BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0003.0048.p (456 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8ISC2.1 D8ISC2_HERSS Transmembrane sensor histidine kinase tran... 509 e-142 F1VYF7.1 F1VYF7_9BURK Sensor histidine kinase 468 e-130 A2SEK0.1 A2SEK0_METPP Putative transmembrane sensor histidine ki... 427 e-117 Q46VQ8.1 Q46VQ8_CUPPJ ATP-binding region, ATPase-like:Histidine ... 425 e-116 Q1LHC9.1 Q1LHC9_RALME Sensor signal transduction histidine kinase 423 e-116 >D8ISC2.1 D8ISC2_HERSS Transmembrane sensor histidine kinase transcription regulator protein EC=2.7.3.- Length = 464 Score = 509 bits (1310), Expect = e-142, Method: Compositional matrix adjust. Identities = 264/453 (58%), Positives = 334/453 (73%), Gaps = 7/453 (1%) Query: 1 MKLRHKIIFFAVTPLLISFGVIAVVVWHQTIRLGEQQRQSIQEAYRSSKDAELRHYVDLA 60 MKLR KIIF A+ PL ++F IA+VV +Q + L QQR +++ AY +SK+ ELRHYVDLA Sbjct: 1 MKLRQKIIFLAIVPLCLAFTAIALVVRYQAVELASQQRAAVEAAYLASKNTELRHYVDLA 60 Query: 61 EHSIAHLYERGDVENA-KREALDILARLDYGDDGYFFAYDFSGNTLVHPRQPELLGKNLW 119 +H++AHLY+ G ++A K EA +LA L++GDDGYFF YD +G +++HPRQPEL+G +W Sbjct: 61 QHALAHLYDTGRTDDAIKEEARHLLADLEFGDDGYFFVYDDTGRSIMHPRQPELVGSEMW 120 Query: 120 DWENVDGTKTIQRLIVRAQEGGGYERYLWRKPSSSTVAPKLAYVIALPKWGWIIGTGMYL 179 +W + G+ TIQ LI RA++GGGYERYLWRKPSS TVAPKL YVI+LP+WGW+IGTG+YL Sbjct: 121 NWRDASGSFTIQHLIERARQGGGYERYLWRKPSSKTVAPKLGYVISLPRWGWVIGTGIYL 180 Query: 180 DDVDAALANVDRQISGHNLDTMRLIAIIALLSVAAVAGFGLMFNLSEQRVADAKLRELAQ 239 DDV+AALA +DRQ SG+ T+ LIA IAL S AV GL+ NLSE RVADAKLR+LAQ Sbjct: 181 DDVEAALAQIDRQNSGYLHQTLLLIASIALASALAVGLAGLLLNLSEHRVADAKLRQLAQ 240 Query: 240 RVVLSQEEERARVARDLHDGISQHLVSIKLQTEAAIIKLEATREIAPACDA-FEHTVEQM 298 RVV SQEEERAR++RDLHDGISQ LVSIKLQ EAA+++L T E A A FE T Q+ Sbjct: 241 RVVRSQEEERARLSRDLHDGISQWLVSIKLQIEAALVRLNGTPEQAATARAGFEKTATQI 300 Query: 299 NRLLGEIRHISHGLRPALLDDLGLISALQFLCDEWNANGELQIDFSFSETSNAS-----P 353 N +L E+R ISH LRPA+LDDLGL +AL+ LC EW ++ F + A P Sbjct: 301 NGVLAEVRRISHDLRPAILDDLGLAAALEHLCGEWRDAAGAGVEIVFENQAQADDGATLP 360 Query: 354 DVVNTVMFRVAQEALNNIWRHAKASSVSLELTEDPGLFLLTIRDNGIGFDTGQIAKHPKR 413 DVVNTV+FR+AQEAL NI RHA AS + + L + L +L ++DNG GFD GQ+ H + Sbjct: 361 DVVNTVLFRIAQEALTNIARHAGASRIKVRLYQGHNLLMLQVQDNGHGFDLGQVDDHSRH 420 Query: 414 GIGLRNMAERLQAVGGSFSVSSSSEGTVVSAQV 446 GIGLRNM ER++AVGG + SS GT +SA + Sbjct: 421 GIGLRNMRERIEAVGGELGIDSSPAGTSISAVI 453 >F1VYF7.1 F1VYF7_9BURK Sensor histidine