BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0711.p (328 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IUQ0.1 D8IUQ0_HERSS D-3-phosphoglycerate dehydrogenase protein... 506 e-141 A6T4C8.1 A6T4C8_JANMA D-isomer specific 2-hydroxyacid dehydrogen... 493 e-137 A4GAM2.1 A4GAM2_HERAR Putative Phosphoglycerate dehydrogenase EC... 489 e-136 B4E7V2.1 B4E7V2_BURCJ D-isomer specific 2-hydroxyacid dehydrogenase 440 e-121 B1K0K1.1 B1K0K1_BURCC D-isomer specific 2-hydroxyacid dehydrogen... 439 e-121 >D8IUQ0.1 D8IUQ0_HERSS D-3-phosphoglycerate dehydrogenase protein EC=1.1.1.95 Length = 328 Score = 506 bits (1302), Expect = e-141, Method: Compositional matrix adjust. Identities = 250/327 (76%), Positives = 280/327 (85%) Query: 1 MKIAILDDYQDSVRQLDCFKLLDGHDVKVFNNTVRGAGQLVARLAPFEALVLIRERTVFT 60 MKIAILDDYQD+VR LDCF+LLDGHDVKVFNNT+RG GQL ARL+PF+A+VLIRERT T Sbjct: 1 MKIAILDDYQDAVRHLDCFRLLDGHDVKVFNNTIRGVGQLAARLSPFDAVVLIRERTALT 60 Query: 61 KAILEKLPALKLISQTGKISGHVDVAAATAQRIGIVEGVGDPTAPAELTWALIMAAARRI 120 + +LEKLP LKL+SQTGK+SGHVDVAA T + I IVEGVGDPTAPAELTWALIMAA RR+ Sbjct: 61 RPLLEKLPLLKLVSQTGKVSGHVDVAACTERGIAIVEGVGDPTAPAELTWALIMAAMRRV 120 Query: 121 PQYTANLKAGIWQQVSAAPERNAIGVALKGRTLGIWGYGKIGRMVAGYGKAFGMKIVVWG 180 PQY + L+AG WQQVS P N IG ALKGRTLGIWGYGKIGR+VAGYG+AFGM+++VWG Sbjct: 121 PQYCSALRAGAWQQVSPTPHHNLIGTALKGRTLGIWGYGKIGRLVAGYGRAFGMQVLVWG 180 Query: 181 RDASLEQAQKDGYTAAASKEEFFSTTDFISVHLRLNDATRGIVTAQDLALMKPTATFINT 240 RD+S EQA KDGY AAASKEEFF+ D +S+HLRLNDATRGIV A DLA MK TA F+NT Sbjct: 181 RDSSREQAIKDGYQAAASKEEFFAQADVLSLHLRLNDATRGIVKASDLARMKATACFVNT 240 Query: 241 SRAELVASGALETALQQGRPGFAGIDVFETEPLPHDSPLLRMDNVVATPHLGYVEKDGYE 300 SRAELV ALE AL GRPG A +DV+E EPLP +S LL+MDNVVA PHLGYVEKDGYE Sbjct: 241 SRAELVEPDALEAALIAGRPGLAALDVYEREPLPVESALLQMDNVVAAPHLGYVEKDGYE 300 Query: 301 LYFRAAFQNIVDFANGAPKNVLNPEAL 327 LYFRAAFQNIV +A GAP +VLNPEAL Sbjct: 301 LYFRAAFQNIVAYAAGAPTHVLNPEAL 327 >A6T4C8.1 A6T4C8_JANMA D-isomer specific 2-hydroxyacid dehydrogenase EC=1.1.1.95 Length = 323 Score = 493 bits (1269), Expect = e-137, Method: Compositional matrix adjust. Identities = 231/322 (71%), Positives = 269/322 (83%) Query: 1 MKIAILDDYQDSVRQLDCFKLLDGHDVKVFNNTVRGAGQLVARLAPFEALVLIRERTVFT 60 MKIAILDDYQDSVR LDCF LL GH+VK+F N RG GQL RLA F+ALVLIRERTV + Sbjct: 1 MKIAILDDYQDSVRHLDCFSLLAGHEVKIFTNGARGVGQLAIRLASFDALVLIRERTVLS 60 Query: 61 KAILEKLPALKLISQTGKISGHVDVAAATAQRIGIVEGVGDPTAPAELTWALIMAAARRI 120 + +LEKLP LKLI+QTGK+SGH+D+ AA A+ I IVEGVGDPTAPAELTW LIMAA R++ Sbjct: 61 