BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0445.p (310 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8ISN3.1 D8ISN3_HERSS Pyruvate dehydrogenase E1 component EC=1.2... 572 e-161 A2SE47.1 A2SE47_METPP Pyruvate dehydrogenase E1 component EC=1.2... 421 e-116 F0Q420.1 F0Q420_ACIAP Alpha-ketoglutarate dehydrogenase EC=1.2.4.1 421 e-116 A1W6D5.1 A1W6D5_ACISJ Pyruvate dehydrogenase E1 component EC=1.2... 420 e-115 A9BZ36.1 A9BZ36_DELAS Pyruvate dehydrogenase E1 component EC=1.2... 420 e-115 >D8ISN3.1 D8ISN3_HERSS Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 893 Score = 572 bits (1474), Expect = e-161, Method: Compositional matrix adjust. Identities = 269/295 (91%), Positives = 285/295 (96%) Query: 5 SASGIAKDIDIDAQETQEWLQALQGVLQEVGPDRARFLLSRMSAAAQQWGINWRDARNTP 64 S S IA+DIDID+QETQEWLQALQ VL E GP+RARFLLSR+SAAAQQWG+NWRDARNTP Sbjct: 5 SDSDIARDIDIDSQETQEWLQALQSVLAEAGPERARFLLSRLSAAAQQWGVNWRDARNTP 64 Query: 65 YINTIRPEQEPPFPGGSDAQAIEEHLASVMRWNALAMVVRANRAYGELGGHIASYASAAD 124 Y+NTIRPEQEPPFPGGSDAQAIEE +AS+MRWNALAMVVRANRAYGELGGHIAS+ASAAD Sbjct: 65 YVNTIRPEQEPPFPGGSDAQAIEERIASIMRWNALAMVVRANRAYGELGGHIASFASAAD 124 Query: 125 LFEVGFNHFFRARDAQFAGDLVYFQPHSAPGIYARAFLEGALTEDDLGFYRREIEAKKHG 184 LFEVGFNHFFRARD QFAGD+VYFQPHSAPGIYARAFLEGAL+EDDL +YRREIEAK+ G Sbjct: 125 LFEVGFNHFFRARDEQFAGDVVYFQPHSAPGIYARAFLEGALSEDDLAYYRREIEAKRVG 184 Query: 185 KQGLSSYPHPWLMPNFWQFPTGSMGIGPINAIYQARFLRYLEHRGLLQDQGRKVWGVFGD 244 +QGLSSYPHPWLMP FWQFPTGSMGIGPINAIYQARFLRY+EHRGLLQDQGRKVWGVFGD Sbjct: 185 RQGLSSYPHPWLMPQFWQFPTGSMGIGPINAIYQARFLRYMEHRGLLQDQGRKVWGVFGD 244 Query: 245 GEMDEPESLAALSLASREKLDNLIFVVNCNLQRLDGPVRGNGHIVDELETIFAGA 299 GEMDEPESLAALSLASREKLDNLIFVVNCNLQRLDGPVRGNGHIVDELET+FAGA Sbjct: 245 GEMDEPESLAALSLASREKLDNLIFVVNCNLQRLDGPVRGNGHIVDELETLFAGA 299 >A2SE47.1 A2SE47_METPP Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 891 Score = 421 bits (1082), Expect = e-116, Method: Compositional matrix adjust. Identities = 207/287 (72%), Positives = 240/287 (83%), Gaps = 4/287 (1%) Query: 14 DIDAQETQEWLQALQGVLQEVGPDRARFLLSRMSAAAQQWGINWRD-ARNTPYINTIRPE 72 D D ET EW AL VL GP+RARFLL +++A A + I W+ +PY+NTI E Sbjct: 16 DTDPAETAEWRDALAAVLAAAGPERARFLLDQLAAQASEPAIAWQPRGGGSPYVNTIPVE 75 Query: 73 QEPPFPGGSDAQAIEEHLASVMRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNH 132 ++P FPG AIEE LAS+MRWNALAMVVRAN+AYGELGGHIASYASAADLFEVGFNH Sbjct: 76 RQPRFPGD---LAIEERLASLMRWNALAMVVRANQAYGELGGHIASYASAADLFEVGFNH 132 Query: 133 FFRARDAQFAGDLVYFQPHSAPGIYARAFLEGALTEDDLGFYRREIEAKKHGKQGLSSYP 192 FFRAR+AQ GDLV++QPHSAPG+YARAFLEG L+E DL YR+E+ A G QGLSSYP Sbjct: 133 FFRARNAQQGGDLVFYQPHSAPGVYARAFLEGRLSEADLAHYRQELAAPAAGAQGLSSYP 192 Query: 193 HPWLMPNFWQFPTGSMGIGPINAIYQARFLRYLEHRGLLQDQGRKVWGVFGDGEMDEPES 252 HPWLMP FWQFPTGSMGIGPI++IYQARF+RYL+HRGLLQ +GR+VWGVFGDGEMDEPES Sbjct: 193 HPWLMPEFWQFPTGSMGIGPISSIYQARFMRYLQHRGLLQTEGRRVWGVFGDGEMDEPES 252 Query: 253 LAALSLASREKLDNLIFVVNCNLQRLDGPVRGNGHIVDELETIFAGA 299 ++AL+LA+REKLDNL +V+NCNLQRLDGPVRGNG I+DELE +FAGA Sbjct: 253 MSALTLAAREKLDNLTWVINCNLQRLDGPVRGNGRIIDELEALFAGA 299 >F0Q420.1 F0Q420_ACIAP Alpha-ketoglutarate dehydrogenase EC=1.2.4.1 Length = 902 Score = 421 bits (1081), Expect = e-116, Method: Compositional matrix adjust. Identities = 205/290 (70%), Positives = 234/290 (80%), Gaps = 7/290 (2%) Query: 14 DIDAQETQEWLQALQGVLQEVGPDRARFLLSRMSAAAQQWGINWRDARNTPYINTIRPEQ 73 D D QET EW A ++ GP+RARF+L ++A A++ W+ NTPY+NT+ E Sbjct: 25 DADPQETAEWRDAFLALVATQGPERARFVLDELAALARRQHTGWQPTLNTPYVNTVAVEA 84 Query: 74 EPPFPGGSDAQAIEEHLASVMRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHF 133 +P FPG AIEE LAS+MRWNALAMVVRAN+AYGELGGHIASYASAADLFE GFNHF Sbjct: 85 QPVFPGD---LAIEERLASLMRWNALAMVVRANQAYGELGGHIASYASAADLFEAGFNHF 141 Query: 134 FRARDA----QFAGDLVYFQPHSAPGIYARAFLEGALTEDDLGFYRREIEAKKHGKQGLS 189 FRAR+ Q GDLV+FQPHSAPG+YARAFLEG LTE DL YR+EI A G QGLS Sbjct: 142 FRAREGTGPGQHRGDLVFFQPHSAPGVYARAFLEGRLTEHDLQHYRQEITAPAAGAQGLS 201 Query: 190 SYPHPWLMPNFWQFPTGSMGIGPINAIYQARFLRYLEHRGLLQDQGRKVWGVFGDGEMDE 249 SYPHPWLMP+FWQFPTGSMGIGPI++IY ARF+RYL HR LL QGRKVWGVFGDGEMDE Sbjct: 202 SYPHPWLMPDFWQFPTGSMGIGPISSIYHARFMRYLTHRNLLDCQGRKVWGVFGDGEMDE 261 Query: 250 PESLAALSLASREKLDNLIFVVNCNLQRLDGPVRGNGHIVDELETIFAGA 299 PES++AL+LA+RE LDNL++VVNCNLQRLDGPVRGNG IVDELE +FAGA Sbjct: 262 PESMSALTLAAREGLDNLVWVVNCNLQRLDGPVRGNGRIVDELERLFAGA 311 >A1W6D5.1 A1W6D5_ACISJ Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 905 Score = 420 bits (1080), Expect = e-115, Method: Compositional matrix adjust. Identities = 202/290 (69%), Positives = 234/290 (80%), Gaps = 7/290 (2%) Query: 14 