLEDNLWHLSKLKAETMLRP 119 T LH ESSLRVKP+CDYFG CGGCAMQHLEPSAQVAMKQRVLEDNLWHL K KAE MLRP Sbjct: 61 TTLHSESSLRVKPRCDYFGTCGGCAMQHLEPSAQVAMKQRVLEDNLWHLGKTKAEVMLRP 120 Query: 120 IYGPTWGYRYRARISVKNVVKKGTVLVGFHEKKSPFVSDMKTCEILPPHVSAMLMPLRAL 179 IYGPTWGYRYRARISV++V KKG VLVGFHEK+S F++DMKTCEILPP+VSAML+PLR L Sbjct: 121 IYGPTWGYRYRARISVRHVAKKGGVLVGFHEKRSSFIADMKTCEILPPNVSAMLVPLREL 180 Query: 180 IGSLSIIDRLPQIELAIGEGDNGVKTTVMVLRVMEPPSADDELKLKAFADEHKVEWWLQP 239 + LSI DR+PQIELA+GEGD+G K TV+VLR+ME S DE+ LK+FADEHK+EWWLQ Sbjct: 181 VAGLSIRDRMPQIELAVGEGDDGNKVTVLVLRIMEALSPADEVLLKSFADEHKIEWWLQT 240 Query: 240 KGPDTAHPFYPPQSNLHYTLPEFGIRMPFKPTDFTQVNHQINRVLVARALRLLDVQPEDR 299 KGPDTA P+YP QS L YTLPEFGIRMPFKPTDFTQVNHQINRVLVARALRLLDVQP+DR Sbjct: 241 KGPDTAAPYYPAQSRLQYTLPEFGIRMPFKPTDFTQVNHQINRVLVARALRLLDVQPQDR 300 Query: 300 VADLFCGLGNFTLPIATLAREVVGIEGSTALTERAAENAKVNGIAGKTAFYCRNLFEATT 359 VADLFCGLGNFTLPIATLAREVVGIEGSTALTERA +NAKVNG+ KT+FYCRNLFEA Sbjct: 301 VADLFCGLGNFTLPIATLAREVVGIEGSTALTERALDNAKVNGVDAKTSFYCRNLFEAKP 360 Query: 360 EDFIALGKFDRMLIDPPREGALEVCKAIAGLGAQHAHLKPRRIVYVSCNPATLARDAGEL 419 EDF+ALGKFDRMLIDPPREGA+EVCKA+ L + HLKP+RIVYVSCNPATLARDAG L Sbjct: 361 EDFVALGKFDRMLIDPPREGAMEVCKALVELPPEQQHLKPKRIVYVSCNPATLARDAGML 420 Query: 420 VNLGGYRLTLAGVVNMFPHTAHVESMAVFDLAD 452 V+LGGY L AGVVNMFPHTAHVES+AVFDL + Sbjct: 421 VHLGGYALKYAGVVNMFPHTAHVESIAVFDLPE 453 >A4G4J6.1 A4G4J6_HERAR 23S rRNA (Uracil-5-)-methyltransferase rumA (23S rRNA(M-5-U1939)-methyltransferase) EC=2.1.1.35 Length = 461 Score = 727 bits (1876), Expect = 0.0, Method: Compositional matrix adjust. Identities = 345/452 (76%), Positives = 392/452 (86%), Gaps = 1/452 (0%) Query: 1 MQQNIINIKALDMDGRGVGHVANEDGTQGKVIFVEGALPGEQVSFQSYRRKPKWEAATMT 60 MQQ II+I++LDM+ RGVGH+ NEDGTQGKVIFVEGALP E+V + SYR+K WEAA M Sbjct: 1 MQQTIIDIESLDMEARGVGHLQNEDGTQGKVIFVEGALPKERVVYSSYRKKANWEAAKMM 60 Query: 61 ALHRESSLRVKPQCDYFGLCGGCAMQHLEPSAQVAMKQRVLEDNLWHLSKLKAETMLRPI 120 L +ESSLRV+P+C YFG+CGGC+MQHLEP+AQVAMKQR+LEDNL H+ K+KAETMLRPI Sbjct: 61 VLLKESSLRVQPKCAYFGICGGCSMQHLEPTAQVAMKQRILEDNLKHIGKVKAETMLRPI 120 Query: 121 YGPTWGYRYRARISVKNVVKKGTVLVGFHEKKSPFVSDMKTCEILPPHVSAMLMPLRALI 180 +GPTWGYRYRARISV+NV KKG VLVGFHE+KS F++DMKTCEILP +VSAML+PLR LI Sbjct: 121 HGPTWGYRYRARISVRNVPKKGGVLVGFHERKSSFITDMKTCEILPANVSAMLVPLRHLI 180 Query: 181 GSLSIIDRLPQIELAIGEGDNGVKTTVMVLRVMEPPSADDELKLKAFADEHKVEWWLQPK 240 GSLSIID LPQIELAIG+G+ K T +VLR+M P SA+D++KLKAFADE+KV+WWLQP Sbjct: 181 GSLSIIDHLPQIELAIGQGEQD-KITALVLRIMAPLSAEDDVKLKAFADEYKVQWWLQPA 239 Query: 241 GPDTAHPFYPPQSNLHYTLPEFGIRMPFKPTDFTQVNHQINRVLVARALRLLDVQPEDRV 300 GPD+A+ FYP NLHY+LPEFGI+MPFKPTDFTQVNHQINRVLVARALRLLD Q DR+ Sbjct: 240 GPDSAYQFYPEDENLHYSLPEFGIKMPFKPTDFTQVNHQINRVLVARALRLLDAQATDRI 299 Query: 301 ADLFCGLGNFTLPIATLAREVVGIEGSTALTERAAENAKVNGIAGKTAFYCRNLFEATTE 360 ADLFCGLGNFTLPIAT A EVVGIEGST LTERA ENA NG+AGKTAFY RNLFEA T+ Sbjct: 300 ADLFCGLGNFTLPIATQAGEVVGIEGSTTLTERALENAVANGLAGKTAFYSRNLFEAKTD 359 Query: 361 DFIALGKFDRMLIDPPREGALEVCKAIAGLGAQHAHLKPRRIVYVSCNPATLARDAGELV 420 DFIALGKFDRMLIDPPR+GAL VC+A+AGL A L P RIVYVSCNP+TLARDA LV Sbjct: 360 DFIALGKFDRMLIDPPRDGALAVCEALAGLNAVRPDLLPSRIVYVSCNPSTLARDAAVLV 419 Query: 421 NLGGYRLTLAGVVNMFPHTAHVESMAVFDLAD 452 N G Y L AGVVNMFPHT+HVESMAVF+L + Sbjct: 420 NEGPYVLKNAGVVNMFPHTSHVESMAVFELKE 451 >A6SZX6.1 A6SZX6_JANMA SAM-dependent methyltransferases related to tRNA (Uracil-5-)-methyltransferase EC=2.1.1.- Length = 457 Score = 717 bits (1852), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/450 (74%), Positives = 386/450 (85%), Gaps = 1/450 (0%) Query: 1 MQQNIINIKALDMDGRGVGHVANEDGTQGKVIFVEGALPGEQVSFQSYRRKPKWEAATMT 60 MQQ II+I++LDM+ RGVGH+ NEDGT GKV+FVEGALP E+V + SYR+K WEAA M Sbjct: 1 MQQTIIDIESLDMEARGVGHLQNEDGTPGKVVFVEGALPKERVVYSSYRKKANWEAAKMM 60 Query: 61 ALHRESSLRVKPQCDYFGLCGGCAMQHLEPSAQVAMKQRVLEDNLWHLSKLKAETMLRPI 120 +L +ESSLR KP+C YFG+CGGC+MQHLEPSAQVA+KQR+LEDNL H+ K+KAETMLRPI Sbjct: 61 SLIKESSLRTKPKCVYFGICGGCSMQHLEPSAQVALKQRILEDNLKHIGKVKAETMLRPI 120 Query: 121 YGPTWGYRYRARISVKNVVKKGTVLVGFHEKKSPFVSDMKTCEILPPHVSAMLMPLRALI 180 +GPTWGYRYRARISV+NV KKG VLVGFHE+KS F++DMKTCEILPP+VSAML+PLR LI Sbjct: 121 HGPTWGYRYRARISVRNVPKKGGVLVGFHERKSSFITDMKTCEILPPNVSAMLVPLRELI 180 Query: 181 GSLSIIDRLPQIELAIGEGDNGVKTTVMVLRVMEPPSADDELKLKAFADEHKVEWWLQPK 240 SLS+ID LPQIELAIG+G K T MVLR+M SADDE+KLKAFAD H+V+WWLQP Sbjct: 181 ASLSVIDHLPQIELAIGQGAQE-KVTAMVLRIMTELSADDEVKLKAFADLHQVQWWLQPA 239 Query: 241 