BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0059.p (475 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IU36.1 D8IU36_HERSS Two component sensor histidine kinase protein 539 e-151 D9SHS9.1 D9SHS9_GALCS Integral membrane sensor signal transducti... 414 e-113 E4QNJ3.1 E4QNJ3_METS6 Histidine kinase 358 1e-96 C6XD75.1 C6XD75_METSD Histidine kinase 357 2e-96 E1MT31.1 E1MT31_9GAMM Integral membrane sensor signal transducti... 355 1e-95 >D8IU36.1 D8IU36_HERSS Two component sensor histidine kinase protein Length = 473 Score = 539 bits (1389), Expect = e-151, Method: Compositional matrix adjust. Identities = 290/474 (61%), Positives = 362/474 (76%), Gaps = 23/474 (4%) Query: 1 VGRLFWKFFFFIMVAQLTATIGVGIMFSLENRERDRRTSDLDQSPPAAFMIRSAAATLQY 60 +GRLFWKFFFFI +AQ+TAT GVG++F +EN ER R S++D SPPA+FMIRSAAATLQ+ Sbjct: 1 MGRLFWKFFFFIAIAQITATFGVGVLFWVENLERSNRNSEIDLSPPASFMIRSAAATLQF 60 Query: 61 GGTEALRKLVLNSERHH---VYAVDEQQHELLGREVHPRLIEEARTLLGAEKQETRRRVV 117 GGTEALR L+ N R H +YA+DE +L+GREV P+L+E+A+ +L E++ VV Sbjct: 61 GGTEALRSLI-NEGRPHRLQLYALDEDNKDLMGREVSPKLVEQAKHILATERERR---VV 116 Query: 118 EEVKAADGHTYLLFLPSPVNPEFG-------GPPPHE--ERGPRRMQPPPFFFPMMPMLV 168 E VKA +GH+YL+F+P+P N EFG PH ERGP+ M FFP MP++V Sbjct: 117 ERVKAPNGHSYLMFIPAP-NDEFGPGGPPGGAREPHRIGERGPKSM-----FFPTMPIVV 170 Query: 169 ATVASLFFAMLLAWYFSQPIRLLKSAFARASSGNLNDRLAPQMGKRNDELTDLGRDFDGM 228 A +ASL FA+LLAWYFS PI LK+AF +A++GNL+ L P M RNDEL DLGRDFD M Sbjct: 171 ALLASLVFALLLAWYFSHPIGHLKNAFNQAANGNLDLELEPVMSARNDELADLGRDFDVM 230 Query: 229 TDKLRALMDSQRRLLHDVSHELRSPIARLQASIGLARLQ-PEKTAATLERIEREGVRMDK 287 T KLR LM+SQRRLLHDVSHELRSPIARLQ +IGLAR+Q +K TLERIERE VRMDK Sbjct: 231 TAKLRTLMESQRRLLHDVSHELRSPIARLQVAIGLARVQDKDKLDLTLERIERESVRMDK 290 Query: 288 LVGELLTLSRLETGVTGAMEDHIRMEDLLTEIIDDARFEAEAVDRHIEGMVRCDVVIKGG 347 LVGELLTLSRLE V G+ME+ I +E +L ++I+DA FEAEA+ +H++ + C V +KG Sbjct: 291 LVGELLTLSRLEANVPGSMEEPIAIEAMLGDMINDASFEAEAIGKHVDDQLDCRVQVKGN 350 Query: 348 AELLYRAIENVVRNAIKQTAVDTTIAINTQVDKDRQSLLVSVIDHGPGVPEEELQLIFEP 407 ELLYRAIENV+RNAIK TA TT+ I+TQ+D+ + L +S++D GPGVPEEE+ IFE Sbjct: 351 PELLYRAIENVLRNAIKHTAPGTTVQIHTQLDEINKLLHLSILDRGPGVPEEEMNSIFEL 410 Query: 408 FFRSSRTRENSNGYGLGLTIARRIIEAHGGRIRAFNRVDGGLCVDIILPYDAIE 461 FFRSSRT+ NS+G+GLGL+IARRI+EAH G I+A NR +GGL VDI LP+ A E Sbjct: 411 FFRSSRTKSNSSGHGLGLSIARRIVEAHQGFIQAANRSNGGLRVDITLPFMADE 464 >D9SHS9.1 D9SHS9_GALCS Integral membrane sensor signal transduction histidine kinase Length = 447 Score = 414 bits (1064), Expect = e-113, Method: Compositional matrix adjust. Identities = 230/462 (49%), Positives = 305/462 (66%), Gaps = 26/462 (5%) Query: 1 VGRLFWKFFFFIMVAQLTATIGVGIMFSLENRERDRRTSDLDQSPPAAFMIRSAAATLQY 60 +GRLFWKFF F +AQ+T+ IGVG L + +R + P + + +AA+TL+Y Sbjct: 1 MGRLFWKFFIFFWLAQVTSVIGVGGAMWLRSPGMERFRA------PQSSAVAAAASTLRY 54 Query: 61 GGTEALRKLVLNSERH---HVYAVDEQQHELLGREVHPRLIEEARTLLGAEKQETRRRVV 117 GG EALR L+ R V+AVDE ++LGR V ++ +A + G++ Sbjct: 55 GGPEALRWLLREQSREPAPSVFAVDENNRDILGRPVSETMLVQANQIRGSQDNFGS---A 111 Query: 118 EEVKAADGHTYLLFLPSPVNPEFGG---PPPHEERGPRRMQPPPFFFPMMPMLVATVASL 174 E+V AADGHTYLLF P P G PPPH+ R M PP +MP+L V SL Sbjct: 112 EKVAAADGHTYLLFAQPPSYPRLDGRMEPPPHD----RGMLPP-----VMPLLAGGVVSL 162 Query: 175 FFAMLLAWYFSQPIRLLKSAFARASSGNLNDRLAPQMGKRNDELTDLGRDFDGMTDKLRA 234 FFA LLAWYFS+PIR L++AFA S+G L+ RLAP MG R DEL+DLGRDFD M +L+ Sbjct: 163 FFAALLAWYFSKPIRTLRAAFAAVSNGLLDVRLAPVMGSRRDELSDLGRDFDSMVQRLQQ 222 Query: 235 LMDSQRRLLHDVSHELRSPIARLQASIGLARLQPEKTAATLERIEREGVRMDKLVGELLT 294 LMD QRR+LHDVSHELRSP+ARLQA+IGLAR QPE+ ++ RIERE VRMD LV ELLT Sbjct: 223 LMDGQRRVLHDVSHELRSPLARLQAAIGLARQQPERIEDSMMRIEREAVRMDTLVSELLT 282 Query: 295 LSRLETGVTGAMEDHIRMEDLLTEIIDDARFEAEAVDRHIEGMVRCDVVIKGGAELLYRA 354 LSRLE G+ G + + + + +L++++ +DARFEA A +E +++G AELL+RA Sbjct: 283 LSRLEAGMMGKLNEQVDLNELVSDVAEDARFEAAASGCRVEIEALSRAIVRGNAELLHRA 342 Query: 355 IENVVRNAIKQTAVDTTIAINTQVDKDRQSLLVSVIDHGPGVPEEELQLIFEPFFRSSRT 414 +ENVVRNA+K + +AI Q + + Q++ ++V D G GVPE + IFEPFFRS++T Sbjct: 343 VENVVRNAVKHSPSGGLVAIKMQKNHN-QTICITVSDQGGGVPEADSYAIFEPFFRSAQT 401 Query: 415 RENSNGYGLGLTIARRIIEAHGGRIRAFNRVDGGLCVDIILP 456 + S+G+GLGL IA+R+I AH G I A N GGLC+ I LP Sbjct: 402 KA-SDGHGLGLAIAQRVIIAHQGEIYARNHPGGGLCITINLP 442 >E4QNJ3.1 E4QNJ3_METS6 Histidine kinase Length = 484 Score = 358 bits (919), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 210/489 (42%), Positives = 299/489 (61%), Gaps = 39/489 (7%) Query: 1 VGRLFWKFFFFIMVAQLTATIGVGIMFSLENRERDRRTSDLDQSPPAAFMIRSAAATLQY 60 +GRL+WKFFFF + AQLT+ GVG+ NR + S ++ SPPA ++ + +ATL++ Sbjct: 1 MGRLYWKFFFFFLFAQLTSVFGVGLAVWAHNRSLENSRSLIEASPPAMSVLAAVSATLEH 60 Query: 61 GGTEALRKLVLNSERH---HVYAVDEQQHELLGREVHPRLIEEARTLLGAEKQETRRRVV 117 GG A RK++ + +Y V+E +LL R V P L++ A + L +K E V Sbjct: 61 GGVGATRKMLEGWPQRRMPQIYVVNEAGEDLLQRRVSPELLQLAISQL--DKDEA----V 114 Query: 118 EEVKAADGHTYLLFLPS-------PVNPEFGGP--PPHEERGPRRM-QPPP--------- 158 + A DGH Y+LF+PS P N G P PP + P M QPPP Sbjct: 115 