BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0114.p (193 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IW28.1 D8IW28_HERSS Aldo/keto reductase protein EC=1.1.1.- 274 5e-72 Q67RQ0.1 Q67RQ0_SYMTH Oxidoreductase 240 6e-62 A4GA81.1 A4GA81_HERAR Putative 2,5-didehydrogluconate reductase ... 238 2e-61 A6T3Y9.1 A6T3Y9_JANMA Oxidoreductase, aldo/keto reductase family... 228 3e-58 B9JXP1.1 B9JXP1_AGRVS Aldo/keto reductase 228 4e-58 >D8IW28.1 D8IW28_HERSS Aldo/keto reductase protein EC=1.1.1.- Length = 280 Score = 274 bits (700), Expect = 5e-72, Method: Compositional matrix adjust. Identities = 129/190 (67%), Positives = 153/190 (80%) Query: 4 GTVKACEASLKRLRVERIDLYLLHWRGTHPFAATIEAMETLIDQGKIGAWGVSNLDLDDM 63 GT+ ACEASLKRL +RIDLYLLHWRG HP AATIE METL+ QGKIG WGVSN D DD+ Sbjct: 91 GTIAACEASLKRLGTDRIDLYLLHWRGAHPLAATIEGMETLVSQGKIGGWGVSNFDTDDI 150 Query: 64 QELLEQDNGHHVQVNQVLYNLSRRGIEFDLRPFAVEQNIALMAYSPIEQGRILKDAALVA 123 +LLE+ +G H NQVLYNLSRRGIE+DL P A + +IA+MAYSPIEQGRILK AL A Sbjct: 151 DDLLEEPHGEHYLCNQVLYNLSRRGIEYDLLPQAQQAHIAVMAYSPIEQGRILKHPALTA 210 Query: 124 VAERHGVTPAQVALAWTLRHPGMISIPKASTVQHVQDNRACLDVTLDATDLAGLDRAFAP 183 +A+ H VTPAQ+ALAW LR PG+++IPKA+ V HVQ NRA LD++L A DL LD AFAP Sbjct: 211 LAQAHRVTPAQIALAWVLRQPGVVAIPKAADVAHVQANRASLDISLSAADLKILDEAFAP 270 Query: 184 PKKRRPLEML 193 P++++PL ML Sbjct: 271 PRRKQPLAML 280 >Q67RQ0.1 Q67RQ0_SYMTH Oxidoreductase Length = 280 Score = 240 bits (613), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 118/190 (62%), Positives = 139/190 (73%) Query: 4 GTVKACEASLKRLRVERIDLYLLHWRGTHPFAATIEAMETLIDQGKIGAWGVSNLDLDDM 63 GT++ACE SL+RLR +RIDLYLLHWRG HP A T+EA L+ GKI WGVSN D DDM Sbjct: 91 GTIEACERSLRRLRTDRIDLYLLHWRGRHPLAETLEAFAELVRAGKIRYWGVSNFDTDDM 150 Query: 64 QELLEQDNGHHVQVNQVLYNLSRRGIEFDLRPFAVEQNIALMAYSPIEQGRILKDAALVA 123 +EL G V NQVLYNLSRRGIE+DL P+ E+ I +MAYSPIEQGRIL++ L Sbjct: 151 EELTGLPGGAAVATNQVLYNLSRRGIEYDLLPWCRERRIPIMAYSPIEQGRILENTVLRR 210 Query: 124 VAERHGVTPAQVALAWTLRHPGMISIPKASTVQHVQDNRACLDVTLDATDLAGLDRAFAP 183 VA RHG TPAQVALAW LR ++ IPKA +HV++NRA LD+ L A DLA LDRAF Sbjct: 211 VAARHGATPAQVALAWLLRQKDVMVIPKAGRPEHVRENRAALDLELTAEDLAELDRAFPS 270 Query: 184 PKKRRPLEML 193 P ++ PLEML Sbjct: 271 PTRKVPLEML 280 >A4GA81.1 A4GA81_HERAR Putative 2,5-didehydrogluconate reductase EC=1.1.1.274 Length = 277 Score = 238 bits (608), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 115/190 (60%), Positives = 138/190 (72%) Query: 4 