BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0428.p (592 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv0066c [C] COG2838 Monomeric isocitrate dehydrogenase Mtu Mycob... 993 0.0 MT0072 [C] COG2838 Monomeric isocitrate dehydrogenase MtC Mycoba... 993 0.0 ML2672 [C] COG2838 Monomeric isocitrate dehydrogenase Mle Mycoba... 986 0.0 PA2624 [C] COG2838 Monomeric isocitrate dehydrogenase Pae Pseudo... 845 0.0 VC1141 [C] COG2838 Monomeric isocitrate dehydrogenase Vch Vibrio... 775 0.0 >Rv0066c [C] COG2838 Monomeric isocitrate dehydrogenase Mtu Mycobacterium tuberculosis H37Rv Length = 745 Score = 993 bits (2567), Expect = 0.0, Method: Compositional matrix adjust. Identities = 466/592 (78%), Positives = 526/592 (88%), Gaps = 5/592 (0%) Query: 1 VTTDNSTIIYTLTDEAPLLATYSLLPIIRTFTAPAGTSXAGVNVVESDISVATRILAEFP 60 ++ + TIIYTLTDEAPLLATY+ LPI+R F PAG + + SDISVA RILAEFP Sbjct: 1 MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAG-----IKIEASDISVAARILAEFP 55 Query: 61 DRLTPEQRVPDNLAALGKLTQDPSANIIKLPNISASVPQLQAAIRELQSRGYAIPDLPED 120 D LT EQRVPDNLA LG+LTQ P NIIKLPNISASVPQL AAI+ELQ +GYA+PD P D Sbjct: 56 DYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPAD 115 Query: 121 PKTDEEKEILKSYSKVLGSAVNPVLREGNSDRRAPASIKRFARKHPHSMGEWSMASRSHV 180 PKTD+EK I + Y++ LGSAVNPVLR+GNSDRRAP ++K +ARKHPHSMGEWSMASR+HV Sbjct: 116 PKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHV 175 Query: 181 AHMTHGDFYHGEKSMTIGAARDVKMELIGKSGKTTVLKAKVALKAGEIIDSMFMSKKALC 240 AHM HGDFY GEKSMT+ AR+V+MEL+ KSGKT VLK +V L G++IDSMFMSKKALC Sbjct: 176 AHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALC 235 Query: 241 EFYEEQFEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKIFYKEAFAKHGKLFDELGVNV 300 +FYEEQ +DA +TGVM SLHVKATMMKVSHPIVFGHAV+IFYK+AFAKH +LFD+LGVNV Sbjct: 236 DFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNV 295 Query: 301 NNGLVNLYEKIETLPSSKKEEIIRDLHACHEHRPSLAMVDSAKGISNLHAPNDVIVDASM 360 NNGL +LY KIE+LP+S+++EII DLH CHEHRP LAMVDSA+GISN H+P+DVIVDASM Sbjct: 296 NNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASM 355 Query: 361 PAMIRIGGKMWDANGKPQDTKAVIPESTFARIYQEVINFCKTNGNFDPTTMGTVPNVGLM 420 PAMIR GGKM+ A+GK +DTKAV PESTF+RIYQE+INFCKTNG FDPTTMGTVPNVGLM Sbjct: 356 PAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLM 415 Query: 421 AQKAEEYGSHDKTFEIAEDGVANIVDLATGEVLLTQNVEQGDIWRMCQVKDEPIRDWVKL 480 AQ+AEEYGSHDKTFEI EDGVANIVD+ATGEVLLT+NVE GDIWRMC VKD PIRDWVKL Sbjct: 416 AQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKL 475 Query: 