kinase Length = 451 Score = 468 bits (1205), Expect = e-130, Method: Compositional matrix adjust. Identities = 249/449 (55%), Positives = 307/449 (68%), Gaps = 2/449 (0%) Query: 1 MKLRHKIIFFAVTPLLISFGVIAVVVWHQTIRLGEQQRQSIQEAYRSSKDAELRHYVDLA 60 M LRHKI AV PL+ + IA+ V +Q+ L +QQR S++ AY SSK+AE+RHYV LA Sbjct: 1 MNLRHKIFLLAVVPLIAALCAIALAVQYQSALLAQQQRNSVESAYLSSKEAEMRHYVTLA 60 Query: 61 EHSIAHLYERGDVEN-AKREALDILARLDYGDDGYFFAYDFSGNTLVHPRQPELLGKNLW 119 SI +Y+ G + A EA I++ LDYGDDGYFF YD G LVHPRQPEL+G+NLW Sbjct: 61 TRSIKEIYDSGRQDTQALDEAKQIISNLDYGDDGYFFVYDMQGVNLVHPRQPELVGRNLW 120 Query: 120 DWENVDGTKTIQRLIVRAQEGGGYERYLWRKPSSSTVAPKLAYVIALPKWGWIIGTGMYL 179 + ++ G TIQRLI RA GGG ERYLW KPS+ V PKL YVI+LP+WGW+IGTG+YL Sbjct: 121 ELRDIKGNPTIQRLIFRASHGGGLERYLWEKPSTRKVVPKLGYVISLPRWGWVIGTGIYL 180 Query: 180 DDVDAALANVDRQISGHNLDTMRLIAIIALLSVAAVAGFGLMFNLSEQRVADAKLRELAQ 239 DDVDA + +D QIS + TM I IA+ SV A+A FGL N SE RVADAKLR LAQ Sbjct: 181 DDVDAVVNKIDGQISHNIQSTMLWITGIAIASVLAIALFGLALNFSEHRVADAKLRVLAQ 240 Query: 240 RVVLSQEEERARVARDLHDGISQHLVSIKLQTEAAIIKLEATREIA-PACDAFEHTVEQM 298 RVV SQEEERAR++RDLHDGISQ LVSIKLQ E+ I KL + A A +F+ Q+ Sbjct: 241 RVVHSQEEERARLSRDLHDGISQWLVSIKLQVESGIAKLAGSHAQADSARHSFDRAATQL 300 Query: 299 NRLLGEIRHISHGLRPALLDDLGLISALQFLCDEWNANGELQIDFSFSETSNASPDVVNT 358 N +LGE+R ISH LRPALLDDLGL +AL++L E+ + L I S V T Sbjct: 301 NDVLGEVRRISHDLRPALLDDLGLAAALEYLTREFADHAGLDISLSVDGPIENLSAVRKT 360 Query: 359 VMFRVAQEALNNIWRHAKASSVSLELTEDPGLFLLTIRDNGIGFDTGQIAKHPKRGIGLR 418 V+FR+AQEAL NI RHA A++V L L+ D + I DNG GFD +A+ PKRGIGLR Sbjct: 361 VLFRIAQEALTNIERHAHATNVCLTLSGDTATVRMAISDNGKGFDMPLVAESPKRGIGLR 420 Query: 419 NMAERLQAVGGSFSVSSSSEGTVVSAQVP 447 NM ER +AV G ++SS+EGT + +P Sbjct: 421 NMHERAEAVDGKLILTSSAEGTQLITILP 449 >A2SEK0.1 A2SEK0_METPP Putative transmembrane sensor histidine kinase transcription regulator protein EC=2.7.3.- Length = 456 Score = 427 bits (1099), Expect = e-117, Method: Compositional matrix adjust. Identities = 228/448 (50%), Positives = 292/448 (65%), Gaps = 3/448 (0%) Query: 1 MKLRHKIIFFAVTPLLISFGVIAVVVWHQTIRLGEQQRQSIQEAYRSSKDAELRHYVDLA 60 M+L+ KI+ AV PLL S +IA+ V HQ L ++R+ ++ AY SSK ELRHYV+LA Sbjct: 1 MRLKSKIVLLAVVPLLASIVLIALAVRHQERALAARERELVESAYMSSKRTELRHYVELA 60 Query: 61 EHSIAHLYERGDVENAKREA-LDILARLDYGDDGYFFAYDFSGNTLVHPRQPELLGKNLW 119 +IA LY+ GD A R+A + +LA LDYG DGYFF YD G +L+HPRQPEL+G +LW Sbjct: 61 RSTIAPLYDSGDDSEATRQAAMKLLASLDYGTDGYFFLYDLQGRSLMHPRQPELVGNDLW 