RSIHADDGHEYILFVPSRSRGGQPPPNEGMGHPDGPPPDMHDPSDMHQPPPGERAGDGPP 174 Query: 159 --------FF--FPMMPMLVATVASLFFAMLLAWYFSQPIRLLKSAFARASSGNLNDRLA 208 F+ FP++P+ +ASL FA LLAWYFS+PIR L+ AF A+ G+L R+A Sbjct: 175 PNGGMRSRFWRVFPLVPLSAGVIASLVFAALLAWYFSKPIRSLRQAFITATDGDLEVRVA 234 Query: 209 PQMGKRNDELTDLGRDFDGMTDKLRALMDSQRRLLHDVSHELRSPIARLQASIGLARLQP 268 MG R DEL+DLGRDFD M +L AL+ Q RLLH VSHELRSP+AR+Q +IGLAR P Sbjct: 235 GSMGHRRDELSDLGRDFDTMASRLGALLQGQSRLLHHVSHELRSPLARMQMAIGLARQSP 294 Query: 269 EKTAATLERIEREGVRMDKLVGELLTLSRLETGVTGAMEDHIRMEDLLTEIIDDARFEAE 328 EK +++LERIERE +RMDKLVGELL SRLE+GVT ++ + + DLL + +DA+FE + Sbjct: 295 EKVSSSLERIERESIRMDKLVGELLAFSRLESGVTNIHKERVDLSDLLFTLAEDAQFEGK 354 Query: 329 AVDRHIEGMVRCDVVIKGGAELLYRAIENVVRNAIKQTAVDTTIAINTQVDKDRQSLLVS 388 + + D V++ +LL+RA+EN+VRNA+K + + I+ D + +L+ Sbjct: 355 DRKMEVRLLPHDDFVLEAQPDLLHRALENIVRNALKYGPDGSDVDIDVSSDPATRMVLIR 414 Query: 389 VIDHGPGVPEEELQLIFEPFFRSSRTRENSNGYGLGLTIARRIIEAHGGRIRAFNRVDGG 448 + D G GV EL+ IF+PF+R++ + S+G+G+GL +A++++E HGG+I A N G Sbjct: 415 IRDQGMGVAPHELETIFQPFYRAN-SGLGSDGHGIGLALAKQVVEMHGGKIAARNISPVG 473 Query: 449 LCVDIILPY 457 V + LPY Sbjct: 474 FEVAVQLPY 482 >C6XD75.1 C6XD75_METSD Histidine kinase Length = 484 Score = 357 bits (916), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 207/489 (42%), Positives = 297/489 (60%), Gaps = 39/489 (7%) Query: 1 VGRLFWKFFFFIMVAQLTATIGVGIMFSLENRERDRRTSDLDQSPPAAFMIRSAAATLQY 60 +GRL+WKFFFF + AQLT+ GVG+ NR + S ++ SPPA ++ + +ATL++ Sbjct: 1 MGRLYWKFFFFFLFAQLTSVFGVGLAVWAHNRSLENSRSLIEASPPAMSVLAAVSATLEH 60 Query: 61 GGTEALRKLVLNSERH---HVYAVDEQQHELLGREVHPRLIEEARTLLGAEKQETRRRVV 117 GG A RK++ + +Y V+E +LL R V P L++ A + Q + V Sbjct: 61 GGVGATRKMLEGWPQRRMPQIYVVNEAGEDLLQRRVSPELLQLAIS------QVDKDEAV 114 Query: 118 EEVKAADGHTYLLFLPS-------PVNPEFGGP--PPHEERGPRRM-QPPP--------- 158 + A DGH Y+LF+P+ P N G P PP + P M QPPP Sbjct: 115 RSIHADDGHEYILFVPARSRGGQPPPNEGMGHPDGPPPDMHDPSDMHQPPPGERAEDGPP 174 Query: 159 --------FF--FPMMPMLVATVASLFFAMLLAWYFSQPIRLLKSAFARASSGNLNDRLA 208 F+ FP++P+ +ASL FA LLAWYFS+PIR L+ AF A+ G+L R+A Sbjct: 175 PNGGMRSRFWRVFPLVPLSAGVIASLVFAALLAWYFSKPIRSLRQAFITATDGDLEVRVA 234 Query: 209 PQMGKRNDELTDLGRDFDGMTDKLRALMDSQRRLLHDVSHELRSPIARLQASIGLARLQP 268 MG R DEL+DLGRDFD M +L AL+ Q RLLH VSHELRSP+AR+Q +IGLAR P Sbjct: 235 GSMGHRRDELSDLGRDFDTMASRLGALLQGQSRLLHHVSHELRSPLARMQMAIGLARQSP 294 Query: 269 EKTAATLERIEREGVRMDKLVGELLTLSRLETGVTGAMEDHIRMEDLLTEIIDDARFEAE 328 EK +++LERIERE +RMDKLVGELL