481 AVTRARNSGMPAVFWLDPYRPHEAELIKKVETYLKDHDTKGLDIQIMSQVRAMRYTLERV 540 AVTRAR SGMP +FWLDPYRPHE ELIKKV+TYLKDHDT+GLDIQIMSQVR+MRYT ER+ Sbjct: 476 AVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERL 535 Query: 541 IRGLDTISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGG 592 +RGLDTI+ TGNILRDYLTDLFPI+ELGTSAKMLS+VPLMAGGGMYETGAGG Sbjct: 536 VRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGG 587 >MT0072 [C] COG2838 Monomeric isocitrate dehydrogenase MtC Mycobacterium tuberculosis CDC1551 Length = 745 Score = 993 bits (2567), Expect = 0.0, Method: Compositional matrix adjust. Identities = 466/592 (78%), Positives = 526/592 (88%), Gaps = 5/592 (0%) Query: 1 VTTDNSTIIYTLTDEAPLLATYSLLPIIRTFTAPAGTSXAGVNVVESDISVATRILAEFP 60 ++ + TIIYTLTDEAPLLATY+ LPI+R F PAG + + SDISVA RILAEFP Sbjct: 1 MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAG-----IKIEASDISVAARILAEFP 55 Query: 61 DRLTPEQRVPDNLAALGKLTQDPSANIIKLPNISASVPQLQAAIRELQSRGYAIPDLPED 120 D LT EQRVPDNLA LG+LTQ P NIIKLPNISASVPQL AAI+ELQ +GYA+PD P D Sbjct: 56 DYLTEEQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPAD 115 Query: 121 PKTDEEKEILKSYSKVLGSAVNPVLREGNSDRRAPASIKRFARKHPHSMGEWSMASRSHV 180 PKTD+EK I + Y++ LGSAVNPVLR+GNSDRRAP ++K +ARKHPHSMGEWSMASR+HV Sbjct: 116 PKTDQEKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHV 175 Query: 181 AHMTHGDFYHGEKSMTIGAARDVKMELIGKSGKTTVLKAKVALKAGEIIDSMFMSKKALC 240 AHM HGDFY GEKSMT+ AR+V+MEL+ KSGKT VLK +V L G++IDSMFMSKKALC Sbjct: 176 AHMRHGDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALC 235 Query: 241 EFYEEQFEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKIFYKEAFAKHGKLFDELGVNV 300 +FYEEQ +DA +TGVM SLHVKATMMKVSHPIVFGHAV+IFYK+AFAKH +LFD+LGVNV Sbjct: 236 DFYEEQMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNV 295 Query: 301 NNGLVNLYEKIETLPSSKKEEIIRDLHACHEHRPSLAMVDSAKGISNLHAPNDVIVDASM 360 NNGL +LY KIE+LP+S+++EII DLH CHEHRP LAMVDSA+GISN H+P+DVIVDASM Sbjct: 296 NNGLSDLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASM 355 Query: 361 PAMIRIGGKMWDANGKPQDTKAVIPESTFARIYQEVINFCKTNGNFDPTTMGTVPNVGLM 420 PAMIR GGKM+ A+GK +DTKAV PESTF+RIYQE+INFCKTNG FDPTTMGTVPNVGLM Sbjct: 356 PAMIRAGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLM 415 Query: 421 AQKAEEYGSHDKTFEIAEDGVANIVDLATGEVLLTQNVEQGDIWRMCQVKDEPIRDWVKL 480 AQ+AEEYGSHDKTFEI EDGVANIVD+ATGEVLLT+NVE GDIWRMC VKD PIRDWVKL Sbjct: 416 AQQAEEYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKL 475 Query: 481 AVTRARNSGMPAVFWLDPYRPHEAELIKKVETYLKDHDTKGLDIQIMSQVRAMRYTLERV 