BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0081.p (508 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value A2RPZ1.1 A2RPZ1_HERSE Bifunctional purine biosynthesis protein purH 949 0.0 D8IX65.1 D8IX65_HERSS Bifunctional purine biosynthesis protein purH 949 0.0 A6SUQ1.1 PUR9_JANMA Bifunctional purine biosynthesis protein pur... 898 0.0 A4G1U6.1 PUR9_HERAR Bifunctional purine biosynthesis protein pur... 891 0.0 Q1LRB3.1 PUR9_RALME Bifunctional purine biosynthesis protein pur... 832 0.0 >A2RPZ1.1 A2RPZ1_HERSE Bifunctional purine biosynthesis protein purH Length = 522 Score = 949 bits (2453), Expect = 0.0, Method: Compositional matrix adjust. Identities = 464/504 (92%), Positives = 483/504 (95%) Query: 5 RHRQAAGRQWXSTGGTAKLLADNGVKVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 64 R A G STGGTAKLLADNGV VTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD Sbjct: 19 RALSAMGVNILSTGGTAKLLADNGVPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 78 Query: 65 FPEHVAALDKHGIPTIDMVVVNLYPFQQTIAKEECSLEDAIENIDIGGPAMLRSSAKNHK 124 FPEHVAAL +HGIPTIDMVVVNLYPFQQT+AKEECSLEDAIENIDIGGPAMLRSSAKNHK Sbjct: 79 FPEHVAALQQHGIPTIDMVVVNLYPFQQTVAKEECSLEDAIENIDIGGPAMLRSSAKNHK 138 Query: 125 DVVVICDPTDYAGVLADLQAGGDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQH 184 DV+VICDPTDY GVLA+L++GGDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQH Sbjct: 139 DVIVICDPTDYEGVLAELKSGGDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQH 198 Query: 185 ATRSAYPETLNLHFEKVQDMRYGENPHQSAAFYRDVRKIDGALASYTQLQGKELSFNNIA 244 +TRSAYP TLNLHFEKVQDMRYGENPHQSAAFYRD++K+DGALA+YTQLQGKELSFNNIA Sbjct: 199 STRSAYPSTLNLHFEKVQDMRYGENPHQSAAFYRDIKKVDGALANYTQLQGKELSFNNIA 258 Query: 245 DADAAWECVKTFDAADTTACVIIKHANPCGVAVGGNPLEAYSKALQTDPTSAFGGIIAFN 304 DADAAWECVK+FD A ACVIIKHANPCGVA+G NPLEAYSKALQTDPTSAFGGIIAFN Sbjct: 259 DADAAWECVKSFDPATEAACVIIKHANPCGVAIGANPLEAYSKALQTDPTSAFGGIIAFN 318 Query: 305 RELDGAAAEAVAKQFVEVLIAPSFSAEAKKIFAAKQNVRLLEIPLGNGMNTHDFKRVGGG 364 RE+D AAAEAVAKQF+EVLIAPSFSAEAK+IFAAKQNVRLLEIPLG G+N +DFKRVGGG Sbjct: 319 REVDAAAAEAVAKQFLEVLIAPSFSAEAKQIFAAKQNVRLLEIPLGTGLNGYDFKRVGGG 378 Query: 365 LLVQSPDARNVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVGA 424 LLVQSPDA+NVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVGA Sbjct: 379 LLVQSPDAKNVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVGA 438 Query: 425 GQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATSVIHPGGSMRD 484 GQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGAT VIHPGGSMRD Sbjct: 439 GQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATCVIHPGGSMRD 498 Query: 485 QEVIDAANERDVVMLLTGTRHFRH 508 QEVIDAANERDVVMLLTGTRHFRH Sbjct: 499 QEVIDAANERDVVMLLTGTRHFRH 522 >D8IX65.1 D8IX65_HERSS Bifunctional purine biosynthesis protein purH Length = 523 Score = 949 bits (2452), Expect = 0.0, Method: Compositional matrix adjust. Identities = 464/504 (92%), Positives = 483/504 (95%) Query: 5 RHRQAAGRQWXSTGGTAKLLADNGVKVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 64 R A G STGGTAKLLADNGV VTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD Sbjct: 20 RALSAMGVNILSTGGTAKLLADNGVPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 79 Query: 65 FPEHVAALDKHGIPTIDMVVVNLYPFQQTIAKEECSLEDAIENIDIGGPAMLRSSAKNHK 124 FPEHVAAL +HGIPTIDMVVVNLYPFQQT+AKEECSLEDAIENIDIGGPAMLRSSAKNHK Sbjct: 80 FPEHVAALQQHGIPTIDMVVVNLYPFQQTVAKEECSLEDAIENIDIGGPAMLRSSAKNHK 139 Query: 125 DVVVICDPTDYAGVLADLQAGGDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQH 184 DV+VICDPTDY GVLA+L++GGDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQH Sbjct: 140 DVIVICDPTDYEGVLAELKSGGDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQH 199 Query: 185 ATRSAYPETLNLHFEKVQDMRYGENPHQSAAFYRDVRKIDGALASYTQLQGKELSFNNIA 244 +TRSAYP TLNLHFEKVQDMRYGENPHQSAAFYRD++K+DGALA+YTQLQGKELSFNNIA Sbjct: 200 STRSAYPSTLNLHFEKVQDMRYGENPHQSAAFYRDIKKVDGALANYTQLQGKELSFNNIA 259 Query: 245 DADAAWECVKTFDAADTTACVIIKHANPCGVAVGGNPLEAYSKALQTDPTSAFGGIIAFN 304 DADAAWECVK+FD A ACVIIKHANPCGVA+G NPLEAYSKALQTDPTSAFGGIIAFN Sbjct: 260 DADAAWECVKSFDPATEAACVIIKHANPCGVAIGANPLEAYSKALQTDPTSAFGGIIAFN 319 Query: 305 RELDGAAAEAVAKQFVEVLIAPSFSAEAKKIFAAKQNVRLLEIPLGNGMNTHDFKRVGGG 364 RE+D AAAEAVAKQF+EVLIAPSFSAEAK+IFAAKQNVRLLEIPLG G+N +DFKRVGGG Sbjct: 320 REVDAAAAEAVAKQFLEVLIAPSFSAEAKQIFAAKQNVRLLEIPLGTGLNGYDFKRVGGG 379 Query: 365 LLVQSPDARNVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVGA 424 LLVQSPDA+NVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVGA Sbjct: 380 LLVQSPDAKNVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVGA 439 Query: 425 GQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATSVIHPGGSMRD 484 GQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGAT VIHPGGSMRD Sbjct: 440 GQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATCVIHPGGSMRD 499 Query: 485 QEVIDAANERDVVMLLTGTRHFRH 508 QEVIDAANERDVVMLLTGTRHFRH Sbjct: 500 QEVIDAANERDVVMLLTGTRHFRH 523 >A6SUQ1.1 PUR9_JANMA Bifunctional purine biosynthesis protein purH Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase EC=2.1.2.3 EC=3.5.4.10 Length = 521 Score = 898 bits (2320), Expect = 0.0, Method: Compositional matrix adjust. Identities = 432/509 (84%), Positives = 464/509 (91%), Gaps = 4/509 (0%) Query: 1 LRARRHRQAAGRQWXSTGGTAKLLADNGVKVTEVADYTGFPEMLDGRVKTLHPKVHGGIL 60 L R G STGGTAKLLA+NG+ VTEVADYTGFPEMLDGRVKTLHPKVHGGIL Sbjct: 16 LEFARALSGMGVNILSTGGTAKLLAENGISVTEVADYTGFPEMLDGRVKTLHPKVHGGIL 75 Query: 61 ARRDFPEHVAALDKHGIPTIDMVVVNLYPFQQTIAKEECSLEDAIENIDIGGPAMLRSSA 120 ARRDF EHV+AL+KH IPTIDMVVVNLYPFQQT+A+E CSLEDAIENIDIGGPAMLRSSA Sbjct: 76 ARRDFAEHVSALEKHNIPTIDMVVVNLYPFQQTVAREHCSLEDAIENIDIGGPAMLRSSA 135 Query: 121 KNHKDVVVICDPTDYAGVLADLQAG-GDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLG 179 KNHKDV+VICDPTDY+ VL +L A G++ YE +F LAKKVFAHTAQYDGAITNYFTSLG Sbjct: 