SRLE+GVT ++ + + DLL + +DA+FE + Sbjct: 295 EKVSSSLERIERESIRMDKLVGELLAFSRLESGVTNIHKERVDLSDLLFTLAEDAQFEGK 354 Query: 329 AVDRHIEGMVRCDVVIKGGAELLYRAIENVVRNAIKQTAVDTTIAINTQVDKDRQSLLVS 388 + + D V++ +LL+RA+EN+VRNA+K + + I+ D + +L+ Sbjct: 355 DRKMEVRLLPHDDFVLEAQPDLLHRALENIVRNALKYGPDGSDVDIDVSSDPATRMVLIR 414 Query: 389 VIDHGPGVPEEELQLIFEPFFRSSRTRENSNGYGLGLTIARRIIEAHGGRIRAFNRVDGG 448 + D G GV EL+ IF+PF+R++ + S+G+G+GL +A++++E HGG+I A N G Sbjct: 415 IRDQGMGVAPHELETIFQPFYRAN-SGLGSDGHGIGLALAKQVVEMHGGKIAARNISPVG 473 Query: 449 LCVDIILPY 457 V + LPY Sbjct: 474 FEVAVQLPY 482 >E1MT31.1 E1MT31_9GAMM Integral membrane sensor signal transduction histidine kinase Length = 475 Score = 355 bits (910), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 220/482 (45%), Positives = 292/482 (60%), Gaps = 34/482 (7%) Query: 1 VGRLFWKFFFFIMVAQLTATIGVGIMFSL-----ENRERDRRTSDLDQSPPAAFMIRSAA 55 +GRLFWKFF +A L A IGVG L + E + T D+ AA + A Sbjct: 1 MGRLFWKFFLTFWLALLVAGIGVGTAVWLRHNAWQGTETVKHTIDVRH---AASFVAVAD 57 Query: 56 ATLQYGGTEALRKLVLNSERHH----VYAVDEQQHELLGREVHPRLIEEARTL-LGAEKQ 110 +++GG LR L + R VYAVD+Q ELL R V P ++++ARTL L A Sbjct: 58 NAIRHGGVAGLRNF-LEAMRDAPFPPVYAVDDQDRELLQRSVVPEVLQQARTLFLQAAYP 116 Query: 111 ETRRRVVEEVKAADGHTYLLFLPSPVNPEFGGPP--PHEERGPRRMQPPP---------- 158 E RRV E DGH YLLF+P P + PP P EE PPP Sbjct: 117 EAIRRVSTE----DGHRYLLFVPLPEHGFADRPPRMPGEEADAGFAPPPPEGHFSRPPRP 172 Query: 159 ---FFFPMMPMLVATVASLFFAMLLAWYFSQPIRLLKSAFARASSGNLNDRLAPQMGKRN 215 P++P+L T ASL F+ LAWYF++PIR L++AF + G+L+ R+ MGKR Sbjct: 173 PRVPPSPLLPILAGTFASLIFSAALAWYFAKPIRSLRNAFTALAQGDLDTRVGSSMGKRR 232 Query: 216 DELTDLGRDFDGMTDKLRALMDSQRRLLHDVSHELRSPIARLQASIGLARLQPEKTAATL 275 DEL+DLG++FD M ++ +L+ +Q+RLLHDVSHELRSP+AR+QA+IGLA+ QPEK A + Sbjct: 233 DELSDLGQNFDHMAGQIHSLVHAQQRLLHDVSHELRSPLARIQAAIGLAQQQPEKIMAMM 292 Query: 276 ERIEREGVRMDKLVGELLTLSRLETGVTGAMEDHIRMEDLLTEIIDDARFEAEAVDRHIE 335 ERIERE R+ LVGELL LSRLE GV+G+ + LL +I+++ARFEAE I Sbjct: 293 ERIERESQRISDLVGELLVLSRLEAGVSGSESHDFDIGGLLDDIVENARFEAEQYGVVIR 352 Query: 336 GMVRCDVVIKGGAELLYRAIENVVRNAIKQTAVDTTIAINTQVDKDRQSLLVSVIDHGPG 395 + V+KG +ELL+RAIENV+RNA++ +A+ + D ++ L V+V D GPG Sbjct: 353 YDGIEETVVKGRSELLHRAIENVLRNALQHCKKGGEVAVIVRFDTGKRRLQVAVYDQGPG 412 Query: 396 VPEEELQLIFEPFFRSSRTRENSNGYGLGLTIARRIIEAHGGRIRAFNRVDGGLCVDIIL 455 V E +L IFEPFFRS R ++ GLGL IA R IEAH GRI+A NR GGL ++I + Sbjct: 413 VAESDLAAIFEPFFRSG-DRGKADSIGLGLAIAYRAIEAHAGRIQASNRPQGGLRIEINI 471 Query: 456 PY 457 P+ Sbjct: 472 PF 473