BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0052.p (359 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IVR7.1 D8IVR7_HERSS CDP-glucose-4,6-dehydratase protein EC=4.2... 591 e-167 C3V129.1 C3V129_HERSE RfbG EC=4.2.1.46 591 e-167 B3E4J4.1 B3E4J4_GEOLS CDP-glucose 4,6-dehydratase 413 e-113 C6E5A1.1 C6E5A1_GEOSM CDP-glucose 4,6-dehydratase 410 e-112 Q124Y8.1 Q124Y8_POLSJ NAD-dependent epimerase/dehydratase 407 e-111 >D8IVR7.1 D8IVR7_HERSS CDP-glucose-4,6-dehydratase protein EC=4.2.1.46 Length = 357 Score = 591 bits (1523), Expect = e-167, Method: Compositional matrix adjust. Identities = 286/357 (80%), Positives = 315/357 (88%), Gaps = 1/357 (0%) Query: 3 AQFWRDKRVFITGHTGFKGSWLTLWLHRWGAKVYGYSLPAPTNPSLFHLARLQNCVQTTT 62 A FWRDKRVFITGHTGFKGSWLTLWLH GAKV GYSLPAPT+PSLFHLARL NCVQTTT Sbjct: 2 ANFWRDKRVFITGHTGFKGSWLTLWLHLMGAKVSGYSLPAPTSPSLFHLARLHNCVQTTT 61 Query: 63 GDVRDLRHLSDTMAAVQPDVVFHLAAQPLVRDSYNTPIDTFAINVMGTAHLLEAVRHTPS 122 GDVRD +HL++TMAAVQPDVVFHLA QP + SY TP+DTFA NVMGTAHLLEAVR TPS Sbjct: 62 GDVRDPKHLAETMAAVQPDVVFHLAGQPQIEHSYLTPLDTFATNVMGTAHLLEAVRSTPS 121 Query: 123 VRSVIVVTSDKCYENREWLWGYREDDPMGGHDPYSSSKGAAELVTSAYRRSYFQHNADAH 182 VR+V+VV+S+KCYENREWLWGYREDDPMGGHDP+SSSKGAAELVT+AYRRS+F + D+ Sbjct: 122 VRAVVVVSSNKCYENREWLWGYREDDPMGGHDPFSSSKGAAELVTAAYRRSFFSADPDSP 181 Query: 183 AAIATVRAGNVIGGGDFAGDRLIPDFIRALEKEEAVSIRNPHAIRPWQFVLEPLSGYLQV 242 +A+VR GNVIGGGDFA DRLIPDFIRALE ++ V+IR PHA+RPWQFVLEPLSGYLQ+ Sbjct: 182 VGVASVRTGNVIGGGDFAADRLIPDFIRALETDQPVTIRQPHAVRPWQFVLEPLSGYLQI 241 Query: 243 AQKLYESGQQFAEGWNFGPADTDLQTVSQLCATFNHSLQKNDVAPVEVRLESQAGAPHEA 302 + LYE G +AE WNFGP DTDLQTVSQLCATFNHSLQKNDV PVEVRLE QAGA Sbjct: 242 GKMLYEHGASYAEAWNFGPTDTDLQTVSQLCATFNHSLQKNDVEPVEVRLE-QAGATLSE 300 Query: 303 AFLRLDISKARQRLDWVPKMELYTALELTAQWYGGYINNEDLRTLSESQIEFYQNLT 359 A LRLD SKARQRLDW+P+MELYTALELTAQWY GY+NNEDLR LSE+QI FYQ+LT Sbjct: 301 AVLRLDTSKARQRLDWIPRMELYTALELTAQWYAGYLNNEDLRALSENQIAFYQSLT 357 >C3V129.1 C3V129_HERSE