GPDTAHPFYPPQSNLHYTLPEFGIRMPFKPTDFTQVNHQINRVLVARALRLLDVQPEDRV 300 GPD+A+ FYP ++NLHY LPEF ++MPFKPTDFTQVNHQINRVLVARALRLLD QP DR+ Sbjct: 240 GPDSAYQFYPTENNLHYALPEFNVKMPFKPTDFTQVNHQINRVLVARALRLLDAQPTDRI 299 Query: 301 ADLFCGLGNFTLPIATLAREVVGIEGSTALTERAAENAKVNGIAGKTAFYCRNLFEATTE 360 ADLFCGLGNFTLPIAT AREVVGIEGST LTER+ ENA NG+A KT+FYCRNLFEA E Sbjct: 300 ADLFCGLGNFTLPIATQAREVVGIEGSTTLTERSLENAVANGLADKTSFYCRNLFEAKAE 359 Query: 361 DFIALGKFDRMLIDPPREGALEVCKAIAGLGAQHAHLKPRRIVYVSCNPATLARDAGELV 420 DF+ LGKFDRMLIDPPR+GAL VC+A++ LG L P RIVYVSCNP+TLARDA LV Sbjct: 360 DFVELGKFDRMLIDPPRDGALAVCEALSELGKSQPDLLPSRIVYVSCNPSTLARDAAVLV 419 Query: 421 NLGGYRLTLAGVVNMFPHTAHVESMAVFDL 450 N G Y L AGV+NMFPHT+HVESMAVF+L Sbjct: 420 NEGLYDLKNAGVINMFPHTSHVESMAVFEL 449 >F1VVJ8.1 F1VVJ8_9BURK 23S rRNA (Uracil-5-)-methyltransferase Length = 434 Score = 657 bits (1694), Expect = 0.0, Method: Compositional matrix adjust. Identities = 312/439 (71%), Positives = 373/439 (84%), Gaps = 5/439 (1%) Query: 13 MDGRGVGHVANEDGTQGKVIFVEGALPGEQVSFQSYRRKPKWEAATMTALHRESSLRVKP 72 M+ RGVG++ NEDG+ GKVIFVEGALPGEQV F S+R+K KWEAA MTAL RES++RV P Sbjct: 1 MEARGVGNLVNEDGSHGKVIFVEGALPGEQVRFLSFRKKSKWEAARMTALVRESAMRVTP 60 Query: 73 QCDYFGLCGGCAMQHLEPSAQVAMKQRVLEDNLWHLSKLKAETMLRPIYGPTWGYRYRAR 132 QC YFG CGGCAMQHL+ +AQVA+KQRVLEDNLWH+ K++ MLRPIYGPTWGYRYRAR Sbjct: 61 QCAYFGTCGGCAMQHLDAAAQVAIKQRVLEDNLWHIGKVRPRLMLRPIYGPTWGYRYRAR 120 Query: 133 ISVKNVVKKGTVLVGFHEKKSPFVSDMKTCEILPPHVSAMLMPLRALIGSLSIIDRLPQI 192 +SV+NV +KG VLVGF EKKS +++DM +C+ILPP VSA+L+PLR LI +LSI++++PQI Sbjct: 121 LSVRNVPRKGGVLVGFIEKKSSYLTDMTSCDILPPKVSALLVPLRELIAALSIVEQIPQI 180 Query: 193 ELAIGEGDNGVKTTVMVLRVMEPPSADDELKLKAFADEHKVEWWLQPKGPDTAHPFYPPQ 252 ELA+GEG++GV TV+VLR+M P S DE+ LKAFAD H++ WWLQ GP++A P+YP Sbjct: 181 ELAVGEGNDGV-VTVLVLRIMAPLSRADEVLLKAFADLHQIVWWLQAAGPESAVPYYPAN 239 Query: 253 SNLHYTLPEFGIRMPFKPTDFTQVNHQINRVLVARALRLLDVQPEDRVADLFCGLGNFTL 312 +L Y+LPEFGI MPFKPTDFTQVNHQINRVLVARALRLLD QP++R+ADLFCGLGNFTL Sbjct: 240 QSLQYSLPEFGITMPFKPTDFTQVNHQINRVLVARALRLLDAQPDERIADLFCGLGNFTL 299 Query: 313 PIATLAREVVGIEGSTALTERAAENAKVNGIAGKTAFYCRNLFEATTEDFIALGKFDRML 372 PIAT AR VVGIEGSTALT+RA +NA+ NG+ KT+F CRNLF+ T D +ALG FDR+L Sbjct: 300 