BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0295.p (525 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8J1A1.1 D8J1A1_HERSS Permease of the major facilitator superfam... 833 0.0 D8NYL4.1 D8NYL4_RALSO Putative multidrug resistance transmembran... 695 0.0 A5VEY4.1 A5VEY4_SPHWW Drug resistance transporter, EmrB/QacA sub... 688 0.0 Q8XVV0.1 Q8XVV0_RALSO Probable multidrug resistance transmembran... 673 0.0 D8N6T5.1 D8N6T5_RALSO Putative multidrug resistance transmembran... 663 0.0 >D8J1A1.1 D8J1A1_HERSS Permease of the major facilitator superfamily protein Length = 514 Score = 833 bits (2152), Expect = 0.0, Method: Compositional matrix adjust. Identities = 446/508 (87%), Positives = 483/508 (95%) Query: 18 SGRKADASAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEI 77 +G KADA+AWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEI Sbjct: 7 NGEKADAAAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEI 66 Query: 78 IIIPLSSWLEKLLGLRTLLLAAAGLFTLFSVMCGLSTTLPMMIVGRIGQGFTGGALIPTA 137 +IIP+S+WLE+LLGLR LLL AA LFTLFSV+CGLSTTLPMMIVGR+GQGFTGGALIPTA Sbjct: 67 VIIPMSAWLERLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTA 126 Query: 138 MTIIATRLPREQQPVGNALFGATAILGPVLGPVLGGWLTENVSWHYSFFLNVPVGIALIT 197 MTIIATRLPR QQPVGNA+FGATAILGPVLGPV+GGWLTENVSWHY+FF+N+PVG ALIT Sbjct: 127 MTIIATRLPRSQQPVGNAMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALIT 186 Query: 198 LLLVAVPYERPKVELLAEADWLGILGMALGLGGLTVVLEEGEREQWFSSPDIRWLAVVSL 257 LLLVA+PYERPK E LAEADW GI G+ALGLGGLTVVLEEGEREQWFSSPDIRWLA S+ Sbjct: 187 LLLVAIPYERPKFEQLAEADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSV 246 Query: 258 LGFILLAIGQWRARHPVIQLRLLRDRQFGSVALMAMAVGVALYGTAYVIPQFLAGIAGYN 317 LGFILLAIGQ RARHPVIQLRLLRDRQFGSV +MAM VGVALYGTAYVIPQFL+GIAGYN Sbjct: 247 LGFILLAIGQVRARHPVIQLRLLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYN 306 Query: 318 SLQSGVIVLLSGVPMILMMPFTPLLMRTVDIRLAVGVGLLLLAASAFMETDLSPLSYGGS 377 SLQSG IVLLSGVPMILMMPFTPLLMR VDIR+AVG G LLLAASAF+ETDLSPLSYGGS Sbjct: 307 SLQSGWIVLLSGVPMILMMPFTPLLMRLVDIRIAVGTGFLLLAASAFIETDLSPLSYGGS 366 Query: 378 FVASQLMRGIGTVLAMLFLNQAAIRSVPASQAGDAAGIYSAARNLGGSLALASIAVIQDQ 