BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0166.p (643 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Q0K0B2.1 Q0K0B2_CUPNH MFS transporter, DHA2 family 492 e-137 Q476R2.1 Q476R2_CUPPJ Drug resistance transporter EmrB/QacA subf... 484 e-134 D8MYA6.1 D8MYA6_ERWBE Multidrug resistant protein 472 e-130 Q1LEB2.1 Q1LEB2_RALME Putative drug resistance transporter, EmrB... 468 e-129 Q1IA27.1 Q1IA27_PSEE4 Putative drug resistance transporter, EmrB... 460 e-127 >Q0K0B2.1 Q0K0B2_CUPNH MFS transporter, DHA2 family Length = 532 Score = 492 bits (1267), Expect = e-137, Method: Compositional matrix adjust. Identities = 227/303 (74%), Positives = 264/303 (87%) Query: 327 IVQRXGWLARVMSTRWLFSASAVGFTIASMLCGLAWDINSMIFFRALQGFLGGSMIPMVF 386 ++ GWL+RVMSTRWLF+ASA GFT+AS+LCG+AWDINSMI FRALQGFLGGSMIPMVF Sbjct: 77 VIPLSGWLSRVMSTRWLFAASAAGFTVASLLCGVAWDINSMIVFRALQGFLGGSMIPMVF 136 Query: 387 TSAFFYFSGHQRVIAAATVGALSSLAPTLGPTVGGWITSNYSWHWLFFINLAPGIFVAVV 446 T+AF +F G QRVIAAATVG L+SLAPTLGPT+GGWIT +YSWHWLFFINL PGIFV + Sbjct: 137 TTAFAFFVGPQRVIAAATVGGLASLAPTLGPTIGGWITDHYSWHWLFFINLVPGIFVTIA 196 Query: 447 VPMLVRIDKPNLSLLRGADYLGMILLAASLGCLEYSLEEGPRLGWMGDDIIRTTVWIAIV 506 VP+LV+ID+P+ SL+RGADYLGM+L+A LGCLEY+LEEGPR W GDD+I T WI+ + Sbjct: 197 VPLLVKIDRPDWSLVRGADYLGMVLMALFLGCLEYTLEEGPRWDWFGDDVILATAWISGL 256 Query: 507 AGVGFIWRSLAYDNPVVDLRALKDRNFALGCFFSFVTGIGIFATVYLTPVFLAHVRGFSA 566 +GVGFIWR+L Y NPVVDLRALKDRNFALGCFFSFVTGIGIFAT+YLTP+FL VRGFSA Sbjct: 257 SGVGFIWRTLTYANPVVDLRALKDRNFALGCFFSFVTGIGIFATIYLTPLFLGRVRGFSA 316 Query: 567 LDIGLAIFATGLFQICAIPFYTYLGRRVDLRWLMMFGMACFALSMWNFTPITHDWGWREL 626 LDIGLA+F+TG+FQ+ +IP Y +L RVDLRWLMM G+ FA+SMW F PITHDWG +L Sbjct: 317 LDIGLAVFSTGVFQMASIPLYAFLANRVDLRWLMMIGLGLFAVSMWYFAPITHDWGAAQL 376 Query: 627 LLP 629 LLP Sbjct: 377 LLP 379 >Q476R2.1 Q476R2_CUPPJ Drug resistance transporter EmrB/QacA subfamily Length = 536 Score = 484 bits (1247), Expect = e-134, Method: Compositional matrix adjust. Identities = 223/303 (73%), Positives = 262/303 (86%) Query: 327 IVQRXGWLARVMSTRWLFSASAVGFTIASMLCGLAWDINSMIFFRALQGFLGGSMIPMVF 386 ++ GWL+RVMSTRWLF+ASA GFT+ S+LCG+AW+I SMI FRA QGFLGGSMIP+VF Sbjct: 81 VIPLSGWLSRVMSTRWLFAASAAGFTLTSLLCGVAWNIQSMIAFRAAQGFLGGSMIPLVF 140 Query: 387 TSAFFYFSGHQRVIAAATVGALSSLAPTLGPTVGGWITSNYSWHWLFFINLAPGIFVAVV 446 T+AF +F+G QRVIAAAT+GAL+SLAPTLGPT+GGWIT N+SWHWLFFINL PGIFV V Sbjct: 