BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0213.p (304 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ML1267 [P] COG0387 Ca2+/H+ antiporter Mle Mycobacterium leprae 170 5e-42 Rv1607 [P] COG0387 Ca2+/H+ antiporter Mtu Mycobacterium tubercul... 169 9e-42 MT1642 [P] COG0387 Ca2+/H+ antiporter MtC Mycobacterium tubercul... 169 9e-42 mlr6933 Non COG 160 3e-39 YPO1958 [P] COG0387 Ca2+/H+ antiporter Ype Yersinia pestis 134 3e-31 >ML1267 [P] COG0387 Ca2+/H+ antiporter Mle Mycobacterium leprae Length = 364 Score = 170 bits (430), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 117/223 (52%), Positives = 151/223 (67%), Gaps = 5/223 (2%) Query: 41 LMASVLAAVYHAEVVAHKVGEPFGTLVLALAVTLIEVALIVSLMLTGGEATTGLARDTVF 100 L +VLAAV+HAEVVAH+VGEPFG+LVLA AVT+IEVALIV+LM +G + LARDT F Sbjct: 39 LTGAVLAAVHHAEVVAHRVGEPFGSLVLAAAVTVIEVALIVTLMASGENESWTLARDTAF 98 Query: 101 AAIMIILNGIVGICLLVGSSQHGEQSFGQRGVSASLATLAAIAVLTLVLPNYTLTTAGPF 160 AA+MI NGI G LL+GS ++G F G A+LATL +A L+LVLP +T + G Sbjct: 99 AALMITTNGIAGFSLLLGSRRYGVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNE 158 Query: 161 YSTSQLAFIAVISLVLYGTFVLVQTVRHRDYFLP--PNAAAG---DAEAHAEPPSNKVAI 215 +S QLAF AV SL LY FV QT+RHRD+FLP G + E+HA+PPS + A+ Sbjct: 159 FSPGQLAFAAVASLGLYLLFVFTQTIRHRDFFLPVAQKGQKGLFEEDESHADPPSARSAL 218 Query: 216 IAALLLLACLGAVVLLAKALAPTLEAGLDNLGAPKSVVGIIIA 258 I+ LLL L AVV LA+ + +E + +G P+ VG++IA Sbjct: 219 ISLALLLVALIAVVGLAELQSSAIEHLVTAVGFPQPFVGVVIA 261 >Rv1607 [P] COG0387 Ca2+/H+ antiporter Mtu Mycobacterium tuberculosis H37Rv Length = 360 Score = 169 bits (427), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 110/209 (52%), Positives = 145/209 (69%), Gaps = 1/209 (0%) Query: 51 HAEVVAHKVGEPFGTLVLALAVTLIEVALIVSLMLTGGEATTGLARDTVFAAIMIILNGI 110 HAEVVA +VGEPFG+LVLA+AVT IEVALIV+LM++GG+ LARDTVFAA+MI NGI Sbjct: 49 HAEVVAARVGEPFGSLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVMITTNGI 108 Query: 111 VGICLLVGSSQHGEQSFGQRGVSASLATLAAIAVLTLVLPNYTLTTAGPFYSTSQLAFIA 170 G+ LL+GS ++G F G A+LAT+ +A L+LVLP +T + +GP S QL F Sbjct: 109 AGLSLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPELSPGQLIFAG 168 Query: 171 VISLVLYGTFVLVQTVRHRDYFLP-PNAAAGDAEAHAEPPSNKVAIIAALLLLACLGAVV 229 SL LY F+ QTVRHRD+FLP A + ++HA+PPS + A+++ LLL L AVV Sbjct: 169 AASLGLYVLFLFTQTVRHRDFFLPVAQKGAVEDDSHADPPSTRAALLSLGLLLVALVAVV 228 Query: 230 LLAKALAPTLEAGLDNLGAPKSVVGIIIA 258 LAK +P +E + G P+S VG++IA Sbjct: 229 GLAKVESPVIEEVVSAAGFPQSFVGVVIA 257 >MT1642 [P] COG0387 Ca2+/H+ antiporter MtC Mycobacterium tuberculosis CDC1551 Length = 360 Score = 169 bits (427), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 110/209 (52%), Positives = 145/209 (69%), Gaps = 1/209 (0%) Query: 51 HAEVVAHKVGEPFGTLVLALAVTLIEVALIVSLMLTGGEATTGLARDTVFAAIMIILNGI 110 HAEVVA +VGEPFG+LVLA+AVT IEVALIV+LM++GG+ LARDTVFAA+MI NGI Sbjct: 49 HAEVVAARVGEPFGSLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVMITTNGI 108 Query: 111 VGICLLVGSSQHGEQSFGQRGVSASLATLAAIAVLTLVLPNYTLTTAGPFYSTSQLAFIA 170 G+ LL+GS ++G F G A+LAT+ +A L+LVLP +T + +GP S QL F Sbjct: 109 AGLSLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPELSPGQLIFAG 168 Query: 171 VISLVLYGTFVLVQTVRHRDYFLP-PNAAAGDAEAHAEPPSNKVAIIAALLLLACLGAVV 229 SL LY F+ QTVRHRD+FLP A + ++HA+PPS + A+++ LLL L AVV Sbjct: 169 AASLGLYVLFLFTQTVRHRDFFLPVAQKGAVEDDSHADPPSTRAALLSLGLLLVALVAVV 228 Query: 230 LLAKALAPTLEAGLDNLGAPKSVVGIIIA 258 LAK +P +E + G P+S VG++IA Sbjct: 229 GLAKVESPVIEEVVSAAGFPQSFVGVVIA 257 >mlr6933 Non COG Length = 382 Score = 160 bits (406), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 98/223 (43%), Positives = 143/223 (64%), Gaps = 13/223 (5%) Query: 41 LMASVLAAVYHAEVVAHKVGEPFGTLVLALAVTLIEVALIVSLMLTGGEATTGLARDTVF 100 + ++ + HAE VA +VGEP+GTLVL AVT IEV++IVS+ML G E LAR++VF Sbjct: 65 MFVTIFVVLDHAEAVARRVGEPYGTLVLTFAVTAIEVSIIVSMMLHG-ENNPTLARESVF 123 Query: 101 AAIMIILNGIVGICLLVGSSQHGEQSFGQRGVSASLATLAAIAVLTLVLPNYTLTTAGPF 160 + +MI G+VG+CL +G +H +Q+ ++G SA LA L A+ V+TL+LP YT T Sbjct: 124 STVMITSTGVVGMCLALGGWRHRKQAIVRQGTSAYLAVLIALTVMTLILPTYTQATDPGT 183 Query: 161 YSTSQLAFIAVISLVLYGTFVLVQTVRHRDYFLPPNAAAGDAEAHAEPPSNKVAIIAALL 220 +S +QL F++V+S++LY +FV QTVRHR+ F+ D A P N A +ALL Sbjct: 184 FSAAQLGFVSVLSVLLYASFVFAQTVRHREDFI--QGQPHDVSVRAAPHGNISA--SALL 239 Query: 221 LLACLGAVVLLAKALAPTLEAGLDNLGAPK-----SVVGIIIA 258 L+A L +V+LA+ +A ++E D L A + S+VG +IA Sbjct: 240 LMAGLIGIVMLAEQVAASVE---DTLVAYRVTQTDSIVGAMIA 279 >YPO1958 [P] COG0387 Ca2+/H+ antiporter Ype Yersinia pestis Length = 366 Score = 134 bits (337), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 80/220 (36%), Positives = 133/220 (60%), Gaps = 5/220 (2%) Query: 39 IGLMASVLAAVYHAEVVAHKVGEPFGTLVLALAVTLIEVALIVSLMLTGGEATTGLARDT 98 +G+++S + V HA+V+AH++GEP+G+L+L+L+V ++EV+LI ++M T G+A L RDT Sbjct: 50 VGILSSAFSVVRHADVLAHRLGEPYGSLILSLSVVVLEVSLISAMMAT-GDAAPALMRDT 108 Query: 99 VFAAIMIILNGIVGICLLVGSSQHGEQSFGQRGVSASLATLAAIAVLTLVLPNYTLTTAG 158 +++ IMI++ G+VG+ LL+G + Q G+ L + +A++ LVLP+ T G Sbjct: 109 LYSIIMIVIGGLVGVSLLLGGRKFATQHVNLVGIKQYLMAIFPLAIIVLVLPS---TLPG 165 Query: 159 PFYSTSQLAFIAVISLVLYGTFVLVQTVRHRDYFLPPNAAAGDAEAHAEPPSNKVAIIAA 218 ++ +Q +A IS +YG F+ +QT H+ F+ + GD H +P S+ ++ Sbjct: 166 GNFTVAQSLVVAAISAAMYGVFLTIQTKTHQSLFVYEHEDEGDDPHHGKPSSHS-SLWHT 224 Query: 219 LLLLACLGAVVLLAKALAPTLEAGLDNLGAPKSVVGIIIA 258 + LL L AV+ + K A LEA L L AP G +IA Sbjct: 225 VWLLIHLIAVIAVTKFDANPLEALLTELNAPAKFTGFLIA 264