BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0146.p (410 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value C1I8C6.1 C1I8C6_9CLOT Diguanylate cyclase/phosphodiesterase doma... 244 2e-62 C6WW26.1 C6WW26_METML Diguanylate cyclase/phosphodiesterase 241 1e-61 E8YMJ9.1 E8YMJ9_9BURK Diguanylate cyclase/phosphodiesterase with... 238 1e-60 E7RDW3.1 E7RDW3_9BACL GGDEF and EAL domain-containing protein 233 5e-59 Q5N5M8.1 Q5N5M8_SYNP6 Two-component response regulator 230 3e-58 >C1I8C6.1 C1I8C6_9CLOT Diguanylate cyclase/phosphodiesterase domain 2 Length = 743 Score = 244 bits (623), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 137/388 (35%), Positives = 226/388 (58%), Gaps = 7/388 (1%) Query: 19 ALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTIETSHA 78 A + I LD+ KY ND +G AGD L++ FA ++ + SL AR F ++ + Sbjct: 352 AFIFIDLDNFKYVNDTYGHDAGDLLLIEFAKIIKNMKIKDSLFARYGGDEF-IIVQYNIQ 410 Query: 79 SRDAIPQI-EHIRRSLPEELLVGGQRHPVQVSMAIAFSRPGETSGDE--LIQRGKLALDS 135 ++ I I ++I + L +++ + + +++I S GD L++R +A+ Sbjct: 411 EKNQIKYILDNIIKKLSNPIIINDK--EIFCTLSIGVSVYPIDGGDMPILLKRADMAMYL 468 Query: 136 ARRSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKVTQDGE-IVGLEAL 194 A+ +G FD + ++ R +IE+ + +A+ ++E++++YQPK+ D E ++G E+L Sbjct: 469 AKVNGKNRYEFFDIKILEILNREFDIEKGLRVAVDKSEIKMLYQPKIKVDTEEVIGFESL 528 Query: 195 IRWRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLDSERRCLPIAINLSA 254 +RW S +LG VSP+EFIP+AE+SG I I +++++ ++ + +AINLS Sbjct: 529 VRWNSKSLGIVSPSEFIPIAESSGLIIPIGKYIINESFRRCKELTLKNNKKFKMAINLSE 588 Query: 255 IDIVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKGYGITIDD 314 + I D++ ++ S + Y +S++++EFEITE+ ++ + IS LE L G + +DD Sbjct: 589 VQIRDEDIVSFISESLKFYDLSAEYIEFEITESIIMKSAERNISTLEKLKKLGVSLALDD 648 Query: 315 FGTGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTTVAEGVET 374 FGTGYSSL L P +KID+SF+ I I EKSE II ++V L+ LS VAEGVET Sbjct: 649 FGTGYSSLSYLRTLPIDVLKIDKSFIDGIVIEEKSEYIINSIVELSHYLSLLVVAEGVET 708 Query: 375 LVQEKFLKAIGCQFFQGFYYYPPMEFQQ 402 Q FLK I C QG+Y+ P+EF + Sbjct: 709 KEQLDFLKRISCDVIQGYYFSRPVEFDE 736 >C6WW26.1 C6WW26_METML Diguanylate cyclase/phosphodiesterase Length = 447 Score = 241 bits (616), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 139/401 (34%), Positives = 215/401 (53%), Gaps = 6/401 (1%) Query: 14 SMPTAALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTI 73 S AL+ I LD+ K ND+ G A GD L++ A+ L + +G +ARL F T+ Sbjct: 46 SQNKGALLFIDLDNFKNLNDSLGHAVGDMLLLQVAERLNNCVREGDTVARLGGDEFVVTL 105 Query: 74 ETSHASRDAIPQI-----EHIRRSLPEELLVGGQRHPVQVSMAIAFSRPGETSGDELIQR 128 E D E I + + +GG H + S+ +A E S DEL+++ Sbjct: 106 EDLSLQLDEAASKTKLIGEKILHQVSQPYNLGGHEHQITCSIGVALFHHHEQSQDELLKQ 165 Query: 129 GKLALDSARRSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKVTQDGEI 188 +A+ A++ G I FD I R+ +E+ + +A+ E + L YQ ++ G+ Sbjct: 166 ADIAMYQAKKVGRNAICFFDPGMQTSINARVELERDLNIAINEQQFELFYQIQLDIHGQA 225 Query: 189 VGLEALIRWRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQ-TLDSERRCLP 247 +G EALIRW P LG +SPA+FIP+AE + I I ++V+D CA ++Q D+ + L Sbjct: 226 IGAEALIRWPHPELGLISPAKFIPLAEETDLIIPIGSWVLDTACAQLKQWQKDTSTQGLV 285 Query: 248 IAINLSAIDIVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKG 307 +++N+SA + + D V + KY ++ + L+ EITE+ L+ + I+ + L G Sbjct: 286 LSVNVSAKQLHQVDFTSTVQNTINKYAINPNLLKLEITESMLLNSIEDTINIMSRLQTIG 345 Query: 308 YGITIDDFGTGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTT 367 ++DDFGTGYSSLQ L R P +KIDQSFV I + E + +IIR ++++A+ L T Sbjct: 346 VRFSLDDFGTGYSSLQYLKRLPLNQLKIDQSFVRDITVDESNRVIIRTIIAMAQSLGLET 405 Query: 368 VAEGVETLVQEKFLKAIGCQFFQGFYYYPPMEFQQVNQLLK 408 +AEGVET Q +L GC FQG+ P+ LK Sbjct: 406 IAEGVETEAQRTYLLTNGCTHFQGYLLGKPLPIHDFESALK 446 >E8YMJ9.1 E8YMJ9_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) Length = 1036 Score = 238 bits (607), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 147/396 (37%), Positives = 216/396 (54%), Gaps = 9/396 (2%) Query: 19 ALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTIETSHA 78 A+V + LD K ND+ G + GD L+ A+ L R +AR F + + Sbjct: 636 AVVFMDLDGFKNVNDSLGHSVGDRLLGVVAERLARCTRTSDTVARHGGDEFVIVMTDTVD 695 Query: 79 SRDAIPQIEHIRRSLPEELLVGGQRHPVQVSMAIA-FSRPGETSGDELIQRGKLALDSAR 137 + I +E +R S+ E + + G V SM + F + G+ + + L+++ LA+ A+ Sbjct: 696 EQSLIAWMERVRVSISEPVWLDGTELYVGCSMGASLFPQDGDDA-ETLMKKADLAMYRAK 754 Query: 138 RSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKVT-QDGEIVGLEALIR 196 G + E A RL +EQ + ALR+N+ L YQP+V G+IVG EAL+R Sbjct: 755 DMGRNTFQFYQPEMNASAGARLALEQRLRRALRDNQFLLHYQPQVDIHTGQIVGTEALVR 814 Query: 197 WRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLDSERRCLP---IAINLS 253 W P G V P+ FIPVAE SG I ++ +V+ + C RQ + LP +++NLS Sbjct: 815 WSDPEAGLVPPSSFIPVAEESGLIGPLSEWVLREAC---RQNKAWQNLGLPPARVSVNLS 871 Query: 254 AIDIVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKGYGITID 313 A + D+ LV + G+ +LE E+TE+ ++ N A+S L L+A G G+ ID Sbjct: 872 ARVFQQRDIAKLVMQVLDETGLEPQYLELELTESAIMRNAEEAVSMLNELSALGIGLAID 931 Query: 314 DFGTGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTTVAEGVE 373 DFGTGYSSL L RFP +KID+SFV+ IGIS E I A+++LA L +AEGVE Sbjct: 932 DFGTGYSSLSYLKRFPVDRLKIDRSFVSDIGISGDDETITSAIIALAHSLKLQVIAEGVE 991 Query: 374 TLVQEKFLKAIGCQFFQGFYYYPPMEFQQVNQLLKG 409 T Q FLK C QGFY+ P+ + +++L+KG Sbjct: 992 TSAQLDFLKERACDEMQGFYFAKPLSTEAISELMKG 1027 >E7RDW3.1 E7RDW3_9BACL GGDEF and EAL domain-containing protein Length = 758 Score = 233 bits (594), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 133/391 (34%), Positives = 217/391 (55%), Gaps = 3/391 (0%) Query: 19 ALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTIETSHA 78 A+V I LD K ND+ G GD L+ F++ ++ L +I+R F+ + + Sbjct: 358 AVVFIDLDRFKNVNDSFGHEFGDLLLQGFSEKIKENLRSDDVISRQGGDEFTIILNNIYD 417 Query: 79 SRDAIPQIEHIRRSLPEELLVGGQRHPVQVSMAIA-FSRPGETSGDELIQRGKLALDSAR 137 D P I+ ++ +L + +++ GQ + +S+ IA + + GET+G EL++ A+ SA+ Sbjct: 418 EHDISPLIQRLQTALAKPMMINGQELHISMSIGIAVYPKDGETTG-ELLKHADSAMYSAK 476 Query: 138 RSGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKV-TQDGEIVGLEALIR 196 G + F D+ A + R++ +E + A+ E L YQP++ + G+I+G+EALIR Sbjct: 477 AKGKNNFQFFSDDMALIASRKIALENEMRRAITNKEFMLYYQPQIQVETGDIIGMEALIR 536 Query: 197 WRSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLDSERRCLPIAINLSAID 256 W++ VSP EFIP+AE + I I +V+ C ++ D+ L IA+NLS + Sbjct: 537 WQTAGGDVVSPGEFIPLAEETRLILPIGEWVLYSACEQAKKWHDAGHSHLKIAVNLSPLQ 596 Query: 257 IVRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKGYGITIDDFG 316 + DL+D+V + +K G + LE EITE V + +A++ + L G I IDDFG Sbjct: 597 FLHDDLMDVVKFTLRKTGFPASSLELEITEGVAVDDAEIAMARMRELREIGVRIAIDDFG 656 Query: 317 TGYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTTVAEGVETLV 376 TGYSSL L +FP ++KI Q FV + + + ++ A+V +A L+ + +AEGVET Sbjct: 657 TGYSSLNYLKQFPLNNLKIAQPFVQDMANNPYDKALVEAMVFIAHSLNMSVIAEGVETDE 716 Query: 377 QEKFLKAIGCQFFQGFYYYPPMEFQQVNQLL 407 Q LK +GC QG+ Y P+ Q +L+ Sbjct: 717 QLALLKELGCDEIQGYLYSKPLSAAQFTELI 747 >Q5N5M8.1 Q5N5M8_SYNP6 Two-component response regulator Length = 929 Score = 230 bits (586), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 130/390 (33%), Positives = 205/390 (52%), Gaps = 1/390 (0%) Query: 19 ALVVIRLDSIKYANDAHGSAAGDALIVAFADALRRLLPDGSLIARLRSVVFSFTIETSHA 78 A++ I LD K ND+ G +GD L+V A + + G +AR+ F + Sbjct: 531 AILFIDLDGFKLINDSIGHRSGDLLLVEVAQRMCEQVRAGDTVARIGGDEFIILLVDLKL 590 Query: 79 SRDAIPQIEHIRRSLPEELLVGGQRHPVQVSMAIAFSRPGETSGDELIQRGKLALDSARR 138 D I + + S+ + G V SM I S +LIQ+ LA+ A++ Sbjct: 591 ENDVISIADRLLASVARPYHIQGIYLHVTASMGITLSDGDIEQPTQLIQQADLAMYKAKQ 650 Query: 139 SGTQDITVFDDEAAALIRRRLNIEQSILMALRENELRLVYQPKVTQ-DGEIVGLEALIRW 197 G + + ++ +R R+++ + A+ L +QPK+ G+++GLEAL+RW Sbjct: 651 EGRNNYQWYTNDLNLRLRERVHLRNELQKAIETEAFELYFQPKIEGCSGQVIGLEALLRW 710 Query: 198 RSPTLGDVSPAEFIPVAETSGAIHFITAFVVDKVCAYIRQTLDSERRCLPIAINLSAIDI 257 + P +G +SPA F+P+AE +G I ++ +V++ C +R L +A+N+S + Sbjct: 711 QHPQMGFISPATFVPIAEDTGQIIPLSQWVLETACRQLRDLLQQGIAAPSVAVNISTVQF 770 Query: 258 VRADLLDLVNASCQKYGVSSDHLEFEITETGLVGNENLAISHLEALNAKGYGITIDDFGT 317 R + + V ++ QKY + S+HLE EITE L N AI L+ L G I+IDDFGT Sbjct: 771 RRINFVKSVQSALQKYQLKSEHLEIEITENVLFDNTEKAIEKLQRLKELGVNISIDDFGT 830 Query: 318 GYSSLQKLSRFPTKSIKIDQSFVAQIGISEKSELIIRAVVSLAKILSCTTVAEGVETLVQ 377 G+SSL L P ++KID+SFV +I + I + ++S+A L VAEGVET Q Sbjct: 831 GFSSLSYLKELPIDTVKIDRSFVQEINTDSRDAAITQGIISMAHHLRLNVVAEGVETEQQ 890 Query: 378 EKFLKAIGCQFFQGFYYYPPMEFQQVNQLL 407 KFL+ C +QG+Y+ PM F+ + Q L Sbjct: 891 FKFLQQSNCDQYQGYYFAKPMPFEALKQYL 920