437 FVASQLMRG+GTVLAMLFLNQAAIRSVP SQAGDA+G+YSAARNLGGSLALA+IAVIQDQ Sbjct: 367 FVASQLMRGVGTVLAMLFLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQDQ 426 Query: 438 RLWLHSRRLEESISANAELVQSSMATQAHLLGGPDIAIRLLGSTIQMQALTMTYADLFWL 497 RLWLHSRRLEES++AN++LVQSSM Q HLLGG D+A++L+G+TIQ QALTMTYADLFW+ Sbjct: 427 RLWLHSRRLEESLNANSDLVQSSMTAQGHLLGGQDVALQLMGATIQSQALTMTYADLFWM 486 Query: 498 LGVAILCITPLVLFLRPLPTNAAPVAAH 525 LGVAILC+TPLVLFLRPLPT+AAPVA+H Sbjct: 487 LGVAILCVTPLVLFLRPLPTHAAPVASH 514 >D8NYL4.1 D8NYL4_RALSO Putative multidrug resistance transmembrane protein Length = 511 Score = 695 bits (1794), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/493 (71%), Positives = 422/493 (85%) Query: 33 GTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIIIIPLSSWLEKLLGL 92 GTLGA+MATLDISIVNS+LPTIQGEIGA+ TEGTWIATAYLVAEIIIIPL+ WLEKLLGL Sbjct: 19 GTLGAMMATLDISIVNSALPTIQGEIGATSTEGTWIATAYLVAEIIIIPLAGWLEKLLGL 78 Query: 93 RTLLLAAAGLFTLFSVMCGLSTTLPMMIVGRIGQGFTGGALIPTAMTIIATRLPREQQPV 152 R LLLAA GLFT FS++CG++ TLPMM++GR GQGFTGG LIPTAMTIIA RLPR QQP+ Sbjct: 79 RNLLLAATGLFTGFSMLCGVAKTLPMMVIGRAGQGFTGGVLIPTAMTIIAARLPRAQQPL 138 Query: 153 GNALFGATAILGPVLGPVLGGWLTENVSWHYSFFLNVPVGIALITLLLVAVPYERPKVEL 212 G ALFG+T ILGPV GP+LGGW+T +SWHY+FF+N+P+ L TLLL+ +P+E+P+ L Sbjct: 139 GTALFGSTVILGPVFGPMLGGWMTTQLSWHYAFFINLPICAVLATLLLLGMPHEKPRTAL 198 Query: 213 LAEADWLGILGMALGLGGLTVVLEEGEREQWFSSPDIRWLAVVSLLGFILLAIGQWRARH 272 L EADW GI G+ALGLGG+TVVLEEG+R WF+SP+IRWLA +S+LGF LL GQ RA Sbjct: 199 LREADWAGITGLALGLGGMTVVLEEGQRLHWFASPEIRWLATLSMLGFALLGWGQARAHA 258 Query: 273 PVIQLRLLRDRQFGSVALMAMAVGVALYGTAYVIPQFLAGIAGYNSLQSGVIVLLSGVPM 332 PVI+L LLRDRQF ++A+MA+A +ALYGTAYVIPQFL GIAGY++LQSG IVLLSG+PM Sbjct: 259 PVIRLGLLRDRQFSAIAVMAIASSMALYGTAYVIPQFLVGIAGYDALQSGWIVLLSGLPM 318 Query: 333 ILMMPFTPLLMRTVDIRLAVGVGLLLLAASAFMETDLSPLSYGGSFVASQLMRGIGTVLA 392 I++MPFTPL++R +D+RLAVG GL +LA SA++ET LSPLS G SFVASQLMRG+GTV+ Sbjct: 319 IVLMPFTPLMLRRLDVRLAVGCGLAMLALSAYVETGLSPLSTGNSFVASQLMRGLGTVMT 378 Query: 393 MLFLNQAAIRSVPASQAGDAAGIYSAARNLGGSLALASIAVIQDQRLWLHSRRLEESISA 452 M+FLNQAAIRSVP S+A DA+G+Y+A RNLGGS+ALA IA +Q+QRLWLHSRR+E+++ A Sbjct: 