DIDAQETQEWLQALQGVLQEVGPDRARFLLSRMSAAAQQWGINWRDARNTPYINTIRPEQ 73 D D QET EW ALQ ++ GP+RARFLL ++ A Q ++WR NTPY+NT+ ++ Sbjct: 35 DTDPQETAEWRDALQALVATAGPERARFLLDELNRLAGQLRVDWRPGLNTPYVNTVSVQE 94 Query: 74 EPPFPGGSDAQAIEEHLASVMRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFNHF 133 + FPG AIEE LAS+MRWNALAMVVRAN+AYGELGGHIASYASAADLFE GFNHF Sbjct: 95 QGVFPGD---LAIEERLASIMRWNALAMVVRANQAYGELGGHIASYASAADLFESGFNHF 151 Query: 134 FRARDA----QFAGDLVYFQPHSAPGIYARAFLEGALTEDDLGFYRREIEAKKHGKQGLS 189 FRAR+ Q GDLV+FQPHSAPG+YARAFLEG L+E DL YR+EI A G +GLS Sbjct: 152 FRAREGLGEGQHRGDLVFFQPHSAPGVYARAFLEGRLSEQDLMHYRQEITAPAQGARGLS 211 Query: 190 SYPHPWLMPNFWQFPTGSMGIGPINAIYQARFLRYLEHRGLLQDQGRKVWGVFGDGEMDE 249 SYPHPWLMP+FWQFPTGSMGIGPI++IY ARF+RYL HR LL RKVWGVFGDGEMDE Sbjct: 212 SYPHPWLMPDFWQFPTGSMGIGPISSIYHARFMRYLTHRNLLDCSARKVWGVFGDGEMDE 271 Query: 250 PESLAALSLASREKLDNLIFVVNCNLQRLDGPVRGNGHIVDELETIFAGA 299 PES++AL+LA+RE LDNL++VVNCNLQRLDGPVRGNG I+DELE +FAGA Sbjct: 272 PESMSALTLAAREGLDNLVWVVNCNLQRLDGPVRGNGRIIDELERLFAGA 321 >A9BZ36.1 A9BZ36_DELAS Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 902 Score = 420 bits (1079), Expect = e-115, Method: Compositional matrix adjust. Identities = 203/292 (69%), Positives = 236/292 (80%), Gaps = 7/292 (2%) Query: 12 DIDIDAQETQEWLQALQGVLQEVGPDRARFLLSRMSAAAQQWGINWRDARNTPYINTIRP 71 DID D QET EW +A ++ GP RARF+L+ ++ A++ + W+ NTPY+N++ Sbjct: 38 DIDTDPQETAEWREAFLALVATEGPQRARFVLAELARMAREQRLGWQPDLNTPYVNSVAA 97 Query: 72 EQEPPFPGGSDAQAIEEHLASVMRWNALAMVVRANRAYGELGGHIASYASAADLFEVGFN 131 +Q+P FPG AIEE LAS+MRWNALAMVVRAN+AYGELGGHIASYASAADLFE GFN Sbjct: 98 QQQPVFPGD---LAIEERLASIMRWNALAMVVRANQAYGELGGHIASYASAADLFETGFN 154 Query: 132 HFFRARDA----QFAGDLVYFQPHSAPGIYARAFLEGALTEDDLGFYRREIEAKKHGKQG 187 HFF AR+ Q GDLV+FQPHSAPG+YARAFLEG LTE DL YR+EI A G QG Sbjct: 155 HFFHAREGLEPGQHRGDLVFFQPHSAPGVYARAFLEGRLTEQDLQHYRQEISAPAAGAQG 214 Query: 188 LSSYPHPWLMPNFWQFPTGSMGIGPINAIYQARFLRYLEHRGLLQDQGRKVWGVFGDGEM 247 LSSYPHPWLMP+FWQFPTGSMGIGPI++IY ARF+RYL HR LL Q RKVWGVFGDGEM Sbjct: 215 LSSYPHPWLMPDFWQFPTGSMGIGPISSIYHARFMRYLTHRRLLDCQERKVWGVFGDGEM 274 Query: 248 DEPESLAALSLASREKLDNLIFVVNCNLQRLDGPVRGNGHIVDELETIFAGA 299 DEPES++AL+LA+RE LDNL++VVNCNLQRLDGPVRGNG IVDELE +FAGA Sbjct: 275 DEPESMSALTLAAREGLDNLVWVVNCNLQRLDGPVRGNGRIVDELERLFAGA 326