BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0005.0040.p (662 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IZW7.1 D8IZW7_HERSS 2-oxoglutarate dehydrogenase oxidoreductas... 660 0.0 F1VWI9.1 F1VWI9_9BURK 2-oxoglutarate dehydrogenase E1 component 633 e-179 A6SY55.1 A6SY55_JANMA 2-oxoglutarate dehydrogenase E1 component ... 620 e-175 A4G5Z1.1 A4G5Z1_HERAR 2-oxoglutarate dehydrogenase E1 component ... 607 e-171 C6BGV2.1 C6BGV2_RALP1 2-oxoglutarate dehydrogenase, E1 subunit E... 596 e-168 >D8IZW7.1 D8IZW7_HERSS 2-oxoglutarate dehydrogenase oxidoreductase (E1 component) protein EC=1.2.4.2 Length = 954 Score = 660 bits (1703), Expect = 0.0, Method: Compositional matrix adjust. Identities = 309/328 (94%), Positives = 322/328 (98%) Query: 335 AGRGTFVHRHAVLHDQNRERWDAGTYIPLQNVAENQAPYTVIDSVLSEEAVLGFEYGYST 394 AGRGTF HRHAVLHDQNRERWDAGT+IPLQNVAENQ+ +TVIDSVLSEEAVL FEYGYST Sbjct: 627 AGRGTFTHRHAVLHDQNRERWDAGTFIPLQNVAENQSTFTVIDSVLSEEAVLAFEYGYST 686 Query: 395 AEPNTLTIWEAQFGDFANGAQVVMDQFISSGEVKWGRASGLVQMLPHGYEGQGPEHSSAR 454 AEPNTLTIWEAQFGDFANGAQVVMDQFISSGEVKWGRASGLVQMLPHGYEGQGPEHSSAR Sbjct: 687 AEPNTLTIWEAQFGDFANGAQVVMDQFISSGEVKWGRASGLVQMLPHGYEGQGPEHSSAR 746 Query: 455 LERYLQLCADNNMQVVQPTTAAQIFHLLRRQMIRLFRKPLIILTPKSLLRNKDAGSPLSD 514 +ERYLQLCADNNMQVVQPTTAAQIFHLLRRQMIRLFRKPLII+TPKSLLRNKDAGSPLSD Sbjct: 747 IERYLQLCADNNMQVVQPTTAAQIFHLLRRQMIRLFRKPLIIMTPKSLLRNKDAGSPLSD 806 Query: 515 LAKGSFQTVIPELDDKLDAKKVKRIIACSGKVYYDLVNARKERGQTDTAIIRVEQLYPFP 574 LAKGSFQTVIPE+D+ +DAKKVKRI+ACSGKVYYDLVNARKERGQTDTAIIRVEQLYPFP Sbjct: 807 LAKGSFQTVIPEVDETIDAKKVKRIVACSGKVYYDLVNARKERGQTDTAIIRVEQLYPFP 866 Query: 575 HKAFAAALKQFPNFQELVWTQDEPQNQGAWLQIQHNIFENLTDGQKLAYAGRPASASPAV 634 HKAFAAALKQFPNF ELVW QDEPQNQGAWLQIQHNIFENL++GQKLAYAGRPASASPAV Sbjct: 867 HKAFAAALKQFPNFNELVWAQDEPQNQGAWLQIQHNIFENLSEGQKLAYAGRPASASPAV 926 Query: 635 GYYDKHYAQQKALIDTAFSKLKGFVLTK 662 GYYDKHYAQQKALI+TAF+KLKGFVLTK Sbjct: 927 GYYDKHYAQQKALIETAFAKLKGFVLTK 954 >F1VWI9.1 F1VWI9_9BURK 2-oxoglutarate dehydrogenase E1 component Length = 951 Score = 633 bits (1633), Expect = e-179, Method: Compositional matrix adjust. Identities = 294/328 (89%), Positives = 309/328 (94%) Query: 335 AGRGTFVHRHAVLHDQNRERWDAGTYIPLQNVAENQAPYTVIDSVLSEEAVLGFEYGYST 394 +GRGTFVHRHAVLHDQNRERWDAG+YIPLQN++E QAP+ VIDSVLSEEAVL FEYGYST Sbjct: 624 SGRGTFVHRHAVLHDQNRERWDAGSYIPLQNISEQQAPFKVIDSVLSEEAVLAFEYGYST 683 Query: 395 AEPNTLTIWEAQFGDFANGAQVVMDQFISSGEVKWGRASGLVQMLPHGYEGQGPEHSSAR 454 AEPNTLTIWEAQFGDFANGAQVV+DQFISSGEVKWGRASGLV MLPHGYEGQGPEHSSAR Sbjct: 684 