BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0002.0044.p (458 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IWA7.1 D8IWA7_HERSS Ribonucleoside-diphosphate reductase EC=1.... 810 0.0 A6T2C2.1 A6T2C2_JANMA Ribonucleoside-diphosphate reductase EC=1.... 790 0.0 A4G8Q0.1 A4G8Q0_HERAR Ribonucleoside-diphosphate reductase EC=1.... 768 0.0 F1VVF9.1 F1VVF9_9BURK Ribonucleotide reductase of class Ia (Aero... 739 0.0 F2L907.1 F2L907_BURGA Ribonucleotide-diphosphate reductase alpha... 653 0.0 >D8IWA7.1 D8IWA7_HERSS Ribonucleoside-diphosphate reductase EC=1.17.4.1 Length = 994 Score = 810 bits (2093), Expect = 0.0, Method: Compositional matrix adjust. Identities = 397/458 (86%), Positives = 424/458 (92%), Gaps = 3/458 (0%) Query: 1 VRSTQEISAKSPTDFGVIPTAGNHDETTSSQLIKPASGLGEYRIIRRNGAVVGFEPSKIS 60 +RSTQEIS KSP +GV +A S + +GLGEYRIIRRNGAVVGFEPSKIS Sbjct: 1 MRSTQEISVKSPAAYGV--SAELEGSAESQAVASQTAGLGEYRIIRRNGAVVGFEPSKIS 58 Query: 61 IAVTKAFLAVNGGQGAASARVREMVEQLTTSVVSALVRRQPTGGTFHIEDIQDQVELALM 120 IAVTKAFLAVNGGQGAASARVREMVEQLTT+VVSALVRRQPTGGTFHIEDIQDQVELALM Sbjct: 59 IAVTKAFLAVNGGQGAASARVREMVEQLTTNVVSALVRRQPTGGTFHIEDIQDQVELALM 118 Query: 121 RSGEHDVARAYVLYRAKRMEERAQQQGSAAKTDFAAPQLHVVEDGQSRLLDLDEVRTLIT 180 RSGEHDVARAYVLYRAKRMEERAQQ G+A KT+ APQLHV EDGQSR LD++EVR+LI Sbjct: 119 RSGEHDVARAYVLYRAKRMEERAQQ-GAATKTEVVAPQLHVTEDGQSRPLDINEVRSLIA 177 Query: 181 AACVGLEKHVDADAILAETVKNLYDGVPVEELHKSAILAARALMEKDPAYSQVTARLLMH 240 AACVGLE+HVD +AILAETVKNLYDGVPVEEL+KSAILAARALMEKDPAYSQVT+RLLMH Sbjct: 178 AACVGLEEHVDGEAILAETVKNLYDGVPVEELYKSAILAARALMEKDPAYSQVTSRLLMH 237 Query: 241 TIRKEVFGKEVAQADAPAEYLDYFAKYIKKGIAADLLDSKLAQFDLVKLAEAIKPERDLQ 300 TIRKEVFGKEVAQADAPAEYL+YF +Y+KKGI A+LLD+KLAQFDL KLA A+KPERDLQ Sbjct: 238 TIRKEVFGKEVAQADAPAEYLEYFPQYVKKGIEAELLDTKLAQFDLAKLAAALKPERDLQ 297 Query: 301 FGYLGLQTLYDRYFLHIQGTRIEMPQAFYMRVAMGLSLNEINREERTIEFYNLLSSFDFM 360 FGY+GLQTLYDRYFLHI GTRIEMPQAFYMRVAMGL+LNEI+RE R IEFY+LLSSFDFM Sbjct: 298 FGYIGLQTLYDRYFLHIGGTRIEMPQAFYMRVAMGLALNEIDRETRAIEFYDLLSSFDFM 357 Query: 361 SSTPTLFNSGTLRSQLSSCYLTTVADDLDGIYEAIKENALLAKYAGGLGNDWTPVRSLGA 420 SSTPTLFNSGT RSQLSSCYLTTVADDLDGIYEAIKENALLAK+AGGLGNDWTPVR+LGA Sbjct: 358 SSTPTLFNSGTQRSQLSSCYLTTVADDLDGIYEAIKENALLAKFAGGLGNDWTPVRALGA 417 Query: 421 HIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCA 458 HIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCA Sbjct: 418 HIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCA 455 >A6T2C2.1 A6T2C2_JANMA