BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0386.p (557 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value C5CLH5.1 C5CLH5_VARPS Diguanylate cyclase with PAS/PAC sensor 252 1e-64 C5CZH7.1 C5CZH7_VARPS Diguanylate cyclase 237 3e-60 A4G5V3.1 A4G5V3_HERAR Putative uncharacterized protein 227 3e-57 C5CVG4.1 C5CVG4_VARPS Diguanylate cyclase with PAS/PAC sensor 224 2e-56 E6UV76.1 E6UV76_VARPD Diguanylate cyclase with PAS/PAC sensor 216 1e-53 >C5CLH5.1 C5CLH5_VARPS Diguanylate cyclase with PAS/PAC sensor Length = 801 Score = 252 bits (643), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 132/360 (36%), Positives = 220/360 (61%) Query: 8 KWTLKAKVIMVVVAAVLVTTAVIVAVSLTIMQRDIKTLIGAQQYTTIKMIATALDESFNT 67 + +L+A++ V+A V +TT + A +L ++R ++ I ++++ I IA A+D+ F + Sbjct: 10 RLSLRARLSAGVLAIVFLTTMGVTAAALYFLKRSMEAAIASEEFERISAIAGAVDQKFLS 69 Query: 68 RRVALRSLSQGLPPEGRHDAHQLQVYLASHTSLTEMFFNLSVFDSNGQLVANFNDTSAIG 127 RR L++ G+ +LQ + H +L E F N+++ +G+LVAN N T IG Sbjct: 70 RRTLLKTFGDGVESRNLAGPGELQELVMQHGALREAFDNVALTGMDGELVANLNGTQPIG 129 Query: 128 RFNVADREYMRRTLELKHGVISEPLRSQISKRAIVLMTEPVFDDSGNIAMVFVASIDLQQ 187 + N+ DREY +RT+ + GVIS+P R+++S A + MTEPV D SGN+A V A ++L++ Sbjct: 130 KVNIKDREYFQRTVAARAGVISKPFRNRVSGLAQIAMTEPVLDRSGNVAYVISAFVNLKE 189 Query: 188 ANFLGQFTNTRIGRTGFIYIITSKGIIVDHVDKARILQHVDHVGGKSGGTEQALAGFEGS 247 NFLG+ N + G++G+++I + GI++DH DK+++LQ VD G ++ E+A+AGFEG+ Sbjct: 190 KNFLGELANVKFGKSGYMFITNADGIVIDHPDKSKLLQRVDAGGVRNPAIERAIAGFEGA 249 Query: 248 MEGLSRSNQPALFSFKRMKTVDWIIGSIYLREEAFVPVRDMQNKALLVSLSLAALAGWLA 307 +E L++FKR+ +W++G++Y R+EAF + ++ A +L L LAG LA Sbjct: 250 IEAADSQGVHGLYAFKRIGQTNWVLGAVYPRDEAFARIARVERYAWAGALLLTLLAGGLA 309 Query: 308 WLIMSRLIDPLLRLHGHIQKIRTSKTYDEVPLSYRDDEIGDLGSAFNSLMRERKDAEMDL 367 ++ + PL RL H+Q R + Y + + DDE+GDL F+ LM ER+ A L Sbjct: 310 FMTARAQLAPLSRLREHMQVSRAASAYAPMREAPPDDEVGDLSRTFDLLMTERQAANEKL 369 Score = 101 bits (251), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 70/177 (39%), Positives = 97/177 (54%), Gaps = 7/177 (3%) Query: 372 VNLESMNKALERLALEDDLTGLANRRQFDLSLQEEFSRAMRNGVSLALVMIDVDHFKQYN 431 