141 TTAFAFFAGPQRVIAAATIGALASLAPTLGPTIGGWITDNFSWHWLFFINLVPGIFVTVA 200 Query: 447 VPMLVRIDKPNLSLLRGADYLGMILLAASLGCLEYSLEEGPRLGWMGDDIIRTTVWIAIV 506 VPMLV++D+PN SL+R ADYLG++L+A LGCLEY++EEGPR W GD++I T WIA + Sbjct: 201 VPMLVKVDRPNWSLVRSADYLGIVLMALFLGCLEYTMEEGPRWDWFGDEVILATAWIAGL 260 Query: 507 AGVGFIWRSLAYDNPVVDLRALKDRNFALGCFFSFVTGIGIFATVYLTPVFLAHVRGFSA 566 +GV F+WRSL Y NPVVDLRAL++RNFALGCFFSFVTGIGIFAT+YLTP+FL VRGFSA Sbjct: 261 SGVAFVWRSLTYANPVVDLRALRERNFALGCFFSFVTGIGIFATIYLTPLFLGRVRGFSA 320 Query: 567 LDIGLAIFATGLFQICAIPFYTYLGRRVDLRWLMMFGMACFALSMWNFTPITHDWGWREL 626 LDIGLAIF+TGLFQ+ +IP Y +L RVDLRWLMMFG+ FALSMW F PITHDWG EL Sbjct: 321 LDIGLAIFSTGLFQVASIPLYAFLANRVDLRWLMMFGLGLFALSMWFFAPITHDWGGAEL 380 Query: 627 LLP 629 LLP Sbjct: 381 LLP 383 >D8MYA6.1 D8MYA6_ERWBE Multidrug resistant protein Length = 524 Score = 472 bits (1214), Expect = e-130, Method: Compositional matrix adjust. Identities = 219/303 (72%), Positives = 260/303 (85%) Query: 327 IVQRXGWLARVMSTRWLFSASAVGFTIASMLCGLAWDINSMIFFRALQGFLGGSMIPMVF 386 ++ GWLARVMSTRWLF+ASA GFT+ S+LCG AW+I SMI FRALQGFLGGSMIPMVF Sbjct: 68 VIPLSGWLARVMSTRWLFAASAAGFTVMSLLCGWAWNIQSMIAFRALQGFLGGSMIPMVF 127 Query: 387 TSAFFYFSGHQRVIAAATVGALSSLAPTLGPTVGGWITSNYSWHWLFFINLAPGIFVAVV 446 T+AF +FSG QRVIAAATVG L+SLAPTLGPTVGGWIT NYSWHWLFFINL PG+F+ + Sbjct: 128 TTAFAFFSGPQRVIAAATVGGLASLAPTLGPTVGGWITDNYSWHWLFFINLVPGMFITIA 187 Query: 447 VPMLVRIDKPNLSLLRGADYLGMILLAASLGCLEYSLEEGPRLGWMGDDIIRTTVWIAIV 506 VP+LV +D+P+ SLL+GADY GM+++A SLGCLEY+LEEGPR GWM D I T WI+ + Sbjct: 188 VPILVNVDEPDWSLLKGADYPGMLMMALSLGCLEYTLEEGPRWGWMDDSTILITAWISGL 247 Query: 507 AGVGFIWRSLAYDNPVVDLRALKDRNFALGCFFSFVTGIGIFATVYLTPVFLAHVRGFSA 566 AG+GFIWR+L + PVVDL ALKDRNFALGCFFSF+ G+GIF+T+YLTP+FL ++RGFSA Sbjct: 248 AGLGFIWRTLRHPRPVVDLLALKDRNFALGCFFSFMAGVGIFSTIYLTPLFLGNLRGFSA 307 Query: 567 LDIGLAIFATGLFQICAIPFYTYLGRRVDLRWLMMFGMACFALSMWNFTPITHDWGWREL 626 LDIGLAIF+TG+FQI +IP Y++ RVDLRWLMM G+A FALSM+ FTPITHDWG +L Sbjct: 308 LDIGLAIFSTGIFQILSIPIYSWFANRVDLRWLMMIGLAAFALSMFFFTPITHDWGAEQL 367 Query: 627 LLP 629 LLP Sbjct: 368 LLP 370 >Q1LEB2.1 Q1LEB2_RALME Putative drug resistance transporter, EmrB/QacA family Length = 508 Score = 468 bits (1204), Expect = e-129, Method: Compositional matrix adjust. Identities = 223/303 (73%), Positives = 256/303 (84%) Query: 327 IVQRXGWLARVMSTRWLFSASAVGFTIASMLCGLAWDINSMIFFRALQGFLGGSMIPMVF 