BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0031.0030.p (595 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ d... 734 0.0 NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ d... 414 e-115 NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ d... 411 e-114 alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ d... 381 e-105 slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ d... 332 1e-90 >RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ domain Rso Ralstonia solanacearum Length = 621 Score = 734 bits (1895), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/604 (61%), Positives = 434/604 (71%), Gaps = 16/604 (2%) Query: 4 PIHYSITSNDCAAHVFDITLRVDAPAADGQVFSLPAWIPGSYMIREFARNIVQLRAEAGG 63 PI Y+I AH+F +T+ VDAP GQ FSLPAWIPGSYMIREFARNIV++ A G Sbjct: 3 PIRYTIAPAAPEAHLFTVTVTVDAPDPQGQRFSLPAWIPGSYMIREFARNIVRIEAMCGE 62 Query: 64 KKVALRKLDKHTWKASPCTGPLTLSYQVYAWDLSVRTAHLDQTHAFFNGTSVFLRVEGQE 123 + V L KLDKHTW+A+PC+GPLT+SY VYAWDLSVR AHLD TH FFNGTSVFLRVEG E Sbjct: 63 RAVRLAKLDKHTWQAAPCSGPLTVSYDVYAWDLSVRAAHLDPTHGFFNGTSVFLRVEGGE 122 Query: 124 QSQHVVDIRRPAGDAYKRWRVATSLSE--------LKAKRYGFGTYVAADYDELIDHPVE 175 Q + +VDI+ PAGDAY+ WRVAT+L E + AKRYGFG Y AADYDELIDHPVE Sbjct: 123 QVRCLVDIQPPAGDAYRGWRVATALREASGRVQGRVGAKRYGFGWYEAADYDELIDHPVE 182 Query: 176 LGTFALATFTAHGVPHDVVITGQVPNLDLPRLSADLKKICEAQIAFFEPKSKRAPM---- 231 +GTFAL +F A G HD V TG+VPNLDL R++ D K+ICEAQI FEP + AP Sbjct: 183 MGTFALVSFEACGAQHDAVFTGRVPNLDLERIARDFKRICEAQIRLFEPHTAAAPFLDSN 242 Query: 232 SRYVFMTMVVGDGYGGLEHRASTALVCARSDLPVKGKSELSDGYRTYLGLCSHEYFHSWN 291 RYVFMTMV DGYGGLEHRASTAL+CAR+DLPV G+ E ++GYRT+LGL SHEYFH+WN Sbjct: 243 RRYVFMTMVTTDGYGGLEHRASTALICARNDLPVTGRDETTEGYRTFLGLVSHEYFHTWN 302 Query: 292 VKRIKPAVFAPYDLREEGYTSLLWLFEGFTSYYDDLFLVRTGLIDEAAYLGMLAKTINGV 351 VKRIKPAVF PY L E +T LLWLFEGFTSYYDDL LVR+GLI EA YL MLAKT NGV Sbjct: 303 VKRIKPAVFVPYALDREVHTPLLWLFEGFTSYYDDLMLVRSGLISEAQYLEMLAKTWNGV 362 Query: 352 LRGSGRRKQSVAESSFDAWVKYYRQDENAPNAIVSYYTKGSLVALALDLTIRSETNGRKS 411 LRGSGR KQSVAESSFDAW KYYRQDENAPNAIVSYYTKGSLVALALDLTIR++T G S Sbjct: 363 LRGSGRLKQSVAESSFDAWTKYYRQDENAPNAIVSYYTKGSLVALALDLTIRTQTGGEHS 422 Query: 412 LDDVMLALWQQYGRQFYSR-NGGHGLGEEEAEALFEAVSGVKLKRFFDRYIRGTEDLPFA 470 LDDVM ALW GR FY+ + G+ E E AL E +G++L+ + G +D P Sbjct: 423 