RfbG EC=4.2.1.46 Length = 357 Score = 591 bits (1523), Expect = e-167, Method: Compositional matrix adjust. Identities = 286/357 (80%), Positives = 315/357 (88%), Gaps = 1/357 (0%) Query: 3 AQFWRDKRVFITGHTGFKGSWLTLWLHRWGAKVYGYSLPAPTNPSLFHLARLQNCVQTTT 62 A FWRDKRVFITGHTGFKGSWLTLWLH GAKV GYSLPAPT+PSLFHLARL NCVQTTT Sbjct: 2 ANFWRDKRVFITGHTGFKGSWLTLWLHLMGAKVSGYSLPAPTSPSLFHLARLHNCVQTTT 61 Query: 63 GDVRDLRHLSDTMAAVQPDVVFHLAAQPLVRDSYNTPIDTFAINVMGTAHLLEAVRHTPS 122 GDVRD +HL++TMAAVQPDVVFHLA QP + SY TP+DTFA NVMGTAHLLEAVR TPS Sbjct: 62 GDVRDPKHLAETMAAVQPDVVFHLAGQPQIEHSYLTPLDTFATNVMGTAHLLEAVRSTPS 121 Query: 123 VRSVIVVTSDKCYENREWLWGYREDDPMGGHDPYSSSKGAAELVTSAYRRSYFQHNADAH 182 VR+V+VV+S+KCYENREWLWGYREDDPMGGHDP+SSSKGAAELVT+AYRRS+F + D+ Sbjct: 122 VRAVVVVSSNKCYENREWLWGYREDDPMGGHDPFSSSKGAAELVTAAYRRSFFSADPDSP 181 Query: 183 AAIATVRAGNVIGGGDFAGDRLIPDFIRALEKEEAVSIRNPHAIRPWQFVLEPLSGYLQV 242 +A+VR GNVIGGGDFA DRLIPDFIRALE ++ V+IR PHA+RPWQFVLEPLSGYLQ+ Sbjct: 182 VGVASVRTGNVIGGGDFAADRLIPDFIRALETDQPVTIRQPHAVRPWQFVLEPLSGYLQI 241 Query: 243 AQKLYESGQQFAEGWNFGPADTDLQTVSQLCATFNHSLQKNDVAPVEVRLESQAGAPHEA 302 + LYE G +AE WNFGP DTDLQTVSQLCATFNHSLQKNDV PVEVRLE QAGA Sbjct: 242 GKMLYEHGASYAEAWNFGPTDTDLQTVSQLCATFNHSLQKNDVEPVEVRLE-QAGATLSE 300 Query: 303 AFLRLDISKARQRLDWVPKMELYTALELTAQWYGGYINNEDLRTLSESQIEFYQNLT 359 A LRLD SKARQRLDW+P+MELYTALELTAQWY GY+NNEDLR LSE+QI FYQ+LT Sbjct: 301 AVLRLDTSKARQRLDWIPRMELYTALELTAQWYAGYLNNEDLRALSENQIAFYQSLT 357 >B3E4J4.1 B3E4J4_GEOLS CDP-glucose 4,6-dehydratase Length = 357 Score = 413 bits (1062), Expect = e-113, Method: Compositional matrix adjust. Identities = 201/361 (55%), Positives = 255/361 (70%), Gaps = 18/361 (4%) Query: 5 FWRDKRVFITGHTGFKGSWLTLWLHRWGAKVYGYSLPAPTNPSLFHLARLQNC---VQTT 61 FW++K+VF+TGHTGFKGSWLTLWL + GA+V+GY+L PT PSLF+L L + + + Sbjct: 3 FWQNKKVFVTGHTGFKGSWLTLWLLKLGAEVHGYALEPPTEPSLFNLLGLNSPSPQLSSQ 62 Query: 62 TGDVRDLRHLSDTMAAVQPDVVFHLAAQPLVRDSYNTPIDTFAINVMGTAHLLEAVRHTP 121 D+RD L+ + QP++V