BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0369.p (278 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr7896 [GER] COG0697 Permeases of the drug/metabolite transport... 228 1e-59 BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transpor... 190 3e-48 mll3062 [GER] COG0697 Permeases of the drug/metabolite transport... 181 2e-45 STM3796A [GER] COG0697 Permeases of the drug/metabolite transpor... 180 4e-45 SMc01807 [GER] COG0697 Permeases of the drug/metabolite transpor... 174 1e-43 >mlr7896 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 278 Score = 228 bits (580), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 127/277 (45%), Positives = 175/277 (63%) Query: 1 MSLAVVALVLCAALLHASWNALLKSSGDRLASLTIMTIGAGVGAIPLVLFTPLPHAAAWP 60 MS V+ L L AA+LHASWNA L++ DRL ++T+M+ AIPL +F P +AWP Sbjct: 1 MSPLVIGLALFAAILHASWNAFLRTGADRLWTVTVMSFSDTALAIPLAIFNGFPATSAWP 60 Query: 61 CIILSAILHTGYNLFLIRAYRIGDFSQSYPIARGSSPMLVSIGAAIFVGEQMSIYTWLGV 120 + LSA L GY++FL+ AYR G+ Q YPI RGS P+LV++G + G+Q+++ +GV Sbjct: 61 YVGLSACLQVGYSVFLVAAYRYGELGQVYPIVRGSVPLLVTLGGFLLAGQQLTVPETVGV 120 Query: 121 ALVSIGIISLANIKDRHNLSGPIAAFTTGAFIAAYTVTDGIGARAAGNALAYSGWLFVLD 180 LV GI+ L+ + R + + A TGA IA Y D IG RAAGN AY+ W+ + Sbjct: 121 VLVGGGIMGLSLGRGRAATTSILYALATGAIIAVYATVDAIGVRAAGNVGAYTAWVLLAY 180 Query: 181 SFPLALIFMWMHRRLPMAAERKQNWLSLAGGVMSLLAYGIVIWAVTLAPMGTVSALRETS 240 L F+ RLP+ + W +L GG+ +LLAYG+V+ A L P G ++A+RETS Sbjct: 181 GALLPATFVACRGRLPVDPRAPETWKALGGGLFALLAYGVVVAAFALGPAGPITAIRETS 240 Query: 241 VLFAALIGTLFLGEKLTMRRILACILITLGAIVLGWH 277 V+FAA IG LFLGE LT RR+ AC ++ LGAI LG+ Sbjct: 241 VVFAAFIGRLFLGETLTPRRVGACAVVALGAICLGYQ 277 >BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bme Brucella melitensis Length = 281 Score = 190 bits (482), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 117/284 (41%), Positives = 170/284 (59%), Gaps = 16/284 (5%) Query: 1 MSLAVVALVLCAALLHASWNALLKSSGDRLASLTIMTIGAGVGAIPLVLFTPLPHAAAWP 60 MS V+ +VL A LH SWNA++K SGD+ +T AG+ A+ LV F PLP AA+W Sbjct: 1 MSGGVLLIVLFGAFLHTSWNAIVKGSGDKFFGAASVTGAAGLIALFLVPFLPLPTAASWI 60 Query: 61 CIILSAILHTGYNLFLIRAYRIGDFSQSYPIARGSSPMLVSIGAAIFVGEQMSIYTWLGV 120 ++LS I T Y + AY+ GD S++YPI RG+ P+LV++ + VGE M +WLG+ Sbjct: 61 YMLLSTITQTFYMSLVAAAYKSGDMSEAYPIMRGTPPLLVALVSGPLVGEIMGWQSWLGI 120 Query: 121 ALVSIGIISLANIKDRHNLSGP----IAAFTTGAFIAAYTVTDGIGARAAGNALAYSGWL 176 L+ G++++A R N + A FIA+YT+ DG+G R +G L+Y+ WL Sbjct: 121 VLICSGVLAMALDARRRNRGASSRTVLLALANAGFIASYTLIDGLGVRVSGEPLSYTLWL 180 Query: 177 FVLDSFPLALIFMWMHRRLPMAAERKQNWL------SLAGGVMSLLAYGIVIWAVTLAPM 230 F+L++ PLA W R P R N++ +L GGV +L +YG+ +WA+T+AP+ Sbjct: 181 FLLNAVPLA---GWALYREP---SRFINYIRNRWRPALIGGVGTLGSYGLALWAMTMAPI 234 Query: 231 GTVSALRETSVLFAALIGTLFLGEKLTMRRILACILITLGAIVL 274 V+ALRET++LF LI L L EK+ + R +A I GAI L Sbjct: 235 AVVAALRETAILFGMLISALILKEKVGLPRFVAAGFIVAGAIAL 278 >mll3062 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 281 Score = 181 bits (458), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 114/264 (43%), Positives = 162/264 (61%), Gaps = 12/264 (4%) Query: 19 WNALLKSSGDRLASLTIMTIGAGVGAIPLVLFTPLPHAAAWPCIILSAILHTGYNLFLIR 78 WNAL+K DR S+T+MT+G G