BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0028.p (299 letters) Database: pfamseq 15,929,002 sequences; 5,169,768,107 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value D8IU22.1 D8IU22_HERSS Membrane-associated Zn-dependent proteases... 447 e-123 A4G4S8.1 A4G4S8_HERAR Putative Peptidase M50 403 e-110 A6SZP4.1 A6SZP4_JANMA Membrane-associated Zn-dependent protease ... 390 e-106 F1W2N0.1 F1W2N0_9BURK Membrane-associated zinc metalloprotease 327 1e-87 C3X7R9.1 C3X7R9_OXAFO Membrane-associated metalloprotease 276 4e-72 >D8IU22.1 D8IU22_HERSS Membrane-associated Zn-dependent proteases 1 protein Length = 457 Score = 447 bits (1149), Expect = e-123, Method: Compositional matrix adjust. Identities = 223/298 (74%), Positives = 255/298 (85%), Gaps = 3/298 (1%) Query: 5 NGEPVHAWTEVRWQLMQHVLEKTPARLDVESAAPNG-GKLLNTVKLSLDGVSTEDLEGDF 63 NG PVH W+EVRW+LMQ VLEK ARLDVE PNG GKLLNTV L L ++ +DLEGDF Sbjct: 158 NGAPVHVWSEVRWKLMQLVLEKADARLDVERPNPNGSGKLLNTVSLPLGSIAADDLEGDF 217 Query: 64 LAKLGISLARPQAILGKIMEGPAMQAGLQKGDLILAVNGAPIKDGLALVELVRASPGKPL 123 LAKLG+SLARP A+LGKIM+GPA AGLQ GD I A++GAP++DGLA VE VR S GKPL Sbjct: 218 LAKLGLSLARPPAVLGKIMDGPAKTAGLQTGDRITAIDGAPVQDGLAFVETVRESGGKPL 277 Query: 124 TLHGLRGQSEFDIAVTPDTLTD--NGQTIGRIKVEVPLAPEMTVVSDPPWTAIAKGAEKT 181 TL +RG + F + VTP+++ + +G+ IGRIKVEVPLAPEM VSD +TA+AKG +T Sbjct: 278 TLEAVRGNAPFTVRVTPESVDEEGSGKRIGRIKVEVPLAPEMATVSDDIFTALAKGVRRT 337 Query: 182 WDTSAMTLKMIGKMIVGQVSWKNITGPITIADYAGQTAKVGLVSYLSFIAFISISLGVMN 241 WDTS M++KMIGKM++GQVS KNITGPITIADYAGQTA+VGLVSYLSF+AFISISLGVMN Sbjct: 338 WDTSVMSIKMIGKMVIGQVSLKNITGPITIADYAGQTARVGLVSYLSFLAFISISLGVMN 397 Query: 242 LLPIPVLDGGHLLYYSLEILTGRPVSERFGEIAQRAGMGILMMLMLVAAFNDIVRLMF 299 LLPIPVLDGGHLLYY+LEILTGRPVSERFGEIAQRAG+GILM LMLVAAFNDIVRLMF Sbjct: 398 LLPIPVLDGGHLLYYALEILTGRPVSERFGEIAQRAGLGILMALMLVAAFNDIVRLMF 455 >A4G4S8.1 A4G4S8_HERAR Putative Peptidase M50 Length = 455 Score = 403 bits (1035), Expect = e-110, Method: Compositional matrix adjust. Identities = 196/297 (65%), Positives = 242/297 (81%), Gaps = 3/297 (1%) Query: 5 NGEPVHAWTEVRWQLMQHVLEKTPARLDVESAA--PNGGKLLNTVKLSLDGVSTEDLEGD 62 NG+P+ W ++RWQ++Q V+ K LDVE AA P+ GK++ TV + +D +S E+LEGD Sbjct: 158 NGKPIQIWNDLRWQMVQAVINKKAVTLDVERAAADPHAGKIIRTVTIPVDSISAEELEGD 217 Query: 63 FLAKLGISLARPQAILGKIM-EGPAMQAGLQKGDLILAVNGAPIKDGLALVELVRASPGK 