BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0047.p (396 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IWA8.1 D8IWA8_HERSS Transmembrane ribonucleoside reductase (Sm... 728 0.0 A4G8P9.1 A4G8P9_HERAR Ribonucleoside-diphosphate reductase subun... 712 0.0 A6T2C1.1 A6T2C1_JANMA Ribonucleoside-diphosphate reductase beta ... 709 0.0 F1VVG0.1 F1VVG0_9BURK Ribonucleotide reductase of class Ia (Aero... 689 0.0 Q1LIR7.1 Q1LIR7_RALME Ribonucleoside-diphosphate reductase beta ... 673 0.0 >D8IWA8.1 D8IWA8_HERSS Transmembrane ribonucleoside reductase (Small chain) protein EC=1.17.4.1 Length = 388 Score = 728 bits (1878), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/397 (89%), Positives = 363/397 (91%), Gaps = 10/397 (2%) Query: 1 MLSWDDEVKA-TPAPSAPHASQTPQPQLQSAAVNARPQFSDVALNPALVTKDEAPVDVTR 59 MLSWDDE K AP P+ QPQLQ A S+ ALNPAL+ + VD TR Sbjct: 1 MLSWDDEAKQPAQAPRTPNL----QPQLQPAFGQ-----SNAALNPALMAGNSEQVDTTR 51 Query: 60 RVNAADKRIINGHTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKDPNGLT 119 RVNAADKRIINGHTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWK+PNGLT Sbjct: 52 RVNAADKRIINGHTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKNPNGLT 111 Query: 120 EDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYIV 179 EDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYIV Sbjct: 112 EDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYIV 171 Query: 180 ESLGLDEAEIFNAYHEVKSIRDKDEFLIPFINTLTDPQFTTGTTENDQKLLKSLIVFACI 239 ESLGLDEAEIFNAYHEV SIRDKDEFLIPFI+TLTDP+F TGT ENDQKLLKSLIVFACI Sbjct: 172 ESLGLDEAEIFNAYHEVASIRDKDEFLIPFIDTLTDPEFKTGTMENDQKLLKSLIVFACI 231 Query: 240 MEGLFFYVGFTQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTVKMENPHLWTP 299 MEGLFFYVGFTQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTVKMENPHLWTP Sbjct: 232 MEGLFFYVGFTQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTVKMENPHLWTP 291 Query: 300 EFRNEIKSLFLSAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLDPLFAQ 359 EFR EIKSLFL AVELEYRYAEDTMPRGVLGLNAPMFK YLRFIANRRAQQIGLDPLFAQ Sbjct: 292 EFREEIKSLFLRAVELEYRYAEDTMPRGVLGLNAPMFKSYLRFIANRRAQQIGLDPLFAQ 351 Query: 360 EENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE 396 EENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL+WE Sbjct: 352 EENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE 388 >A4G8P9.1 A4G8P9_HERAR Ribonucleoside-diphosphate reductase subunit beta (Ribonucleotide reductase small subunit) EC=1.17.4.1 Length = 395 Score = 712 bits (1837), Expect = 0.0, Method: Compositional matrix adjust. Identities = 342/399 (85%), Positives = 365/399 (91%), Gaps = 7/399 (1%) Query: 1 MLSWDDEVKATPAPSAPHASQTPQPQLQSA--AVNARPQFSDVALNPALVT-KDEAPVDV 57 MLSWD+E K P+AP A T QP LQ A R Q DVAL+PA++ K A VD Sbjct: 1 MLSWDEEAK----PAAPQAQPTLQPALQQVRDAAAQRVQAQDVALDPAVMAGKPAATVDP 56 Query: 58 TRRVNAADKRIINGHTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKDPNG 117 TRR++AADKRIING TDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWK+PNG Sbjct: 57 TRRMDAADKRIINGKTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKNPNG 116 Query: 118 LTEDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQY 177 LT+DERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQY Sbjct: 117 LTDDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQY 176 Query: 178 IVESLGLDEAEIFNAYHEVKSIRDKDEFLIPFINTLTDPQFTTGTTENDQKLLKSLIVFA 237 IVESLGLDE EIFNAY+E++SIRDKD+FLIPFI+ LTDP FTTGTTENDQ LL+SLIVFA Sbjct: 177 IVESLGLDEGEIFNAYNEIESIRDKDQFLIPFIDVLTDPNFTTGTTENDQTLLRSLIVFA 236 Query: 238 CIMEGLFFYVGFTQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTVKMENPHLW 297 C+MEGLFFYVGF QILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINT+K+ENPHLW Sbjct: 237 CLMEGLFFYVGFAQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTIKLENPHLW 296 Query: 298 TPEFRNEIKSLFLSAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLDPLF 357 TP+FR+EIK+LFL AVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGL+P+F Sbjct: 297 TPQFRDEIKALFLRAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLEPMF 356 Query: 358 AQEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE 396 QEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE Sbjct: 357 EQEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE 395 >A6T2C1.1 A6T2C1_JANMA Ribonucleoside-diphosphate reductase beta chain EC=1.17.4.1 Length = 392 Score = 709 bits (1829), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/396 (86%), Positives = 363/396 (91%), Gaps = 4/396 (1%) Query: 1 MLSWDDEVKATPAPSAPHASQTPQPQLQSAAVNARPQFSDVALNPALVTKDEAPVDVTRR 60 MLSWD+EVK A + Q++ AA R Q DVAL+PALV KD A VD TRR Sbjct: 1 MLSWDEEVKPAAPAPALQPALQ---QVRDAAAQ-RLQTQDVALDPALVAKDAAAVDPTRR 56 Query: 61 VNAADKRIINGHTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKDPNGLTE 120 ++AADKR+ING TDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWK+PNGLT+ Sbjct: 57 MDAADKRVINGQTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKNPNGLTD 116 Query: 121 DERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYIVE 180 DERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYIVE Sbjct: 117 DERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYIVE 176 Query: 181 SLGLDEAEIFNAYHEVKSIRDKDEFLIPFINTLTDPQFTTGTTENDQKLLKSLIVFACIM 240 SLGLDE EIFNAY+EV+SIRDKD+FLIPFI TLTDP+F TGTTENDQKLL+SLIVFAC+M Sbjct: 177 SLGLDEGEIFNAYNEVESIRDKDQFLIPFIETLTDPEFKTGTTENDQKLLRSLIVFACLM 236 Query: 241 EGLFFYVGFTQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTVKMENPHLWTPE 300 EGLFFYVGF QILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINT+K+ENPHLWTP+ Sbjct: 237 EGLFFYVGFAQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTIKLENPHLWTPQ 296 Query: 301 FRNEIKSLFLSAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLDPLFAQE 360 FR EIK+LFL AVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGL+P+F QE Sbjct: 297 FREEIKTLFLRAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLEPMFEQE 356 Query: 361 ENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE 396 ENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE Sbjct: 357 ENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE 392 >F1VVG0.1 F1VVG0_9BURK Ribonucleotide reductase of class Ia (Aerobic), beta subunit Length = 416 Score = 689 bits (1779), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/396 (84%), Positives = 359/396 (90%), Gaps = 6/396 (1%) Query: 1 MLSWDDEVKATPAPSAPHASQTPQPQLQSAAVNARPQFSDVALNPALVTKDEAPVDVTRR 60 MLSWD+EV P+ +A L +A A +DVAL+P+LV + E D RR Sbjct: 27 