BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0414.p (428 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1286 [GEPR] COG0477 Permeases of the major facilitator superfa... 286 5e-77 SMc02603 [GEPR] COG0477 Permeases of the major facilitator super... 280 6e-75 AGc1918 [GEPR] COG0477 Permeases of the major facilitator superf... 268 2e-71 NMA0047 [GEPR] COG0477 Permeases of the major facilitator superf... 232 1e-60 RSp0107 [GEPR] COG0477 Permeases of the major facilitator superf... 105 2e-22 >PA1286 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 399 Score = 286 bits (733), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 185/398 (46%), Positives = 245/398 (61%), Gaps = 15/398 (3%) Query: 19 ALWVVIAAALVLSVVMGTRQTFGLYINPFSYDRGLPVTVIAFAIALHNLVWGFAQPFAGA 78 A W++++ AL+L++ +G R FGL++ P S D G V AFAIAL NLVWG AQPF GA Sbjct: 5 AFWILLSGALILALSLGVRHGFGLFLAPMSADFGWGREVFAFAIALQNLVWGLAQPFTGA 64 Query: 79 ASDRYGATPVVAFGAVTFAAGLALAAVAPSGLLLIIGLGLLVGIGISCTSFGVVLASVGR 138 +DRYGA V G + +A GL L ++ S L + GLL+G+G+S TSF V+L +VGR Sbjct: 65 LADRYGAARAVLVGGLLYALGLVLMGLSQSASGLSLSAGLLIGLGLSGTSFSVILGAVGR 124 Query: 139 VATPQQRSMAMGIASAGGSLGQVLLVPLAQTVRESTGVSASLFVLAAIALAIAP-AGLIL 197 +QRSMAMGI+SA GS GQ ++P + G S++L L + I P AGL+ Sbjct: 125 AVPAEQRSMAMGISSAAGSFGQFAMLPGTLGLIGWLGWSSALLALGLLVALIVPLAGLMK 184 Query: 198 DRGRKKSSAFSSSPATHPAAEPPASSLKEVLTLAGRHHGYRLLTIGFFTCGFQLAFIGTH 257 DR P H SL E L A H G+ LL +GFF CGFQ+ FIG H Sbjct: 185 DR--------PLPPQGHE------QSLGEALREACAHSGFWLLALGFFVCGFQVVFIGVH 230 Query: 258 LPGYLTLCHMPLGLGATALALIGLFNMAGSWGCGWLGGHFRQQYVLGWLYLVRSGAIAAF 317 LP YL H+P +G T LAL+GLFN+ G++ GWLGG + + +L LYLVR I F Sbjct: 231 LPAYLVDQHLPAQVGTTVLALVGLFNVFGTYIAGWLGGRWSKPRLLTALYLVRGVVIVLF 290 Query: 318 LALPKTSASVMVFAAVMGLTWLGTVPLTSGLVAKVFGTRHLGTLFGVCFLSHQIGSFLGA 377 L LP + S F MGL WL TVPLT+G VA +FG R+L L G+ FL HQ+G+FLG Sbjct: 291 LWLPLSVYSAYAFGVAMGLLWLSTVPLTNGTVATLFGVRNLSMLGGIVFLFHQLGAFLGG 350 Query: 378 WLGGYMFDLTGSYTMVWGATVAAGVLAALLHFAINDQP 415 WLGG ++D TGSY +VW ++ +LAALL++ + ++P Sbjct: 351 WLGGVVYDRTGSYDLVWQLSILLSLLAALLNWPVRERP 388 >SMc02603 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 412 Score = 280 bits (715), Expect = 6e-75, Method: Compositional matrix adjust. Identities = 179/414 (43%), Positives = 243/414 (58%), Gaps = 10/414 (2%) Query: 1 MSATSQPTPAHLSRAGNPALWVVIAAALVLSVVMGTRQTFGLYINPFSYDRGLPVTVIAF 60 MSA S + R+G P L +++A +++ + G R G + P ++G T Sbjct: 1 MSAVSSAVSRPVERSGLPWL-IIVAGSIIAMLTFGPRSAMGFFQLPMLAEKGWDRTTFGL 59 Query: 61 AIALHNLVWGFAQPFAGAASDRYGATPVVAFGAVTFAAGLALAAVAPSGLLLIIGLGLLV 120 A+A NL WG QPF GA +D++G V+A + +AAGL L A A + + L IG G+LV Sbjct: 60 AMAFQNLCWGLGQPFFGAIADKFGTWRVLALSGLVYAAGLILMAFADAPIWLHIGGGVLV 119 Query: 121 GIGISCTSFGVVLASVGRVATPQQRSMAMGIASAGGSLGQVLLVPLAQTVRESTGVSASL 180 G+G++ SFG+VL++ R P+QRS+A GI +A GS G L PL+Q + + G S SL Sbjct: 120 GLGVASGSFGIVLSAFARNVAPEQRSLAFGIGTAAGSAGMFLFAPLSQGLISAYGWSDSL 179 Query: 181 FVLAAIALAIAPAGLILDRGRKKSSAFSSSPATHPAAEPPASSLKEVLTLAGRHHGYRLL 240 L + L + + L RG S S + E +LKE L H Y LL Sbjct: 180 VYLGLLMLLVPLFAIPL-RGNASSGRQSEALFKQTVGE----ALKEALG----HKSYLLL 230 Query: 241 TIGFFTCGFQLAFIGTHLPGYLTLCHMPLGLGATALALIGLFNMAGSWGCGWLGGHFRQQ 300 GFF CG+Q+AFI H P Y+ + ALALIG FN+ GS+ G +G + + Sbjct: 231 VSGFFVCGYQVAFITAHFPAYIGDIGIDARYAVIALALIGFFNIIGSFSAGIIGQRYSKP 290 Query: 301 YVLGWLYLVRSGAIAAFLALPKTSASVMVFAAVMGLTWLGTVPLTSGLVAKVFGTRHLGT 360 Y L +YL RS ++AFL LP+T SV+VFA VMGL WL TVP T+GLVA +FGTRHLG Sbjct: 291 YFLALIYLARSVVVSAFLLLPQTPTSVIVFAVVMGLLWLSTVPPTNGLVAIMFGTRHLGL 350 Query: 361 LFGVCFLSHQIGSFLGAWLGGYMFDLTGSYTMVWGATVAAGVLAALLHFAINDQ 414 L G+ FLSHQIGSFLG W+GGY++D GSY VW VA GV AA++H+ I ++ Sbjct: 351 LGGIVFLSHQIGSFLGVWMGGYLYDHFGSYDPVWWVGVALGVFAAIVHWPIEER 404 >AGc1918 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 414 Score = 268 bits (685), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 169/397 (42%), Positives = 234/397 (58%), Gaps = 10/397 (2%) Query: 21 WVVIAAALVLSVV-MGTRQTFGLYINPFSYDRGLPVTVIAFAIALHNLVWGFAQPFAGAA 79 W++IAA +++V+ G R G + P D G + A+AL NL WG QPF GA Sbjct: 21 WLIIAAGSLIAVMTFGPRSAMGFFQLPMLADTGWDRSTFGLAMALQNLFWGLGQPFFGAI 80 Query: 80 SDRYGATPVVAFGAVTFAAGLALAAVAPSGLLLIIGLGLLVGIGISCTSFGVVLASVGRV 