BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0082.p (374 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IU53.1 D8IU53_HERSS Quinolinate synthase A EC=2.5.1.72 709 0.0 A6SZJ3.1 A6SZJ3_JANMA Quinolinate synthase 661 0.0 Q0K7A8.1 Q0K7A8_CUPNH Quinolinate synthase A EC=2.5.1.72 650 0.0 B3R6E0.1 B3R6E0_CUPTR Quinolinate synthase A EC=2.5.1.72 650 0.0 Q46XN5.1 Q46XN5_CUPPJ Quinolinate synthase A EC=2.5.1.72 648 0.0 >D8IU53.1 D8IU53_HERSS Quinolinate synthase A EC=2.5.1.72 Length = 379 Score = 709 bits (1829), Expect = 0.0, Method: Compositional matrix adjust. Identities = 338/373 (90%), Positives = 354/373 (94%) Query: 2 KVVEFERPQMETGSSCTANAWAKVPATPTADERQALKARIRQLLKEKQAVLVAHYYVDGD 61 KVVEFERPQMETG SCTANAWAKVPATP+ +ER LKARIRQLLKEKQAVLVAHYYVDGD Sbjct: 7 KVVEFERPQMETGGSCTANAWAKVPATPSPEERAQLKARIRQLLKEKQAVLVAHYYVDGD 66 Query: 62 LQDLAEETGGCVSDSLEMARFGRDHAAQTLVVAGVRFMGETAKILSPEKRILMPDLDATC 121 LQDLAEETGGCVSDSLEMARFGRDHAAQTLVVAGVRFMGETAKILSPEKRILMPDL+ATC Sbjct: 67 LQDLAEETGGCVSDSLEMARFGRDHAAQTLVVAGVRFMGETAKILSPEKRILMPDLEATC 126 Query: 122 SLDLGCPTDEFNAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLDIVKHLHAQGKKI 181 SLDLGCP DEF AFCD HPDRTVVVYANTSAAVKARADWMVTS IGL+IV+HLHAQGKKI Sbjct: 127 SLDLGCPADEFAAFCDQHPDRTVVVYANTSAAVKARADWMVTSGIGLEIVQHLHAQGKKI 186 Query: 182 LWAPDKHLGGYIQKQTGADMLLWQGSCLVHDEFKGVELELLRKEYPKALILVHPESPEGV 241 LWAPDKHLG YIQKQTGADMLLWQGSCLVHDEFKGVELEL+R E+P AL+LVHPESPE V Sbjct: 187 LWAPDKHLGSYIQKQTGADMLLWQGSCLVHDEFKGVELELMRAEHPDALVLVHPESPEAV 246 Query: 242 VAQADVIGSTSQLIAAVQSSDAKEFIVATDNGILHKMRAAAPGKVFIDAPTAGNSATCKS 301 VAQADVIGSTSQLIAAVQ+SDA FIVATDNGILHKMRAAAPGK FIDAPTAGNSATCKS Sbjct: 247 VAQADVIGSTSQLIAAVQASDAPAFIVATDNGILHKMRAAAPGKRFIDAPTAGNSATCKS 306 Query: 302 CAHCPWMAMNGLQNLLHVLETGSNEIHVDPAIGRKAVVCIDRMLDFAAQKKANVRPTGAL 361 CAHCPWMAMNGLQNLLHVLETG+NEIHVDPA+G++AVVCIDRMLDFAAQ+KA VRP+ L Sbjct: 307 CAHCPWMAMNGLQNLLHVLETGANEIHVDPAVGKQAVVCIDRMLDFAAQRKAKVRPSARL 366 Query: 362 ENEQTLFAGIGPA 374 E+EQ LFAGIGPA Sbjct: 367 EDEQQLFAGIGPA 379 >A6SZJ3.1 A6SZJ3_JANMA Quinolinate synthase Length = 446 Score = 661 bits (1705), Expect = 0.0, Method: Compositional