Ribonucleoside-diphosphate reductase EC=1.17.4.1 Length = 963 Score = 790 bits (2041), Expect = 0.0, Method: Compositional matrix adjust. Identities = 390/456 (85%), Positives = 416/456 (91%), Gaps = 6/456 (1%) Query: 3 STQEISAKSPTDFGVIPTAGNHDETTSSQLIKPASGLGEYRIIRRNGAVVGFEPSKISIA 62 STQEISAKSPT+ G I + T+++Q + GLGE+RIIRRNGAVVGFEPSKISIA Sbjct: 3 STQEISAKSPTEIGNIASLAVAPSTSNTQTV----GLGEHRIIRRNGAVVGFEPSKISIA 58 Query: 63 VTKAFLAVNGGQGAASARVREMVEQLTTSVVSALVRRQPTGGTFHIEDIQDQVELALMRS 122 VTKAFLAVNGGQGAASARVRE+VEQLT++VV+ALVRRQP GGTFHIEDIQDQVELALMRS Sbjct: 59 VTKAFLAVNGGQGAASARVRELVEQLTSNVVNALVRRQPAGGTFHIEDIQDQVELALMRS 118 Query: 123 GEHDVARAYVLYRAKRMEERAQQQGSAAKTDFAAPQLHVVEDGQSRLLDLDEVRTLITAA 182 GEHDVARAYVLYRAKRMEERAQQQ AAK QLHV EDGQ R LD+++VR LI AA Sbjct: 119 GEHDVARAYVLYRAKRMEERAQQQ--AAKPVAETHQLHVTEDGQRRPLDMNQVRDLINAA 176 Query: 183 CVGLEKHVDADAILAETVKNLYDGVPVEELHKSAILAARALMEKDPAYSQVTARLLMHTI 242 C+GLEKHVDA+AIL ETVKNLYDGVPVEELHKSAILAARALMEKDPAYS VTARLLMHTI Sbjct: 177 CIGLEKHVDAEAILHETVKNLYDGVPVEELHKSAILAARALMEKDPAYSTVTARLLMHTI 236 Query: 243 RKEVFGKEVAQADAPAEYLDYFAKYIKKGIAADLLDSKLAQFDLVKLAEAIKPERDLQFG 302 RKEVFG EVAQADAPA+YL+YF K+IKKGI A+LLD+KL QFDL KL +A+ PERDLQFG Sbjct: 237 RKEVFGLEVAQADAPAQYLEYFPKFIKKGIEAELLDAKLGQFDLKKLGDALVPERDLQFG 296 Query: 303 YLGLQTLYDRYFLHIQGTRIEMPQAFYMRVAMGLSLNEINREERTIEFYNLLSSFDFMSS 362 YLGLQTLYDRYFLHI+ TRIEMPQAFYMRVAMGL+LNEINREER IEFYNLLSSFDFMSS Sbjct: 297 YLGLQTLYDRYFLHIRDTRIEMPQAFYMRVAMGLALNEINREERAIEFYNLLSSFDFMSS 356 Query: 363 TPTLFNSGTLRSQLSSCYLTTVADDLDGIYEAIKENALLAKYAGGLGNDWTPVRSLGAHI 422 TPTLFNSGT RSQLSSCYLTTVADDLDGIYEAIKENALLAKYAGGLGNDWTPVRSLGAHI Sbjct: 357 TPTLFNSGTQRSQLSSCYLTTVADDLDGIYEAIKENALLAKYAGGLGNDWTPVRSLGAHI 416 Query: 423 KGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCA 458 KGTNG+SQGVVPFLKVVNDTAVAVNQGGKRKGAVCA Sbjct: 417 KGTNGRSQGVVPFLKVVNDTAVAVNQGGKRKGAVCA 452 >A4G8Q0.1 A4G8Q0_HERAR Ribonucleoside-diphosphate reductase EC=1.17.4.1 Length = 966 Score = 768 bits (1984), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/456 (83%), Positives = 408/456 (89%), Gaps = 5/456 (1%) Query: 3 STQEISAKSPTDFGVIPTAGNHDETTSSQLIKPASGLGEYRIIRRNGAVVGFEPSKISIA 62 STQE S +SPT+ I T S ++ LG+YRI+RRNGAVVGFEPSKISIA Sbjct: 3 STQETSGQSPTEISNIAPLAVAASTPSVN----SAALGDYRILRRNGAVVGFEPSKISIA 58 Query: 63 VTKAFLAVNGGQGAASARVREMVEQLTTSVVSALVRRQPTGGTFHIEDIQDQVELALMRS 122 VTKAFLAVNGGQGAASARVRE+VEQLTT+VV+AL+RRQP GGTFHIEDIQDQVELALMRS Sbjct: 59 VTKAFLAVNGGQGAASARVRELVEQLTTNVVNALMRRQPAGGTFHIEDIQDQVELALMRS 