BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0146.p (361 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Q3SI04.1 Q3SI04_THIDA GDP-mannose 4,6-dehydratase 659 0.0 A1KBJ7.1 A1KBJ7_AZOSB GDP-mannose 4,6-dehydratase EC=4.2.1.47 655 0.0 C6WVI5.1 C6WVI5_METML GDP-mannose 4,6-dehydratase 650 0.0 Q2KC60.1 Q2KC60_RHIEC GDP-mannose 4,6-dehydratase protein EC=4.2... 647 0.0 C6B1M9.1 C6B1M9_RHILS GDP-mannose 4,6-dehydratase 646 0.0 >Q3SI04.1 Q3SI04_THIDA GDP-mannose 4,6-dehydratase Length = 361 Score = 659 bits (1699), Expect = 0.0, Method: Compositional matrix adjust. Identities = 311/361 (86%), Positives = 335/361 (92%) Query: 1 MSKVALITGVTGQDGAYLAELLLDKGYEVHGIKRRTSLLNTDRIDHLYQDPHEKNVRFKL 60 M K ALITGVTGQDGAYLAE LL KGYEVHGIKRRTSL NTDRIDHLYQDPHEK+ RF L Sbjct: 1 MIKKALITGVTGQDGAYLAEFLLGKGYEVHGIKRRTSLFNTDRIDHLYQDPHEKDRRFIL 60 Query: 61 HHGDLTDSTSLIRIIQLVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL 120 HHGDLTDS+SLIRIIQ V+PDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL Sbjct: 61 HHGDLTDSSSLIRIIQQVRPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL 120 Query: 121 GLEKKARFYQASTSELYGLVQEMPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGIYAC 180 GLEKK RFYQASTSELYGLVQE PQKETTPFYPRSPYAVAKLYAYWITVNYREAYG+YAC Sbjct: 121 GLEKKTRFYQASTSELYGLVQETPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGMYAC 180 Query: 181 NGILFNHESPIRGETFVTRKITRALARIKLGLQDCVYLGNLNAKRDWGHARDYVEMQWLM 240 NGILFNHESPIRGETFVTRKITRALARIKLGLQDC++LGN++AKRDWGHA+DYVEMQWLM Sbjct: 181 NGILFNHESPIRGETFVTRKITRALARIKLGLQDCLFLGNMDAKRDWGHAKDYVEMQWLM 240 Query: 241 LQQEQAEDFVIATGVQYSVRDFINAAAKEIDIEIRWEGEGLEEKGYDASGKCIVAVDPRY 300 LQQE+ EDFVIATGVQYSVRDF++AAAKE+ + IRWEGEG+ EKGYD G+C+VAVDPRY Sbjct: 241 LQQEKPEDFVIATGVQYSVRDFVDAAAKELGMSIRWEGEGVAEKGYDDKGRCVVAVDPRY 300 Query: 301 FRPAEVETLLGDASKAKQKLGWTPKTTFAELVQEMMREDLKSAERDEIVKRHGYKTFENR 360 FRP EVETLLGD +KAK KLGWTPK +F ELV EM+REDLK+AERDE+VK+HGYK + Sbjct: 301 FRPTEVETLLGDPAKAKDKLGWTPKISFDELVTEMVREDLKAAERDELVKKHGYKAMDYH 360 Query: 361 E 361 E Sbjct: 361 E 361 >A1KBJ7.1 A1KBJ7_AZOSB GDP-mannose 4,6-dehydratase EC=4.2.1.47 Length = 361 Score = 655 bits (1690), Expect = 0.0, Method: Compositional matrix adjust. Identities = 306/361 (84%), Positives = 339/361 (93%) Query: 1 MSKVALITGVTGQDGAYLAELLLDKGYEVHGIKRRTSLLNTDRIDHLYQDPHEKNVRFKL 60 M KVALITGVTGQDG+YLAELLL KGYEVHGIKRRTSL NTDRIDHLYQDPHE+ RF L Sbjct: 1 MKKVALITGVTGQDGSYLAELLLAKGYEVHGIKRRTSLFNTDRIDHLYQDPHEEGRRFIL 60 Query: 61 HHGDLTDSTSLIRIIQLVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL 120 H+GD+TDS+SLIRIIQ VQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL Sbjct: 61 HYGDMTDSSSLIRIIQQVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL 120 Query: 121 