121 FL KLGI LARP+AILG+++ +GPAM AGLQ GDLI+AVNG I DG+ALV+ VRA+PGK Sbjct: 218 FLVKLGIDLARPRAILGQVVPDGPAMLAGLQSGDLIVAVNGNAITDGVALVDAVRAAPGK 277 Query: 122 PLTLHGLRGQSEFDIAVTPDTLTDNGQTIGRIKVEVPLAPEMTVVSDPPWTAIAKGAEKT 181 L + LR + VTP+ + +GQ GRIKVEVP+ P+M + S P+ A+AKG +KT Sbjct: 278 MLQIDLLRNGKPLSVNVTPEAVDKDGQVFGRIKVEVPMMPDMVLASHGPFAALAKGVQKT 337 Query: 182 WDTSAMTLKMIGKMIVGQVSWKNITGPITIADYAGQTAKVGLVSYLSFIAFISISLGVMN 241 WDTS MTLKM+GKMIVG+VSWKN+TGPITIADYAGQTA++GL+SYLSFIAF+SISLGVMN Sbjct: 338 WDTSTMTLKMVGKMIVGEVSWKNVTGPITIADYAGQTARIGLISYLSFIAFVSISLGVMN 397 Query: 242 LLPIPVLDGGHLLYYSLEILTGRPVSERFGEIAQRAGMGILMMLMLVAAFNDIVRLM 298 LLPIPVLDGGHLLYY++E+LTGRPVSERFG IAQRAG+GILM LMLVA FNDI RL+ Sbjct: 398 LLPIPVLDGGHLLYYAVEVLTGRPVSERFGAIAQRAGIGILMTLMLVAVFNDINRLI 454 >A6SZP4.1 A6SZP4_JANMA Membrane-associated Zn-dependent protease EC=3.4.24.- Length = 455 Score = 390 bits (1001), Expect = e-106, Method: Compositional matrix adjust. Identities = 191/297 (64%), Positives = 236/297 (79%), Gaps = 3/297 (1%) Query: 5 NGEPVHAWTEVRWQLMQHVLEKTPARLDVESAAPNG--GKLLNTVKLSLDGVSTEDLEGD 62 NGEPV W ++RWQ++Q V+ K P RL+VE P K + TV L +D +S +LEGD Sbjct: 158 NGEPVQIWNDLRWQMVQSVINKQPVRLEVERPVPGSPDAKNIQTVTLPVDSISANELEGD 217 Query: 63 FLAKLGISLARPQAILGKIM-EGPAMQAGLQKGDLILAVNGAPIKDGLALVELVRASPGK 121 FL KLGI LARP AILG+++ +GPAM+AGLQ+GD +++VNGA I DGL+LVELVRASPGK Sbjct: 218 FLGKLGIDLARPPAILGQVVADGPAMKAGLQQGDRVVSVNGATIADGLSLVELVRASPGK 277 Query: 122 PLTLHGLRGQSEFDIAVTPDTLTDNGQTIGRIKVEVPLAPEMTVVSDPPWTAIAKGAEKT 181 L + LR + V P+ + +GQ GRIKVEVP+AP+M V + A+ KG +KT Sbjct: 278 VLNVDVLRNGQPVSLRVVPEEVNADGQVFGRIKVEVPMAPDMVVAHHSLFAALLKGVQKT 337 Query: 182 WDTSAMTLKMIGKMIVGQVSWKNITGPITIADYAGQTAKVGLVSYLSFIAFISISLGVMN 241 WDTS +T+KM+GKMI+G+VSWKN+TGPITIADYAGQTA++GL+SYLSFIAF+SISLGVMN Sbjct: 338 WDTSVLTIKMVGKMIIGEVSWKNVTGPITIADYAGQTARIGLISYLSFIAFVSISLGVMN 397 Query: 242 LLPIPVLDGGHLLYYSLEILTGRPVSERFGEIAQRAGMGILMMLMLVAAFNDIVRLM 298 LLPIPVLDGG LLYY++E+LTGRPVSERFG IAQRAG+GILM LMLVA FNDI RL+ Sbjct: 398 LLPIPVLDGGLLLYYAVEVLTGRPVSERFGAIAQRAGIGILMTLMLVAVFNDINRLI 454 >F1W2N0.1 F1W2N0_9BURK Membrane-associated zinc metalloprotease Length = 455 Score = 327 bits (838), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 167/297 (56%), Positives = 215/297 (72%), Gaps = 3/297 (1%) Query: 5 