L+ L+ LA ED LTGL NRR F+ ++ +R+ R G+ + L+ +D+D+FK N Sbjct: 608 TELKQKQMKLDALAREDALTGLPNRRSFEEHARDAMARSRRAGLPVCLLFLDIDYFKTIN 667 Query: 432 DIYGHLAGDQCLRKVGRVIKAQQTRPGDLMARYGGEEVGILLPGADEAG-AMAVAERIRL 490 D GH AGD LR+ GR ++ + R D+ ARY G+E ILL GA A A VA ++ Sbjct: 668 DSLGHAAGDAVLREFGRRLR-ESVRETDMAARYAGDEFVILLEGASGAAEAQVVAGKVLA 726 Query: 491 AVRQLGLLHEGNDAGIVTISAGVSAFVPIRDIDAADKLMRAADKALYLAKAQGRDRI 547 A+R H T S GV+ V D D A +R AD ALY AK +G++R Sbjct: 727 AMRP--AFHLPGRTLQATTSIGVA--VSEDDEDFASLFVR-ADTALYAAKKEGKNRF 778 >C5CZH7.1 C5CZH7_VARPS Diguanylate cyclase Length = 512 Score = 237 bits (605), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 172/480 (35%), Positives = 250/480 (52%), Gaps = 70/480 (14%) Query: 86 DAHQLQVYLASHTSLTEMFFNLSVFDSNGQLVANFNDTSAIGRFNVADREYM--RRTLEL 143 D +L+ LA + L ++D +G +AN T N ADREY RT Sbjct: 83 DVARLRQLLALRVAELPQLDGLHIYDQDGNWIANSRPTRP-ENLNNADREYFAFHRTHAE 141 Query: 144 KHGVISEPLRSQISKRAIVLMTEPVFDDSGNIAMVFVASIDLQQANFLGQFTNT-RIGRT 202 + I P++S+ S R +V ++ + G+ A V +A+I +F +F ++ IG+ Sbjct: 142 RGPHIGIPVQSRTSGRLLVPVSRRINHADGSFAGVALATI---HVDFFSRFYDSLDIGQA 198 Query: 203 GFIYIITSKGIIV-------DHVDKARILQHVDHVGGKSGGTEQALAGFEGSMEGLSRSN 255 G + ++ G ++ D V + + + G A + + +G++R N Sbjct: 199 GAVALVLENGTMMTRRPYSPDMVGRNMLETQLFRSYAAHGPVGTAY--IKSAQDGVTRLN 256 Query: 256 QPALFSFKRMKTVDWIIGSIYLREEAFVPV-RD-MQNKALLVSLSLAALAGWLAWLIMSR 313 SF+R+ + + ++E RD + + +V LSL + G++ W Sbjct: 257 -----SFRRLDNYPLFVSAALSKDEILANWWRDTLWHSGGVVLLSL--IVGFIGW----- 304 Query: 314 LIDPLLRLHGHIQKIRTSKTYDEVPLSYRDDEIGDLGSAFNSLMRERKDAEMDLDQARVN 373 RL Q ++ R +AE L QAR Sbjct: 305 ------RLVRQFQ------------------------------LQTRTEAE--LRQARDA 326 Query: 374 LESMNKALERLALEDDLTGLANRRQFDLSLQEEFSRAMRNGVSLALVMIDVDHFKQYNDI 433 LE++NK L LA+ED LTGLANRRQFD++L E+SRA RN +LAL+M+DVD FKQYNDI Sbjct: 327 LETLNKTLNTLAMEDGLTGLANRRQFDVALDSEYSRAARNASTLALIMMDVDCFKQYNDI 386 Query: 434 YGHLAGDQCLRKVGRVI-KAQQTRPGDLMARYGGEEVGILLPGADEAGAMAVAERIRLAV 492 YGH AGD+CL+ +GR I + RPGDL ARYGGEE+ +LLP D AGA+ +AERIR AV Sbjct: 387 YGHAAGDECLQTIGRTIARVASRRPGDLAARYGGEELAVLLPNTDVAGAVMLAERIRSAV 446 Query: 