379 MMFLNQAAIRSVPPSRASDASGLYNALRNLGGSIALACIATLQEQRLWLHSRRIEDTLPA 438 Query: 453 NAELVQSSMATQAHLLGGPDIAIRLLGSTIQMQALTMTYADLFWLLGVAILCITPLVLFL 512 NA VQ +A+QAHLLGG A+ + TIQ+QALTMTYADLFWLL VAIL +TPLV+FL Sbjct: 439 NAAGVQDYIASQAHLLGGQTAALLSMEQTIQVQALTMTYADLFWLLSVAILLVTPLVVFL 498 Query: 513 RPLPTNAAPVAAH 525 RPLP NA PV H Sbjct: 499 RPLPRNAGPVTGH 511 >A5VEY4.1 A5VEY4_SPHWW Drug resistance transporter, EmrB/QacA subfamily Length = 523 Score = 688 bits (1776), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/523 (67%), Positives = 432/523 (82%), Gaps = 1/523 (0%) Query: 3 SPAASPGTGQTSGQTSGRKADASAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASG 62 S AA+ G + +T +ADASAWLAV AG+LGA+MATLD+SIVNSSLPTIQGEIGASG Sbjct: 2 SAAAADGHMAPAVETPVGRADASAWLAVIAGSLGAMMATLDVSIVNSSLPTIQGEIGASG 61 Query: 63 TEGTWIATAYLVAEIIIIPLSSWLEKLLGLRTLLLAAAGLFTLFSVMCGLSTTLPMMIVG 122 TEGTWIATAYLVAEI+IIPLS+WLE++LGLRTLL+ AA LFT FS+MCG ST L MMI+G Sbjct: 62 TEGTWIATAYLVAEIVIIPLSAWLERVLGLRTLLIVAAALFTGFSMMCGFSTNLTMMIIG 121 Query: 123 RIGQGFTGGALIPTAMTIIATRLPREQQPVGNALFGATAILGPVLGPVLGGWLTENVSWH 182 R+GQGFTGGALIPTAMTIIATRLPREQQPVGNALFG TAILGPVLGP++GGWLTEN+SWH Sbjct: 122 RVGQGFTGGALIPTAMTIIATRLPREQQPVGNALFGVTAILGPVLGPLIGGWLTENISWH 181 Query: 183 YSFFLNVPVGIALITLLLVAVPYERPKVELLAEADWLGILGMALGLGGLTVVLEEGEREQ 242 Y+FFLN+P+GI LI+LLL+ +P+ + ++ L +ADWLGI G+ GLGGLTVVLEEG+REQ Sbjct: 182 YAFFLNLPIGILLISLLLLTMPHHKARLGELLQADWLGIAGLMFGLGGLTVVLEEGQREQ 241 Query: 243 WFSSPDIRWLAVVSLLGFILLAIGQWRARHPVIQLRLLRDRQFGSVALMAMAVGVALYGT 302 WF S I +++V+ LGFI L GQ+ AR PVI+L+LL DRQFG+VA+MA+ +G+ LYGT Sbjct: 242 WFQSDVIVKVSIVAALGFISLFAGQFLARRPVIKLKLLLDRQFGAVAVMAIVIGMMLYGT 301 Query: 303 AYVIPQFLAGIAGYNSLQSGVIVLLSGVPMILMMPFTPLLMRTVDIRLAVGVGLLLLAAS 362 +YVIPQFLA IAGYN+LQSG IVL+SG+P +L+MPFTPLL+R VDIR+AVG+GL ++A S Sbjct: 302 SYVIPQFLAAIAGYNALQSGKIVLISGIPSLLLMPFTPLLIRYVDIRIAVGIGLAIMATS 361 Query: 363 AFMETDLSPLSYGGSFVASQLMRGIGTVLAMLFLNQAAIRSVPASQAGDAAGIYSAARNL 422 ++T LS S GGSFV SQL+RG+GT++A LFLNQAAI SV A GDAAG++SA RNL Sbjct: 362 CGIDTALSAQSDGGSFVDSQLLRGVGTIMAFLFLNQAAIASVSARDVGDAAGLFSAMRNL 421 Query: 423 GGSLALASIAVIQDQRLWLHSRRLEESISANAELVQSSMATQAHLLGGPDIAIRLLGSTI 