RQLLEKLPNLKLIAQTGKVSGHIDLPAAAARGITIVEGVGDPTAPAELTWTLIMAAMRKL 120 Query: 121 PQYTANLKAGIWQQVSAAPERNAIGVALKGRTLGIWGYGKIGRMVAGYGKAFGMKIVVWG 180 PQY NLK G+WQ S +P RN +G ALKGRTL IWGYG+IG+M+A YGKAFGM ++VWG Sbjct: 121 PQYVNNLKDGLWQIASMSPARNTLGTALKGRTLAIWGYGRIGQMIAAYGKAFGMDVMVWG 180 Query: 181 RDASLEQAQKDGYTAAASKEEFFSTTDFISVHLRLNDATRGIVTAQDLALMKPTATFINT 240 R AS E A +DGY AA+S++ FFS D +++HLRLNDATRGIVTA DLA MKP A F+NT Sbjct: 181 RPASCEAAVRDGYRAASSQQAFFSEADVLTLHLRLNDATRGIVTADDLARMKPQALFVNT 240 Query: 241 SRAELVASGALETALQQGRPGFAGIDVFETEPLPHDSPLLRMDNVVATPHLGYVEKDGYE 300 SRAELVA+ AL+ AL+QGRPG+A +DVFE EPLP SPLLRM+NV+A+PHLGYVEKD YE Sbjct: 241 SRAELVATDALQAALEQGRPGYAALDVFENEPLPPGSPLLRMENVLASPHLGYVEKDSYE 300 Query: 301 LYFRAAFQNIVDFANGAPKNVL 322 LYF +AFQNIVDFANG PKNVL Sbjct: 301 LYFGSAFQNIVDFANGTPKNVL 322 >A4GAM2.1 A4GAM2_HERAR Putative Phosphoglycerate dehydrogenase EC=1.1.1.95 Length = 327 Score = 489 bits (1260), Expect = e-136, Method: Compositional matrix adjust. Identities = 239/325 (73%), Positives = 277/325 (85%) Query: 1 MKIAILDDYQDSVRQLDCFKLLDGHDVKVFNNTVRGAGQLVARLAPFEALVLIRERTVFT 60 MKIAILDDYQD VRQLDCF LLDGH+VKVF N+ RG GQL RLA F+ALVLIRERT + Sbjct: 1 MKIAILDDYQDCVRQLDCFSLLDGHEVKVFTNSARGVGQLAIRLADFDALVLIRERTALS 60 Query: 61 KAILEKLPALKLISQTGKISGHVDVAAATAQRIGIVEGVGDPTAPAELTWALIMAAARRI 120 + +LEKLP LKLISQTGK+SGH+D++AA A+ I IVEGVGDPTAPAELTWALIMAA R++ Sbjct: 61 RPLLEKLPKLKLISQTGKVSGHIDLSAAAARNITIVEGVGDPTAPAELTWALIMAAMRKL 120 Query: 121 PQYTANLKAGIWQQVSAAPERNAIGVALKGRTLGIWGYGKIGRMVAGYGKAFGMKIVVWG 180 PQY NLK G+WQ S + N +G LKGRTLGIWGYG+IGRMVAGYG+AFGMK++VWG Sbjct: 121 PQYVGNLKDGLWQIASLSSAHNTLGAVLKGRTLGIWGYGRIGRMVAGYGQAFGMKVLVWG 180 Query: 181 RDASLEQAQKDGYTAAASKEEFFSTTDFISVHLRLNDATRGIVTAQDLALMKPTATFINT 240 RDAS A +DGY AA+S+EEFFST D +S+HLRLNDATRGIVTA DLA MK +A F+NT Sbjct: 181 RDASRAAAVQDGYQAASSREEFFSTADVLSLHLRLNDATRGIVTASDLAHMKSSALFVNT 240 Query: 241 SRAELVASGALETALQQGRPGFAGIDVFETEPLPHDSPLLRMDNVVATPHLGYVEKDGYE 300 SRAELVAS AL+TAL+QGRPG+A +DVFE+EPL S LLRM+NV+A+PHLGYVEKD YE Sbjct: 241 SRAELVASDALQTALEQGRPGYAALDVFESEPLAPTSSLLRMENVLASPHLGYVEKDSYE 300 Query: 301 LYFRAAFQNIVDFANGAPKNVLNPE 325 LYFR+AF+NIV FANGAPKNVL P+ Sbjct: 301 LYFRSAFENIVAFANGAPKNVLLPK 325 >B4E7V2.1 B4E7V2_BURCJ D-isomer specific 2-hydroxyacid dehydrogenase Length = 337 Score = 440 bits (1131), Expect = e-121, Method: Compositional matrix adjust. Identities = 208/331 (62%), Positives = 253/331 (76%), Gaps = 4/331 (1%) Query: 1 MKIAILDDYQDSVRQLDCFKLLDGHDVKVFNNTVRGAGQLVARLAPFEALVLIRERTVFT 60 MKIAILDDYQD+VR+L+CF++L