BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0338.p (423 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMB0360 [GEPR] COG0477 Permeases of the major facilitator superf... 462 e-130 NMA2127 [GEPR] COG0477 Permeases of the major facilitator superf... 449 e-126 PM0285 [GEPR] COG0477 Permeases of the major facilitator superfa... 426 e-119 HI0350 [GEPR] COG0477 Permeases of the major facilitator superfa... 372 e-102 RSc0154 [GEPR] COG0477 Permeases of the major facilitator superf... 305 1e-82 >NMB0360 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 427 Score = 462 bits (1190), Expect = e-130, Method: Compositional matrix adjust. Identities = 238/405 (58%), Positives = 308/405 (76%), Gaps = 8/405 (1%) Query: 13 NRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKALGLFALVMFPYTWKFLWSPLMD 72 +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKFLWSPLMD Sbjct: 14 SRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSPLMD 73 Query: 73 RFHFGRMGRRRGWMLFTQIGLFFGIGGMGMLDPQTQIGTIAFMASVVAFLSASQDIVVDA 132 +GRRRGWML TQ GL + L+P+ + IA ++ +VAF SASQDIV+DA Sbjct: 74 AVRLPVLGRRRGWMLLTQAGLLAALAVYAFLNPRNHLPLIAGLSVLVAFFSASQDIVLDA 133 Query: 133 YRREILPEEELGLGSAIHVNAYKLSGMVPGALSLVLADLMPWQSVFWITAGFMLPGLLCT 192 +RREIL +EELGLG+++HVNAY+++ ++PG+LSLVLAD MPW VF IT+ FMLPGLL T Sbjct: 134 FRREILSDEELGLGNSVHVNAYRIAALIPGSLSLVLADRMPWLEVFVITSLFMLPGLLMT 193 Query: 193 L-AVKEPVVYGVPPKNLREAVVLPFREFVTRGGWSKALWVLAFIFLYKLGDSMATALATK 251 L +EPV+ PK L++ VV PF+EF TR G + A+ VL FIFLYKLGDSMATALAT Sbjct: 194 LFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATALATP 253 Query: 252 FYIDLGFSMTQIGVVSKTTSLWASVVGGIIGGVWMIRLGINKALWVFGVVQAVAILGFAW 311 FY+D+GFS T IG+++K LW +V GI+GGVWM+++G+NKALW+FG VQAV +LGF W Sbjct: 254 FYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLGFVW 313 Query: 312 LAQVG-------ASTVALAVVIGIEAFGVGLGTAAFVAYIMRETDPRYTATQFALFTSLA 364 LA G + LA VIG EA GVGLGTAAFV+Y+ RET+P +TATQ ALFTSL+ Sbjct: 314 LAGFGPFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFTSLS 373 Query: 365 AVPRTFVNSSVGYIVAYMGWFNFFILCFILALPGMVMLLKIAPWN 409 AVPRT +NS GY++ ++G+ FF LCF LALPGM++LLK+APWN Sbjct: 374 AVPRTVINSFAGYLIEWLGYVPFFQLCFALALPGMLLLLKVAPWN 418 >NMA2127 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 427 Score = 449 bits (1156), Expect = e-126, Method: Compositional matrix adjust. Identities = 238/405 (58%), Positives = 309/405 (76%), Gaps = 8/405 (1%) Query: 13 NRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKALGLFALVMFPYTWKFLWSPLMD 72 +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKFLWSPLMD Sbjct: 14 SRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSPLMD 73 Query: 73 RFHFGRMGRRRGWMLFTQIGLFFGIGGMGMLDPQTQIGTIAFMASVVAFLSASQDIVVDA 132 +GRRRGWML TQ GL + L+P+ + IA ++ +VAF SASQDIV+DA Sbjct: 74 AVRLPVLGRRRGWMLLTQAGLLAALAAYAFLNPRNHLPLIAGLSVLVAFFSASQDIVLDA 133 Query: 133 YRREILPEEELGLGSAIHVNAYKLSGMVPGALSLVLADLMPWQSVFWITAGFMLPGLLCT 192 +RREIL +EELGLG+++HVNAY+++ ++PG+LSLVLAD MPW VF IT+ FMLPGLL T Sbjct: 134 FRREILSDEELGLGNSVHVNAYRVAALIPGSLSLVLADRMPWSEVFVITSLFMLPGLLMT 193 Query: 193 L-AVKEPVVYGVPPKNLREAVVLPFREFVTRGGWSKALWVLAFIFLYKLGDSMATALATK 251 L +EPV+ PK L++ VV PF+EF TR G + A+ VL FIFLYKLGDSMATALAT Sbjct: 194 LFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATALATP 253 Query: 252 FYIDLGFSMTQIGVVSKTTSLWASVVGGIIGGVWMIRLGINKALWVFGVVQAVAILGFAW 311 FY+D+GFS T IG+++K LW +V GI+GGVWM+++G+NKALW+FG VQAV +LGF W Sbjct: 254 FYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLGFVW 313 Query: 312 LAQVG-------ASTVALAVVIGIEAFGVGLGTAAFVAYIMRETDPRYTATQFALFTSLA 364 LA G + LA VIG EA GVGLGTAAFV+Y+ RET+P +TATQ ALFTSL+ Sbjct: 314 LAGFGHFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFTSLS 373 Query: 365 AVPRTFVNSSVGYIVAYMGWFNFFILCFILALPGMVMLLKIAPWN 409 AVPRT +NS GY++ ++G+ FF LCF+LALPGM++LLK+APWN Sbjct: 374 AVPRTVINSFAGYLIEWLGYVPFFQLCFVLALPGMLLLLKVAPWN 418 >PM0285 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 425 Score = 426 bits (1096), Expect = e-119, Method: Compositional matrix adjust. Identities = 212/412 (51%), Positives = 291/412 (70%), Gaps = 11/412 (2%) Query: 13 NRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKALGLFALVMFPYTWKFLWSPLMD 72 +R ML+C+F GF+SGLPL++L ++ AWL+ S ++VK +G F L+ FPYTWKF+ SPL+D Sbjct: 14 SRNMLLCIFTGFSSGLPLYVLFQMVPAWLSSSNVDVKTIGFFTLIGFPYTWKFIISPLLD 73 Query: 73 RFHFGRMGRRRGWMLFTQIGLFFGIGGMGMLDPQTQIGTIAFMASVVAFLSASQDIVVDA 132 R++ +GRRR WM TQ+ L + +G DP I +A +++ +A SA QDIV+DA Sbjct: 74 RYYPNFLGRRRSWMFMTQVALLALLALLGQYDPVANITIVAVISTSIAVFSAVQDIVIDA 133 Query: 133 YRREILPEEELGLGSAIHVNAYKLSGMVPGALSLVLADLMPWQSVFWITAGFMLPGLLCT 192 YRREIL +EELGLG++IHVNAY++SG++PG LSL+LAD +PW VF TA FM+PGL+ + Sbjct: 134 YRREILTDEELGLGNSIHVNAYRISGLIPGGLSLILADSLPWDVVFIFTALFMIPGLILS 193 Query: 193 LAV-KEPVVYGVPPK-NLREAVVLPFREFVTRGGWSKALWVLAFIFLYKLGDSMATALAT 250 L + KEP V + LPF+EF +R G + AL ++ FIFLYK GDS+AT+L T Sbjct: 194 LFLSKEPDVPQIDRSLPFYHTFALPFKEFFSRKGVASALGLIFFIFLYKFGDSLATSLQT 253 Query: 251 KFYIDLGFSMTQIGVVSKTTSLWASVVGGIIGGVWMIRLGINKALWVFGVVQAVAILGFA 310 KF +D+GFS T IG V K SLWAS++ G++GG+ M+R+GIN++LW+FG VQ + ILGF Sbjct: 254 KFILDMGFSKTDIGTVVKLNSLWASIISGMLGGILMLRIGINRSLWLFGFVQLITILGFV 313 Query: 311 WLAQVGAST--------VALAVVIGIEAFGVGLGTAAFVAYIMRETDPRYTATQFALFTS 362 W+A G V V+IG E GVGLGTAAFVA++ RET+P YTATQ A+FTS Sbjct: 314 WMASYGKFNTIGSFEFFVLTTVIIG-EYIGVGLGTAAFVAFMARETNPLYTATQLAIFTS 372 Query: 363 LAAVPRTFVNSSVGYIVAYMGWFNFFILCFILALPGMVMLLKIAPWNHVEHR 414 L+A+P ++ G +VA G++ FF +CF A+PGM+ML K+APW+ E R Sbjct: 373 LSAIPSKIFSAFSGVLVADYGYYTFFWICFFAAIPGMLMLFKVAPWHSAEQR 424 >HI0350 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 425 Score = 372 bits (954), Expect = e-102, Method: Compositional matrix adjust. Identities = 200/414 (48%), Positives = 276/414 (66%), Gaps = 9/414 (2%) Query: 13 NRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKALGLFALVMFPYTWKFLWSPLMD 72 R+MLIC F GF SGLPLF+L +L WL