GLEKKARFYQASTSELYGLVQEMPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGIYAC 180 GLEKK+RFYQASTSELYGLVQE+PQKETTPFYPRSPYAVAK+YAYWITVNYREAYGIYAC Sbjct: 121 GLEKKSRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKMYAYWITVNYREAYGIYAC 180 Query: 181 NGILFNHESPIRGETFVTRKITRALARIKLGLQDCVYLGNLNAKRDWGHARDYVEMQWLM 240 NGILFNHESP+RGETFVTRKITRALARIKLGLQDC++LGNLNAKRDWGHA+DYVEMQW+M Sbjct: 181 NGILFNHESPVRGETFVTRKITRALARIKLGLQDCLFLGNLNAKRDWGHAKDYVEMQWMM 240 Query: 241 LQQEQAEDFVIATGVQYSVRDFINAAAKEIDIEIRWEGEGLEEKGYDASGKCIVAVDPRY 300 LQQ++ EDFVIATGVQYSVR+F++AAA+EI I I W+GEG++EKGYD SG+CIVAVD RY Sbjct: 241 LQQDKPEDFVIATGVQYSVREFVDAAAREIGIRITWKGEGVDEKGYDESGRCIVAVDERY 300 Query: 301 FRPAEVETLLGDASKAKQKLGWTPKTTFAELVQEMMREDLKSAERDEIVKRHGYKTFENR 360 FRP EVETLLGDASKA++ LGWTP+ +F+ELV EMMRED+K+AERDE+VK HGY ++ Sbjct: 301 FRPTEVETLLGDASKARRLLGWTPRISFSELVSEMMREDMKAAERDELVKTHGYSAYDYH 360 Query: 361 E 361 E Sbjct: 361 E 361 >C6WVI5.1 C6WVI5_METML GDP-mannose 4,6-dehydratase Length = 361 Score = 650 bits (1678), Expect = 0.0, Method: Compositional matrix adjust. Identities = 307/361 (85%), Positives = 329/361 (91%) Query: 1 MSKVALITGVTGQDGAYLAELLLDKGYEVHGIKRRTSLLNTDRIDHLYQDPHEKNVRFKL 60 M+KVALITGVTGQDGAYLAE LL KGYEVHG+KRR+SL NT RIDHL+ D HEK + F L Sbjct: 1 MTKVALITGVTGQDGAYLAEFLLKKGYEVHGVKRRSSLFNTARIDHLFHDVHEKGLPFFL 60 Query: 61 HHGDLTDSTSLIRIIQLVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL 120 HHGD+TDS+SL IIQ VQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL Sbjct: 61 HHGDMTDSSSLTHIIQKVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRIL 120 Query: 121 GLEKKARFYQASTSELYGLVQEMPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGIYAC 180 GL+ K RFYQASTSELYGLVQE PQKETTPFYPRSPYAVAKLYAYWIT+NYREAYGIYAC Sbjct: 121 GLQNKTRFYQASTSELYGLVQETPQKETTPFYPRSPYAVAKLYAYWITINYREAYGIYAC 180 Query: 181 NGILFNHESPIRGETFVTRKITRALARIKLGLQDCVYLGNLNAKRDWGHARDYVEMQWLM 240 NGILFNHESPIRGETFVTRKITRALARIKLGLQ+C+YLGN+NA RDWGHA+DYVEMQWLM Sbjct: 181 NGILFNHESPIRGETFVTRKITRALARIKLGLQECLYLGNMNALRDWGHAKDYVEMQWLM 240 Query: 241 LQQEQAEDFVIATGVQYSVRDFINAAAKEIDIEIRWEGEGLEEKGYDASGKCIVAVDPRY 300 LQQEQ EDFVIATGVQYSVRDF+NAAAKE+ + I W+GEG++EKGYDASGKCIVAVD RY Sbjct: 241 LQQEQPEDFVIATGVQYSVRDFVNAAAKELGMAIAWKGEGVDEKGYDASGKCIVAVDSRY 300 Query: 301 FRPAEVETLLGDASKAKQKLGWTPKTTFAELVQEMMREDLKSAERDEIVKRHGYKTFENR 360 FRP EVETLLGDASKAK KLGW PK +F ELV EM+REDLKSAERDE+VKRHGY F Sbjct: 301 FRPTEVETLLGDASKAKNKLGWVPKISFDELVSEMVREDLKSAERDELVKRHGYSAFNYH 360 Query: 361 E 361 E Sbjct: 361 E 361 >Q2KC60.1 Q2KC60_RHIEC GDP-mannose 4,6-dehydratase protein EC=4.2.1.47 Length = 360 Score = 647 bits (1668), Expect = 0.0, Method: Compositional matrix adjust. Identities = 303/359 (84%), Positives = 331/359 (92%) Query: 3 KVALITGVTGQDGAYLAELLLDKGYEVHGIKRRTSLLNTDRIDHLYQDPHEKNVRFKLHH 62 