NGEPVHAWTEVRWQLMQHVLEKTPARLDVESA--APNGGKLLNTVKLSLDGVSTEDLEGD 62 NG+ V W+++RWQL+Q +EKT A++D+E A P GGK ++T+ + + +DLEGD Sbjct: 158 NGKAVQGWSDLRWQLVQLSVEKTSAKIDLERANDGPAGGKRMSTITIPSTALGADDLEGD 217 Query: 63 FLAKLGISLARPQAILGKIMEGPA-MQAGLQKGDLILAVNGAPIKDGLALVELVRASPGK 121 FL KLG+ LAR + LG+I G A QAGLQ GD IL VNG + DG A V LVRASP Sbjct: 218 FLGKLGLGLARSKTTLGRIEAGGAGQQAGLQSGDRILTVNGNVVADGDAFVNLVRASPAT 277 Query: 122 PLTLHGLRGQSEFDIAVTPDTLTDNGQTIGRIKVEVPLAPEMTVVSDPPWTAIAKGAEKT 181 L L LR E VTP ++ +G++IG+IKVE+ EM + P A+++ +T Sbjct: 278 ALNLTLLRAGQEVAAIVTPASIVRDGKSIGQIKVEIASGVEMVTLRAAPVQALSQAVVRT 337 Query: 182 WDTSAMTLKMIGKMIVGQVSWKNITGPITIADYAGQTAKVGLVSYLSFIAFISISLGVMN 241 WD+S + LKM+GK+I G+ S KNI+GPITIADYAGQTA++GLV+YL FIA ISI LGVMN Sbjct: 338 WDSSILQLKMLGKVITGEASIKNISGPITIADYAGQTARIGLVTYLGFIAAISIGLGVMN 397 Query: 242 LLPIPVLDGGHLLYYSLEILTGRPVSERFGEIAQRAGMGILMMLMLVAAFNDIVRLM 298 LLPIPVLDGG L+YYSLE+LTGRPVSER G++ QR G+G+LM LM+VA FNDIVRL+ Sbjct: 398 LLPIPVLDGGLLMYYSLEVLTGRPVSERVGQLGQRLGIGLLMTLMMVAVFNDIVRLV 454 >C3X7R9.1 C3X7R9_OXAFO Membrane-associated metalloprotease Length = 459 Score = 276 bits (705), Expect = 4e-72, Method: Compositional matrix adjust. Identities = 148/302 (49%), Positives = 209/302 (69%), Gaps = 7/302 (2%) Query: 5 NGEPVHAWTEVRWQLMQHVLE-KTPARLDVESAAPNGGKLL-----NTVKLSLDGVSTED 58 +G P+H W +VRW++ + ++E ++ + V S+ P + TV L ++ VS ED Sbjct: 158 DGMPIHNWQQVRWKMTEMLMEARSAVSVGVASSGPTDAEGAPRVPEKTVMLPMNQVSIED 217 Query: 59 LEGDFLAKLGISLARPQAILGKIMEG-PAMQAGLQKGDLILAVNGAPIKDGLALVELVRA 117 ++ DF+ KLG+ + RP AI+GK +EG A Q+GL +GD I+ ++G P+ D LALV ++R Sbjct: 218 VDKDFIGKLGLGVERPPAIVGKTIEGGVAAQSGLMEGDKIVKIDGEPVLDSLALVNIIRQ 277 Query: 118 SPGKPLTLHGLRGQSEFDIAVTPDTLTDNGQTIGRIKVEVPLAPEMTVVSDPPWTAIAKG 177 SPGK L L LR I +TP+ T Q IG++ + + PEMT++S A+ +G Sbjct: 278 SPGKTLALDVLRNNEPVSITLTPEAKTVKDQLIGKMDANISVMPEMTILSYSVPVALMEG 337 Query: 178 AEKTWDTSAMTLKMIGKMIVGQVSWKNITGPITIADYAGQTAKVGLVSYLSFIAFISISL 237 KTWDTS +T+KMIG+M+VG VS KNITGPI IADYAGQTA+ GL+ YL FI FISIS+ Sbjct: 338 ISKTWDTSYITVKMIGRMLVGDVSLKNITGPIAIADYAGQTARAGLIRYLHFIVFISISI 397 Query: 238 GVMNLLPIPVLDGGHLLYYSLEILTGRPVSERFGEIAQRAGMGILMMLMLVAAFNDIVRL 297 GVMNLLPIPVLDGG LLYY++E++TG +S+R +I + G+GIL +L+LVA FND++R+ Sbjct: 398 GVMNLLPIPVLDGGLLLYYAVEVVTGGSISDRIAKIGYKIGVGILGLLLLVAVFNDVIRI 457 Query: 298 MF 299 F Sbjct: 458 FF 459