BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0352.p (485 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value E6V5Q1.1 E6V5Q1_VARPD Phosphonoacetaldehyde dehydrogenase 752 0.0 Q0K2Z9.1 Q0K2Z9_CUPNH NAD-dependent aldehyde dehydrogenase EC=1.... 739 0.0 B3R8E5.1 B3R8E5_CUPTR NAD+ DEPENDENT ACETALDEHYDE DEHYDROGENASE ... 738 0.0 Q46NR4.1 Q46NR4_CUPPJ Aldehyde dehydrogenase 729 0.0 E8TX19.1 E8TX19_ALIDB Phosphonoacetaldehyde dehydrogenase 728 0.0 >E6V5Q1.1 E6V5Q1_VARPD Phosphonoacetaldehyde dehydrogenase Length = 482 Score = 752 bits (1941), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/477 (74%), Positives = 411/477 (86%) Query: 8 LKDGLPLHQKMRIGGKLVGSDRVIEVRNPYNGKLVGTIPKATVGDIRDAFRIGCQFKSSL 67 LK G + +RI G+ V DR IEV PY G+++ T+PKAT+ D+R+A RI +K +L Sbjct: 6 LKPGTIHREALRIAGERVHRDRTIEVTYPYTGEVIATVPKATLDDVRNALRIARDYKPTL 65 Query: 68 TRFERSKIMLRASELLRANTDAISDLITAESGLCKKDSLYEVGRACDVFVFAANQTLVDD 127 TR+ER KI++RA E++ + D +S +IT ESGLC+KDSLYEVGRA DV +FAANQ LVDD Sbjct: 66 TRYERYKILMRAGEIIASRLDEMSRVITMESGLCRKDSLYEVGRASDVLLFAANQALVDD 125 Query: 128 GQVFSCDLTPHGKQRKVYTMKEPLLGAISAITPFNHPLNQVAHKVAPSIATNNRMVLKPT 187 GQVFSCDLT HGK RKVYTM+EPLLGAI+AITPFNHPLNQV HKVAP+IATNNR+VLKP+ Sbjct: 126 GQVFSCDLTHHGKSRKVYTMREPLLGAITAITPFNHPLNQVIHKVAPAIATNNRIVLKPS 185 Query: 188 EKTPFSALLLADILYEAGLPPEMFSVVTGDPKEIADEMLTNADVDLVTFTGGVPIGKYIA 247 EKTP +A LLADILYEAGLPP+M SV+TGDPKEIADE+LTNADVDLVTFTGGVPIGKYIA Sbjct: 186 EKTPLTAFLLADILYEAGLPPQMLSVLTGDPKEIADELLTNADVDLVTFTGGVPIGKYIA 245 Query: 248 GKAVYKRQVLELGGNDPIIVMEDADIEEAATLAVSGSYKNSGQRCTAIKRMIVHQAVADE 307 GKAVYKRQ+LELGGNDPIIVMEDAD+EEAATLA +GSYKNSGQRCTA+KRM+VH++VAD+ Sbjct: 246 GKAVYKRQILELGGNDPIIVMEDADVEEAATLAANGSYKNSGQRCTAVKRMLVHESVADQ 305 Query: 308 FVDKLVAKTRAIKFGNPMDAGNDMGTVIDERAAMEFEAKVKDAERCGAKLLYGNVRDGAL 367 FV+ LVAKTRA+K+G+PMD DMGTVIDE AA +FEA V +A GAKL YGN R GAL Sbjct: 306 FVELLVAKTRALKYGDPMDPDTDMGTVIDEAAAKQFEAVVNEAIAAGAKLRYGNERRGAL 365 Query: 368 YSPTVLDHVPADCKLVAQETFGPVSPVIRCTDIADAIRISNSTPYGLSSSVCTNRMDYIT 427 YSPTVLDHV + + ETFGPVSPVIR +I +AIRISN T YGLSS+VCTNR+DYIT Sbjct: 366 YSPTVLDHVDPEMTVAKHETFGPVSPVIRFKNIDEAIRISNGTAYGLSSAVCTNRLDYIT 425 Query: 428 RFVRELEVGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSFSNTKTYSVPW 484 RF+REL VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSF+NTKTYS+PW Sbjct: 426 RFIRELNVGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSFTNTKTYSLPW 482 >Q0K2Z9.1 Q0K2Z9_CUPNH NAD-dependent aldehyde dehydrogenase EC=1.2.1.3 Length = 481 Score = 739 bits (1907), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/470 (74%), Positives = 402/470 (85%) Query: 15 HQKMRIGGKLVGSDRVIEVRNPYNGKLVGTIPKATVGDIRDAFRIGCQFKSSLTRFERSK 74 H+ +RI G+ + + VIEV PY G+++ T+PKAT+ ++R A+RI ++ +LTR+ER K Sbjct: 12 HEALRIAGEKIYREDVIEVTYPYTGEVIATVPKATLDEVRRAYRIARDYQPTLTRYERYK 71 Query: 75 IMLRASELLRANTDAISDLITAESGLCKKDSLYEVGRACDVFVFAANQTLVDDGQVFSCD 134 I++RA E++ + D IS IT ESGLC+KDSLYEVGRA DV +FAANQ LVDDGQVFSCD Sbjct: 72 ILMRAGEIIASRLDEISRTITLESGLCRKDSLYEVGRASDVLLFAANQALVDDGQVFSCD 131 Query: 135 LTPHGKQRKVYTMKEPLLGAISAITPFNHPLNQVAHKVAPSIATNNRMVLKPTEKTPFSA 194 LT HGK RKVYT++EPLLG I+AITPFNHPLNQV HKVAP++ATNNRMVLKP+EKTP +A Sbjct: 132 LTHHGKSRKVYTLREPLLGVITAITPFNHPLNQVIHKVAPAVATNNRMVLKPSEKTPLAA 191 Query: 195 LLLADILYEAGLPPEMFSVVTGDPKEIADEMLTNADVDLVTFTGGVPIGKYIAGKAVYKR 254 LLADILYEAGLPP+M SV+TGDP+EIADEMLT+ DVDLVTFTGGVPIGKYIA A YKR Sbjct: 192 YLLADILYEAGLPPQMLSVITGDPREIADEMLTHPDVDLVTFTGGVPIGKYIAATATYKR 251 Query: 255 QVLELGGNDPIIVMEDADIEEAATLAVSGSYKNSGQRCTAIKRMIVHQAVADEFVDKLVA 314 QVLELGGNDPIIVMEDAD+EEAATLA SGSYKNSGQRCTAIKRM+VH++VAD FVD LVA Sbjct: 252 QVLELGGNDPIIVMEDADLEEAATLAASGSYKNSGQRCTAIKRMLVHESVADRFVDLLVA 311 Query: 315 KTRAIKFGNPMDAGNDMGTVIDERAAMEFEAKVKDAERCGAKLLYGNVRDGALYSPTVLD 374 KT A+ +G+PMD DMGTVIDE AA++FEA V +A GA L YGN+R GALYSPTVLD Sbjct: 312 KTEALNYGDPMDPKVDMGTVIDEAAAIQFEAVVNEAIAAGATLRYGNIRRGALYSPTVLD 371 Query: 375 HVPADCKLVAQETFGPVSPVIRCTDIADAIRISNSTPYGLSSSVCTNRMDYITRFVRELE 434 HV + + ETFGPVSPVIR DI DAIRISN T YGLSSSVCTNR+DYITRFVREL+ Sbjct: 372 HVDPEMTVARHETFGPVSPVIRFRDIEDAIRISNGTAYGLSSSVCTNRLDYITRFVRELK 431 Query: 435 VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSFSNTKTYSVPW 484 VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAM+SF+NTKTYS+PW Sbjct: 432 VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMRSFTNTKTYSLPW 481 >B3R8E5.1 B3R8E5_CUPTR NAD+ DEPENDENT ACETALDEHYDE DEHYDROGENASE EC=1.2.1.- Length = 481 Score = 738 bits (1906), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/470 (74%), Positives = 403/470 (85%) Query: 15 HQKMRIGGKLVGSDRVIEVRNPYNGKLVGTIPKATVGDIRDAFRIGCQFKSSLTRFERSK 74 H+ +RI G+ + + VIEV PY G+++ T+P+AT+ D+R A+RI ++ +LTR+ER K Sbjct: 12 HEALRIAGEKIFREDVIEVTYPYTGEVIATVPRATLDDVRRAYRIARDYQPTLTRYERYK 71 Query: 75 IMLRASELLRANTDAISDLITAESGLCKKDSLYEVGRACDVFVFAANQTLVDDGQVFSCD 134 I++RA E++ + D IS IT ESGLC+KDSLYEVGRA DV +FAANQ LVDDGQVFSCD Sbjct: 72 ILMRAGEIIASRLDEISRTITLESGLCRKDSLYEVGRASDVLLFAANQALVDDGQVFSCD 131 Query: 135 LTPHGKQRKVYTMKEPLLGAISAITPFNHPLNQVAHKVAPSIATNNRMVLKPTEKTPFSA 