540 AVTRAR SGMP +FWLDPYRPHE ELIKKV+TYLKDHDT+GLDIQIMSQVR+MRYT ER+ Sbjct: 476 AVTRARISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERL 535 Query: 541 IRGLDTISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGG 592 +RGLDTI+ TGNILRDYLTDLFPI+ELGTSAKMLS+VPLMAGGGMYETGAGG Sbjct: 536 VRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGG 587 >ML2672 [C] COG2838 Monomeric isocitrate dehydrogenase Mle Mycobacterium leprae Length = 746 Score = 986 bits (2548), Expect = 0.0, Method: Compositional matrix adjust. Identities = 467/592 (78%), Positives = 517/592 (87%), Gaps = 5/592 (0%) Query: 1 VTTDNSTIIYTLTDEAPLLATYSLLPIIRTFTAPAGTSXAGVNVVESDISVATRILAEFP 60 ++ + TIIYTLTDEAPLLATY+ LPI+R FT PAG + V SDISVA RILAEFP Sbjct: 1 MSAEQWTIIYTLTDEAPLLATYAFLPIVRAFTKPAG-----IKVQTSDISVAARILAEFP 55 Query: 61 DRLTPEQRVPDNLAALGKLTQDPSANIIKLPNISASVPQLQAAIRELQSRGYAIPDLPED 120 D LT EQRVP+NLA LG+LTQ P NIIKLPNISASVPQL AAI+ELQ++G+ +PD P+D Sbjct: 56 DYLTEEQRVPNNLAELGRLTQLPDTNIIKLPNISASVPQLMAAIKELQAKGFKLPDYPQD 115 Query: 121 PKTDEEKEILKSYSKVLGSAVNPVLREGNSDRRAPASIKRFARKHPHSMGEWSMASRSHV 180 PK+ +E +I Y K LGSAVNPVLREGNSDRRAP ++K +AR +PHSMGEWSMASR+HV Sbjct: 116 PKSYQEIDIRNRYGKCLGSAVNPVLREGNSDRRAPKAVKEYARNNPHSMGEWSMASRTHV 175 Query: 181 AHMTHGDFYHGEKSMTIGAARDVKMELIGKSGKTTVLKAKVALKAGEIIDSMFMSKKALC 240 A M HGDFYHGEKSMT+ ARDVKMEL K GK VLK KV+L+ G+IIDSMFMSKKALC Sbjct: 176 ATMRHGDFYHGEKSMTLDRARDVKMELATKKGKIVVLKPKVSLRDGDIIDSMFMSKKALC 235 Query: 241 EFYEEQFEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKIFYKEAFAKHGKLFDELGVNV 300 EFYEEQ EDARKTGVM SLHVKATMMKVSHPIVFGHAVK FYKEAFAKH LFDELGVNV Sbjct: 236 EFYEEQMEDARKTGVMFSLHVKATMMKVSHPIVFGHAVKTFYKEAFAKHQDLFDELGVNV 295 Query: 301 NNGLVNLYEKIETLPSSKKEEIIRDLHACHEHRPSLAMVDSAKGISNLHAPNDVIVDASM 360 NNGLV+LY KIETL +S+++EII+DLHACHEHRP LAMVDSA+GISN ++P+DVIVDASM Sbjct: 296 NNGLVDLYSKIETLTASQRDEIIQDLHACHEHRPELAMVDSARGISNFYSPSDVIVDASM 355 Query: 361 PAMIRIGGKMWDANGKPQDTKAVIPESTFARIYQEVINFCKTNGNFDPTTMGTVPNVGLM 420 PAMIR GGKM+ A+G+ +DTKAV PESTF+RIYQE+INFCKTNG FDP TMGTVPNVGLM Sbjct: 356 PAMIRAGGKMYGADGRAKDTKAVNPESTFSRIYQEIINFCKTNGAFDPATMGTVPNVGLM 415 Query: 421 AQKAEEYGSHDKTFEIAEDGVANIVDLATGEVLLTQNVEQGDIWRMCQVKDEPIRDWVKL 480 AQ+AEEYGSHDKTFEI EDGVANIVDL TGEVLLTQNVE GDIWR+C V D IRDWVKL Sbjct: 416 AQQAEEYGSHDKTFEIPEDGVANIVDLTTGEVLLTQNVETGDIWRLCVVTDAAIRDWVKL 475 Query: 481 AVTRARNSGMPAVFWLDPYRPHEAELIKKVETYLKDHDTKGLDIQIMSQVRAMRYTLERV 540 AV+R RNSGMP +FWLDPYRPHE ELIKKV YLKDHDT GLDIQIMSQVR+MRYT ER+ Sbjct: 476 