BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0004.0034.p (459 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A6SYR4.1 A6SYR4_JANMA Sensor kinase of copper sensing two-compon... 502 e-140 A4G5D0.1 A4G5D0_HERAR Sensor kinase CusS 499 e-139 Q46YD1.1 Q46YD1_CUPPJ Heavy metal sensor signal transduction his... 468 e-129 Q1LBE4.1 Q1LBE4_RALME Sensory histidine kinase in two-component ... 438 e-120 Q58AD4.1 Q58AD4_RALME Two component sensor histidine kinase tran... 437 e-120 >A6SYR4.1 A6SYR4_JANMA Sensor kinase of copper sensing two-component system EC=2.7.3.- Length = 458 Score = 502 bits (1292), Expect = e-140, Method: Compositional matrix adjust. Identities = 259/454 (57%), Positives = 330/454 (72%), Gaps = 1/454 (0%) Query: 4 QRSLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVNERGAD 63 + SLT RLT LFA S AVLVG G LI S + +HF +QD+ LL+ ELQLI+ V+ E+G D Sbjct: 3 RNSLTARLTTLFAATSVAVLVGFGTLISSAIEEHFAEQDQLLLQNELQLIQKVIKEKGID 62 Query: 64 AITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAPILAAAQSAVPGRSFAVPVGQHQ 123 +I+ TFGEALHNHP FYV + + G+ +YSTL IL+ + F V + H+ Sbjct: 63 SISQTFGEALHNHPDFYVDVRDIDGKEIYSTLGPFRDAILSREPNIETENDFDVRIDAHR 122 Query: 124 KFQAIKARLKDDQSARELQVIVAVDTEIHDHFMRNFQTTLVLYIAGSVLIVVLLSWWAAR 183 +FQAI+A LK + + V++AVD IH HFM F+TTL+LYI + + ++L WWAAR Sbjct: 123 EFQAIRAELKASVGSPVI-VVIAVDKAIHTHFMSMFRTTLMLYILVAAMATIMLGWWAAR 181 Query: 184 RGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEIADLAAKLNAMLERLQRDFNRITNFST 243 +GL+PLR M+ + QAV+S N ERM V+ +P E+ DLA KLNAML+RLQ D R+T FS Sbjct: 182 QGLSPLRTMAARAQAVTSQNMKERMPVDAVPTEMTDLAVKLNAMLDRLQNDIARLTEFSA 241 Query: 244 DIAHELRTPITNLLTQTDVVLTQQRTNEAYRDILSSNAEELQRLARTISDMLFLAQTENG 303 D+AHELRTPI+N+LTQT VVL Q R+ YRD LSSNAEELQRL +TISDMLFLAQTENG Sbjct: 242 DLAHELRTPISNMLTQTHVVLNQSRSAADYRDSLSSNAEELQRLGKTISDMLFLAQTENG 301 Query: 304 ITLPSYERLSLQEEISELFDFYDALAEEKNVLMRLAGEASIRGDRLMVRRALSNLISNAM 363 + LPS E+L++ +E L +FY+ALAEEK V +R G+A + GDRLM RRAL+NL+SNA+ Sbjct: 302 LALPSVEKLNMAQECQALLEFYEALAEEKEVTLRCEGDAVVIGDRLMFRRALNNLLSNAL 361 Query: 364 RYTPPAGVIAVSIDRSEKDISVHVENDGPEIPSEHLPHLFDRFYRADKARTKLDSDSAGL 423 RYTP G I++ I ++ V VENDG EIP E PHLFDRFYRADK+R K +SDSAGL Sbjct: 362 RYTPSHGTISIKIKAAQAGTVVTVENDGKEIPIEIQPHLFDRFYRADKSRKKSESDSAGL 421 Query: 424 GLSITKAIMRAHQGEVSVRSAQGKTRFTLLFPNA 457 GLSIT+AIM+AH G VSV S + KT F+L FP++ Sbjct: 422 GLSITRAIMQAHGGSVSVVSGESKTAFSLYFPSS 455 >A4G5D0.1 A4G5D0_HERAR Sensor kinase CusS Length = 458 Score = 499 bits (1285), Expect = e-139, Method: Compositional matrix adjust. Identities = 254/452 (56%), Positives = 329/452 (72%), Gaps = 1/452 (0%) Query: 6 SLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVNERGADAI 65 SLT RLT LFA S AVLVG G I S + +HF++QD+ LL+ ELQLI+ V+ E+G D+I Sbjct: 5 SLTGRLTTLFAATSVAVLVGFGTFISSAIEEHFSEQDQLLLQNELQLIQKVIEEKGVDSI 64 Query: 66 TSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAPILAAAQSAVPGRSFAVPVGQHQKF 125 + TFGEALHNHP FYV + L+G+ +YST IL+ S+ F V + +H++F Sbjct: 65 SQTFGEALHNHPDFYVDVRDLNGKEIYSTFGAFRDAILSRIPSSKTKNGFDVKIDEHREF 124 Query: 126 QAIKARLKDDQSARELQVIVAVDTEIHDHFMRNFQTTLVLYIAGSVLIVVLLSWWAARRG 185 QAI+A LK + + V++AVD IH HFM F+TTL+LY+ + + V+L WWAAR+G Sbjct: 125 QAIRAELKA-SAGSPVIVVIAVDKAIHTHFMSMFRTTLMLYVMVAAIATVMLGWWAARQG 183 Query: 186 LAPLRAMSDKVQAVSSHNFGERMSVEMLPIEIADLAAKLNAMLERLQRDFNRITNFSTDI 245 L+PLR M+ + Q V+S N ERM V+ +P E+ DLA KLNAML+RLQ D R+T FS D+ Sbjct: 184 LSPLRTMAARAQTVTSQNMNERMPVDAVPTEMTDLAVKLNAMLDRLQNDIARLTEFSADL 243 Query: 246 AHELRTPITNLLTQTDVVLTQQRTNEAYRDILSSNAEELQRLARTISDMLFLAQTENGIT 305 AHELRTPI+N+LTQT VVL Q R+ YRD LSSNAEELQRL TISDMLFLAQTENG+ Sbjct: 244 AHELRTPISNMLTQTHVVLNQSRSTADYRDSLSSNAEELQRLGNTISDMLFLAQTENGLA 303 Query: 306 LPSYERLSLQEEISELFDFYDALAEEKNVLMRLAGEASIRGDRLMVRRALSNLISNAMRY 365 LPS +L++ E L +FY+ALAEEK V++R G+A + GD+LM RRAL+NL+SNA+RY Sbjct: 304 LPSVAKLNMARECQALLEFYEALAEEKKVVLRCEGDAVVIGDQLMFRRALNNLLSNAIRY 363 Query: 366 TPPAGVIAVSIDRSEKDISVHVENDGPEIPSEHLPHLFDRFYRADKARTKLDSDSAGLGL 425 TP G I++ I +E ++ V+NDG EIP+E PHLFDRF+RADK+R K +SDSAGLGL Sbjct: 364 TPSYGTISIKITSAESGTTITVQNDGEEIPAEIQPHLFDRFFRADKSRKKSESDSAGLGL 423 Query: 426 SITKAIMRAHQGEVSVRSAQGKTRFTLLFPNA 457 SIT+AIM+AH G VSV S KT F+L FP++ Sbjct: 424 SITRAIMQAHGGSVSVVSRDSKTAFSLYFPSS 455 >Q46YD1.1 Q46YD1_CUPPJ Heavy metal sensor signal transduction histidine kinase EC=2.7.3.- Length = 465 Score = 468 bits (1203), Expect = e-129, Method: Compositional matrix adjust. Identities = 236/456 (51%), Positives = 317/456 (69%), Gaps = 5/456 (1%) Query: 2 IRQRSLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVNERG 61 +R+ SLT RLTALF L+S VL+GLG+LI + + +HF ++D L ++LI + E Sbjct: 1 MRRFSLTTRLTALFCLSSAGVLLGLGILIATAMDQHFAEEDFASLGDNVRLIERIATENA 60 Query: 62 ADAITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAPILAAAQSAVPGRSFAVPVGQ 121 A +++ AL +HPGF H+S+ G LY++ +L A GR Sbjct: 61 AASVSERLAVALEHHPGFIAHVSAADGTLLYASNGFDFRTVLGTASVLPAGRESFDWEQD 120 Query: 122 HQKFQAIKARLK---DDQSARELQVIVAVDTEIHDHFMRNFQTTLVLYIAGSVLIVVLLS 178 + ++ ++A ++ D Q L ++V +DTEIH