386 ++ GWLARVMSTRWLF+ASA GFT S+LCG+AW+I SMI FRA QGFLGGSMIPMVF Sbjct: 53 VIPLSGWLARVMSTRWLFAASAAGFTATSLLCGIAWNIQSMIAFRAAQGFLGGSMIPMVF 112 Query: 387 TSAFFYFSGHQRVIAAATVGALSSLAPTLGPTVGGWITSNYSWHWLFFINLAPGIFVAVV 446 T+ F +F G QRV AAA +G L+SLAPTLGPT+GGWIT N+SWHWLFFINL PGIFV + Sbjct: 113 TTVFAFFQGRQRVAAAAIIGGLASLAPTLGPTIGGWITDNFSWHWLFFINLVPGIFVTIA 172 Query: 447 VPMLVRIDKPNLSLLRGADYLGMILLAASLGCLEYSLEEGPRLGWMGDDIIRTTVWIAIV 506 VP LV+ID+P+ SLL+GADYLG++L+A LGCLEY+LEEGPR W+GD I TT WI+ + Sbjct: 173 VPALVKIDEPDWSLLKGADYLGIVLMALFLGCLEYTLEEGPRWDWLGDRTILTTAWISGL 232 Query: 507 AGVGFIWRSLAYDNPVVDLRALKDRNFALGCFFSFVTGIGIFATVYLTPVFLAHVRGFSA 566 AG+GF+WRSL Y NPVVDLRALKD NFALGCFFSFV GIGIFAT+YLTP+FL VRGFSA Sbjct: 233 AGIGFLWRSLTYKNPVVDLRALKDINFALGCFFSFVVGIGIFATIYLTPLFLGQVRGFSA 292 Query: 567 LDIGLAIFATGLFQICAIPFYTYLGRRVDLRWLMMFGMACFALSMWNFTPITHDWGWREL 626 L IGLAIF+TGLFQ+ +IPFY YL RVDLRWL+MFG+A FALSMWNF PITHDWG EL Sbjct: 293 LQIGLAIFSTGLFQVLSIPFYAYLANRVDLRWLLMFGLALFALSMWNFAPITHDWGGAEL 352 Query: 627 LLP 629 L P Sbjct: 353 LFP 355 >Q1IA27.1 Q1IA27_PSEE4 Putative drug resistance transporter, EmrB/QacA family Length = 521 Score = 460 bits (1184), Expect = e-127, Method: Compositional matrix adjust. Identities = 212/303 (69%), Positives = 252/303 (83%) Query: 327 IVQRXGWLARVMSTRWLFSASAVGFTIASMLCGLAWDINSMIFFRALQGFLGGSMIPMVF 386 ++ GWL+RVMSTRWLF+ASA GFT+ S+LC LAW+I SMI FRALQGFLGGSMIP+VF Sbjct: 66 VIPLSGWLSRVMSTRWLFAASAAGFTLTSLLCALAWNIQSMIAFRALQGFLGGSMIPLVF 125 Query: 387 TSAFFYFSGHQRVIAAATVGALSSLAPTLGPTVGGWITSNYSWHWLFFINLAPGIFVAVV 446 T+AF YFSG QRVIAA+ +GA++SLAPTLGP VGGWIT SWHWLF+INL PG+FV V Sbjct: 126 TTAFIYFSGKQRVIAASVIGAIASLAPTLGPAVGGWITDISSWHWLFYINLVPGLFVTVA 185 Query: 447 VPMLVRIDKPNLSLLRGADYLGMILLAASLGCLEYSLEEGPRLGWMGDDIIRTTVWIAIV 506 VP+LV++D+PN LL+GADYLGM L+A LGCLEY+LEEGPR W D I TT W+A Sbjct: 186 VPLLVKVDRPNPGLLKGADYLGMGLMAVFLGCLEYTLEEGPRWNWFSDATITTTAWLAGA 245 Query: 507 AGVGFIWRSLAYDNPVVDLRALKDRNFALGCFFSFVTGIGIFATVYLTPVFLAHVRGFSA 566 GV FIWRSL +P+VDLRAL DRNFALGC FSF+TGIGIFAT+YLTP+FL VRG+ A Sbjct: 246 CGVLFIWRSLKIADPIVDLRALGDRNFALGCLFSFITGIGIFATIYLTPLFLGRVRGYGA 305 Query: 567 LDIGLAIFATGLFQICAIPFYTYLGRRVDLRWLMMFGMACFALSMWNFTPITHDWGWREL 626 LDIGLA+F+TG+FQ+ AIP Y +L RVDLRW++MFG+A F +SMW+FTPITHDWG +EL Sbjct: 306 LDIGLAVFSTGVFQLLAIPVYAFLANRVDLRWILMFGLALFGISMWDFTPITHDWGAKEL 365 Query: 627 LLP 629 LLP Sbjct: 366 LLP 368