194 LT HGK RKVYT++EPLLG I+AITPFNHPLNQV HKVAP++ATNNRMVLKP+EKTP +A Sbjct: 132 LTHHGKSRKVYTLREPLLGVITAITPFNHPLNQVVHKVAPAVATNNRMVLKPSEKTPLAA 191 Query: 195 LLLADILYEAGLPPEMFSVVTGDPKEIADEMLTNADVDLVTFTGGVPIGKYIAGKAVYKR 254 +LADILYEAGLPP+M SV+TGDP+EIADEMLT+ DVDLVTFTGGVPIGKYIA KA YKR Sbjct: 192 YMLADILYEAGLPPQMLSVITGDPREIADEMLTHPDVDLVTFTGGVPIGKYIAAKATYKR 251 Query: 255 QVLELGGNDPIIVMEDADIEEAATLAVSGSYKNSGQRCTAIKRMIVHQAVADEFVDKLVA 314 QVLELGGNDPIIVMEDAD+EEAATLA SGSYKNSGQRCTAIKRM+VH++VAD FVD LVA Sbjct: 252 QVLELGGNDPIIVMEDADLEEAATLAASGSYKNSGQRCTAIKRMLVHESVADRFVDLLVA 311 Query: 315 KTRAIKFGNPMDAGNDMGTVIDERAAMEFEAKVKDAERCGAKLLYGNVRDGALYSPTVLD 374 KT A+ +G+PMD DMGTVIDE AA++FE V +A GA L YGN+R GALYSPTVLD Sbjct: 312 KTEALNYGDPMDPKVDMGTVIDEAAAIQFEQVVNEAIAAGATLRYGNIRRGALYSPTVLD 371 Query: 375 HVPADCKLVAQETFGPVSPVIRCTDIADAIRISNSTPYGLSSSVCTNRMDYITRFVRELE 434 HV + +V ETFGPVSPVIR +DI +AIRISN T YGLSSSVCTNR+DYITRFVREL+ Sbjct: 372 HVDPEMTVVKHETFGPVSPVIRFSDIDEAIRISNGTAYGLSSSVCTNRLDYITRFVRELK 431 Query: 435 VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSFSNTKTYSVPW 484 VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSF NTKTYS+PW Sbjct: 432 VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSFCNTKTYSLPW 481 >Q46NR4.1 Q46NR4_CUPPJ Aldehyde dehydrogenase Length = 480 Score = 729 bits (1881), Expect = 0.0, Method: Compositional matrix adjust. Identities = 344/470 (73%), Positives = 400/470 (85%) Query: 15 HQKMRIGGKLVGSDRVIEVRNPYNGKLVGTIPKATVGDIRDAFRIGCQFKSSLTRFERSK 74 H+ +RI G+ V DRVIEV PY G+++ T+PKA + D+R A RI Q++S+LTR+ER + Sbjct: 11 HEALRIAGEKVYRDRVIEVTYPYTGEVIATVPKANIEDVRRALRIAHQYRSTLTRYERYR 70 Query: 75 IMLRASELLRANTDAISDLITAESGLCKKDSLYEVGRACDVFVFAANQTLVDDGQVFSCD 134 I++RA E++ + I+ LIT ESGL KD+LYEVGRA DV +FAANQ LVDDGQVFSCD Sbjct: 71 ILMRAGEIIAKRKEEIATLITLESGLSLKDTLYEVGRASDVLLFAANQALVDDGQVFSCD 130 Query: 135 LTPHGKQRKVYTMKEPLLGAISAITPFNHPLNQVAHKVAPSIATNNRMVLKPTEKTPFSA 194 LTPHGK RKVYT+KEPLLGAISAITPFNHPLNQV HKVAP++ATNNRMVLKP+EKTP +A Sbjct: 131 LTPHGKSRKVYTLKEPLLGAISAITPFNHPLNQVIHKVAPAVATNNRMVLKPSEKTPLAA 190 Query: 195 LLLADILYEAGLPPEMFSVVTGDPKEIADEMLTNADVDLVTFTGGVPIGKYIAGKAVYKR 254 LADILYEAGLPP+M SVVTGDP+EIADE+LT+ VDLVTFTGGV IGKYIA KA YKR Sbjct: 191 FALADILYEAGLPPQMLSVVTGDPREIADELLTSQYVDLVTFTGGVSIGKYIAAKAAYKR 250 Query: 255 QVLELGGNDPIIVMEDADIEEAATLAVSGSYKNSGQRCTAIKRMIVHQAVADEFVDKLVA 314 QVLELGGNDPIIVMEDAD+EEAATLA GSYKNSGQRCTA+KRM+V ++VAD FV+ LVA Sbjct: 251 QVLELGGNDPIIVMEDADLEEAATLAAGGSYKNSGQRCTAVKRMLVQESVADRFVELLVA 310 Query: 315 