120 Query: 120 DWENVDGTKTIQRLIVRAQEGGGYERYLWRKPSSSTVAPKLAYVIALPKWGWIIGTGMYL 179 + + G TIQ+LI +A EGGG+ YLWRKPS+ PKL YVIALP+W W++GTG+YL Sbjct: 121 ELRDEAGHPTIQQLIAKASEGGGFIDYLWRKPSTRQTTPKLGYVIALPRWNWMLGTGLYL 180 Query: 180 DDVDAALANVDRQISGHNLDTMRLIAIIALLSVAAVAGFGLMFNLSEQRVADAKLRELAQ 239 DDV A +A +D Q++ + T IA IAL +A + GL NLSE + ADAKLR+LAQ Sbjct: 181 DDVQATMAQLDHQVAANIETTFLWIAGIALSGIALITVCGLALNLSEHKEADAKLRQLAQ 240 Query: 240 RVVLSQEEERARVARDLHDGISQHLVSIKLQTEAAIIKLEATREIAPACDAFEHTVEQMN 299 +VV SQE ERA ++R+LHDG SQ LVSIKL E+AI ++E RE A A E ++ Sbjct: 241 QVVQSQESERAHLSRELHDGTSQTLVSIKLLIESAIEQIE--REPAQAAVPLERAAVRLA 298 Query: 300 RLLGEIRHISHGLRPALLDDLGLISALQFLCDEWNANGELQIDFSFSETSNASPDVVNTV 359 L E+R ISH LRPA+LD LGL +AL+ L E+ + L S PD V TV Sbjct: 299 DALTEVRRISHRLRPAMLDVLGLPAALEHLGREFGDHSGLAFSMRMRGPSIELPDDVKTV 358 Query: 360 MFRVAQEALNNIWRHAKASSVSLELTEDPGLFLLTIRDNGIGFDTGQIAKHPKRGIGLRN 419 +FRV QEAL NI +HA A SV + L P L I D+G GFD + P+RGIGLRN Sbjct: 359 LFRVTQEALTNIEKHAAAQSVRIRLAFRPSGLRLAILDDGRGFDLAAVQLDPRRGIGLRN 418 Query: 420 MAERLQAVGGSFSVSSSSEGTVVSAQVP 447 M ERL ++GGSF + S S T + A VP Sbjct: 419 MRERLASIGGSFRIRSRSGLTELIADVP 446 >Q46VQ8.1 Q46VQ8_CUPPJ ATP-binding region, ATPase-like:Histidine kinase, dimerisation and phosphoacceptor region Length = 481 Score = 425 bits (1092), Expect = e-116, Method: Compositional matrix adjust. Identities = 217/450 (48%), Positives = 294/450 (65%), Gaps = 2/450 (0%) Query: 1 MKLRHKIIFFAVTPLLISFGVIAVVVWHQTIRLGEQQRQSIQEAYRSSKDAELRHYVDLA 60 MKLR KI+ AV PL ++ IA+ V Q +L +R ++ AY SK+ ELRHYV+LA Sbjct: 14 MKLRQKILLLAVAPLAVAMLGIALAVRFQATQLARHERALVEAAYIQSKETELRHYVELA 73 Query: 61 EHSIAHLYERGDVENAKREA-LDILARLDYGDDGYFFAYDFSGNTLVHPRQPELLGKNLW 119 + +IA + G + A R+A ++ LARLDYG DGYFF YD G L+HPRQPEL+G++LW Sbjct: 74 QSAIAPMVRSGHTDAATRQAAMEALARLDYGPDGYFFLYDMQGRNLMHPRQPELVGQDLW 133 Query: 120 DWENVDGTKTIQRLIVRAQEGGGYERYLWRKPSSSTVAPKLAYVIALPKWGWIIGTGMYL 179 + G TIQ+LI A+ GGG RYLW+KPSS +APKL YV+A+P+WGW++GTG+YL Sbjct: 134 TLRDPQGALTIQKLIAAAKAGGGSVRYLWKKPSSQQLAPKLGYVVAVPEWGWMLGTGIYL 193 Query: 180 DDVDAALANVDRQISGHNLDTMRLIAIIALLSVAAVAGFGLMFNLSEQRVADAKLRELAQ 239 DDV+ L +D + +TM I +IA +S+ VA GL N+SE R ADAKLR+LAQ Sbjct: 194 DDVENTLRQLDARAETDIRETMAWIGVIAAVSILLVAASGLALNISEHREADAKLRQLAQ 253 Query: 240 RVVLSQEEERARVARDLHDGISQHLVSIKLQTEAAIIKLE-ATREIAPACDAFEHTVEQM 298 RVV SQEEERAR++R+LHDGISQ LVS+KL EAA +L A