L+++ +G VM PY KFLW+PL+D Sbjct: 11 TRKMLICAFTGFNSGLPLFVLSQMLPVWLTDKHLSIELIGAVTGVMLPYGLKFLWAPLLD 70 Query: 73 RFHFGRMGRRRGWMLFTQIGLFFGIGGMGMLDPQTQIGTIAFMASVVAFLSASQDIVVDA 132 R+ +GRRR WML +Q+ L + + + DP TQ+GT+A +A ++AF SA+QDIV+DA Sbjct: 71 RYFPSFLGRRRSWMLLSQVALLILLYIISLFDPLTQLGTVANIALLIAFFSATQDIVLDA 130 Query: 133 YRREILPEEELGLGSAIHVNAYKLSGMVPGALSLVLADLMPWQSVFWITAGFMLPGLLCT 192 YRREIL + ELGLG+ IH+NAY+++G++PG LSL LA + PW++VF TA ML G+ T Sbjct: 131 YRREILSDHELGLGNTIHINAYRIAGLIPGGLSLYLAAIYPWETVFLWTALCMLAGIFMT 190 Query: 193 LAV-KEPVV-YGVPPKNLREAVVLPFREFVTRGGWSKALWVLAFIFLYKLGDSMATALAT 250 L + KEP + + +A +P +EF R G +A+ L F+FLYK GDS AT L T Sbjct: 191 LFLAKEPKIDMQQTNQPFYQAFWIPLQEFFQRKGVIQAIGFLLFLFLYKFGDSFATTLQT 250 Query: 251 KFYIDLGFSMTQIGVVSKTTSLWASVVGGIIGGVWMIRLGINKALWVFGVVQAVAILGFA 310 KF D+GFS I +V K+T+LW+S++ G+ GG+ M++LGIN+ALW+FG+VQ V I GF Sbjct: 251 KFIYDMGFSKEDIAIVVKSTALWSSILSGLAGGMIMLKLGINRALWLFGLVQMVTIGGFI 310 Query: 311 WLAQVGASTV-------ALAVVIGIEAFGVGLGTAAFVAYIMRETDPRYTATQFALFTSL 363 WLA G V L VVI E GVGLGTAAFVA++ RE++P YTATQ ALFTSL Sbjct: 311 WLAAFGHFDVITSAELWKLGVVIAAEYIGVGLGTAAFVAFMARESNPLYTATQLALFTSL 370 Query: 364 AAVPRTFVNSSVGYIVAYMGWFNFFILCFILALPGMVMLLKIAPWNHVEHRPKT 417 +A+P + GY+V +G++ +F C LA+PGM+ L +AP ++ + Sbjct: 371 SALPSKVLGILSGYVVGAVGYYQYFWFCLFLAIPGMLCLFWVAPLKQENNKTSS 424 >RSc0154 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 426 Score = 305 bits (782), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 179/404 (44%), Positives = 259/404 (64%), Gaps = 11/404 (2%) Query: 6 ISWHSYL----NRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKALGLFALVMFPY 61 +++H YL NRR+ + LGF SGLPL + LQAW+ GL+++ +GLF+LV Y Sbjct: 1 MTFHDYLDVFRNRRIGAMLLLGFASGLPLALTSGTLQAWMTVEGLDIRTIGLFSLVGQAY 60 Query: 62 TWKFLWSPLMDRFHFGRMGRRRGWMLFTQIGLFFGIGGMGMLDPQTQIGTIAFMASVVAF 121 +KFLW+PLMDRF +GRRRGW++ TQ GL I M P + +A +A +VAF Sbjct: 61 IFKFLWAPLMDRFTPPLIGRRRGWLVLTQAGLAASIAAMAFCPPHAALWALAGLAVLVAF 120 Query: 122 LSASQDIVVDAYRREILPEEELGLGSAIHVNAYKLSGMVPGALSLVLAD-LMPWQSVFWI 180 LSASQDIV DAY ++L E G+G+A+ V Y+L+ +V G L+L LAD +M W S++ + Sbjct: 121 LSASQDIVFDAYSTDVLHASERGVGAAVKVLGYRLAMLVSGGLALWLADRVMGWSSMYLL 180 Query: 181 TAGFMLPGLLCTLAVKEPVVYGVPPKNLREAVVLPFRE-FVTRGGWSKALWVLAFIFLYK 239 AG M +L TL EP PP++L+EAVV P R+ F RG W+ +LA I LYK Sbjct: 181 MAGLMALFVLATLWSPEPEAAARPPRSLQEAVVGPLRDFFARRGAWA----LLALIVLYK 236 Query: 240 LGDSMATALATKFYID-LGFSMTQIGVVSKTTSLWASVVGGIIGGVWMIRLGINKALWVF 298 LGD+ A +L+T F I +GFS ++G+V+KT L A+++G + GG M+RLG+ +AL +F Sbjct: 237 LGDAFAGSLSTTFLIRGVGFSAGEVGIVNKTLGLVATIIGALYGGTLMVRLGLVRALLLF 296 Query: 299 GVVQAVAILGFAWLAQVGASTVALAVVIGIEAFGVGLGTAAFVAYIMRETDPRYTATQFA 358 GV+QAV+ LG+ LA +A+ IGIE G+GTAAFVA +M + ++ATQ+A Sbjct: 297 GVLQAVSNLGYWVLAVTPQHLWTMALAIGIENLCGGMGTAAFVALLMALCNRSFSATQYA 356 Query: 359 LFTSLAAVPRTFVNSSVGYIVAYMGWFNFFILCFILALPGMVML 402 L ++LA++ R +V + GY+V GW F+++ A PG+ +L Sbjct: 357 LLSALASIGRVYVGPTSGYLVEAYGWPAFYLMTVAFAFPGLALL 400