BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0444.p (525 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8ISN3.1 D8ISN3_HERSS Pyruvate dehydrogenase E1 component EC=1.2... 830 0.0 E3HUL3.1 E3HUL3_ACHXA Pyruvate dehydrogenase E1 component EC=1.2... 711 0.0 D4X9E0.1 D4X9E0_9BURK Pyruvate dehydrogenase E1 component EC=1.2... 702 0.0 A9IIU2.1 A9IIU2_BORPD Pyruvate dehydrogenase E1 component EC=1.2... 701 0.0 Q7WDA6.1 Q7WDA6_BORBR Pyruvate dehydrogenase E1 component EC=1.2... 692 0.0 >D8ISN3.1 D8ISN3_HERSS Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 893 Score = 830 bits (2143), Expect = 0.0, Method: Compositional matrix adjust. Identities = 410/525 (78%), Positives = 461/525 (87%), Gaps = 11/525 (2%) Query: 1 MKKIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFK 60 MKKI++AY AAA HRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEE L+ FR+RFK Sbjct: 380 MKKIYSAYQAAARHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEESLLQFRDRFK 439 Query: 61 LPISDEQCKSLAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETHAR 120 LP+SDEQC++LAFYKPA DS EMKHL ARRA+L G +PRR A +A+ VPP+ H++ Sbjct: 440 LPLSDEQCRALAFYKPADDSPEMKHLHARRAALSGYLPRRQAG---QARRAVPPLAAHSK 496 Query: 121 FALDAEGKEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQG 180 FAL+A+GKEMSSTMALVR LG++LKD D G+YVVPIVADEARTFGMANLFRQVGIYSSQG Sbjct: 497 FALEADGKEMSSTMALVRQLGNLLKDKDFGQYVVPIVADEARTFGMANLFRQVGIYSSQG 556 Query: 181 QLYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSMF 240 QLYEPEDIGSIL YREAKDGQILEEGITEAGAISSWTAAAT+YSVHG PMLPFYIYYSMF Sbjct: 557 QLYEPEDIGSILYYREAKDGQILEEGITEAGAISSWTAAATAYSVHGTPMLPFYIYYSMF 616 Query: 241 GFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPAY 300 GFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDG+S VTAA IPNCVSYDPAY Sbjct: 617 GFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGNSLVTAASIPNCVSYDPAY 676 Query: 301 AYEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMYCLAPQAD 360 AYE+AVI+D+GMRRM+ER +DVFYY+TVTNENE QPSLP+G V+DGILRG+YCLA + Sbjct: 677 AYELAVILDEGMRRMMERGDDVFYYITVTNENEAQPSLPEG--VQDGILRGLYCLARKPQ 734 Query: 361 AQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARLQPGAKG 420 AQ RLL +GP+LKEA++AA +LQ+ + + AEVWSVTS+TELARDG+AA+R RL Sbjct: 735 AQARLLGSGPILKEAVAAAALLQQHWQIEAEVWSVTSYTELARDGVAAQRAQRL--AGSA 792 Query: 421 ALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFGRSDTRANLR 480 ALPYV TQQLQ PVIAVSDY+RTL ESIRA+VPA YVTLGTDGFGRSDTR NLR Sbjct: 793 ALPYV----TQQLQGSAVPVIAVSDYIRTLPESIRAFVPAPYVTLGTDGFGRSDTRVNLR 848 Query: 481 DFFEVDARWIAYTALAEVFGADAARLKDAAAKLGVDLDKPLSTSV 525 DFFE+DARWIAYTAL EV+G D ARL++AA LG+D KPLS++V Sbjct: 849 DFFEIDARWIAYTALCEVWGDDRARLQEAARTLGIDTAKPLSSTV 893 >E3HUL3.1 E3HUL3_ACHXA Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 903 Score = 711 bits (1836), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/496 (71%), Positives = 402/496 (81%), Gaps = 10/496 (2%) Query: 1 MKKIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFK 60 M KIHAAYH AASHRGQPTVILAQTKKG+GMG+AG+GKMTTHQQKKLD+E L+AFR+RF Sbjct: 389 MVKIHAAYHRAASHRGQPTVILAQTKKGFGMGSAGQGKMTTHQQKKLDDEALLAFRDRFA 448 Query: 61 LPISDEQCKSLAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETHAR 120 LPISD C +L FY+PA DSAE++HL ARRA+LGG +PRR A +L P E AR Sbjct: 449 LPISDADCLALKFYRPAEDSAELRHLQARRAALGGHIPRRNTEA---PRLAPPDAEHWAR 505 Query: 121 FALDAEGKEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQG 180 FAL A+GKEMSSTMA+VRML ++LKDA +G +VPIVADEARTFGMANLFRQ+GIYS+QG Sbjct: 506 FALAADGKEMSSTMAIVRMLTALLKDAAVGPRIVPIVADEARTFGMANLFRQIGIYSAQG 565 Query: 181 QLYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSMF 240 QLYEPEDIGS+L YREA+DGQILEEGITEAGAISSWTAA TSYSV+GLPMLPFYIYYSMF Sbjct: 566 QLYEPEDIGSVLYYREARDGQILEEGITEAGAISSWTAAGTSYSVNGLPMLPFYIYYSMF 625 Query: 241 GFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPAY 300 GFQRIGDLIWAAADQR RGFLIGATSGRTTLGGEGLQHQDGSSH+ AA +PNC +YDPAY Sbjct: 626 GFQRIGDLIWAAADQRTRGFLIGATSGRTTLGGEGLQHQDGSSHIIAATVPNCRAYDPAY 685 Query: 301 AYEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMYCLAP-QA 359 A+E+AVIV+ GMRRML+ D FYY+TVTNEN QP +P G DV++GILRGMY L P +A Sbjct: 686 AFEVAVIVEHGMRRMLDEQRDEFYYLTVTNENLAQPDMPAGEDVREGILRGMYRLRPARA 745 Query: 360 DAQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARLQPGAK 419 AQVRLL AGPML+EA AA LQ +GV AEVWSVTS++ELAR G AER L Sbjct: 746 QAQVRLLGAGPMLREAELAAERLQADYGVDAEVWSVTSYSELARAGREAERARAL----- 800 Query: 420 GALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFGRSDTRANL 479 LP + L + APV+A SDYVR + E IRA+ PA Y TLGTDGFGRSDTRA L Sbjct: 801 -GLPASVDWVRTCLGASNAPVVAASDYVRAVPEQIRAWAPAPYRTLGTDGFGRSDTRAQL 859 Query: 480 RDFFEVDARWIAYTAL 495 RDFFEV A WI AL Sbjct: 860 RDFFEVSADWIVLHAL 875 >D4X9E0.1 D4X9E0_9BURK Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 895 Score = 702 bits (1813), Expect = 0.0, Method: Compositional matrix adjust. Identities = 358/515 (69%), Positives = 408/515 (79%), Gaps = 11/515 (2%) Query: 1 MKKIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFK 60 M KIHAAYH AA H GQPTVILAQTKKG+GMGAAG+GKMTTHQQKKLD+E L+AFR+RF Sbjct: 379 MVKIHAAYHRAARHTGQPTVILAQTKKGFGMGAAGQGKMTTHQQKKLDDEALLAFRDRFA 438 Query: 61 LPISDEQCKSLAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETHAR 120 LPISD C +L FY+PA DSAE++HL ARR +LGG +PRR A +L P +E AR Sbjct: 439 LPISDADCLALKFYRPAPDSAELRHLQARREALGGHIPRRRTEA---PRLAAPAVEQWAR 495 Query: 121 FALDAEGKEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQG 180 FAL A+GKEMSSTMA+VRML ++LKD ++G +VPIVADEARTFGMANLFRQ+GIYS+QG Sbjct: 496 FALAADGKEMSSTMAIVRMLTALLKDGEVGSRIVPIVADEARTFGMANLFRQIGIYSAQG 555 Query: 181 QLYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSMF 240 QLYEPEDIGS+L YREA+DGQILEEGITEAGAISSWTAA TSYSV+GLPMLPFYIYYSMF Sbjct: 556 QLYEPEDIGSVLYYREARDGQILEEGITEAGAISSWTAAGTSYSVNGLPMLPFYIYYSMF 615 Query: 241 GFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPAY 300 GFQRIGDLIWAAADQR RGFLIGATSGRTTLGGEGLQHQDGSSH+ AA +PNC +YDPAY Sbjct: 616 GFQRIGDLIWAAADQRTRGFLIGATSGRTTLGGEGLQHQDGSSHIMAAAVPNCRAYDPAY 675 Query: 301 AYEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMYCLAP-QA 359 AYE+AVIV+ GM RML+ D F+Y+TVTNEN QP +P V++GILRG+Y L P + Sbjct: 676 AYEVAVIVEHGMHRMLDEQRDEFFYLTVTNENLAQPDMPADPGVREGILRGLYRLRPARK 735 Query: 360 DAQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARLQPGAK 419 +AQVRLL AGPML+EA AA L +GV AEVWSVTSF+ELARDG AER L Sbjct: 736 EAQVRLLGAGPMLREAEVAAERLHADYGVDAEVWSVTSFSELARDGRQAERARVLGLDTA 795 Query: 420 GALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFGRSDTRANL 479 G +V L + APVIA +DYVR + E IRA+VPA Y TLGTDGFGRSDTRA L Sbjct: 796 GQADWVRTCLG----ASDAPVIAATDYVRAVPEQIRAWVPASYRTLGTDGFGRSDTRAQL 851 Query: 480 RDFFEVDARWI---AYTALAEVFGADAARLKDAAA 511 RDFFEV A WI A +L + ADA RL+ AA Sbjct: 852 RDFFEVSADWIVLYALDSLGKREAADALRLRLNAA 886 >A9IIU2.1 A9IIU2_BORPD Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 897 Score = 701 bits (1808), Expect = 0.0, Method: Compositional matrix adjust. Identities = 360/495 (72%), Positives = 401/495 (81%), Gaps = 15/495 (3%) Query: 3 KIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFKLP 62 KIHAAYH A HRGQPTVILAQTKKGYGMGAAG+GKMTTHQQKKLD+E L+AFR+RF LP Sbjct: 383 KIHAAYHRAVRHRGQPTVILAQTKKGYGMGAAGQGKMTTHQQKKLDDETLLAFRDRFALP 442 Query: 63 ISDEQCKSLAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETHARFA 122 ISD C +L FYKPAADSAE+++L ARR +LGG +PRR A +L VPP ARFA Sbjct: 443 ISDADCLALKFYKPAADSAELRYLQARRQALGGHLPRRRTEA---PRLPVPPAAQWARFA 499 Query: 123 LDAEGKEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQGQL 182 L A+GKEMSSTMA+VRMLG +LKD LGR +VPIVADEARTFGMANLFRQ+GIYS+QGQL Sbjct: 500 LQADGKEMSSTMAIVRMLGGLLKDEALGRRIVPIVADEARTFGMANLFRQIGIYSAQGQL 559 Query: 183 YEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSMFGF 242 YEPEDIGS+L YREA DGQILEEGITEAGAISSWTAA TSYSV+GLPMLPFYIYYSMFGF Sbjct: 560 YEPEDIGSVLYYREALDGQILEEGITEAGAISSWTAAGTSYSVNGLPMLPFYIYYSMFGF 619 Query: 243 QRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPAYAY 302 QRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSH+ AA +PNC +YDPAYAY Sbjct: 620 QRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHLVAATVPNCRAYDPAYAY 679 Query: 303 EMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMY--CLAPQAD 360 E+AVI++ GM+RML+ D FYY+TVTNEN QP+LP D + GILRGM+ +AP Sbjct: 680 EVAVILEHGMQRMLDEQHDEFYYLTVTNENLPQPTLPT-EDARTGILRGMHRVRVAP-GS 737 Query: 361 AQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARLQPGAKG 420 AQVRLL AGPML EAL AA +LQE GV AEVWSVTSF+EL+RDG A ER L G Sbjct: 738 AQVRLLGAGPMLSEALRAADLLQEH-GVAAEVWSVTSFSELSRDGRACERARTL--GLDT 794 Query: 421 ALPYVTQQLTQQLQSGQAPVIAVSDYVRTLSESIRAYVPARYVTLGTDGFGRSDTRANLR 480 +V Q L G APV+A SDYVR + E IRA++ A Y T+GTDGFGRSDTRA LR Sbjct: 795 PPAWVEQCL-----PGDAPVVAASDYVRAVPEQIRAWIAAPYRTVGTDGFGRSDTRARLR 849 Query: 481 DFFEVDARWIAYTAL 495 DFFEV A WIA AL Sbjct: 850 DFFEVGADWIALQAL 864 >Q7WDA6.1 Q7WDA6_BORBR Pyruvate dehydrogenase E1 component EC=1.2.4.1 Length = 898 Score = 692 bits (1785), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/497 (70%), Positives = 397/497 (79%), Gaps = 11/497 (2%) Query: 1 MKKIHAAYHAAASHRGQPTVILAQTKKGYGMGAAGEGKMTTHQQKKLDEEVLIAFRNRFK 60 M KIHAAYH A HRGQPTVILAQTKKG+GMG AG+GKMTTHQQKKLD+E L+AFR+RF Sbjct: 378 MVKIHAAYHRATHHRGQPTVILAQTKKGFGMGTAGQGKMTTHQQKKLDDEALLAFRDRFA 437 Query: 61 LPISDEQCKSLAFYKPAADSAEMKHLLARRASLGGRMPRRVANADDKAQLRVPPIETHAR 120 LPISD C +L FYKPA DSAE+++L +RRA+LGG +PRR A +L PP+ AR Sbjct: 438 LPISDADCLALKFYKPAEDSAELRYLESRRAALGGYLPRRRTEA---PRLAPPPVADWAR 494 Query: 121 FALDAEGKEMSSTMALVRMLGSMLKDADLGRYVVPIVADEARTFGMANLFRQVGIYSSQG 180 FAL A GKEMSSTMA+VRML ++LKD LG +VPIVADEARTFGMANLFRQVGIYS+QG Sbjct: 495 FALQAAGKEMSSTMAIVRMLTALLKDPQLGPRIVPIVADEARTFGMANLFRQVGIYSAQG 554 Query: 181 QLYEPEDIGSILSYREAKDGQILEEGITEAGAISSWTAAATSYSVHGLPMLPFYIYYSMF 240 QLYEPEDIGS+L+YREA+DGQILEEGITEAGAISSWTAA TSYSV+GLPMLPFYIYYSMF Sbjct: 555 QLYEPEDIGSVLAYREARDGQILEEGITEAGAISSWTAAGTSYSVNGLPMLPFYIYYSMF 614 Query: 241 GFQRIGDLIWAAADQRARGFLIGATSGRTTLGGEGLQHQDGSSHVTAAGIPNCVSYDPAY 300 GFQRIGDLIWAAADQR RGFLIGATSGRTTLGGEGLQHQDG SH+ AA +PNC +YDPAY Sbjct: 615 GFQRIGDLIWAAADQRTRGFLIGATSGRTTLGGEGLQHQDGYSHLAAAAVPNCRAYDPAY 674 Query: 301 AYEMAVIVDDGMRRMLERNEDVFYYVTVTNENEEQPSLPQGRDVKDGILRGMYCL-APQA 359 AYE+AV+V+ GM+RML+ D FYY+TVTNEN QP +P+G + + GILRGM+ + A A Sbjct: 675 AYEVAVLVEHGMQRMLDEQCDEFYYLTVTNENLAQPDMPEGEETRTGILRGMHRVRAADA 734 Query: 360 DAQVRLLAAGPMLKEALSAARMLQEQFGVTAEVWSVTSFTELARDGIAAERRARLQPGAK 419 QVRLL AGPML EA+ AA++L+++ GV AEVWSVTSF+ELAR G AER L Sbjct: 735 TPQVRLLGAGPMLDEAMRAAQLLRDEHGVDAEVWSVTSFSELARGGRGAERAQAL----- 789 Query: 420 GALPYVTQQLTQQLQSGQA-PVIAVSDYVRTLSESIRAYVPARYVTLGTDGFGRSDTRAN 478 LP Q QA PV+AVSDYVR + E IRA+VP Y LGTDGFGRSDTRA Sbjct: 790 -GLPCPDGNWLAQCLGDQATPVVAVSDYVRAVPEQIRAWVPGPYRVLGTDGFGRSDTRAR 848 Query: 479 LRDFFEVDARWIAYTAL 495 LRDFFEV A WI AL Sbjct: 849 LRDFFEVGAPWIVLHAL 865