GHDVKVFNNTVRG GQL +RLA EALVLIRERT T Sbjct: 1 MKIAILDDYQDAVRKLNCFEMLAGHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIT 60 Query: 61 KAILEKLPALKLISQTGKISGHVDVAAATAQRIGIVEGVGDPTAPAELTWALIMAAARRI 120 +L KLP L++ISQTG++S H+D+ A T + I ++EG G P APAELTWAL+MAA RRI Sbjct: 61 SQLLSKLPNLRMISQTGRVSSHIDLDACTDRGIAVLEGTGSPVAPAELTWALVMAAQRRI 120 Query: 121 PQYTANLKAGIWQQ----VSAAPERNAIGVALKGRTLGIWGYGKIGRMVAGYGKAFGMKI 176 PQY ANLK G WQQ SA P +G L+G+TLGIWGYGKIGR+VAGYGKAFGM + Sbjct: 121 PQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV 180 Query: 177 VVWGRDASLEQAQKDGYTAAASKEEFFSTTDFISVHLRLNDATRGIVTAQDLALMKPTAT 236 +VWGR+ SLE A+ DGYTAA S+E F +D +S+HLRL+D TRGIV +DL MKPT+ Sbjct: 181 LVWGREHSLEAARADGYTAADSREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL 240 Query: 237 FINTSRAELVASGALETALQQGRPGFAGIDVFETEPLPHDSPLLRMDNVVATPHLGYVEK 296 +NTSRAEL+ AL AL RPG IDVFE+EP+ LLRM+NV+ TPH+GYVE+ Sbjct: 241 LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER 300 Query: 297 DGYELYFRAAFQNIVDFANGAPKNVLNPEAL 327 + YELYF AAF+NI+ F +G +V NPEAL Sbjct: 301 ESYELYFSAAFRNILAFDDGDMSSVANPEAL 331 >B1K0K1.1 B1K0K1_BURCC D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Length = 337 Score = 439 bits (1129), Expect = e-121, Method: Compositional matrix adjust. Identities = 207/331 (62%), Positives = 253/331 (76%), Gaps = 4/331 (1%) Query: 1 MKIAILDDYQDSVRQLDCFKLLDGHDVKVFNNTVRGAGQLVARLAPFEALVLIRERTVFT 60 MKIAILDDYQD+VR+L+CF++L GHDVKVFNNTVRG GQL +RLA EALVLIRERT T Sbjct: 1 MKIAILDDYQDAVRKLNCFEMLAGHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIT 60 Query: 61 KAILEKLPALKLISQTGKISGHVDVAAATAQRIGIVEGVGDPTAPAELTWALIMAAARRI 120 +L KLP L++ISQTG+IS H+D+ A T + + ++EG G P APAELTWAL+MAA RRI Sbjct: 61 SQLLAKLPNLRMISQTGRISSHIDLDACTDRGVAVLEGTGSPVAPAELTWALVMAAQRRI 120 Query: 121 PQYTANLKAGIWQQ----VSAAPERNAIGVALKGRTLGIWGYGKIGRMVAGYGKAFGMKI 176 PQY ANLK G WQQ SA P +G L+G+TLGIWGYGKIGR+VAGYGKAFGM + Sbjct: 121 PQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV 180 Query: 177 VVWGRDASLEQAQKDGYTAAASKEEFFSTTDFISVHLRLNDATRGIVTAQDLALMKPTAT 236 ++WGR+ SLE A+ DGYTAA S+E F +D +S+HLRL+D TRGIV +DL MKPT+ Sbjct: 181 LIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL 240 Query: 237 FINTSRAELVASGALETALQQGRPGFAGIDVFETEPLPHDSPLLRMDNVVATPHLGYVEK 296 +NTSRAEL+ AL AL RPG IDVFE+EP+ LLRM+NV+ TPH+GYVE+ Sbjct: 241 LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER 300 Query: 297 DGYELYFRAAFQNIVDFANGAPKNVLNPEAL 327 + YELYF AAF+NI+ F +G +V NPEAL Sbjct: 301 ESYELYFSAAFRNILAFDDGDMSSVANPEAL 331