493 RQLGLLHEGNDAGIVTISAGVSAFVPIRDIDAADK-LMRAADKALYLAKAQGRDRICSSS 551 R+L + H G G VT+SAGV A P I K L+R+ADKALY AK+ GR+R+C+S+ Sbjct: 447 RELKIEHAGTADGFVTLSAGVDALSPQAGIGGQPKELIRSADKALYAAKSGGRNRVCAST 506 >A4G5V3.1 A4G5V3_HERAR Putative uncharacterized protein Length = 519 Score = 227 bits (579), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 166/473 (35%), Positives = 237/473 (50%), Gaps = 86/473 (18%) Query: 103 MFFNLSVFDSNGQLVANFNDTSAIGRFNVADREYM--RRTLELKHGVISEPLRSQISKRA 160 + L V+D +GQ VAN +T N ADREY RT + P+RS+ + Sbjct: 109 LLHGLFVYDEHGQWVANSQETLRTD-LNNADREYFIFHRTHTDSGPHLGPPIRSRSTGDW 167 Query: 161 IVLMTEPVFDDSGNIAMVFVASIDLQQANFLGQFTNTRIGRTGFIYIITSKGIIVDHVDK 220 I+ ++ + GN A V +A+I++Q F + + IG+ G I + T Sbjct: 168 IITVSRRLEHADGNFAGVVLATINMQY--FSAYYKDFDIGKAGAIVLTTDS--------- 216 Query: 221 ARILQHVDHVGGKSGGTEQALAGFEGSMEGLSRSNQPALFSFKRMKTVDWIIGSIYL-RE 279 GT F+ ++ G SN P +KR + I + + R Sbjct: 217 ---------------GTLLVRRPFDEAVIGGDISNGPVYQFYKRQGSSGTAILTANIDRT 261 Query: 280 EAFVPVRDMQNKALLVSLSLAALAGWLAWLIMSRLIDPLLRLHGHIQKIRTSKTYDEVPL 339 E R + LL++++ ++ DEV Sbjct: 262 ERIYSYRHLDRYPLLIAVA---------------------------------QSTDEVLE 288 Query: 340 SYRDDEIGDLGSAFNSLM------------------RERKDAEMDLDQARVNLESMNKAL 381 S+R+ + AF S M RER A+ +L AR +LE N L Sbjct: 289 SWRN---STMRFAFFSAMVLLLLWLLGARLVHQITVRER--AQSELRTARDDLERSNGEL 343 Query: 382 ERLALEDDLTGLANRRQFDLSLQEEFSRAMRNGVSLALVMIDVDHFKQYNDIYGHLAGDQ 441 LAL D LTGLANRR+FD +L +EF+RAMRN SLAL+M+DVDHFK+YND YGH GD+ Sbjct: 344 AALALLDSLTGLANRRRFDAALDDEFARAMRNQTSLALIMLDVDHFKKYNDRYGHPQGDE 403 Query: 442 CLRKVGRVIKAQQTRPGDLMARYGGEEVGILLPGADEAGAMAVAERIRLAVRQLGLLHEG 501 CL+++ +++K R GDL+ARYGGEE ILLPG D AGA AVAER+RLA++ L + H Sbjct: 404 CLKEISKILKTATARTGDLVARYGGEEFVILLPGTDRAGAAAVAERVRLAIQALNMEHAE 463 Query: 502 NDAGIVTISAGVSAFVPIRDIDAADKLMRAADKALYLAKAQGRDRICSSSELS 554 GIVT S G++A +P R ++ +L+ AAD+ALY AK GR++ C S++ S Sbjct: 464 TPDGIVTASLGIAALIPQRQQNSPQQLVHAADQALYKAKEDGRNQSCISTQAS 516 >C5CVG4.1 C5CVG4_VARPS Diguanylate cyclase with PAS/PAC sensor Length = 1026 Score = 224 bits (572), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 