HFMR F+ +L Y+ + L LL Sbjct: 121 GKSYRGMRATVQATGDKQV--PLTIVVGMDTEIHAHFMRAFRRSLTFYVTLAALASGLLG 178 Query: 179 WWAARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEIADLAAKLNAMLERLQRDFNRI 238 WWAARRGLAPLR M+ + +AV++H RM V+ +P+E+ADLA LNAMLERLQ DF R+ Sbjct: 179 WWAARRGLAPLRTMASRARAVTAHKLDARMPVDAVPVEMADLAGTLNAMLERLQSDFQRL 238 Query: 239 TNFSTDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDILSSNAEELQRLARTISDMLFLA 298 ++FS+DIAHELRTP+TNL+TQT VVL+Q R E YRD+L+SNAEELQRL+R +SDML+LA Sbjct: 239 SDFSSDIAHELRTPLTNLMTQTHVVLSQPRAAEKYRDVLASNAEELQRLSRMVSDMLYLA 298 Query: 299 QTENGITLPSYERLSLQEEISELFDFYDALAEEKNVLMRLAGEASIRGDRLMVRRALSNL 358 Q E+G+TLPS E + + E+ LF+FYDALAE+K V ++L GE I GDRLM+RRALSNL Sbjct: 299 QMEHGLTLPSAEPIDVAVEVHALFEFYDALAEDKAVRLQLRGEGHIVGDRLMLRRALSNL 358 Query: 359 ISNAMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPSEHLPHLFDRFYRADKARTKLDS 418 +SNA+RYTPP GVI + I S I+V VENDG +I + LP +FDRF R DK+R + +S Sbjct: 359 LSNALRYTPPGGVIVIEIGGSADTITVSVENDGQDIRPDLLPVIFDRFSRGDKSRVRPES 418 Query: 419 DSAGLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLF 454 DS GLGLSIT+AIM AH G ++V+SA GKTRFTL F Sbjct: 419 DSVGLGLSITRAIMAAHGGTIAVQSASGKTRFTLAF 454 >Q1LBE4.1 Q1LBE4_RALME Sensory histidine kinase in two-component regulatory system with CopR, senses copper ions Length = 462 Score = 438 bits (1126), Expect = e-120, Method: Compositional matrix adjust. Identities = 225/459 (49%), Positives = 310/459 (67%), Gaps = 8/459 (1%) Query: 2 IRQRSLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVNERG 61 +R SLT RLTALF+L S VL+GLG+LI + + +HF +D LL ++L+ + + Sbjct: 1 MRGYSLTTRLTALFSLTSACVLLGLGVLIFTAMDRHFAVEDYALLRDNMRLVEKTIADNT 60 Query: 62 ADAITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAPILA----AAQSAVPGRSFAV 117 + + +A +H G V+ +GQ Y+T + A L A++ V Sbjct: 61 GSTLPTRLADAYQHHSGLLVYTRGANGQVHYATPDFDFAAALKTSIEASRKHVGDDDVFQ 120 Query: 118 PVGQHQKFQAIKARLKDDQSAREL-QVIVAVDTEIHDHFMRNFQTTLVLYIAGSVLIVVL 176 + ++ ++A + +A EL V++ +DTEIH+HF+ F+ +LV Y+A +VL + Sbjct: 121 WTQDGKTYRGMRATVN---AAGELTDVLLGMDTEIHEHFVHAFRRSLVSYVALAVLASGV 177 Query: 177 LSWWAARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEIADLAAKLNAMLERLQRDFN 236 WWAARRGLAPLRAM+ + + V+ ERM VE +P E+A+LAA LNAMLERLQ DF Sbjct: 178 FGWWAARRGLAPLRAMATRAKVVTGDKLHERMPVEAVPEEVANLAANLNAMLERLQDDFR 237 Query: 237 RITNFSTDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDILSSNAEELQRLARTISDMLF 296 R++ FS+D+AHELRTP+TNL+TQT V L+Q R E YR+IL+SNAEELQRL+R +SDML+ Sbjct: 238 