BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0045.p (377 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZW5.1 D8IZW5_HERSS 2-oxoglutarate dehydrogenase, E3 component... 537 e-150 A6SY57.1 A6SY57_JANMA Dihydrolipoamide dehydrogenase EC=1.8.1.4 519 e-145 F1VWJ1.1 F1VWJ1_9BURK Dihydrolipoamide dehydrogenase of 2-oxoglu... 506 e-141 A4G5Y9.1 A4G5Y9_HERAR Dihydrolipoyl dehydrogenase (E3 component ... 489 e-136 A2SHC9.1 A2SHC9_METPP Dihydrolipoamide dehydrogenase EC=1.8.1.4 474 e-132 >D8IZW5.1 D8IZW5_HERSS 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase protein EC=1.8.1.4 Length = 475 Score = 537 bits (1384), Expect = e-150, Method: Compositional matrix adjust. Identities = 276/308 (89%), Positives = 288/308 (93%) Query: 1 MSKNFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNEKGGPAPGGTCTNVGCIPSKAL 60 MSKNFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNEKGGPAPGGTCTNVGCIPSKAL Sbjct: 1 MSKNFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNEKGGPAPGGTCTNVGCIPSKAL 60 Query: 61 LQSSEHYEHAGHAFKDHGIDVKGLSLNLPQMLGRKNTVVKQNNDGILYLFKKNKVTFFHG 120 LQSSEHYEHA H F +HGI+VKGL LNL +MLGRKNTVVKQNNDGILYLFKKNKV+FFHG Sbjct: 61 LQSSEHYEHASHGFAEHGIEVKGLGLNLEKMLGRKNTVVKQNNDGILYLFKKNKVSFFHG 120 Query: 121 RGSFVKGDANGYEIKVAGATEESITAKQVIVATGSNARALPGAPFDEELILSNTGALAIT 180 RGSFVKGDANGYEIKVAGA EE+ITAK VIVATGSNARALPGA FDE+LILSNTGAL+IT Sbjct: 121 RGSFVKGDANGYEIKVAGAAEETITAKHVIVATGSNARALPGAEFDEKLILSNTGALSIT 180 Query: 181 EVPKKLGVIGAGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKLLAKQGLT 240 EVPKKLGVIGAGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKLL KQGL Sbjct: 181 EVPKKLGVIGAGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKLLTKQGLA 240 Query: 241 VNLGVKIGDIKAGKKDVSVDYTDDKGNAQKAVFDKLIISIGRTPNTTGLNAEAIGLKLDE 300 VNLGVKIG IKAGK VSV+YTD KG+A FDKLI+SIGRTPNT GLNAE +GLKLDE Sbjct: 241 VNLGVKIGAIKAGKNSVSVEYTDAKGDAHTGEFDKLIVSIGRTPNTIGLNAEGVGLKLDE 300 Query: 301 RGFIAVNG 308 RGFIAV+G Sbjct: 301 RGFIAVDG 308 >A6SY57.1 A6SY57_JANMA Dihydrolipoamide dehydrogenase EC=1.8.1.4 Length = 475 Score = 519 bits (1337), Expect = e-145, Method: Compositional matrix adjust. Identities = 251/307 (81%), Positives = 277/307 (90%) Query: 1 MSKNFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNEKGGPAPGGTCTNVGCIPSKAL 60 MSKNFDVVVIG GPGGY+AAIRAAQLGF ACIDEWKNEKGGPAPGGTCTNVGCIPSKA+ Sbjct: 1 MSKNFDVVVIGAGPGGYVAAIRAAQLGFTVACIDEWKNEKGGPAPGGTCTNVGCIPSKAM 60 Query: 61 LQSSEHYEHAGHAFKDHGIDVKGLSLNLPQMLGRKNTVVKQNNDGILYLFKKNKVTFFHG 120 LQSSE+Y HAGHAF +HGI+VKGLSLN+ +M+ RK+TVVKQNNDGILYLFKKNKVTFFHG Sbjct: 61 LQSSENYHHAGHAFAEHGIEVKGLSLNVKKMVARKDTVVKQNNDGILYLFKKNKVTFFHG 120 Query: 121 RGSFVKGDANGYEIKVAGATEESITAKQVIVATGSNARALPGAPFDEELILSNTGALAIT 180 RGSFVK G+EIK+AGATEE+I AK V+VATGSN RALPGA FDE+LILSNTGAL IT Sbjct: 121 RGSFVKAADGGHEIKIAGATEENIFAKHVVVATGSNPRALPGAAFDEKLILSNTGALEIT 180 Query: 181 EVPKKLGVIGAGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKLLAKQGLT 240 EVPK+LGVIGAGVIGLEMGSVWRRLG+EVTVLEALP FLGAVD+ +AKEA K KQGL Sbjct: 181 EVPKRLGVIGAGVIGLEMGSVWRRLGSEVTVLEALPAFLGAVDDAVAKEAFKQFTKQGLA 240 Query: 241 VNLGVKIGDIKAGKKDVSVDYTDDKGNAQKAVFDKLIISIGRTPNTTGLNAEAIGLKLDE 300 ++LGV+IG I AGK DV+V+Y DDKG AQKAVFDKLI+SIGR PNT GLNAEA+GLKLDE Sbjct: 241 ISLGVQIGAITAGKNDVTVNYVDDKGAAQKAVFDKLIVSIGRVPNTIGLNAEAVGLKLDE 300 Query: 301 RGFIAVN 307 RGFIAV+ Sbjct: 301 RGFIAVD 307 >F1VWJ1.1 F1VWJ1_9BURK Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase Length = 499 Score = 506 bits (1303), Expect = e-141, Method: Compositional matrix adjust. Identities = 256/307 (83%), Positives = 276/307 (89%) Query: 1 MSKNFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNEKGGPAPGGTCTNVGCIPSKAL 60 MSKNFDVVVIGGGPGGYIAAIRAAQLGF+ ACIDEWKN GGPAPGGTCTNVGCIPSKAL Sbjct: 25 MSKNFDVVVIGGGPGGYIAAIRAAQLGFSVACIDEWKNAAGGPAPGGTCTNVGCIPSKAL 84 Query: 61 LQSSEHYEHAGHAFKDHGIDVKGLSLNLPQMLGRKNTVVKQNNDGILYLFKKNKVTFFHG 120 LQSSEH+EHAGHAF +HGIDVKGLSLNLPQML RK+TVVKQNNDGILYLFKKNK+TFFHG Sbjct: 85 LQSSEHFEHAGHAFAEHGIDVKGLSLNLPQMLSRKDTVVKQNNDGILYLFKKNKITFFHG 144 Query: 121 RGSFVKGDANGYEIKVAGATEESITAKQVIVATGSNARALPGAPFDEELILSNTGALAIT 180 RG+FVK DA+G E+ V G T ES+ AK V++ATGSNARALPG PFDE++ILSNTGALAI Sbjct: 145 RGAFVKNDASGTEVSVTGKTNESLIAKHVVIATGSNARALPGTPFDEKMILSNTGALAIG 204 Query: 181 EVPKKLGVIGAGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKLLAKQGLT 240 VPK+LGVIGAGVIGLEMGSVWRRLG+ VTVLE LPTFLGAVDEQIAKEA KL KQGL Sbjct: 205 AVPKRLGVIGAGVIGLEMGSVWRRLGSAVTVLEGLPTFLGAVDEQIAKEAFKLFTKQGLG 264 Query: 241 VNLGVKIGDIKAGKKDVSVDYTDDKGNAQKAVFDKLIISIGRTPNTTGLNAEAIGLKLDE 300 + LGVKIG I GKKDV+V+Y D KG AQKAVFDKLIISIGRTPNT GLNAEAIGLKLDE Sbjct: 265 IQLGVKIGTITTGKKDVTVEYVDAKGEAQKAVFDKLIISIGRTPNTIGLNAEAIGLKLDE 324 Query: 301 RGFIAVN 307 RGF+ V+ Sbjct: 325 RGFVVVD 331 >A4G5Y9.1 A4G5Y9_HERAR Dihydrolipoyl dehydrogenase (E3 component of 2-oxoglutarate dehydrogenase complex) (Dihydrolipoamide dehydrogenase) EC=1.8.1.4 Length = 475 Score = 489 bits (1260), Expect = e-136, Method: Compositional matrix adjust. Identities = 250/308 (81%), Positives = 274/308 (88%) Query: 1 MSKNFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNEKGGPAPGGTCTNVGCIPSKAL 60 MSKNFDVVVIGGGPGGY+AAIRAAQLGF+ ACIDEWKN KGG APGGTCTNVGCIPSKAL Sbjct: 1 MSKNFDVVVIGGGPGGYVAAIRAAQLGFSVACIDEWKNAKGGAAPGGTCTNVGCIPSKAL 60 Query: 61 LQSSEHYEHAGHAFKDHGIDVKGLSLNLPQMLGRKNTVVKQNNDGILYLFKKNKVTFFHG 120 LQSSEHYEHAGHAF +HGI+VK L+LN+ +M+ RK+TVVKQNNDGILYL KKNKVTFFHG Sbjct: 61 LQSSEHYEHAGHAFAEHGIEVKDLTLNVKKMVARKDTVVKQNNDGILYLLKKNKVTFFHG 120 Query: 121 RGSFVKGDANGYEIKVAGATEESITAKQVIVATGSNARALPGAPFDEELILSNTGALAIT 180 RGSF K A GYEIKVAGA EE+I K VIVATGS R LPGA FDE++ILSNTGALA+T Sbjct: 121 RGSFAKAGAGGYEIKVAGAGEETIATKHVIVATGSTPRVLPGADFDEKMILSNTGALAMT 180 Query: 181 EVPKKLGVIGAGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKLLAKQGLT 240 EVPK+LG+IGAGVIGLEMGSVWRRLG+EVTVLEALP FLGAVDEQ+AKEAQK KQGL Sbjct: 181 EVPKRLGLIGAGVIGLEMGSVWRRLGSEVTVLEALPVFLGAVDEQVAKEAQKQFVKQGLA 240 Query: 241 VNLGVKIGDIKAGKKDVSVDYTDDKGNAQKAVFDKLIISIGRTPNTTGLNAEAIGLKLDE 300 +NLGVKIG I GK +V+V+Y DDKG AQKAVFDKLI+SIGR PNT GLN EA+GLKLDE Sbjct: 241 INLGVKIGAIAVGKNEVTVNYVDDKGAAQKAVFDKLIVSIGRIPNTVGLNTEAVGLKLDE 300 Query: 301 RGFIAVNG 308 RGFIAV+G Sbjct: 301 RGFIAVDG 308 >A2SHC9.1 A2SHC9_METPP Dihydrolipoamide dehydrogenase EC=1.8.1.4 Length = 475 Score = 474 bits (1220), Expect = e-132, Method: Compositional matrix adjust. Identities = 243/307 (79%), Positives = 269/307 (87%) Query: 1 MSKNFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNEKGGPAPGGTCTNVGCIPSKAL 60 MSK FDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKN+KGGPAPGGTCTNVGCIPSKAL Sbjct: 1 MSKTFDVVVIGGGPGGYIAAIRAAQLGFNTACIDEWKNDKGGPAPGGTCTNVGCIPSKAL 60 Query: 61 LQSSEHYEHAGHAFKDHGIDVKGLSLNLPQMLGRKNTVVKQNNDGILYLFKKNKVTFFHG 120 LQSSEH+EHAGHAF DHGI +K LS+++ +MLGRK+TVVKQNNDGILYLFKKNKV+FFHG Sbjct: 61 LQSSEHFEHAGHAFADHGIGLKDLSIDVAKMLGRKDTVVKQNNDGILYLFKKNKVSFFHG 120 Query: 121 RGSFVKGDANGYEIKVAGATEESITAKQVIVATGSNARALPGAPFDEELILSNTGALAIT 180 RGSFVK GYEIKV+GATE+++ K +I+ATGS+ARALPGAPFDEE ILSN GAL I Sbjct: 121 RGSFVKAGDAGYEIKVSGATEDTLIGKDIIIATGSSARALPGAPFDEESILSNDGALRIP 180 Query: 181 EVPKKLGVIGAGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKLLAKQGLT 240 VP KLGVIG+GVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQK +Q L Sbjct: 181 SVPAKLGVIGSGVIGLEMGSVWRRLGAEVTVLEALPTFLGAVDEQIAKEAQKAFMRQRLK 240 Query: 241 VNLGVKIGDIKAGKKDVSVDYTDDKGNAQKAVFDKLIISIGRTPNTTGLNAEAIGLKLDE 300 + LGVKI ++K KK VSV YT KG+A+ DKLI+SIGR PNTTGLNAEA+GLKLDE Sbjct: 241 IELGVKISEVKKDKKGVSVSYTSAKGDAKTLEVDKLIVSIGRVPNTTGLNAEAVGLKLDE 300 Query: 301 RGFIAVN 307 RG I V+ Sbjct: 301 RGAIVVD 307