H+AAQPLVRDSY P+DT+AIN+MGT ++LEA+RH P Sbjct: 63 IADIRDSSALATAIQQAQPEIVIHMAAQPLVRDSYLIPVDTYAINIMGTVNMLEAIRHCP 122 Query: 122 SVRSVIVVTSDKCYENREWLWGYREDDPMGGHDPYSSSKGAAELVTSAYRRSYFQHNADA 181 SVR+V+ VT+DKCYENREW+WGYRED+PMGG DPYSSSKG +ELVT+AYR+SYF Sbjct: 123 SVRAVVNVTTDKCYENREWVWGYREDEPMGGFDPYSSSKGCSELVTAAYRQSYFNSRQPT 182 Query: 182 H--AAIATVRAGNVIGGGDFAGDRLIPDFIRALEKEEAVSIRNPHAIRPWQFVLEPLSGY 239 A+A+ RAGNVIGGGD+A DRL+PD +RAL +E VSIRNP A+RPWQ VLEPLSGY Sbjct: 183 QHGVALASARAGNVIGGGDWAADRLVPDIVRALLNKEPVSIRNPLAVRPWQHVLEPLSGY 242 Query: 240 LQVAQKLYESGQQFAEGWNFGPADTDLQTVS----QLCATFNHSLQKNDVAPVEVRLESQ 295 L +A+ LYE G FAEGWNFGPAD D + V+ LC + +S V+ Sbjct: 243 LCLARHLYEHGTAFAEGWNFGPADEDAKPVAWIVDHLCKLWGNSASYTIVS--------- 293 Query: 296 AGAPHEAAFLRLDISKARQRLDWVPKMELYTALELTAQWYGGYINNEDLRTLSESQIEFY 355 PHEA +L+LD SKA+ RL W P+ L TALE W Y E +RT+ +QI Y Sbjct: 294 GDHPHEAQYLKLDCSKAKMRLGWKPRWNLETALEQVVTWTKAYSKKESIRTICLNQIASY 353 Query: 356 Q 356 + Sbjct: 354 E 354 >C6E5A1.1 C6E5A1_GEOSM CDP-glucose 4,6-dehydratase Length = 372 Score = 410 bits (1053), Expect = e-112, Method: Compositional matrix adjust. Identities = 200/355 (56%), Positives = 251/355 (70%), Gaps = 9/355 (2%) Query: 4 QFWRDKRVFITGHTGFKGSWLTLWLHRWGAKVYGYSLPAPTNPSLFHLARLQNCVQTTTG 63 +F+R +RV +TGHTGFKGSWL+LWLHR GA+V GY+L PT+PSLF LA L V + TG Sbjct: 15 EFFRGRRVLVTGHTGFKGSWLSLWLHRLGAQVTGYALSPPTDPSLFELAGLAELVHSVTG 74 Query: 64 DVRDLRHLSDTMAAVQPDVVFHLAAQPLVRDSYNTPIDTFAINVMGTAHLLEAVRHTPSV 123 DVRD L+ + P++V H+AAQPLVR+SY P++T++ NVMGT HLLEAVR++P V Sbjct: 75 DVRDQAALTTAVKDAAPEIVIHMAAQPLVRESYLNPVETYSTNVMGTVHLLEAVRNSPGV 134 Query: 124 RSVIVVTSDKCYENREWLWGYREDDPMGGHDPYSSSKGAAELVTSAYRRSYFQHN--ADA 181 ++V+ VT+DKCYENREW WGYRE++PMGG+DPYSSSKG +ELVT+AYR SYF AD Sbjct: 135 KAVVNVTTDKCYENREWAWGYRENEPMGGYDPYSSSKGCSELVTAAYRNSYFNETRYADH 194 Query: 182 HAAIATVRAGNVIGGGDFAGDRLIPDFIRALEKEEAVSIRNPHAIRPWQFVLEPLSGYLQ 241 A+A+ RAGNVIGGGD+AGDRLIPD + AL K E V IRNPHAIRPWQ VLEPLSGYL Sbjct: 195 