GTVKACEASLKRLRVERIDLYLLHWRGTHPFAATIEAMETLIDQGKIGAWGVSNLDLDDM 63 GT+ ACE SLKRL +RIDLYLLHWRG PFA TI A E L D GKI WGVSN+D+DDM Sbjct: 88 GTIAACERSLKRLGTDRIDLYLLHWRGRTPFAETIAAFEALQDAGKIRHWGVSNMDVDDM 147 Query: 64 QELLEQDNGHHVQVNQVLYNLSRRGIEFDLRPFAVEQNIALMAYSPIEQGRILKDAALVA 123 +E+ G V VNQVLYNL+RRGIE+DL P A ++ + +MAYSPIEQGR+ + + Sbjct: 148 REIARASGGEAVAVNQVLYNLTRRGIEYDLLPQAQQRGLPIMAYSPIEQGRLTESPEVQD 207 Query: 124 VAERHGVTPAQVALAWTLRHPGMISIPKASTVQHVQDNRACLDVTLDATDLAGLDRAFAP 183 +A+RHG +PAQ+ALAW LR PG+I+IPKAST HVQ NRA LD+ L A DLA LD F P Sbjct: 208 IADRHGASPAQIALAWVLRQPGVIAIPKASTPAHVQQNRAALDIKLTAQDLAELDDTFPP 267 Query: 184 PKKRRPLEML 193 P LEM+ Sbjct: 268 PDGPESLEMI 277 >A6T3Y9.1 A6T3Y9_JANMA Oxidoreductase, aldo/keto reductase family, related to diketogulonate reductase Length = 277 Score = 228 bits (582), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 113/191 (59%), Positives = 138/191 (72%) Query: 3 AGTVKACEASLKRLRVERIDLYLLHWRGTHPFAATIEAMETLIDQGKIGAWGVSNLDLDD 62 +GT+ ACE SL+RL + IDLYLLHWRG PFA TI A E L D GKI WGVSN+D+DD Sbjct: 87 SGTIAACERSLRRLGTDCIDLYLLHWRGRTPFAETIAAFEALQDAGKIRHWGVSNMDVDD 146 Query: 63 MQELLEQDNGHHVQVNQVLYNLSRRGIEFDLRPFAVEQNIALMAYSPIEQGRILKDAALV 122 M+E+ G + NQVLYNL+RRGIEFDL P A + + LMAYSPIEQGR+ + ++ Sbjct: 147 MREIARAPGGDAMATNQVLYNLTRRGIEFDLLPQAQARGLPLMAYSPIEQGRLTEYPEVL 206 Query: 123 AVAERHGVTPAQVALAWTLRHPGMISIPKASTVQHVQDNRACLDVTLDATDLAGLDRAFA 182 +A+RHGVTPAQVALAW LR G+I+IPKAST +HV++NRA LD+ L A DL LD F Sbjct: 207 DIADRHGVTPAQVALAWVLRQEGVIAIPKASTPEHVRENRAALDLQLTAEDLEELDDMFP 266 Query: 183 PPKKRRPLEML 193 PP LEM+ Sbjct: 267 PPDGPESLEMI 277 >B9JXP1.1 B9JXP1_AGRVS Aldo/keto reductase Length = 281 Score = 228 bits (580), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 105/190 (55%), Positives = 139/190 (73%) Query: 4 GTVKACEASLKRLRVERIDLYLLHWRGTHPFAATIEAMETLIDQGKIGAWGVSNLDLDDM 63 GT+ ACE SLKRL + +DLYLLHWRG HP T+EA ETL +QGKI AWGVSN D+ DM Sbjct: 92 GTMSACEGSLKRLGTDCLDLYLLHWRGEHPLTDTVEAFETLKNQGKIKAWGVSNFDVADM 151 Query: 64 QELLEQDNGHHVQVNQVLYNLSRRGIEFDLRPFAVEQNIALMAYSPIEQGRILKDAALVA 123 +EL +NG + Q NQ+LYNLSRRG+E+DL P+ E+ +A+MAYSPIEQGR+LK L+ Sbjct: 152 EELFAVENGANCQANQILYNLSRRGVEYDLLPWCQERGLAIMAYSPIEQGRLLKHPELIH 211 Query: 124 VAERHGVTPAQVALAWTLRHPGMISIPKASTVQHVQDNRACLDVTLDATDLAGLDRAFAP 183 VA+ + TPAQVALA+ L ++ IPK + +++NR +D+ L DLA LD AF P Sbjct: 212 VAKANQATPAQVALAFLLERDNVLPIPKTTATTRIEENRGSVDIELTEDDLARLDAAFPP 271 Query: 184 PKKRRPLEML 193 P++++P+EML Sbjct: 272 PQRKQPMEML 281