K ALITGVTGQDG+YLAELLL KGYEVHGIKRR SL NTDRIDHLYQDPHE R LH+ Sbjct: 2 KKALITGVTGQDGSYLAELLLSKGYEVHGIKRRASLFNTDRIDHLYQDPHEDRRRLILHY 61 Query: 63 GDLTDSTSLIRIIQLVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGL 122 GD+TDS+SLIRI+Q VQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGL Sbjct: 62 GDMTDSSSLIRIMQNVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGL 121 Query: 123 EKKARFYQASTSELYGLVQEMPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGIYACNG 182 EKK+RFYQASTSELYGLVQE PQ+ETTPFYPRSPYAVAKLYAYWITVNYREAYGIYACNG Sbjct: 122 EKKSRFYQASTSELYGLVQETPQRETTPFYPRSPYAVAKLYAYWITVNYREAYGIYACNG 181 Query: 183 ILFNHESPIRGETFVTRKITRALARIKLGLQDCVYLGNLNAKRDWGHARDYVEMQWLMLQ 242 ILFNHESP+RGETFVTRKITRALARIKLGLQDC+YLGNL+AKRDWGHA+DYVEMQWLMLQ Sbjct: 182 ILFNHESPVRGETFVTRKITRALARIKLGLQDCLYLGNLDAKRDWGHAKDYVEMQWLMLQ 241 Query: 243 QEQAEDFVIATGVQYSVRDFINAAAKEIDIEIRWEGEGLEEKGYDASGKCIVAVDPRYFR 302 QEQ EDFVIATG+QYSVRDF+NAAA+EI + + W G G++EKG+DA+GKCIV+VDPRYFR Sbjct: 242 QEQPEDFVIATGIQYSVRDFVNAAAREIGLSVNWVGTGIDEKGFDANGKCIVSVDPRYFR 301 Query: 303 PAEVETLLGDASKAKQKLGWTPKTTFAELVQEMMREDLKSAERDEIVKRHGYKTFENRE 361 P EVETLLGDASKAK KLGW P+ +F LV EM+REDLKSAERDE+VKRHG+ ++ E Sbjct: 302 PTEVETLLGDASKAKDKLGWEPQISFEALVAEMVREDLKSAERDELVKRHGFSAYDYHE 360 >C6B1M9.1 C6B1M9_RHILS GDP-mannose 4,6-dehydratase Length = 360 Score = 646 bits (1666), Expect = 0.0, Method: Compositional matrix adjust. Identities = 301/359 (83%), Positives = 334/359 (93%) Query: 3 KVALITGVTGQDGAYLAELLLDKGYEVHGIKRRTSLLNTDRIDHLYQDPHEKNVRFKLHH 62 K ALITG+TGQDG+YLAELL++KGYEVHGIKRRTSL NTDRIDHLYQDPH+ N R LH+ Sbjct: 2 KRALITGITGQDGSYLAELLIEKGYEVHGIKRRTSLFNTDRIDHLYQDPHDTNRRLVLHY 61 Query: 63 GDLTDSTSLIRIIQLVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGL 122 GD+TDS+SL+RI+Q VQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGL Sbjct: 62 GDMTDSSSLVRIVQQVQPDEIYNLAAQSHVAVSFEEPEYTANSDALGALRILEAIRILGL 121 Query: 123 EKKARFYQASTSELYGLVQEMPQKETTPFYPRSPYAVAKLYAYWITVNYREAYGIYACNG 182 EKK RFYQASTSELYGLVQE+PQ+ETTPFYPRSPYAVAKLYAYWITVNYREAYGIYACNG Sbjct: 122 EKKTRFYQASTSELYGLVQEIPQRETTPFYPRSPYAVAKLYAYWITVNYREAYGIYACNG 181 Query: 183 ILFNHESPIRGETFVTRKITRALARIKLGLQDCVYLGNLNAKRDWGHARDYVEMQWLMLQ 242 ILFNHESP+RGETFVTRKITRALARIKLGLQDC+YLGNL+AKRDWGHA+DYVEMQWLMLQ Sbjct: 182 ILFNHESPVRGETFVTRKITRALARIKLGLQDCLYLGNLDAKRDWGHAKDYVEMQWLMLQ 241 Query: 243 QEQAEDFVIATGVQYSVRDFINAAAKEIDIEIRWEGEGLEEKGYDASGKCIVAVDPRYFR 302 Q++ EDFVIATGVQYSVR+F++AAA EI + I W+G G EEKGYD +G+CIVAVDPRYFR Sbjct: 242 QDEPEDFVIATGVQYSVREFVDAAAHEIGLPISWKGSGAEEKGYDENGRCIVAVDPRYFR 301 Query: 303 PAEVETLLGDASKAKQKLGWTPKTTFAELVQEMMREDLKSAERDEIVKRHGYKTFENRE 361 P EVETLLGD SKAK+KLGW P+ TF +LV+EMMREDLKSAERDE+VKRHG+ ++ E Sbjct: 302 PTEVETLLGDPSKAKEKLGWEPRITFKQLVEEMMREDLKSAERDELVKRHGFSAYDYHE 360