KTRAIKFGNPMDAGNDMGTVIDERAAMEFEAKVKDAERCGAKLLYGNVRDGALYSPTVLD 374 KT+ +K+G+P+D DMGTVIDE AA++FE+ V A GA+LL G+ RDGALY+PTVLD Sbjct: 311 KTQEVKYGDPLDPATDMGTVIDEAAAIQFESVVNAAIAGGARLLAGHTRDGALYAPTVLD 370 Query: 375 HVPADCKLVAQETFGPVSPVIRCTDIADAIRISNSTPYGLSSSVCTNRMDYITRFVRELE 434 HV + +V ETFGPVSPVIR DI DAIRISN T YGLSSSVCTNR+DYITRF+REL+ Sbjct: 371 HVDPEMAVVRHETFGPVSPVIRFKDIDDAIRISNGTAYGLSSSVCTNRLDYITRFIRELQ 430 Query: 435 VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSFSNTKTYSVPW 484 VG+VNVREVPGYRLE+TPFGGIKDSGLGYKEGVLEAMKSF NTKTYS+PW Sbjct: 431 VGTVNVREVPGYRLEMTPFGGIKDSGLGYKEGVLEAMKSFCNTKTYSLPW 480 >E8TX19.1 E8TX19_ALIDB Phosphonoacetaldehyde dehydrogenase Length = 482 Score = 728 bits (1879), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/480 (72%), Positives = 403/480 (83%) Query: 5 LSKLKDGLPLHQKMRIGGKLVGSDRVIEVRNPYNGKLVGTIPKATVGDIRDAFRIGCQFK 64 + +LK H+ +RI G+ V D VIEV PY G+++ T+PKAT+ D+R A+RI +K Sbjct: 3 VQQLKPAEIRHEALRIAGERVFRDEVIEVTYPYTGEVIATVPKATLEDVRRAYRIARDYK 62 Query: 65 SSLTRFERSKIMLRASELLRANTDAISDLITAESGLCKKDSLYEVGRACDVFVFAANQTL 124 +LTR+ER +I++RA E++ + D IS LIT ESGL +KD+LYEVGRA DV +FAANQ L Sbjct: 63 PTLTRYERYRILMRAGEIIASRLDEISRLITLESGLSRKDTLYEVGRASDVLLFAANQAL 122 Query: 125 VDDGQVFSCDLTPHGKQRKVYTMKEPLLGAISAITPFNHPLNQVAHKVAPSIATNNRMVL 184 VDDGQVFSCDLT HGK RKVYT KEPLLG I+AITPFNHPLNQV HKVAP++ATNNRMVL Sbjct: 123 VDDGQVFSCDLTHHGKSRKVYTTKEPLLGVITAITPFNHPLNQVIHKVAPAVATNNRMVL 182 Query: 185 KPTEKTPFSALLLADILYEAGLPPEMFSVVTGDPKEIADEMLTNADVDLVTFTGGVPIGK 244 KP+EKTP SA +LADILYEAGLPPEM S+VTGDP+EIADEMLT+ DVDLVTFTGGV IGK Sbjct: 183 KPSEKTPLSACVLADILYEAGLPPEMLSIVTGDPREIADEMLTHPDVDLVTFTGGVAIGK 242 Query: 245 YIAGKAVYKRQVLELGGNDPIIVMEDADIEEAATLAVSGSYKNSGQRCTAIKRMIVHQAV 304 YIAGK+VYKRQ+LELGGNDPIIVMEDAD+EEAATLA SGSYKNSGQRCTA+KRM+VH+ V Sbjct: 243 YIAGKSVYKRQILELGGNDPIIVMEDADVEEAATLAASGSYKNSGQRCTAVKRMLVHEKV 302 Query: 305 ADEFVDKLVAKTRAIKFGNPMDAGNDMGTVIDERAAMEFEAKVKDAERCGAKLLYGNVRD 364 AD+FV+ LV KT+A+K+G+PMD DMGTVIDE AA FE V +A GA+LL G+VR Sbjct: 303 ADQFVELLVQKTKAVKYGDPMDPHTDMGTVIDEPAAQHFERVVDEAIAGGARLLAGHVRR 362 Query: 365 GALYSPTVLDHVPADCKLVAQETFGPVSPVIRCTDIADAIRISNSTPYGLSSSVCTNRMD 424 GALY+PTVLD V + +V ETFGPVSPVIR DI +AIRISN T YGLSSSVCTNR+D Sbjct: 363 GALYAPTVLDQVKPEMTVVKHETFGPVSPVIRFKDIDEAIRISNGTAYGLSSSVCTNRLD 422 Query: 425 YITRFVRELEVGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVLEAMKSFSNTKTYSVPW 484 YITRFVREL VGSVNVREVPGYRLELTPFGGIKDSGLGYKEGV EAMKSF NTKTYS+PW Sbjct: 423 YITRFVRELNVGSVNVREVPGYRLELTPFGGIKDSGLGYKEGVQEAMKSFCNTKTYSLPW 482