matrix adjust. Identities = 311/374 (83%), Positives = 338/374 (90%) Query: 1 MKVVEFERPQMETGSSCTANAWAKVPATPTADERQALKARIRQLLKEKQAVLVAHYYVDG 60 +K VEFERP M++G+SCTA AWA+ PA P+ +E+ ALK RI++LLKE++AVLVAHYYVD Sbjct: 73 IKTVEFERPAMQSGTSCTAQAWARTPAAPSPEEKIALKERIKRLLKEREAVLVAHYYVDS 132 Query: 61 DLQDLAEETGGCVSDSLEMARFGRDHAAQTLVVAGVRFMGETAKILSPEKRILMPDLDAT 120 DLQDLAEETGGCVSDSLEMARFGRDH A+TLVVAGV+FMGETAKILSPEK ILMPDLDAT Sbjct: 133 DLQDLAEETGGCVSDSLEMARFGRDHPAKTLVVAGVKFMGETAKILSPEKTILMPDLDAT 192 Query: 121 CSLDLGCPTDEFNAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLDIVKHLHAQGKK 180 CSLDLGCPTDEF+AFCDAHPDR VVVYANTSAAVKARADWMVTSSIGL IV HLHAQGKK Sbjct: 193 CSLDLGCPTDEFSAFCDAHPDRVVVVYANTSAAVKARADWMVTSSIGLKIVAHLHAQGKK 252 Query: 181 ILWAPDKHLGGYIQKQTGADMLLWQGSCLVHDEFKGVELELLRKEYPKALILVHPESPEG 240 ILWAPDKHLGGYIQKQTGADMLLWQGSCLVHDEFK +ELELL+KE+P A +LVHPESP Sbjct: 253 ILWAPDKHLGGYIQKQTGADMLLWQGSCLVHDEFKSIELELLKKEHPLAKVLVHPESPAS 312 Query: 241 VVAQADVIGSTSQLIAAVQSSDAKEFIVATDNGILHKMRAAAPGKVFIDAPTAGNSATCK 300 VVA AD +GSTSQLI A Q+ DA EFIVATDNGILHKM+AAAPGK+FIDAPTAGNSATCK Sbjct: 313 VVALADAVGSTSQLIHAAQTMDAPEFIVATDNGILHKMKAAAPGKIFIDAPTAGNSATCK 372 Query: 301 SCAHCPWMAMNGLQNLLHVLETGSNEIHVDPAIGRKAVVCIDRMLDFAAQKKANVRPTGA 360 SCAHCPWMAMNGLQNL VLE+G NEIHVDP IGRKA VCIDRMLDFAA +KANVRP+ Sbjct: 373 SCAHCPWMAMNGLQNLADVLESGRNEIHVDPEIGRKATVCIDRMLDFAAAEKANVRPSSD 432 Query: 361 LENEQTLFAGIGPA 374 L EQ LF+GIGPA Sbjct: 433 LAKEQKLFSGIGPA 446 >Q0K7A8.1 Q0K7A8_CUPNH Quinolinate synthase A EC=2.5.1.72 Length = 384 Score = 650 bits (1677), Expect = 0.0, Method: Compositional matrix adjust. Identities = 312/379 (82%), Positives = 332/379 (87%), Gaps = 5/379 (1%) Query: 1 MKVVEFERPQME-----TGSSCTANAWAKVPATPTADERQALKARIRQLLKEKQAVLVAH 55 +K VEFE+P + TGSSC A+AWAKVP T DERQ+LK RIR+LLKE+ AVLVAH Sbjct: 6 IKTVEFEKPNLADAENATGSSCVAHAWAKVPPVLTPDERQSLKTRIRRLLKERNAVLVAH 65 Query: 56 YYVDGDLQDLAEETGGCVSDSLEMARFGRDHAAQTLVVAGVRFMGETAKILSPEKRILMP 115 YYVD DLQDLAEETGGCVSDSLEMARFGRDH A+TLVVAGVRFMGETAKILSPEK +LMP Sbjct: 66 YYVDADLQDLAEETGGCVSDSLEMARFGRDHEARTLVVAGVRFMGETAKILSPEKTVLMP 125 Query: 116 DLDATCSLDLGCPTDEFNAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLDIVKHLH 175 DLDATCSLDLGCP DEF AFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGL IV+HLH Sbjct: 126 DLDATCSLDLGCPADEFAAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLKIVEHLH 185 Query: 176 AQGKKILWAPDKHLGGYIQKQTGADMLLWQGSCLVHDEFKGVELELLRKEYPKALILVHP 235 AQGKKILWAPDKHLG YIQKQTGADMLLWQGSCLVHDEFKG+EL+LLR+E+P A ILVHP Sbjct: 186 AQGKKILWAPDKHLGSYIQKQTGADMLLWQGSCLVHDEFKGIELDLLRREFPNAKILVHP 245 Query: 236 ESPEGVVAQADVIGSTSQLIAAVQSSDAKEFIVATDNGILHKMRAAAPGKVFIDAPTAGN 295 ESPE VVAQADV+GSTSQLI A Q DA EFIVATDNGILHKMR AAPGK FI+APTAGN Sbjct: 246 ESPENVVAQADVVGSTSQLIEAAQKLDATEFIVATDNGILHKMRMAAPGKHFIEAPTAGN 305 Query: 296 SATCKSCAHCPWMAMNGLQNLLHVLETGSNEIHVDPAIGRKAVVCIDRMLDFAAQKKANV 355 SATCKSCAHCPWMAMN L NL VLETG NEIHVDP IGR+AV CI+RMLDFAA +K NV Sbjct: 306 SATCKSCAHCPWMAMNALTNLAEVLETGRNEIHVDPVIGRQAVTCINRMLDFAAAQKRNV 365 Query: 356 RPTGALENEQTLFAGIGPA 374 RP+ L EQ LF GIGPA Sbjct: 366 RPSADLAKEQALFKGIGPA 384 >B3R6E0.1 B3R6E0_CUPTR Quinolinate synthase A EC=2.5.1.72 Length = 384 Score = 650 bits (1676), Expect = 0.0, Method: Compositional matrix adjust. Identities = 312/379 (82%), Positives = 333/379 (87%), Gaps = 5/379 (1%) Query: 1 MKVVEFERP-----QMETGSSCTANAWAKVPATPTADERQALKARIRQLLKEKQAVLVAH 55 +K VEFE+P Q G+SC A+AWAKVP + DERQ+LKARIR+LLKE+ AVLVAH Sbjct: 6 IKTVEFEKPNLAGAQNAAGASCVAHAWAKVPPVLSPDERQSLKARIRRLLKERNAVLVAH 65 Query: 56 YYVDGDLQDLAEETGGCVSDSLEMARFGRDHAAQTLVVAGVRFMGETAKILSPEKRILMP 115 YYVD DLQDLAEETGGCVSDSLEMARFGRDH A+TLVVAGVRFMGETAKILSPEK +LMP Sbjct: 66 YYVDADLQDLAEETGGCVSDSLEMARFGRDHEARTLVVAGVRFMGETAKILSPEKTVLMP 125 Query: 116 DLDATCSLDLGCPTDEFNAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLDIVKHLH 175 DLDATCSLDLGCP DEF AFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGL IV+HLH Sbjct: 126 DLDATCSLDLGCPADEFAAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLKIVEHLH 185 Query: 176 AQGKKILWAPDKHLGGYIQKQTGADMLLWQGSCLVHDEFKGVELELLRKEYPKALILVHP 235 AQGKKILWAPDKHLG YIQKQTGADMLLWQGSCLVHDEFKG+EL+LLR+E+P A ILVHP Sbjct: 186 AQGKKILWAPDKHLGSYIQKQTGADMLLWQGSCLVHDEFKGIELDLLRREFPNAKILVHP 245 Query: 236 