PIATQARAVVGIEGSTALTQRAMDNARFNGVQDKTSFGCRNLFDITGADLVALGYFDRLL 359 Query: 373 IDPPREGALEVCKAIAGLGAQHAHLKPRRIVYVSCNPATLARDAGELVNLGGYRLTLAGV 432 IDPPR+GA+ +C+A+A L Q A KPRRIVYVSCNPATLARDA +L+ GGY L+ AGV Sbjct: 360 IDPPRDGAMALCEALAEL--QPAQ-KPRRIVYVSCNPATLARDA-QLLVAGGYVLSQAGV 415 Query: 433 VNMFPHTAHVESMAVFDLA 451 VNMFPHTAHVESMAVFDLA Sbjct: 416 VNMFPHTAHVESMAVFDLA 434 >Q0K956.1 RUMA_CUPNH 23S rRNA (uracil-5-)-methyltransferase RumA EC=2.1.1.190 Length = 441 Score = 641 bits (1653), Expect = 0.0, Method: Compositional matrix adjust. Identities = 298/444 (67%), Positives = 366/444 (82%), Gaps = 5/444 (1%) Query: 6 INIKALDMDGRGVGHVANEDGTQGKVIFVEGALPGEQVSFQSYRRKPKWEAATMTALHRE 65 ++I +LDM+ RGVG + NEDGT GKVIFVEGALPGE VS++S+RRKP +E A + + +E Sbjct: 1 MSIDSLDMEARGVGRLLNEDGTPGKVIFVEGALPGETVSYRSFRRKPSYEQAHLVEVRQE 60 Query: 66 SSLRVKPQCDYFGLCGGCAMQHLEPSAQVAMKQRVLEDNLWHLSKLKAETMLRPIYGPTW 125 S +RVKP C +FG+CGGC+MQHL+ AQ+A+KQRVLEDNLWHLSK+K + + RPI GP W Sbjct: 61 SVMRVKPGCQHFGVCGGCSMQHLDSRAQLAIKQRVLEDNLWHLSKVKPDVVFRPIAGPDW 120 Query: 126 GYRYRARISVKNVVKKGTVLVGFHEKKSPFVSDMKTCEILPPHVSAMLMPLRALIGSLSI 185 GYRYRAR++V++V KKG VLVGFHE+KS +V+DM CEILPPHVSAML+PLR L+G LSI Sbjct: 121 GYRYRARLTVRHVAKKGGVLVGFHERKSSYVADMTRCEILPPHVSAMLVPLRELVGGLSI 180 Query: 186 IDRLPQIELAIGEGDNGVKTTVMVLRVMEPPSADDELKLKAFADEHKVEWWLQPKGPDTA 245 DR+PQIELA+G+ + T +VLR++EP + D+ L+AFAD+HKV++WLQPKGPDT Sbjct: 181 RDRMPQIELAVGQ-----EVTALVLRILEPLTDADKDLLRAFADQHKVQFWLQPKGPDTV 235 Query: 246 HPFYPPQSNLHYTLPEFGIRMPFKPTDFTQVNHQINRVLVARALRLLDVQPEDRVADLFC 305 +PFYP + L YTLPEFGIRMPFKPTDFTQVNHQINRVL+ RALRLLD QP+DR+ DLFC Sbjct: 236 YPFYPADAELAYTLPEFGIRMPFKPTDFTQVNHQINRVLIGRALRLLDAQPQDRLLDLFC 295 Query: 306 GLGNFTLPIATLAREVVGIEGSTALTERAAENAKVNGIAGKTAFYCRNLFEATTEDFIAL 365 G+GNFTLP+AT + V+GIEGS ALT RA NA+ NG+A +T F CRNLFE T ED AL Sbjct: 296 GIGNFTLPLATQGKSVMGIEGSEALTTRALANAEYNGLAARTEFACRNLFEVTAEDIAAL 355 Query: 366 GKFDRMLIDPPREGALEVCKAIAGLGAQHAHLKPRRIVYVSCNPATLARDAGELVNLGGY 425 G+FDR L+DPPREGAL VCKA+ L Q +++ P+RIVYVSC+PATLARDAG LV+ GY Sbjct: 356 GRFDRWLVDPPREGALAVCKALGELAQQGSNVLPQRIVYVSCSPATLARDAGLLVHGAGY 415 Query: 426 RLTLAGVVNMFPHTAHVESMAVFD 449 RL AGVVNMFPHT+HVES+AVF+ Sbjct: 416 RLAGAGVVNMFPHTSHVESIAVFE 439