AEPNTLTIWEAQFGDFANGAQVVIDQFISSGEVKWGRASGLVMMLPHGYEGQGPEHSSAR 743 Query: 455 LERYLQLCADNNMQVVQPTTAAQIFHLLRRQMIRLFRKPLIILTPKSLLRNKDAGSPLSD 514 ER+LQLCADNNMQVVQPTT+AQIFHLLRRQMIRLFRKPL+I+TPKSLLRNKDAGSPLSD Sbjct: 744 PERFLQLCADNNMQVVQPTTSAQIFHLLRRQMIRLFRKPLVIMTPKSLLRNKDAGSPLSD 803 Query: 515 LAKGSFQTVIPELDDKLDAKKVKRIIACSGKVYYDLVNARKERGQTDTAIIRVEQLYPFP 574 LA GSF+TVI E DDK+DAKKVKR+IACSGKVYYDLVNARKERGQ DTAI R+EQLYPFP Sbjct: 804 LATGSFKTVIGECDDKIDAKKVKRVIACSGKVYYDLVNARKERGQVDTAIFRIEQLYPFP 863 Query: 575 HKAFAAALKQFPNFQELVWTQDEPQNQGAWLQIQHNIFENLTDGQKLAYAGRPASASPAV 634 HK AA LK+FPNF ELVW QDEPQNQG W QIQHNIFENL DGQKLAYAGRPASASPAV Sbjct: 864 HKTLAAELKKFPNFTELVWAQDEPQNQGPWFQIQHNIFENLVDGQKLAYAGRPASASPAV 923 Query: 635 GYYDKHYAQQKALIDTAFSKLKGFVLTK 662 GYYDKHYAQQK LIDTAFSKLKGFVLTK Sbjct: 924 GYYDKHYAQQKTLIDTAFSKLKGFVLTK 951 >A6SY55.1 A6SY55_JANMA 2-oxoglutarate dehydrogenase E1 component EC=1.2.4.2 Length = 952 Score = 620 bits (1599), Expect = e-175, Method: Compositional matrix adjust. Identities = 288/328 (87%), Positives = 309/328 (94%) Query: 335 AGRGTFVHRHAVLHDQNRERWDAGTYIPLQNVAENQAPYTVIDSVLSEEAVLGFEYGYST 394 +GRGTFVHRHAVLHDQNRERWDAGTY+PLQN+++ QA + VIDSVLSEEAVL +EYGYST Sbjct: 625 SGRGTFVHRHAVLHDQNRERWDAGTYVPLQNISDQQAWFRVIDSVLSEEAVLAYEYGYST 684 Query: 395 AEPNTLTIWEAQFGDFANGAQVVMDQFISSGEVKWGRASGLVQMLPHGYEGQGPEHSSAR 454 AEPNTL IWEAQFGDF NGAQVV+DQFISSGEVKWGRASGLV MLPHGYEGQGPEHSSAR Sbjct: 685 AEPNTLVIWEAQFGDFVNGAQVVIDQFISSGEVKWGRASGLVMMLPHGYEGQGPEHSSAR 744 Query: 455 LERYLQLCADNNMQVVQPTTAAQIFHLLRRQMIRLFRKPLIILTPKSLLRNKDAGSPLSD 514 ER+LQLCADNNMQVVQPTT+AQIFHLLRRQMIRLFRKPL+ILTPKSLLRNKDAGSPL+D Sbjct: 745 PERFLQLCADNNMQVVQPTTSAQIFHLLRRQMIRLFRKPLVILTPKSLLRNKDAGSPLTD 804 Query: 515 LAKGSFQTVIPELDDKLDAKKVKRIIACSGKVYYDLVNARKERGQTDTAIIRVEQLYPFP 574 L KGSFQTVI E+DDK+DAKKVKR+IACSG+VYYDLV ARKERGQ+D AIIR+EQLYPFP Sbjct: 805 LVKGSFQTVIGEVDDKIDAKKVKRVIACSGRVYYDLVAARKERGQSDVAIIRIEQLYPFP 864 Query: 575 HKAFAAALKQFPNFQELVWTQDEPQNQGAWLQIQHNIFENLTDGQKLAYAGRPASASPAV 634 HKAFAA LK+FPNF ELVWTQDEPQNQGAW QIQHNI EN+ DGQKLAYAGRPASASPAV Sbjct: 865 HKAFAAELKKFPNFTELVWTQDEPQNQGAWFQIQHNILENMADGQKLAYAGRPASASPAV 924 Query: 635 GYYDKHYAQQKALIDTAFSKLKGFVLTK 662 GYYDKHYAQQKALID AF+KLKGFV TK Sbjct: 925 GYYDKHYAQQKALIDAAFAKLKGFVQTK 952 >A4G5Z1.1 A4G5Z1_HERAR 2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate dehydrogenase) EC=1.2.4.2 Length = 952 Score = 607 bits (1564), Expect = e-171, Method: Compositional matrix adjust. Identities = 280/328 (85%), Positives = 305/328 (92%) Query: 335 AGRGTFVHRHAVLHDQNRERWDAGTYIPLQNVAENQAPYTVIDSVLSEEAVLGFEYGYST 