120/377 (31%), Positives = 208/377 (55%) Query: 1 LNNLLRVKWTLKAKVIMVVVAAVLVTTAVIVAVSLTIMQRDIKTLIGAQQYTTIKMIATA 60 L L ++ +L ++ + + A VL T I V+L +++ +K IG++ + + IA Sbjct: 3 LPGLRNIRISLNTRLGLGIAAVVLAATLAIATVALQLVKTSMKASIGSEAFARLSAIANT 62 Query: 61 LDESFNTRRVALRSLSQGLPPEGRHDAHQLQVYLASHTSLTEMFFNLSVFDSNGQLVANF 120 +D+ F +RR L + + D LQ +L H SL + F N++ F + G LVA+ Sbjct: 63 IDQKFVSRRTLLETFADSTALNEFPDTPALQAFLEKHPSLRKAFSNVAFFTAEGDLVASL 122 Query: 121 NDTSAIGRFNVADREYMRRTLELKHGVISEPLRSQISKRAIVLMTEPVFDDSGNIAMVFV 180 + G+ N+ DR Y ++TL + GVISEP ++++ A + MTEPV D +GN+ V Sbjct: 123 SGAQQPGKVNIKDRAYFQQTLAARAGVISEPYLNRLTGLAQIAMTEPVLDAAGNVRYVIS 182 Query: 181 ASIDLQQANFLGQFTNTRIGRTGFIYIITSKGIIVDHVDKARILQHVDHVGGKSGGTEQA 240 +I+L+ N LG+ + + G TG+++I +++G+++DH RI+ G + E+ Sbjct: 183 GAINLKDRNILGELADLKFGETGYLFITSTEGVVIDHPRTERIINQTGLKGVGNPEIERP 242 Query: 241 LAGFEGSMEGLSRSNQPALFSFKRMKTVDWIIGSIYLREEAFVPVRDMQNKALLVSLSLA 300 + G+EG+ EG + + L++FKR+ +W++GS+Y EAF V ++ A + ++ LA Sbjct: 243 IDGYEGATEGFNHAGVHGLYAFKRIPQTNWVLGSMYPSTEAFARVDAIERSAWIGTVVLA 302 Query: 301 ALAGWLAWLIMSRLIDPLLRLHGHIQKIRTSKTYDEVPLSYRDDEIGDLGSAFNSLMRER 360 LAG + + + PL LH H+ + VP +YR DEIGDL F++LM++R Sbjct: 303 MLAGAAVLGFVRQQLTPLRHLHRHMLDVDNPALQTAVPRTYRHDEIGDLARTFDTLMQQR 362 Query: 361 KDAEMDLDQARVNLESM 377 K +E L NL ++ Sbjct: 363 KSSEKFLRDITDNLPAL 379 Score = 68.2 bits (165), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 62/173 (35%), Positives = 90/173 (52%), Gaps = 3/173 (1%) Query: 374 LESMNKALERLALEDDLTGLANRRQFDLSLQEEFSRAMRNGVSLALVMIDVDHFKQYNDI 433 L+++ + L LA D LTGLANR F+ L +RA R+G +LA++ +D+D+FK ND Sbjct: 850 LKAVERKLIDLARIDTLTGLANRLAFNEFLPGAIARAQRSGNALAVLFLDIDYFKTINDT 909 Query: 434 YGHLAGDQCLRKVGRVIKAQQTRPGDLMARYGGEEVGILLPGAD-EAGAMAVAERIRLAV 492 GH GD L + + + A R D +AR G+E ++L A+AVA +I V Sbjct: 910 LGHATGDGVLVEYAQRLLA-SVRSTDTVARLAGDEFVVVLENVHTREAAVAVARKIVERV 968 Query: 493 RQLGLLHEGNDAGIVTISAGVSAFVPIRDIDAADKLMRAADKALYLAKAQGRD 545 + +G VT S G++ A L+ AD ALY AKA GR+ Sbjct: 969 GTVPFELDGRSLN-VTTSIGIAFHQAADASAGAADLLARADAALYRAKAAGRN 1020 >E6UV76.1 E6UV76_VARPD Diguanylate