139 +D+YG V+ + +AAGL + S L G G+LVG+GI+ SF V+L++ R Sbjct: 81 ADKYGTGRVLVLSGILYAAGLVCMSFGTSPFWLHFGGGVLVGLGIAAGSFSVILSAFARH 140 Query: 140 ATPQQRSMAMGIASAGGSLGQVLLVPLAQTVRESTGVSASLFVLAAIALAIAPAGLILDR 199 TPQQRS+A GI +A GS G L P++Q + + G S SL LAA+ + + P R Sbjct: 141 VTPQQRSLAFGIGTAAGSAGMFLFAPISQGLISAYGWSDSLVWLAAM-MVLVPLLAWPMR 199 Query: 200 GRKKSSAFSSSPATHPAAEPPASSLKEVLTLAGRHHGYRLLTIGFFTCGFQLAFIGTHLP 259 G S + S + E +LKE L H Y LLT GFF CGFQ+AFI H P Sbjct: 200 GNSSSGSQSQAQFQQTVGE----ALKEALG----HKSYLLLTTGFFVCGFQVAFITAHFP 251 Query: 260 GYLTLCHMPLGLGATALALIGLFNMAGSWGCGWLGGHFRQQYVLGWLYLVRSGAIAAFLA 319 YL + A+ALIG FN+ GS G + + + Y+L ++Y+ RS + AFL Sbjct: 252 AYLGDIGIEPRYAVIAMALIGFFNIIGSLAAGVIAQRYSKPYLLAYIYIARSVVVTAFLL 311 Query: 320 LPKTSASVMVFAAVMGLTWLGTVPLTSGLVAKVFGTRHLGTLFGVCFLSHQIGSFLGAWL 379 LP++ SV++FA+ MG+ WL TVP T+ LVA +FGTRHLG L GV FL+HQIGSFLG WL Sbjct: 312 LPQSPLSVILFASFMGILWLSTVPPTNALVAIMFGTRHLGMLGGVVFLTHQIGSFLGVWL 371 Query: 380 GGYMFDLTGSYTMVWGATVAAGVLAALLHFAINDQPA 416 GG+++D G+Y +VW V G+ AA++H+ I ++PA Sbjct: 372 GGFLYDRFGTYDIVWWLGVGMGIFAAIVHWPIQERPA 408 >NMA0047 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 405 Score = 232 bits (592), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 143/381 (37%), Positives = 206/381 (54%), Gaps = 10/381 (2%) Query: 17 NPALWVVI-AAALVLSVVMGTRQTFGLYINPFSYDRGLPVTVIAFAIALHNLVWGFAQPF 75 P W+ I AAA +L + +G R T GL++ P L + + IA+ L+WG +QP Sbjct: 8 TPKFWLTITAAAFILLITIGMRMTLGLFVQPVVNTTELSIAQFSLIIAVFQLMWGVSQPL 67 Query: 76 AGAASDRYGATPVVAFGAVTFAAGLALAAVAPSGLLLIIGLGLLVGIGISCTSFGVVLAS 135 +GA +DR+GA V++ GAV +A P+ L+I +GLL+ G F +++ Sbjct: 68 SGALADRFGAFRVLSGGAVLLVCACLIAPNIPTYWGLMIAVGLLLAFGTGSGGFSIIMGQ 127 Query: 136 VGRVATPQQRSMAMGIASAGGSLGQVLLVPLAQ--TVRESTGVSASLFVLAAIALAIAPA 193 V +R +A G+ +AGGS GQ L PL Q V G + + +V AIAL P Sbjct: 128 VAAQVPAHKRGLASGLVNAGGSAGQFLFAPLVQGLVVLPEVGWTGTFYVWGAIALLTLPV 187 Query: 194 GLILDRGRKKSSAFSSSPATHPAAEPPASSLKEVLTLAGRHHGYRLLTIGFFTCGFQLAF 253 L G + + ATH SL E + A + Y LL + FF CGF +AF Sbjct: 188 SWWLAGGNNAAHT-QHAQATH------GQSLGEAVKTAFKTPSYILLHLSFFACGFHIAF 