A+ ++ F P A WP I+ S + H GY FLI Sbjct: 19 WNALVKVHLDRFLSITLMTLGMGFAALFVLPFVEFPKAEVWPFILASVVFHMGYRTFLIG 78 Query: 79 AYRIGDFSQSYPIARGSSPMLVSIGAAIFVGEQMSIYTWLGVALVSIGIISLANIK---- 134 AYR GDF+Q+YP+ARG++P+L ++G + V E + + LG+ L+S G + ++ Sbjct: 79 AYRAGDFAQTYPLARGTAPLLAALGGIVVVQEVPAPFAILGILLLSAGTLVMSFRGGAHL 138 Query: 135 DRHNLSGPIAAFTTGAFIAAYTVTDGIGARAAGNALAYSGWLFVLDSFPLALIFMWMHR- 193 +R NL A T FIA+YT++DG GAR A A +Y+ WLFV D+ AL+ + R Sbjct: 139 ERLNLRAVGFALGTSIFIASYTLSDGSGARLAATAQSYAAWLFVCDA-TWALVLCVVFRG 197 Query: 194 --RLPMAAERKQNWLS-LAGGVMSLLAYGIVIWAVTLAPMGTVSALRETSVLFAALIGTL 250 LP+ A ++W + L GV+S AY IV+WA+T AP+ +V++LRETS+LFA LI Sbjct: 198 PQSLPVLA---RDWKAGLFTGVLSGAAYWIVMWAMTKAPIASVASLRETSILFAMLISVY 254 Query: 251 FLGEKLTMRRILACILITLGAIVL 274 LGEK+T R A + I G I L Sbjct: 255 ALGEKMTGWRGAAALSIVAGVIAL 278 >STM3796A [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sty Salmonella typhimurium LT2 Length = 286 Score = 180 bits (456), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 105/277 (37%), Positives = 169/277 (61%), Gaps = 6/277 (2%) Query: 1 MSLAVVALVLCAALLHASWNALLKSSGDRLASLTIMTIGAGVGAIPLVLFTPLPHAAAWP 60 M+L+V ++L AALLHASWNA++K+ D+L + ++ A V A+ L+ F+P P A+ P Sbjct: 10 MTLSVFCILLFAALLHASWNAIVKAGNDKLYAAIGVSGSAAVMALILLPFSPQPAHASIP 69 Query: 61 CIILSAILHTGYNLFLIRAYRIGDFSQSYPIARGSSPMLVSIGAAIFVGEQMSIYTWLGV 120 + S L Y + + + Y++ D SQ+YP+ RG++P+LV++ + +F+G+ +S W+G+ Sbjct: 70 FLAASTALQVVYTVLVAKTYQVSDMSQTYPLMRGTAPLLVALISVLFLGDSLSSLAWVGI 129 Query: 121 ALVSIGIISLANIKDRHNLSGPIAAFTTGAFIAAYTVTDGIGARAAGNALAYSGWLFVLD 180 A++ + I+ +A + G + A T FIA YT+ DG G R + AL Y+ W F L+ Sbjct: 130 AVICMAILGMACNGRASSQRGVVLALTNACFIAGYTLVDGTGVRLSETALGYTLWSFFLN 189 Query: 181 SFPLALIFMW--MHRRLPMAAERKQNWLS-LAGGVMSLLAYGIVIWAVTLAPMGTVSALR 237 A + W + RR + Q W + GG+ ++ +YG+ +WA+T AP+ V+ALR Sbjct: 190 G---ACLLTWAMIARRREASRYLAQQWKKGIFGGIGTMGSYGLALWAMTQAPLAVVAALR 246 Query: 238 ETSVLFAALIGTLFLGEKLTMRRILACILITLGAIVL 274 ETS+LF ALI L L EK+ R++A I LGAI+L Sbjct: 247 ETSILFGALIAWLLLKEKVAGLRLVAAGGIALGAILL 283 >SMc01807 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 278 Score = 174 bits (442), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 101/271 (37%), Positives = 165/271 (60%), Gaps = 7/271 (2%) Query: 1 MSLAVVALVLCAALLHASWNALLKSSGDRLASLTIMTIGAGVGAIPLVLFTPLPHAAAWP 60 M V+ALVL ALLHA+WNAL+K+ ++ ++++G V A+P + F P+P + A P Sbjct: 1 MPPDVIALVLLGALLHATWNALVKAGTEKSLDAAMVSLGGAVVALPFLPFLPMPGSEAVP 60 Query: 61 CIILSAILHTGYNLFLIRAYRIGDFSQSYPIARGSSPMLVSIGAAIFVGEQMSIYTWLGV 120 I++SA+ Y + AYR GD YP+ RG +P++V+ +++ +GE+++ G+ Sbjct: 61 YILVSALFQFAYFQLVAAAYRAGDIGLVYPLMRGVAPLIVAATSSLVIGEKLTGGAMAGI 120 Query: 121 ALVSIGIISLANIKDRHNLSGPIAAFTTGAFIAAYTVTDGIGARAAGNALAYSGWLFVLD 180 +S G+++LA + + A IA+YT DGIGAR +GNA++Y+ W+ +L Sbjct: 121 MTISAGVLTLAFESRKGGRHAIVLALLNACVIASYTYVDGIGARISGNAISYTLWMALL- 179 Query: 181 SFPLALIFMWMHRR---LPMAAERKQN-WLSLAGGVMSLLAYGIVIWAVTLAPMGTVSAL 236 P L+F W R P+A ++ W L GG S+ +YG+ +WA+T AP+ TV+AL Sbjct: 180 --PPVLLFGWAFARRGVKPVARHVSRHWWRGLIGGAGSIGSYGLALWAMTKAPVATVAAL 237 Query: 237 RETSVLFAALIGTLFLGEKLTMRRILACILI 267 RET++LFA +I +FL E+++ RI+A +I Sbjct: 238 RETAILFAVVISVVFLKERVSAWRIIAAFII 268