118 Query: 123 GEHDVARAYVLYRAKRMEERAQQQGSAAKTDFAAPQLHVVEDGQSRLLDLDEVRTLITAA 182 GEHDVARAYVLYR KRMEERAQQQ + + QLHV E+GQ R LD+++VR LITAA Sbjct: 119 GEHDVARAYVLYRFKRMEERAQQQAAKPVVE-TEHQLHVTENGQRRPLDMNQVRDLITAA 177 Query: 183 CVGLEKHVDADAILAETVKNLYDGVPVEELHKSAILAARALMEKDPAYSQVTARLLMHTI 242 C+GLEKHVDADAIL ETVKNLYDGVPVEELHKSAILAARALMEKDPAYS VTARLLMHTI Sbjct: 178 CIGLEKHVDADAILRETVKNLYDGVPVEELHKSAILAARALMEKDPAYSTVTARLLMHTI 237 Query: 243 RKEVFGKEVAQADAPAEYLDYFAKYIKKGIAADLLDSKLAQFDLVKLAEAIKPERDLQFG 302 RKEVFG+EVAQA+APAEYL YFA++IKKGIAA+LLD+KL +FDL KLA+A+KPERDLQFG Sbjct: 238 RKEVFGREVAQANAPAEYLVYFAEFIKKGIAAELLDAKLGEFDLKKLADALKPERDLQFG 297 Query: 303 YLGLQTLYDRYFLHIQGTRIEMPQAFYMRVAMGLSLNEINREERTIEFYNLLSSFDFMSS 362 YLGLQTLYDRYFLHI RIEMPQAFYMRVAMGL+LNE NREER IEFYNLLSSFDFMSS Sbjct: 298 YLGLQTLYDRYFLHIADQRIEMPQAFYMRVAMGLALNEANREERAIEFYNLLSSFDFMSS 357 Query: 363 TPTLFNSGTLRSQLSSCYLTTVADDLDGIYEAIKENALLAKYAGGLGNDWTPVRSLGAHI 422 TPTLFNSGT RSQLSSCYLTTVADDL GIY+AIKENALLAKYAGGLGNDWTPVRSLGAHI Sbjct: 358 TPTLFNSGTQRSQLSSCYLTTVADDLGGIYDAIKENALLAKYAGGLGNDWTPVRSLGAHI 417 Query: 423 KGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCA 458 KGTNG+SQGVVPFLKVVNDTAVAVNQGGKRKGAVCA Sbjct: 418 KGTNGRSQGVVPFLKVVNDTAVAVNQGGKRKGAVCA 453 >F1VVF9.1 F1VVF9_9BURK Ribonucleotide reductase of class Ia (Aerobic), alpha subunit Length = 969 Score = 739 bits (1909), Expect = 0.0, Method: Compositional matrix adjust. Identities = 359/422 (85%), Positives = 388/422 (91%), Gaps = 2/422 (0%) Query: 37 SGLGEYRIIRRNGAVVGFEPSKISIAVTKAFLAVNGGQGAASARVREMVEQLTTSVVSAL 96 + L +YRI+RRNGAVV FEPSKISIAVTKAFLAVNGGQGAASARVRE+VEQLT +VV+AL Sbjct: 33 AALADYRILRRNGAVVAFEPSKISIAVTKAFLAVNGGQGAASARVRELVEQLTATVVAAL 92 Query: 97 VRRQPTGGTFHIEDIQDQVELALMRSGEHDVARAYVLYRAKRMEERAQQQGSAAKTDFAA 156 VRRQP GGTFHIEDIQDQVELALMRSGEHDVARAYVLYRAKRMEERA QQ AA+ A+ Sbjct: 93 VRRQPAGGTFHIEDIQDQVELALMRSGEHDVARAYVLYRAKRMEERALQQ--AARPAAAS 150 Query: 157 PQLHVVEDGQSRLLDLDEVRTLITAACVGLEKHVDADAILAETVKNLYDGVPVEELHKSA 216 QLHV EDGQ RLLD+ +V LI AAC+GLEKHVDA+AI AETVKNLYDGVPVEELHKSA Sbjct: 151 VQLHVTEDGQRRLLDMQQVHKLIDAACIGLEKHVDANAIFAETVKNLYDGVPVEELHKSA 210 Query: 217 ILAARALMEKDPAYSQVTARLLMHTIRKEVFGKEVAQADAPAEYLDYFAKYIKKGIAADL 276 ILAARALMEKDPAY+ VTAR+LMH IRKEVFGKEVAQADA A YL+YF ++I GIAA+L Sbjct: 211 ILAARALMEKDPAYTTVTARILMHVIRKEVFGKEVAQADAQAHYLEYFPQFIHNGIAAEL 270 Query: 277 LDSKLAQFDLVKLAEAIKPERDLQFGYLGLQTLYDRYFLHIQGTRIEMPQAFYMRVAMGL 336 LD+KLA FDL +LA+A+ P+RDLQFGY+GLQTLYDRYFLHI+ RIEMPQAFYMRVAMGL Sbjct: 271 LDAKLAGFDLDRLAKALVPDRDLQFGYIGLQTLYDRYFLHIRDIRIEMPQAFYMRVAMGL 330 Query: 337 SLNEINREERTIEFYNLLSSFDFMSSTPTLFNSGTLRSQLSSCYLTTVADDLDGIYEAIK 396 +LNE REER IEFYNLLSSFDFMSSTPTLFNSGTLRSQLSSCYLTTVADDL+GIY+AIK Sbjct: 331 ALNEAKREERAIEFYNLLSSFDFMSSTPTLFNSGTLRSQLSSCYLTTVADDLEGIYDAIK 390 Query: 397 ENALLAKYAGGLGNDWTPVRSLGAHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAV 456 +NALLAKYAGGLGNDWTPVRSLGAHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAV Sbjct: 391 DNALLAKYAGGLGNDWTPVRSLGAHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAV 450 Query: 457 CA 458 CA Sbjct: 451 CA 452 >F2L907.1 F2L907_BURGA Ribonucleotide-diphosphate reductase alpha subunit Length = 993 Score = 653 bits (1685), Expect = 0.0, Method: Compositional matrix adjust. Identities = 313/426 (73%), Positives = 362/426 (84%), Gaps = 1/426 (0%) Query: 33 IKPASGLGEYRIIRRNGAVVGFEPSKISIAVTKAFLAVNGGQGAASARVREMVEQLTTSV 92 + P + +Y++IRRNG+VV FEPSKI+IAVTKAFLAVNGGQGAASARVRE+VEQLT SV Sbjct: 29 LAPQATFADYKVIRRNGSVVAFEPSKIAIAVTKAFLAVNGGQGAASARVRELVEQLTQSV 88 Query: 93 VSALVRRQPTGGTFHIEDIQDQVELALMRSGEHDVARAYVLYRAKRMEERAQQQGSAAKT 152 V AL+R +P GGTFHIEDIQDQVELALMR GEH+VARAYVLYR KR ERA Sbjct: 89 VRALLRSRPNGGTFHIEDIQDQVELALMRGGEHNVARAYVLYREKRHLERAHSDAPVETP 148 Query: 153 DFAAPQLHVVEDGQSRLLDLDEVRTLITAACVGLEKHVDADAILAETVKNLYDGVPVEEL 212 D + L V + G SR LD+ + L+ AAC GL V+ D I+AETVKNLYDGVP+ ++ Sbjct: 149 D-GSSGLTVTDKGVSRPLDMKALHGLVAAACEGLGSAVNPDPIVAETVKNLYDGVPLSQV 207 Query: 213 HKSAILAARALMEKDPAYSQVTARLLMHTIRKEVFGKEVAQADAPAEYLDYFAKYIKKGI 272 + SAILAAR ++EKDPAYSQVTAR+L+HTIR+E+ G+EVAQ + A Y +YF +++K+G+ Sbjct: 208 YDSAILAARTMIEKDPAYSQVTARILLHTIRREILGEEVAQGEMQARYAEYFPQFLKRGV 267 Query: 273 AADLLDSKLAQFDLVKLAEAIKPERDLQFGYLGLQTLYDRYFLHIQGTRIEMPQAFYMRV 332 A+LLD KL QFDLV+L EA+ RDLQFGYLGLQTLYDRYFLH++GTRIEMPQAFYMRV Sbjct: 268 EAELLDDKLLQFDLVRLGEALDASRDLQFGYLGLQTLYDRYFLHVEGTRIEMPQAFYMRV 327 Query: 333 AMGLSLNEINREERTIEFYNLLSSFDFMSSTPTLFNSGTLRSQLSSCYLTTVADDLDGIY 392 AMGL+LNEI+RE R IEFYN+LSSFDFMSSTPTLFNSGT RSQLSSCYLTTVADDLDGIY Sbjct: 328 AMGLALNEIDREARAIEFYNVLSSFDFMSSTPTLFNSGTRRSQLSSCYLTTVADDLDGIY 387 Query: 393 EAIKENALLAKYAGGLGNDWTPVRSLGAHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKR 452 EA+KENALL+K+AGGLGNDWT VR+LG+HIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKR Sbjct: 388 EALKENALLSKFAGGLGNDWTRVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKR 447 Query: 453 KGAVCA 458 KGAVCA Sbjct: 448 KGAVCA 453