GVALASARAGNVIGGGDWAGDRLIPDCVAALLKHEPVRIRNPHAIRPWQHVLEPLSGYLT 254 Query: 242 VAQKLYESGQQFAEGWNFGPADTDLQTVSQLCATFNHSLQKNDVAPVEVRLESQAGA-PH 300 +AQ+LY+ G ++A WNFGP D D + V + Q E R E G PH Sbjct: 255 LAQRLYQEGPRYAGAWNFGPGDDDAREVEWIVKRMCSRWQG------EARYEVDQGEHPH 308 Query: 301 EAAFLRLDISKARQRLDWVPKMELYTALELTAQWYGGYINNEDLRTLSESQIEFY 355 EA +L+LD SKA+ +L W P+ L TA+E W Y ++LR + QI+ Y Sbjct: 309 EAHYLKLDCSKAKAKLGWSPRWSLETAIEKIIDWSLAYQRGDELRAVCLQQIDSY 363 >Q124Y8.1 Q124Y8_POLSJ NAD-dependent epimerase/dehydratase Length = 358 Score = 407 bits (1046), Expect = e-111, Method: Compositional matrix adjust. Identities = 199/367 (54%), Positives = 254/367 (69%), Gaps = 19/367 (5%) Query: 1 MAAQFWRDKRVFITGHTGFKGSWLTLWLHRWGAKVYGYSLPAPTNPSLFHLARLQNCVQT 60 M FW +RVF+TGHTGFKGSW++LWL GA + GY+L +PT PSLF A++ +++ Sbjct: 1 MNPAFWHGRRVFLTGHTGFKGSWMSLWLQSLGANLTGYALQSPTQPSLFDEAKVGLGMRS 60 Query: 61 TTGDVRDLRHLSDTMAAVQPDVVFHLAAQPLVRDSYNTPIDTFAINVMGTAHLLEAVRHT 120 GD+RDL L M QP++V H+AAQPLVR SY P++T++ NVMGT HLLE VRH Sbjct: 61 IIGDIRDLAFLQKAMQECQPEIVIHMAAQPLVRYSYANPVETYSTNVMGTVHLLETVRHA 120 Query: 121 PSVRSVIVVTSDKCYENREWLWGYREDDPMGGHDPYSSSKGAAELVTSAYRRSYFQHNAD 180 PSV++V+ +T+DKCYENREW WGYRE++PMGG+DPYS+SKG AELV+SAYR S+F NA+ Sbjct: 121 PSVKAVVNITTDKCYENREWAWGYRENEPMGGYDPYSNSKGCAELVSSAYRSSFF--NAN 178 Query: 181 AHA----AIATVRAGNVIGGGDFAGDRLIPDFIRALEKEEAVSIRNPHAIRPWQFVLEPL 236 +HA +ATVRAGNVIGGGD+A DRLIPD + A E+ + V+IRNPH+IRPWQ VLEPL Sbjct: 179 SHAQHGVGLATVRAGNVIGGGDWAQDRLIPDILAAFEQGQRVNIRNPHSIRPWQHVLEPL 238 Query: 237 SGYLQVAQKLYESGQQFAEGWNFGPADTDLQ----TVSQLCATFNHSLQKNDVAPVEVRL 292 GYL +A++L+E G +AEGWNFGP D D + V Q+ A + Q Sbjct: 239 RGYLTLAERLFEHGPSYAEGWNFGPNDEDAKPVGWIVEQMAAMWGEGAQSQI-------- 290 Query: 293 ESQAGAPHEAAFLRLDISKARQRLDWVPKMELYTALELTAQWYGGYINNEDLRTLSESQI 352 PHEA +L+LDISKAR RLDW P + L AL L +W D+R L+ +QI Sbjct: 291 -DNGEHPHEANYLKLDISKARSRLDWHPTLRLNDALALIIEWSKQRQAGADIRELTLAQI 349 Query: 353 EFYQNLT 359 YQ LT Sbjct: 350 HSYQTLT 356