394 AGRGTFVHRHAVLHDQNRERWDAG+Y+PLQN+++ QA + VIDSVLSEEAVL +EYGYST Sbjct: 625 AGRGTFVHRHAVLHDQNRERWDAGSYVPLQNISDQQAWFRVIDSVLSEEAVLAYEYGYST 684 Query: 395 AEPNTLTIWEAQFGDFANGAQVVMDQFISSGEVKWGRASGLVQMLPHGYEGQGPEHSSAR 454 AEPNTL IWEAQFGDFANGAQVV+DQFISSGEVKWGR SGLV MLPHGYEGQGPEHSSAR Sbjct: 685 AEPNTLVIWEAQFGDFANGAQVVIDQFISSGEVKWGRVSGLVMMLPHGYEGQGPEHSSAR 744 Query: 455 LERYLQLCADNNMQVVQPTTAAQIFHLLRRQMIRLFRKPLIILTPKSLLRNKDAGSPLSD 514 ER+LQLCADNNMQVVQPTTAAQIFHLLRRQMIR FRKPL+ILTPKSLLRNK+AGSPL+D Sbjct: 745 PERFLQLCADNNMQVVQPTTAAQIFHLLRRQMIRKFRKPLVILTPKSLLRNKEAGSPLTD 804 Query: 515 LAKGSFQTVIPELDDKLDAKKVKRIIACSGKVYYDLVNARKERGQTDTAIIRVEQLYPFP 574 LA GSFQTVI E+D +DAKKVKR+IACSG+VYYDLV+ARKER Q D AI+R+EQLYPFP Sbjct: 805 LASGSFQTVIGEVDTSIDAKKVKRVIACSGRVYYDLVHARKERAQNDVAIVRIEQLYPFP 864 Query: 575 HKAFAAALKQFPNFQELVWTQDEPQNQGAWLQIQHNIFENLTDGQKLAYAGRPASASPAV 634 HKAFAA LK+FPNF +LVW QDEPQNQGAW QIQHNI EN++DGQKLAYAGRPASASPAV Sbjct: 865 HKAFAAELKKFPNFTDLVWAQDEPQNQGAWFQIQHNILENMSDGQKLAYAGRPASASPAV 924 Query: 635 GYYDKHYAQQKALIDTAFSKLKGFVLTK 662 GYYDKHYAQQK LI+TAFSKLKGF+ TK Sbjct: 925 GYYDKHYAQQKTLIETAFSKLKGFIQTK 952 >C6BGV2.1 C6BGV2_RALP1 2-oxoglutarate dehydrogenase, E1 subunit EC=1.2.4.2 Length = 954 Score = 596 bits (1536), Expect = e-168, Method: Compositional matrix adjust. Identities = 279/328 (85%), Positives = 301/328 (91%) Query: 335 AGRGTFVHRHAVLHDQNRERWDAGTYIPLQNVAENQAPYTVIDSVLSEEAVLGFEYGYST 394 AGRGTF HRHAVLHDQNRERWDAG+YIPLQNV+E+QAP+TVIDSVLSEEAV+GFEYGYS+ Sbjct: 627 AGRGTFTHRHAVLHDQNRERWDAGSYIPLQNVSESQAPFTVIDSVLSEEAVMGFEYGYSS 686 Query: 395 AEPNTLTIWEAQFGDFANGAQVVMDQFISSGEVKWGRASGLVQMLPHGYEGQGPEHSSAR 454 AEPNTL IWEAQFGDFANGAQVV+DQFISSGEVKWGRASGL MLPHGYEGQGPEHSSAR Sbjct: 687 AEPNTLVIWEAQFGDFANGAQVVIDQFISSGEVKWGRASGLTLMLPHGYEGQGPEHSSAR 746 Query: 455 LERYLQLCADNNMQVVQPTTAAQIFHLLRRQMIRLFRKPLIILTPKSLLRNKDAGSPLSD 514 LERYLQLCAD+NMQVVQPTT AQIFHLLRRQMIR+FRKPLIILTPKSLLR+KDA SPLSD Sbjct: 747 LERYLQLCADHNMQVVQPTTPAQIFHLLRRQMIRMFRKPLIILTPKSLLRSKDAVSPLSD 806 Query: 515 LAKGSFQTVIPELDDKLDAKKVKRIIACSGKVYYDLVNARKERGQTDTAIIRVEQLYPFP 574 LAKG F+TVI + + L+A KVKR++ACSGKVYYDLVNARKERG TDTAIIRVEQLYPFP Sbjct: 807 LAKGHFETVIADTAEDLNAAKVKRVVACSGKVYYDLVNARKERGLTDTAIIRVEQLYPFP 866 Query: 575 HKAFAAALKQFPNFQELVWTQDEPQNQGAWLQIQHNIFENLTDGQKLAYAGRPASASPAV 634 HKAFAA LK++PN E+VW QDEPQNQGAW +QH I EN+T+GQKL YAGRPASASPAV Sbjct: 867 HKAFAAELKKYPNLAEVVWCQDEPQNQGAWFFVQHYILENMTEGQKLGYAGRPASASPAV 926 Query: 635 GYYDKHYAQQKALIDTAFSKLKGFVLTK 662 GYY KH QQKALID AFSKLKGFVL K Sbjct: 927 GYYAKHNEQQKALIDAAFSKLKGFVLNK 954