cyclase with PAS/PAC sensor Length = 1013 Score = 216 bits (549), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 127/359 (35%), Positives = 204/359 (56%) Query: 19 VVAAVLVTTAVIVAVSLTIMQRDIKTLIGAQQYTTIKMIATALDESFNTRRVALRSLSQG 78 V A VL T + V+L ++ ++ I +++ + +A A+D+ F +RR L++ Sbjct: 5 VAAVVLAATFAVATVALQFVKTSMRESIAQEEFARVSALADAVDQKFISRRTLLKTFGDS 64 Query: 79 LPPEGRHDAHQLQVYLASHTSLTEMFFNLSVFDSNGQLVANFNDTSAIGRFNVADREYMR 138 + DA LQ +L H SL E F N++ D +G LVAN ++ + R NV DR Y R Sbjct: 65 VEALALADAAPLQAFLERHASLREAFDNVAFIDMDGNLVANLSNAGQVRRINVKDRAYFR 124 Query: 139 RTLELKHGVISEPLRSQISKRAIVLMTEPVFDDSGNIAMVFVASIDLQQANFLGQFTNTR 198 T+ K GVISEP R++++ A V +TEPV D G + V SI+L++ N LG + R Sbjct: 125 DTVASKEGVISEPYRNRLNGLAQVAITEPVLDSEGRVQFVISGSINLKERNILGDLASVR 184 Query: 199 IGRTGFIYIITSKGIIVDHVDKARILQHVDHVGGKSGGTEQALAGFEGSMEGLSRSNQPA 258 G TG+++I T+ GI+VDH + R+L+ ++ E+A+ GFEG+ EG++R Sbjct: 185 FGETGYLFITTTNGIVVDHPREERVLEAASPQTARNPEIERAIRGFEGATEGVNREGVHG 244 Query: 259 LFSFKRMKTVDWIIGSIYLREEAFVPVRDMQNKALLVSLSLAALAGWLAWLIMSRLIDPL 318 L++F+R++ DWI+G++Y R+EAF V ++ A + LA LAG +A ++ + + PL Sbjct: 245 LYAFRRLRQADWIMGAMYPRDEAFAHVDAIERAAWAGAFVLALLAGAIALAVVRQQLKPL 304 Query: 319 LRLHGHIQKIRTSKTYDEVPLSYRDDEIGDLGSAFNSLMRERKDAEMDLDQARVNLESM 377 LH H+ + + + T Y +DEIGDL F+ L+R+R+ E L NL +M Sbjct: 305 TALHRHMLRAQAAPTEVTALRRYTNDEIGDLSRTFDRLIRQRQADEKFLRDITDNLPAM 363 Score = 78.6 bits (192), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/180 (32%), Positives = 91/180 (50%), Gaps = 13/180 (7%) Query: 374 LESMNKALERLALEDDLTGLANRRQFDLSLQEEFSRAMRNGVSLALVMIDVDHFKQYNDI 433 L+++ L LA D LTGL NR F+ L RA R G ++AL+ +D+D FK ND Sbjct: 837 LKAVESQLIELARLDTLTGLPNRLAFNELLPAALLRAQRTGSAMALMFLDIDAFKTINDT 896 Query: 434 YGHLAGDQCLRKVGRVIKAQQTRPGDLMARYGGEEVGIL---LPGADEAGAMAVAERIRL 490 GH +GD L + +++ R D++AR G+E ++ LP D A VA++I Sbjct: 897 LGHASGDSVLVEYANRLRS-SVRATDIVARLAGDEFVVVLENLPARD--AAAGVAQKILA 953 Query: 491 AVRQLGLLHEGNDAGIVT---ISAGVSAFVPIRDIDAADKLMRAADKALYLAKAQGRDRI 547 +R + + T I+ + P+ A++L+ AD ALY AK+ GR+R Sbjct: 954 QIRAPAFRLDSQPLQVTTSIGIAFRLGGDAPV----TAEELLAHADSALYAAKSAGRNRF 1009