482 GGS ALA IA++QDQR WLH+RR+EES++AN+ +Q +A H LG D A+R L TI Sbjct: 422 GGSFALAGIAIVQDQRQWLHNRRIEESLNANSVGLQDYLAGLTHALGNADAALRTLAGTI 481 Query: 483 QMQALTMTYADLFWLLGVAILCITPLVLFLRPLPTNAAPVAAH 525 Q AL MT+ D+FWL+ V I+C+ PLVLFLRPLP A +A H Sbjct: 482 QRDALVMTFNDIFWLMTVGIVCVMPLVLFLRPLPKGQA-IAMH 523 >Q8XVV0.1 Q8XVV0_RALSO Probable multidrug resistance transmembrane protein Length = 511 Score = 673 bits (1737), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/493 (71%), Positives = 417/493 (84%) Query: 33 GTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIIIIPLSSWLEKLLGL 92 GTLGA+MATLDISIVNS+LPTIQGEIGA+ TEGTWIATAYLVAEIIIIPL+ WLEKLLGL Sbjct: 19 GTLGAMMATLDISIVNSALPTIQGEIGATSTEGTWIATAYLVAEIIIIPLAGWLEKLLGL 78 Query: 93 RTLLLAAAGLFTLFSVMCGLSTTLPMMIVGRIGQGFTGGALIPTAMTIIATRLPREQQPV 152 R LLLAA GLFT FS++CG++ TLPMM++GR GQGFTGG LIPTAMTIIA RLPR QQP+ Sbjct: 79 RNLLLAATGLFTGFSMLCGVAETLPMMVIGRAGQGFTGGVLIPTAMTIIAARLPRAQQPL 138 Query: 153 GNALFGATAILGPVLGPVLGGWLTENVSWHYSFFLNVPVGIALITLLLVAVPYERPKVEL 212 G ALFG+T ILGPV GP+LGGW+T ++WHY+FF+N+P+ L LLL+ +P+ERP+ L Sbjct: 139 GTALFGSTVILGPVFGPMLGGWMTTQLNWHYAFFINLPICGVLAALLLLGMPHERPRTAL 198 Query: 213 LAEADWLGILGMALGLGGLTVVLEEGEREQWFSSPDIRWLAVVSLLGFILLAIGQWRARH 272 L EADW GI G+ALGLGG+TVVLEEG+R QWF+SP IRWLA VS LGF LL GQ RAR Sbjct: 199 LREADWAGIAGLALGLGGMTVVLEEGQRLQWFTSPAIRWLAAVSALGFGLLGWGQARARA 258 Query: 273 PVIQLRLLRDRQFGSVALMAMAVGVALYGTAYVIPQFLAGIAGYNSLQSGVIVLLSGVPM 332 PVI+L LLRDRQFG++A+MA+A +ALYGTAYVIPQFL GIAGY++LQSG IVLLSG+PM Sbjct: 259 PVIRLGLLRDRQFGAIAVMAIAASMALYGTAYVIPQFLVGIAGYDALQSGWIVLLSGLPM 318 Query: 333 ILMMPFTPLLMRTVDIRLAVGVGLLLLAASAFMETDLSPLSYGGSFVASQLMRGIGTVLA 392 I++MP PL++R +D+RLAVG GLL+LA SA++ET LSPLS G SFVASQLMRG+GTVL Sbjct: 319 IVLMPMLPLMLRWLDVRLAVGGGLLVLALSAYIETGLSPLSTGNSFVASQLMRGLGTVLT 378 Query: 393 MLFLNQAAIRSVPASQAGDAAGIYSAARNLGGSLALASIAVIQDQRLWLHSRRLEESISA 452 M+FLNQAAIRSVP SQA DA+G+Y+ RNLGGS+ALA IA +Q+QRLWLHSRR+E+++ A Sbjct: 379 MMFLNQAAIRSVPPSQASDASGLYNGLRNLGGSIALACIATLQEQRLWLHSRRIEDTLQA 438 Query: 453 NAELVQSSMATQAHLLGGPDIAIRLLGSTIQMQALTMTYADLFWLLGVAILCITPLVLFL 512 NA VQ +A QAH LG A+ + +IQ+QALTM YADLFWLL VAIL +TPLV+FL