MLSWDEEVTPAVNPAIRNAV------LPTAVTAATTAAADVALDPSLVPQAEPKADPARR 80 Query: 61 VNAADKRIINGHTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKDPNGLTE 120 +NAADKRIING+TDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWK PNGLT+ Sbjct: 81 MNAADKRIINGNTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKSPNGLTD 140 Query: 121 DERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYIVE 180 DERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYI E Sbjct: 141 DERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHAYQYITE 200 Query: 181 SLGLDEAEIFNAYHEVKSIRDKDEFLIPFINTLTDPQFTTGTTENDQKLLKSLIVFACIM 240 SLGLDEAEIFNAYHEVKSIRDKDEFLIPFI+ LTDP FTTGTT NDQKLLKSLIVF+C+M Sbjct: 201 SLGLDEAEIFNAYHEVKSIRDKDEFLIPFIDALTDPLFTTGTTINDQKLLKSLIVFSCLM 260 Query: 241 EGLFFYVGFTQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTVKMENPHLWTPE 300 EGLFFYVGF QILALGRQNKM+GAAEQYQYILRDESMHCNFGIDL+NT+KMENPHLWTPE Sbjct: 261 EGLFFYVGFAQILALGRQNKMVGAAEQYQYILRDESMHCNFGIDLVNTIKMENPHLWTPE 320 Query: 301 FRNEIKSLFLSAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLDPLFAQE 360 FR+EIK+LFL+AVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGL+P+F E Sbjct: 321 FRDEIKALFLTAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLEPMFENE 380 Query: 361 ENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE 396 ENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL+WE Sbjct: 381 ENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE 416 >Q1LIR7.1 Q1LIR7_RALME Ribonucleoside-diphosphate reductase beta subunit EC=1.17.4.1 Length = 395 Score = 673 bits (1737), Expect = 0.0, Method: Compositional matrix adjust. Identities = 325/402 (80%), Positives = 348/402 (86%), Gaps = 13/402 (3%) Query: 1 MLSWDDEVKATPAPSAPHASQTPQPQLQSAAV----NARPQFSDVALNPALVTKD--EAP 54 MLSWDD+V+ATP + PQP LQ AAV + + A P ++ + A Sbjct: 1 MLSWDDDVQATPQAA-------PQPALQPAAVATSVDQQGVLPPAATEPGILGNNPNAAA 53 Query: 55 VDVTRRVNAADKRIINGHTDVNQLVPFKYKWAWDKYLAGCANHWMPQEINMQRDIELWKD 114 TRRVNAADKR+ING TDVNQLVPFKYKWAW+KYLAGCANHWMPQEINM RDI LWKD Sbjct: 54 AQSTRRVNAADKRVINGATDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKD 113 Query: 115 PNGLTEDERRLVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQYLLRQAFEEAIHTHA 174 PNGLTEDERR++KRNLGFFVTADSLAANNIVLGTYR ITAPECRQYLLRQAFEEAIHTHA Sbjct: 114 PNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPECRQYLLRQAFEEAIHTHA 173 Query: 175 YQYIVESLGLDEAEIFNAYHEVKSIRDKDEFLIPFINTLTDPQFTTGTTENDQKLLKSLI 234 YQYIVESLGL+EAEIFNAYHEV+SIRDKDEFLIPFI+TLTDP F TGT ENDQKLLKSLI Sbjct: 174 YQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLI 233 Query: 235 VFACIMEGLFFYVGFTQILALGRQNKMMGAAEQYQYILRDESMHCNFGIDLINTVKMENP 294 VFACIMEGLFFYVGFTQILA+GRQNKM GAAEQYQYILRDES+HCNFGIDLIN +K+ENP Sbjct: 234 VFACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENP 293 Query: 295 HLWTPEFRNEIKSLFLSAVELEYRYAEDTMPRGVLGLNAPMFKGYLRFIANRRAQQIGLD 354 HLWT EF+ EI LF AV+LEYRYAEDTMPRGVLGLNAPMFKGYLRFI NRR QQIGLD Sbjct: 294 HLWTAEFKAEITELFKKAVDLEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLD 353 Query: 355 PLFAQEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALNWE 396 LF EENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL+W+ Sbjct: 354 QLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWD 395