136 KNHKDVIVICDPTDYSQVLGELSANQGEVSYETKFTLAKKVFAHTAQYDGAITNYFTSLG 195 Query: 180 EDKQHATRSAYPETLNLHFEKVQDMRYGENPHQSAAFYRDVRKIDGALASYTQLQGKELS 239 DKQHATRS+YP TLNLHFEKVQ+MRYGENPHQSAAFYR+ GALA+YTQLQGKELS Sbjct: 196 ADKQHATRSSYPATLNLHFEKVQEMRYGENPHQSAAFYRESNPQVGALANYTQLQGKELS 255 Query: 240 FNNIADADAAWECVKTFDAADTTACVIIKHANPCGVAVGGNPLEAYSKALQTDPTSAFGG 299 +NNIADADAAWECVKTFD +ACVIIKHANPCGVAVG +PLEAYSKALQTDPTSAFGG Sbjct: 256 YNNIADADAAWECVKTFD---ESACVIIKHANPCGVAVGASPLEAYSKALQTDPTSAFGG 312 Query: 300 IIAFNRELDGAAAEAVAKQFVEVLIAPSFSAEAKKIFAAKQNVRLLEIPLGNGMNTHDFK 359 IIAFNRELDG AAEAVAKQFVEVLIAPSFS +AK+IFA KQNVRLLEIPLGN +N HDFK Sbjct: 313 IIAFNRELDGNAAEAVAKQFVEVLIAPSFSEKAKQIFAGKQNVRLLEIPLGNAVNAHDFK 372 Query: 360 RVGGGLLVQSPDARNVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMT 419 RVGGGLLVQSPDA+NV+LA++KVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFC NGMT Sbjct: 373 RVGGGLLVQSPDAKNVVLAELKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCANGMT 432 Query: 420 LGVGAGQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATSVIHPG 479 +GVGAGQMSRIDSARIASIKAQNAGL+L G+AVASDAFFPFRDGLDVVV AGATSVIHPG Sbjct: 433 MGVGAGQMSRIDSARIASIKAQNAGLSLVGTAVASDAFFPFRDGLDVVVAAGATSVIHPG 492 Query: 480 GSMRDQEVIDAANERDVVMLLTGTRHFRH 508 GSMRDQEVIDAA+E+ VVML+TGTRHFRH Sbjct: 493 GSMRDQEVIDAADEQGVVMLMTGTRHFRH 521 >A4G1U6.1 PUR9_HERAR Bifunctional purine biosynthesis protein purH Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase EC=2.1.2.3 EC=3.5.4.10 Length = 521 Score = 891 bits (2303), Expect = 0.0, Method: Compositional matrix adjust. Identities = 430/505 (85%), Positives = 461/505 (91%), Gaps = 4/505 (0%) Query: 5 RHRQAAGRQWXSTGGTAKLLADNGVKVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 64 R A G STGGTAKLLA+NG+ VTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD Sbjct: 20 RALSAMGVNILSTGGTAKLLAENGISVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 79 Query: 65 FPEHVAALDKHGIPTIDMVVVNLYPFQQTIAKEECSLEDAIENIDIGGPAMLRSSAKNHK 124 FPEHVAAL KH IPTIDMVVVNLYPFQQT+A+ ECSLEDAIENIDIGGPAMLRSSAKNHK Sbjct: 80 FPEHVAALSKHDIPTIDMVVVNLYPFQQTVARAECSLEDAIENIDIGGPAMLRSSAKNHK 139 Query: 125 DVVVICDPTDYAGVLADLQAG-GDLPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQ 183 DV+VICDP+DY+ VL +L G+ YE +FALAKKVFAHTAQYDGAITNYFTSLG DKQ Sbjct: 140 DVIVICDPSDYSLVLHELNTNNGEATYETKFALAKKVFAHTAQYDGAITNYFTSLGADKQ 199 Query: 184 HATRSAYPETLNLHFEKVQDMRYGENPHQSAAFYRDVRKIDGALASYTQLQGKELSFNNI 243 HATRS+YP TLNLHFEKVQ+MRYGENPHQSAAFYR+ GALA+Y QLQGKELS+NNI Sbjct: 200 HATRSSYPATLNLHFEKVQEMRYGENPHQSAAFYRESNPQAGALANYAQLQGKELSYNNI 259 Query: 244 ADADAAWECVKTFDAADTTACVIIKHANPCGVAVGGNPLEAYSKALQTDPTSAFGGIIAF 303 ADADAAWECVKTFD A ACVIIKHANPCGVAVG P EAYSKALQTDPTSAFGGIIAF Sbjct: 260 ADADAAWECVKTFDEA---ACVIIKHANPCGVAVGITPFEAYSKALQTDPTSAFGGIIAF 316 Query: 304 NRELDGAAAEAVAKQFVEVLIAPSFSAEAKKIFAAKQNVRLLEIPLGNGMNTHDFKRVGG 363 NRE+DG AAEAVAKQFVEVLIAPSF+ +AKKIFAAKQNVRLLEIPLG+ +N+HDFKRVGG Sbjct: 317 NREVDGNAAEAVAKQFVEVLIAPSFTEQAKKIFAAKQNVRLLEIPLGDAVNSHDFKRVGG 376 Query: 364 GLLVQSPDARNVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVG 423 GLLVQSPDA+NV LA++KVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFC NGMT+GVG Sbjct: 377 GLLVQSPDAKNVTLAELKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCANGMTMGVG 436 Query: 424 AGQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATSVIHPGGSMR 483 AGQMSRIDSARIA+IKAQNAGL+L G+AVASDAFFPFRDGLDVVV+AGATSVIHPGGSMR Sbjct: 437 AGQMSRIDSARIAAIKAQNAGLSLVGTAVASDAFFPFRDGLDVVVEAGATSVIHPGGSMR 496 Query: 484 DQEVIDAANERDVVMLLTGTRHFRH 508 DQEVIDAA+E +VMLLTGTRHFRH Sbjct: 497 DQEVIDAADEHGIVMLLTGTRHFRH 521 >Q1LRB3.1 PUR9_RALME Bifunctional purine biosynthesis protein purH Phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase EC=2.1.2.3 EC=3.5.4.10 Length = 524 Score = 832 bits (2148), Expect = 0.0, Method: Compositional matrix adjust. Identities = 398/505 (78%), Positives = 445/505 (88%), Gaps = 1/505 (0%) Query: 5 RHRQAAGRQWXSTGGTAKLLADNGVKVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 64 R A G STGGTAKLLA+ G+ VTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD Sbjct: 20 RELNALGVTLLSTGGTAKLLAEAGLPVTEVADYTGFPEMLDGRVKTLHPKVHGGILARRD 79 Query: 65 FPEHVAALDKHGIPTIDMVVVNLYPFQQTIAKEECSLEDAIENIDIGGPAMLRSSAKNHK 124 PEH+AAL +H IPTID++VVNLYPFQQT+AK++C+L DAIENIDIGGP MLRS+AKNH+ Sbjct: 80 LPEHMAALAEHNIPTIDLLVVNLYPFQQTVAKDDCTLPDAIENIDIGGPTMLRSAAKNHR 139 Query: 125 DVVVICDPTDYAGVLADLQAGGD-LPYEKRFALAKKVFAHTAQYDGAITNYFTSLGEDKQ 183 DV VI DP DYA VL +++A G+ + Y+ F LA KVFAHTAQYDGAITNY TSLG DK Sbjct: 140 DVTVIVDPADYAVVLGEMRANGNSVGYDTNFRLATKVFAHTAQYDGAITNYLTSLGADKS 199 Query: 184 HATRSAYPETLNLHFEKVQDMRYGENPHQSAAFYRDVRKIDGALASYTQLQGKELSFNNI 243 H RSAYP+TLNL FEKVQ+MRYGENPHQSAAFYRD++ DGALA+Y QLQGKELS+NNI Sbjct: 200 HQARSAYPQTLNLAFEKVQEMRYGENPHQSAAFYRDLKAFDGALANYVQLQGKELSYNNI 259 Query: 244 ADADAAWECVKTFDAADTTACVIIKHANPCGVAVGGNPLEAYSKALQTDPTSAFGGIIAF 303 ADADAAWECVK+FDAA++ ACVIIKHANPCGVAVG N LEAY KA +TD TSAFGGIIAF Sbjct: 260 ADADAAWECVKSFDAANSAACVIIKHANPCGVAVGANALEAYDKAFKTDSTSAFGGIIAF 319 Query: 304 NRELDGAAAEAVAKQFVEVLIAPSFSAEAKKIFAAKQNVRLLEIPLGNGMNTHDFKRVGG 363 N ELD AAA+AVAKQFVEVLIAPSFSA A+ +FAAKQNVRLLEIPLG G+N +D KRVGG Sbjct: 320 NVELDEAAAQAVAKQFVEVLIAPSFSAAARNVFAAKQNVRLLEIPLGKGVNQYDLKRVGG 379 Query: 364 GLLVQSPDARNVLLADVKVVSKKQPTPQQLQDLMFAWRVAKFVKSNAIVFCGNGMTLGVG 423 GLLVQ PDARNV ++++VV+++ PTP+++ DLMFAWRVAKFVKSNAIVFCGNGMTLGVG Sbjct: 380 GLLVQGPDARNVQPSELRVVTRRHPTPKEMDDLMFAWRVAKFVKSNAIVFCGNGMTLGVG 439 Query: 424 AGQMSRIDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATSVIHPGGSMR 483 AGQMSR+DSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGAT VI PGGSMR Sbjct: 440 AGQMSRVDSARIASIKAQNAGLTLAGSAVASDAFFPFRDGLDVVVDAGATCVIQPGGSMR 499 Query: 484 DQEVIDAANERDVVMLLTGTRHFRH 508 D EVI AA+ER + M+LTGTRHFRH Sbjct: 500 DDEVIAAADERGIAMVLTGTRHFRH 524