Sbjct: 439 NAAGVQDYIAGQAHALGSQAAALLSMEQSIQVQALTMAYADLFWLLTVAILLVTPLVVFL 498 Query: 513 RPLPTNAAPVAAH 525 RPLP +A PVA H Sbjct: 499 RPLPRHAGPVAGH 511 >D8N6T5.1 D8N6T5_RALSO Putative multidrug resistance transmembrane protein Length = 511 Score = 663 bits (1710), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/493 (71%), Positives = 417/493 (84%) Query: 33 GTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIIIIPLSSWLEKLLGL 92 GTLGA+MATLDISIVNS+LPTIQGEIGA+ TEGTWIATAYLVAEIIIIPL+ WLEKLLGL Sbjct: 19 GTLGAMMATLDISIVNSALPTIQGEIGATSTEGTWIATAYLVAEIIIIPLAGWLEKLLGL 78 Query: 93 RTLLLAAAGLFTLFSVMCGLSTTLPMMIVGRIGQGFTGGALIPTAMTIIATRLPREQQPV 152 R LLL A GLFT FS++CG++ TLPMM++GR GQGFTGG LIPTAMTIIA RLPR QQP+ Sbjct: 79 RNLLLLATGLFTGFSMLCGVAETLPMMVIGRAGQGFTGGVLIPTAMTIIAARLPRAQQPL 138 Query: 153 GNALFGATAILGPVLGPVLGGWLTENVSWHYSFFLNVPVGIALITLLLVAVPYERPKVEL 212 G ALFG+T ILGPV GP+LGGWLT +SWHY+FF+N+P+ + L LLL+ +P+ERP+ L Sbjct: 139 GTALFGSTVILGPVFGPMLGGWLTTQLSWHYAFFINLPICVVLAALLLLGMPHERPRTAL 198 Query: 213 LAEADWLGILGMALGLGGLTVVLEEGEREQWFSSPDIRWLAVVSLLGFILLAIGQWRARH 272 L EADW GI G+ALGLGG+TVVLEEG+R QWF+SP IRWLA VS+LGF LL GQ RAR Sbjct: 199 LREADWAGIAGLALGLGGMTVVLEEGQRLQWFASPAIRWLAAVSVLGFGLLGWGQARARA 258 Query: 273 PVIQLRLLRDRQFGSVALMAMAVGVALYGTAYVIPQFLAGIAGYNSLQSGVIVLLSGVPM 332 PVI+L LLRDRQFG++A+MA+A +ALYGTAYVIPQFL GIAGY++LQSG IVLLSG+PM Sbjct: 259 PVIRLGLLRDRQFGAIAIMAIAASMALYGTAYVIPQFLVGIAGYDALQSGWIVLLSGLPM 318 Query: 333 ILMMPFTPLLMRTVDIRLAVGVGLLLLAASAFMETDLSPLSYGGSFVASQLMRGIGTVLA 392 I++MP PL++R +D+RLAVG GLL+LA SA++ET LSPLS G SFVASQLMRG+GTVL Sbjct: 319 IVLMPMLPLMLRRLDVRLAVGGGLLVLALSAYIETGLSPLSTGNSFVASQLMRGLGTVLT 378 Query: 393 MLFLNQAAIRSVPASQAGDAAGIYSAARNLGGSLALASIAVIQDQRLWLHSRRLEESISA 452 M+FLNQAAIRSVP SQA DA+G+Y+ RNLGGS+ALA I +Q+QRLWLHSRR+E+++ A Sbjct: 379 MMFLNQAAIRSVPPSQASDASGLYNGLRNLGGSIALACIGTLQEQRLWLHSRRIEDTLPA 438 Query: 453 NAELVQSSMATQAHLLGGPDIAIRLLGSTIQMQALTMTYADLFWLLGVAILCITPLVLFL 512 NA VQ +A QAH LG A+ + +IQ QALTM YADLFWLL VAIL +TPLV+FL Sbjct: 439 NAASVQDYIAGQAHALGSQAAALLSMEQSIQTQALTMAYADLFWLLTVAILLVTPLVVFL 498 Query: 513 RPLPTNAAPVAAH 525 RPLP+NA PVA H Sbjct: 499 RPLPSNAGPVAGH 511