E A + ++ Sbjct: 254 RVVQSQEEERARLSRELHDGISQLLVSVKLVLEAAANRLRLAPAEGAAVAPVLGMALNRL 313 Query: 299 NRLLGEIRHISHGLRPALLDDLGLISALQFLCDEWNANGELQIDFSFSETSNASPDVVNT 358 + + E+R ++ LRPALLDDLG+ +ALQ L E +L+I + PD T Sbjct: 314 DTVFNEVRRVARNLRPALLDDLGIFAALQHLAREMQGGSQLEITVAQRGAPRELPDEQAT 373 Query: 359 VMFRVAQEALNNIWRHAKASSVSLELTEDPGLFLLTIRDNGIGFDTGQIAKHPKRGIGLR 418 ++R+AQEAL N+ RHA A V++ L DP LT+RD+G GFD ++ P+RGIGLR Sbjct: 374 ALYRIAQEALTNVERHAGARQVTVALVFDPDATSLTVRDDGRGFDVARMQLDPQRGIGLR 433 Query: 419 NMAERLQAVGGSFSVSSSSEGTVVSAQVPL 448 N+ ER+ A+GG F + S GT + A +P+ Sbjct: 434 NLRERIAALGGQFGIVSGIGGTELVATLPV 463 >Q1LHC9.1 Q1LHC9_RALME Sensor signal transduction histidine kinase Length = 475 Score = 423 bits (1088), Expect = e-116, Method: Compositional matrix adjust. Identities = 218/449 (48%), Positives = 294/449 (65%), Gaps = 2/449 (0%) Query: 1 MKLRHKIIFFAVTPLLISFGVIAVVVWHQTIRLGEQQRQSIQEAYRSSKDAELRHYVDLA 60 MKLR KI+ AV PL ++ IA+ V Q L +R ++ AY SK+ ELRHYV+LA Sbjct: 14 MKLRQKILLLAVAPLAVAMLGIALAVRFQATALVRHERMLVEAAYLQSKETELRHYVELA 73 Query: 61 EHSIAHLYERGDVENAKREA-LDILARLDYGDDGYFFAYDFSGNTLVHPRQPELLGKNLW 119 + +IA + + G + A R+A +D LARLDYG DGYFF YD G L+HPRQPEL+G++LW Sbjct: 74 QSAIAPMVKSGRTDEATRQAAMDALARLDYGRDGYFFLYDLQGRNLMHPRQPELVGQDLW 133 Query: 120 DWENVDGTKTIQRLIVRAQEGGGYERYLWRKPSSSTVAPKLAYVIALPKWGWIIGTGMYL 179 + +G TIQ+L+ A+ GGG RYLW+KPSS VAPKL YV+A+P W W++GTG+YL Sbjct: 134 LLRDPEGALTIQKLVAAAKAGGGSVRYLWKKPSSQQVAPKLGYVVAVPAWNWMLGTGIYL 193 Query: 180 DDVDAALANVDRQISGHNLDTMRLIAIIALLSVAAVAGFGLMFNLSEQRVADAKLRELAQ 239 DDV+ L +D + +TM I +IA +S+ VA GL N+SE R ADAKLR+LAQ Sbjct: 194 DDVEQTLRQLDARAETDIRETMAWIGVIAAISILLVAASGLALNVSEHREADAKLRQLAQ 253 Query: 240 RVVLSQEEERARVARDLHDGISQHLVSIKLQTEAAIIKLE-ATREIAPACDAFEHTVEQM 298 RVV SQEEERAR++R+LHDGISQ LVS+KL EAA ++ A E A + ++ Sbjct: 254 RVVQSQEEERARLSRELHDGISQLLVSVKLVLEAATNRIRLAPTEGASVAPILGMALNRL 313 Query: 299 NRLLGEIRHISHGLRPALLDDLGLISALQFLCDEWNANGELQIDFSFSETSNASPDVVNT 358 + + E+R ++ LRPALLDDLGL +ALQ L E A L I+ + + + D T Sbjct: 314 DSVFNEVRRVARNLRPALLDDLGLYAALQHLAREMQAGSTLTINVTQTGKPRSLADEPAT 373 Query: 359 VMFRVAQEALNNIWRHAKASSVSLELTEDPGLFLLTIRDNGIGFDTGQIAKHPKRGIGLR 418 +FR+AQEAL N+ RHA A+ V + L LT+RDNG GFD ++ P RGIGLR Sbjct: 374 ALFRIAQEALTNVERHAHATRVDVTLDFADRATRLTVRDNGTGFDVARMQVDPSRGIGLR 433 Query: 419 NMAERLQAVGGSFSVSSSSEGTVVSAQVP 447 N+ ER+ A+GGSF + S+ GT+++A +P Sbjct: 434 NLRERVAALGGSFEILSAPTGTLLTASLP 462