ESPEGVVAQADVIGSTSQLIAAVQSSDAKEFIVATDNGILHKMRAAAPGKVFIDAPTAGN 295 ESPE VVAQADV+GSTSQLI A Q DA EFIVATDNGILHKMR AAPGK FI+APTAGN Sbjct: 246 ESPENVVAQADVVGSTSQLIEAAQKLDATEFIVATDNGILHKMRMAAPGKHFIEAPTAGN 305 Query: 296 SATCKSCAHCPWMAMNGLQNLLHVLETGSNEIHVDPAIGRKAVVCIDRMLDFAAQKKANV 355 SATCKSCAHCPWMAMN L NL VLETG NEIHVDP IGR+AV CI+RMLDFAA +K NV Sbjct: 306 SATCKSCAHCPWMAMNALTNLAEVLETGRNEIHVDPVIGRQAVTCINRMLDFAAAQKRNV 365 Query: 356 RPTGALENEQTLFAGIGPA 374 RP+ L NEQ LF GIGPA Sbjct: 366 RPSADLANEQALFQGIGPA 384 >Q46XN5.1 Q46XN5_CUPPJ Quinolinate synthase A EC=2.5.1.72 Length = 384 Score = 648 bits (1672), Expect = 0.0, Method: Compositional matrix adjust. Identities = 312/379 (82%), Positives = 333/379 (87%), Gaps = 5/379 (1%) Query: 1 MKVVEFERPQME-----TGSSCTANAWAKVPATPTADERQALKARIRQLLKEKQAVLVAH 55 +K VEFE+P + G SC A+AWAKVP T DERQALKARI++LLKE+ AVLVAH Sbjct: 6 IKTVEFEKPDLTDTESPAGGSCVAHAWAKVPPVLTPDERQALKARIKRLLKERNAVLVAH 65 Query: 56 YYVDGDLQDLAEETGGCVSDSLEMARFGRDHAAQTLVVAGVRFMGETAKILSPEKRILMP 115 YYVD DLQDLAEETGGCVSDSLEMARFGRDH+AQTLVVAGVRFMGETAKILSPEK ILMP Sbjct: 66 YYVDADLQDLAEETGGCVSDSLEMARFGRDHSAQTLVVAGVRFMGETAKILSPEKTILMP 125 Query: 116 DLDATCSLDLGCPTDEFNAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLDIVKHLH 175 DLDATCSLDLGCP DEF AFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGL IV+HLH Sbjct: 126 DLDATCSLDLGCPADEFAAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLKIVQHLH 185 Query: 176 AQGKKILWAPDKHLGGYIQKQTGADMLLWQGSCLVHDEFKGVELELLRKEYPKALILVHP 235 A+G+KILWAPDKHLG YIQK+TGADMLLWQGSCLVHDEFKG+EL+LLR+E+PKA ILVHP Sbjct: 186 ARGEKILWAPDKHLGSYIQKETGADMLLWQGSCLVHDEFKGIELDLLRREFPKAKILVHP 245 Query: 236 ESPEGVVAQADVIGSTSQLIAAVQSSDAKEFIVATDNGILHKMRAAAPGKVFIDAPTAGN 295 ESP VV QADV+GSTSQLIAA Q DA EFIVATDNGILHKMR AAPGK FI+APTAGN Sbjct: 246 ESPANVVEQADVVGSTSQLIAAAQELDATEFIVATDNGILHKMRMAAPGKHFIEAPTAGN 305 Query: 296 SATCKSCAHCPWMAMNGLQNLLHVLETGSNEIHVDPAIGRKAVVCIDRMLDFAAQKKANV 355 SATCKSCAHCPWMAMN L NL VLETG NEIHVDPA GR+AV CI+RMLDFAAQ+KANV Sbjct: 306 SATCKSCAHCPWMAMNALSNLAEVLETGRNEIHVDPATGRQAVTCINRMLDFAAQQKANV 365 Query: 356 RPTGALENEQTLFAGIGPA 374 RP L EQ LF GIGPA Sbjct: 366 RPAADLAKEQALFQGIGPA 384