240 Query: 254 IGTHLPGYLTLCHMPLGLGATALALIGLFNMAGSWGCGWLGGHFRQQYVLGWLYLVRSGA 313 + THLP + LC +P + +T++A+IGL N+AG GW R +YVL LY R+ Sbjct: 241 LVTHLPTEVALCGLPATVASTSIAIIGLANIAGCIFSGWCTSRVRGKYVLFGLYASRAAM 300 Query: 314 IAAFLALPKTSASVMVFAAVMGLTWLGTVPLTSGLVAKVFGTRHLGTLFGVCFLSHQIGS 373 I ++ PKT + +FAA +G TWL TV T+ + K+FGTR+L TLFG+ LSHQIG Sbjct: 301 ILIYIFSPKTDLNFYIFAAALGFTWLATVTPTASITGKLFGTRYLATLFGLTMLSHQIGG 360 Query: 374 FLGAWLGGYMFDLTGSYTMVW 394 FLG+++GG + G Y +W Sbjct: 361 FLGSYIGGIVITQFGDYGWMW 381 >RSp0107 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 432 Score = 105 bits (263), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 121/420 (28%), Positives = 186/420 (44%), Gaps = 35/420 (8%) Query: 21 WVVIAAA-LVLSVVMGTRQTFGLYINPFSYDRGLPVTVIAFAIALHNLVWGFAQPFAGAA 79 W+ +A L+L GTR T + + P ++ G I+ AI++ ++G PFA A+ Sbjct: 16 WIALAVVFLILLCAAGTRATPSVMMLPLEHEFGWSRGTISLAISIGIALYGLTGPFAAAS 75 Query: 80 SDRYGATPVVAFGAVTFAAGLALAAV--APSGLLLIIGLGLLVGIGISCTSFGVVLASVG 137 +G P V V +G AL+A+ P ++L+ G+ + G G++ + G + V Sbjct: 76 MQYFGIRPTVLGALVVLISGTALSAMMSQPWQMVLLWGVMVGGGTGVAAITLGATV--VN 133 Query: 138 RVATPQQRSMAMGIASAGGSLGQVLLVPLAQTVRESTGVSASLFVLAAIALAIAPAGLIL 197 R T R +AMGI +A + GQ++ +P+ V E G + ++A + + P +L Sbjct: 134 RWFT-THRGLAMGILTASSATGQLVFLPMMAAVVERHGWRPVVLIVAGALVLLLPIVGLL 192 Query: 198 DRGRKKSSAFSS--SPATHPAAE--PPASSLK---EVLTLAGRHHGYRLLTIGFFTCGFQ 250 KS + PA P A+ P A+ + L A R + LL FF CG Sbjct: 193 LPESPKSVGLRTYGEPADAPEADHGPRANPIALAMHTLMQAMRKRDFWLLFASFFICGAS 252 Query: 251 L-AFIGTHLPGYLTLCHMPLGLGATALALIGLFNMAGSWGCGWLGGHFRQQYVLGWLYLV 309 +IGTH + GA+ LA +G+F++ G+ GWL + + +L W Y + Sbjct: 253 TNGYIGTHFIAMCADHGLTEVKGASLLAAMGIFDLVGTTLSGWLSDRYNSRVLLFWYYGL 312 Query: 310 RSGAIA--------AFLALPKTSASVMVFAAVMGLTWLGTVPLTSGLVAKVFGTRHLGTL 361 R ++ F LP VFA GL W+ TVP T L VFG + Sbjct: 313 RGLSLIYLPYAFGFEFFGLP-------VFAIFYGLDWIATVPPTVRLTNDVFGKAAAPIV 365 Query: 362 FGVCFLSHQIGSFLGAWLGGYMFDLTGSYT---MVWGATVAAGVLAALLHFAINDQPADD 418 FG HQ+G+ G M G+YT M+ G AG A L I+ Q D Sbjct: 366 FGWIVAGHQLGAAFATLGAGLMRASLGNYTLASMISGGLCVAG---AFLVLRIHRQRKPD 422