AVSRMRNSGMPVLFWLDPYRPHENELIKKVRAYLKDHDTSGLDIQIMSQVRSMRYTCERL 535 Query: 541 IRGLDTISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGG 592 IRGLDTI+ TGNILRDYLTDLFPI+ELGTSAKMLSIVPLMAGGGMYETGAGG Sbjct: 536 IRGLDTIAATGNILRDYLTDLFPILELGTSAKMLSIVPLMAGGGMYETGAGG 587 >PA2624 [C] COG2838 Monomeric isocitrate dehydrogenase Pae Pseudomonas aeruginosa Length = 741 Score = 845 bits (2182), Expect = 0.0, Method: Compositional matrix adjust. Identities = 399/587 (67%), Positives = 475/587 (80%), Gaps = 7/587 (1%) Query: 6 STIIYTLTDEAPLLATYSLLPIIRTFTAPAGTSXAGVNVVESDISVATRILAEFPDRLTP 65 S I YT TDEAP LATYSLLPI++ F A AG++V SDIS+A RILA F DRL Sbjct: 5 SKITYTFTDEAPALATYSLLPIVKAFAA-----SAGIDVETSDISLAGRILANFADRLEA 59 Query: 66 EQRVPDNLAALGKLTQDPSANIIKLPNISASVPQLQAAIRELQSRGYAIPDLPEDPKTDE 125 +QR+ D+LA L L P ANIIKLPNISASVPQL+ AI ELQ GY +PD PEDP+TDE Sbjct: 60 DQRIEDDLARLAVLATSPDANIIKLPNISASVPQLKGAIAELQGLGYKVPDFPEDPQTDE 119 Query: 126 EKEILKSYSKVLGSAVNPVLREGNSDRRAPASIKRFARKHPHSMGEWSMASRSHVAHMTH 185 EKE+ Y+K+LGSAVNPVLREGNSDRRAPA++K +ARKHPHSMG+WSMASRSH +M Sbjct: 120 EKEVRARYAKILGSAVNPVLREGNSDRRAPAAVKAYARKHPHSMGKWSMASRSHADYMRG 179 Query: 186 GDFYHGEKSMTIGAARDVKMELIGKSGKTTVLKAKVALKAGEIIDSMFMSKKALCEFYEE 245 GDF+ E+S+T+ A DV++E +GK GK V K +++L+ GE++DSMFMS L +F+E+ Sbjct: 180 GDFFSSEQSITMAKAGDVRIEFVGKDGKVEV-KKQLSLQEGEVLDSMFMSCGKLRDFFEK 238 Query: 246 QFEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKIFYKEAFAKHGKLFDELGVNVNNGLV 305 +D ++TGVM SLHVKATMMK+SHPIVFGHAV ++YK+ F K G+LF+ELGVN NNG+ Sbjct: 239 TLQDCKETGVMWSLHVKATMMKISHPIVFGHAVSVYYKDVFDKWGQLFEELGVNPNNGIS 298 Query: 306 NLYEKIETLPSSKKEEIIRDLHACHEHRPSLAMVDSAKGISNLHAPNDVIVDASMPAMIR 365 ++Y+KI++LP+S++EEI+ D+H + HRP +AMVDS KGI+NLH P+DVIVDASMPAMIR Sbjct: 299 SVYDKIKSLPASQQEEILHDIHEVYSHRPEMAMVDSVKGITNLHIPSDVIVDASMPAMIR 358 Query: 366 IGGKMWDANGKPQDTKAVIPESTFARIYQEVINFCKTNGNFDPTTMGTVPNVGLMAQKAE 425 G+MW +GK +DTKAV+PEST+ARIYQE+INFCKTNG FDPTTMG+VPNVGLMAQKAE Sbjct: 359 NSGQMWGKDGKQKDTKAVMPESTYARIYQEMINFCKTNGAFDPTTMGSVPNVGLMAQKAE 418 Query: 426 EYGSHDKTFEIAEDGVANIVDLATGEVLLTQNVEQGDIWRMCQVKDEPIRDWVKLAVTRA 485 EYGSHDKTFE+ DG +V LA G VL+ VE GDIWR CQ KD PIRDWVKLAVTRA Sbjct: 419 EYGSHDKTFEMTADGTMRVV-LADGSVLMQHKVETGDIWRACQTKDAPIRDWVKLAVTRA 477 Query: 486 RNSGMPAVFWLDPYRPHEAELIKKVETYLKDHDTKGLDIQIMSQVRAMRYTLERVIRGLD 545 R S PA+FWLDP R H+ EL KKVE YLKDHD GLDI IM A+R ++ER+IRG D Sbjct: 478 RQSDTPAIFWLDPERAHDRELRKKVELYLKDHDLTGLDISIMGYNEAIRVSMERLIRGKD 537 Query: 546 TISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGG 592 