RLSEFSSDLAHELRTPLTNLMTQTQVALSQPRDAEKYREILASNAEELQRLSRMVSDMLY 297 Query: 297 LAQTENGITLPSYERLSLQEEISELFDFYDALAEEKNVLMRLAGEASIRGDRLMVRRALS 356 LA+ E+G+ LP E +S+ +E LF+FY+ALAE+K V +RL G+ + GDRLM+RRALS Sbjct: 298 LAKMEHGLDLPHKETISIAQEAGALFEFYEALAEDKQVALRLQGDGIVEGDRLMLRRALS 357 Query: 357 NLISNAMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPSEHLPHLFDRFYRADKARTKL 416 NL+SNA+R+TP AG + V + V VENDGPEIP+E L LFDRF+R DK+R + Sbjct: 358 NLLSNALRHTPQAGAVVVEAHAEGDSVVVAVENDGPEIPAELLSSLFDRFFRGDKSRRRP 417 Query: 417 DSDSAGLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLFP 455 +SDS GLGLSIT+AIM AH G +SV+SA GKTRF L FP Sbjct: 418 ESDSVGLGLSITRAIMTAHGGGISVQSANGKTRFVLRFP 456 >Q58AD4.1 Q58AD4_RALME Two component sensor histidine kinase transcription regulator Length = 463 Score = 437 bits (1125), Expect = e-120, Method: Compositional matrix adjust. Identities = 225/460 (48%), Positives = 312/460 (67%), Gaps = 6/460 (1%) Query: 2 IRQR-SLTVRLTALFALASTAVLVGLGLLIISTVAKHFTDQDEQLLEKELQLIRMVVNER 60 +R R SLTVRLT LF+L+S VL+GLG+LI + +HF ++D +L ++LI V +E Sbjct: 1 MRHRLSLTVRLTILFSLSSAVVLLGLGVLIWLAMDRHFANEDFVVLGDNIRLIERVADET 60 Query: 61 GADAITSTFGEALHNHPGFYVHISSLSGQALYSTLNHATAPILAAAQSAVPGRSFAVPVG 120 + + + E + +HPGF + + G+ +++T + P +A V Sbjct: 61 PVERLPARLQELVEHHPGFVARVQTAQGKTIFATRDFDFRPAESATNEGPNSEGTFVWQQ 120 Query: 121 QHQKFQAIKAR---LKDDQSARELQVIVAVDTEIHDHFMRNFQTTLVLYIAGSVLIVVLL 177 + + ++ ++A L D A L+V+V +DTEIH HFM F+ +L Y + LL Sbjct: 121 ETKHYRGMRAEVPVLGSDVGA--LKVVVGMDTEIHAHFMHAFRRSLAFYTTLAAFASGLL 178 Query: 178 SWWAARRGLAPLRAMSDKVQAVSSHNFGERMSVEMLPIEIADLAAKLNAMLERLQRDFNR 237 WWAARRGLAPLR M+ + + V+++ RM V +P+E+ADLAA LNAMLERLQ DF R Sbjct: 179 GWWAARRGLAPLRMMASRAKDVTANRLDARMPVAAVPVEMADLAATLNAMLERLQNDFQR 238 Query: 238 ITNFSTDIAHELRTPITNLLTQTDVVLTQQRTNEAYRDILSSNAEELQRLARTISDMLFL 297 ++ FS+D+AHELRTPITNL+TQT VVL+Q R YRD+L+SNAEELQRL R +SDML+L Sbjct: 239 LSEFSSDLAHELRTPITNLMTQTHVVLSQPRDAAKYRDVLTSNAEELQRLGRMVSDMLYL 298 Query: 298 AQTENGITLPSYERLSLQEEISELFDFYDALAEEKNVLMRLAGEASIRGDRLMVRRALSN 357 A+ E+GITLP+ E + + +E+ LFDFYDALAE+K V ++L G A + GDRLM+RRALSN Sbjct: 299 AKMEHGITLPNEESIDIADEVLALFDFYDALAEDKGVNLQLQGNAKLAGDRLMMRRALSN 358 Query: 358 LISNAMRYTPPAGVIAVSIDRSEKDISVHVENDGPEIPSEHLPHLFDRFYRADKARTKLD 417 L+SNA+RYT I VS+ D + VEN+G EI + LP++FDRF+RADK+RT+LD Sbjct: 359 LLSNALRYTAEGRQILVSVREHGTDAMIVVENEGEEIRPDLLPYIFDRFFRADKSRTRLD 418 Query: 418 SDSAGLGLSITKAIMRAHQGEVSVRSAQGKTRFTLLFPNA 457 SDS GLGLSITKAI+ AH G+++ + GKTRFT+ FP+ Sbjct: 419 SDSVGLGLSITKAIVVAHGGKIAADCSGGKTRFTMTFPHG 458