TISVTGN+LRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGG Sbjct: 538 TISVTGNVLRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGG 584 >VC1141 [C] COG2838 Monomeric isocitrate dehydrogenase Vch Vibrio cholerae Length = 741 Score = 775 bits (2000), Expect = 0.0, Method: Compositional matrix adjust. Identities = 377/590 (63%), Positives = 468/590 (79%), Gaps = 6/590 (1%) Query: 3 TDNSTIIYTLTDEAPLLATYSLLPIIRTFTAPAGTSXAGVNVVESDISVATRILAEFPDR 62 T+ TIIYT+TDEAP LATYSLLPII++FTA +G+NV DIS+A RILA FP+ Sbjct: 3 TNKPTIIYTITDEAPALATYSLLPIIQSFTA-----SSGINVETRDISLAGRILANFPEH 57 Query: 63 LTPEQRVPDNLAALGKLTQDPSANIIKLPNISASVPQLQAAIRELQSRGYAIPDLPEDPK 122 LT EQR+ D L LG+L + P ANIIKLPNISASVPQL+AAI+ELQ +GYA+P+ PE+P Sbjct: 58 LTEEQRISDALTELGELAKTPEANIIKLPNISASVPQLKAAIKELQDKGYALPNYPEEPS 117 Query: 123 TDEEKEILKSYSKVLGSAVNPVLREGNSDRRAPASIKRFARKHPHSMGEWSMASRSHVAH 182 + EE+ I +Y K+ GSAVNPVLREGNSDRRAPAS+K +A+K+PHSMG WS S+SHVA Sbjct: 118 SYEEEAIKATYDKIKGSAVNPVLREGNSDRRAPASVKNYAKKNPHSMGAWSKDSKSHVAS 177 Query: 183 MTHGDFYHGEKSMTIGAARDVKMELIGKSGKTTVLKAKVALKAGEIIDSMFMSKKALCEF 242 M+ DF+ EKSMT+ A V +E +GK G VLK AL+ EIID+ MSKKAL F Sbjct: 178 MSDKDFFGSEKSMTVSGATKVAIEFVGKEGAVKVLKKPFALQDKEIIDTSVMSKKALIAF 237 Query: 243 YEEQFEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKIFYKEAFAKHGKLFDELGVNVNN 302 +E++ DA+ V+ SLH+KATMMKVS P++FGHAVK++YK F K+G+LFD+LGV+VNN Sbjct: 238 FEKEIADAKAQDVLFSLHMKATMMKVSDPVIFGHAVKVYYKAVFDKYGQLFDQLGVDVNN 297 Query: 303 GLVNLYEKIETLPSSKKEEIIRDLHACHEHRPSLAMVDSAKGISNLHAPNDVIVDASMPA 362 GL ++Y KI++LP +++ EI + A + +P+LAMVDS +GI+NLH P+DVIVDASMPA Sbjct: 298 GLGDVYAKIQSLPEAQRAEIEAAIQAVYATQPALAMVDSDRGITNLHVPSDVIVDASMPA 357 Query: 363 MIRIGGKMWDANGKPQDTKAVIPESTFARIYQEVINFCKTNGNFDPTTMGTVPNVGLMAQ 422 MIR G+MW +GK +DTKA IP+ +A +YQ VI+FCK +G FDPTTMG+VPNVGLMAQ Sbjct: 358 MIRTSGQMWGPDGKQKDTKATIPDRCYAGVYQTVIDFCKQHGAFDPTTMGSVPNVGLMAQ 417 Query: 423 KAEEYGSHDKTFEIAEDGVANIVDLATGEVLLTQNVEQGDIWRMCQVKDEPIRDWVKLAV 482 KAEEYGSHDKTF + +GV ++D A G+VLL Q+VE GDI+RMCQVKD PI+DWVKLAV Sbjct: 418 KAEEYGSHDKTFILDAEGVVRVIDEA-GKVLLEQSVEAGDIFRMCQVKDAPIQDWVKLAV 476 Query: 483 TRARNSGMPAVFWLDPYRPHEAELIKKVETYLKDHDTKGLDIQIMSQVRAMRYTLERVIR 542 TRAR S PAVFWLDP R H+AELIKKV YL +HDT GL+I+I+S + A +Y+L R+ Sbjct: 477 TRARASNTPAVFWLDPARAHDAELIKKVNQYLPNHDTSGLEIKILSPIEATQYSLVRMKA 536 Query: 543 GLDTISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGG 592 G DTISVTGN+LRDYLTDLFPI+ELGTSAKMLSIVPLM GGG++ETGAGG Sbjct: 537 GQDTISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGLFETGAGG 586