LDDVMRALWAAGGRDFYAPGHAQRGVTEAELIALMEETTGLRLRTLVRQLAEGRDDPPLP 482 Query: 471 QLLPDMAIKFDDAGKDRKPSLGLRVVRDGADAKVANVYEGGAGHRAGVSAGDKLVALDGL 530 L + + + LG +V + K+ V++GG RAG+SAGD +VA+DGL Sbjct: 483 ALFKAIGVTATRKPAEAALGLGAKVGAENGFVKLLQVFDGGPAQRAGLSAGDLVVAVDGL 542 Query: 531 RVPPTGADGLLARYRENDVVALHVFRRDELMSFSVKLKNDDAPQTALTSEAKPAAAVRKR 590 RV D LAR+R D V +HVFRRDELM V L D PQ AL A+P+ R Sbjct: 543 RVLSGQLDKSLARHRAGDTVPVHVFRRDELMQLDVTLSADATPQFALALSAEPSPL---R 599 Query: 591 KSWL 594 +WL Sbjct: 600 SAWL 603 >NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nme Neisseria meningitidis MC58 Length = 582 Score = 414 bits (1065), Expect = e-115, Method: Compositional matrix adjust. Identities = 234/570 (41%), Positives = 323/570 (56%), Gaps = 42/570 (7%) Query: 5 IHYSITSN--DCAAHVF-DITLRVDAPAADGQVFSLPAWIPGSYMIREFARNIVQLRAEA 61 IHY IT + D H+ T D P SLP W+PGSY+IR+F+R+I + A Sbjct: 2 IHYKITPSPLDHEWHILLTFTQDDDLPIE----ISLPNWVPGSYLIRDFSRHITSIHASC 57 Query: 62 GGKKVALRKLDKHTWKASPCTGPLTLSYQVYAWDLSVRTAHLDQTHAFFNGTSVFLRVEG 121 G + L ++ K+ W A+ G + Y VYA+DLSVR + L FF+G+ +FL+VEG Sbjct: 58 NGTSMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFLKVEG 117 Query: 122 QEQSQHVVDIRRPAGDAYKRWRVATSLSELKAKRYGFGTYVAADYDELIDHPVELGTFAL 181 E H +++ + WR+AT+L E G + AA Y ELID PVE+G Sbjct: 118 TETLPHRLELTGIPSE----WRIATTLPET-----GRFVFQAASYAELIDRPVEMGLIEF 168 Query: 182 ATFTAHGVPHDVVITGQVPNLDLPRLSADLKKICEAQIAFFEPKSKRAPMSRYVFMTMVV 241 F A G+PH + ++G P+ D RL +D+KKICE ++A F S AP +Y+F+ V Sbjct: 169 LDFEAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELAVF---SSPAPFQKYLFLLHVG 225 Query: 242 GDGYGGLEHRASTALVCARSDLPVKGKSELSDGYRTYLGLCSHEYFHSWNVKRIKPAVFA 301 YGGLEH STAL+ R LP G ++ D Y T LGL SHEYFH+WNVK IKPA F Sbjct: 226 DHIYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKPAAFV 285 Query: 302 PYDLREEGYTSLLWLFEGFTSYYDDLFLVRTGLIDEAAYLGMLAKTINGVLRGSGRRKQS 361 PYDL +E YT LW FEG TSYYDDLFL R+ I +YL +LA+ I V + GR +Q+ Sbjct: 286 PYDLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGRLRQT 345 Query: 362 VAESSFDAWVKYYRQDENAPNAIVSYYTKGSLVALALDLTIRSETNGRKSLDDVMLALWQ 421 +AESSF AW K+Y+ DEN+PNAIVSYY KG+L AL LDL IR+ +NGR SLD +M L++ Sbjct: 346 LAESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTLMDKLYR 405 Query: 422 QYGRQFYSRNGGHGLGEEEAEALFEAVSGVKLKRFFDRYIRGTEDLPFAQLLPDMAIKFD 481 ++ R+ G+ E+ + + ++G+ L+ FF + + TEDLP A+ L + Sbjct: 406 EW------RDTHSGIPEKHWQIRCQEITGLDLEDFFQKALYSTEDLPLAECLATAGVGLT 459 Query: 482 DAGKDRK------------PS---LGLRVVRDGADAKVANVYEGGAGHRAGVSAGDKLVA 526 R+ PS G R ++ + +V+ GG+ A + DK++A Sbjct: 460 FLPLPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQDKIIA 519 Query: 527 LDGLRVPPTGADGLLARYRENDVVALHVFR 556 LDG T ARY N + +H FR Sbjct: 520 LDGYAC--TDFTAQWARYHVNAKINIHFFR 547 >NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ domain NmA Neisseria meningitidis Z2491 Length = 585 Score = 411 bits (1057), Expect = e-114, Method: Compositional matrix adjust. Identities = 236/574 (41%), Positives = 324/574 (56%), Gaps = 42/574 (7%) Query: 1 MTTPIHYSITSN--DCAAHVF-DITLRVDAPAADGQVFSLPAWIPGSYMIREFARNIVQL 57 M IHY IT + D H+ T D P SLP W+PGSY+IR+F+R+I + Sbjct: 1 MIVMIHYKITPSPLDHEWHILLTFTQDDDLPIE----ISLPNWVPGSYLIRDFSRHITSI 56 Query: 58 RAEAGGKKVALRKLDKHTWKASPCTGPLTLSYQVYAWDLSVRTAHLDQTHAFFNGTSVFL 117 A G + L ++ K+ W A+ G + Y VYA+DLSVR + L FF+G+ +FL Sbjct: 57 HASCNGTSMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFL 116 Query: 118 RVEGQEQSQHVVDIRRPAGDAYKRWRVATSLSELKAKRYGFGTYVAADYDELIDHPVELG 177 +VEG E H +++ G +R R+AT+L E G + AA Y ELID PVE+G Sbjct: 117 KVEGTETLLHRLEL---TGIPSER-RIATTLPET-----GRFVFQAASYAELIDRPVEMG 167 Query: 178 TFALATFTAHGVPHDVVITGQVPNLDLPRLSADLKKICEAQIAFFEPKSKRAPMSRYVFM 237 F A G+PH + ++G P+ D RL +D+KKICE ++ F S AP +Y+F+ Sbjct: 168 LIEFLDFEAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELTVF---SSPAPFQKYLFL 224 Query: 238 TMVVGDGYGGLEHRASTALVCARSDLPVKGKSELSDGYRTYLGLCSHEYFHSWNVKRIKP 297 V YGGLEH STAL+ R LP G ++ D Y T LGL SHEYFH+WNVK IKP Sbjct: 225 LHVGDHIYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKP 284 Query: 298 AVFAPYDLREEGYTSLLWLFEGFTSYYDDLFLVRTGLIDEAAYLGMLAKTINGVLRGSGR 357 A F PYDL +E YT LW FEG TSYYDDLFL R+ I +YL +LA+ I V + GR Sbjct: 285 AAFVPYDLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGR 344 Query: 358 RKQSVAESSFDAWVKYYRQDENAPNAIVSYYTKGSLVALALDLTIRSETNGRKSLDDVML 417 +Q++AESSF AW K+Y+ DEN+PNAIVSYY KG+L AL LDL IR+ +NGR SLD VM Sbjct: 345 LRQTLAESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTVMD 404 Query: 418 ALWQQYGRQFYSRNGGHGLGEEEAEALFEAVSGVKLKRFFDRYIRGTEDLPFAQLLPDMA 477 L++++ R+ G+ E+ + + ++G+ L+ FF + + TEDLP A+ L Sbjct: 405 KLYREW------RDTHSGIPEKHWQIRCQEITGLDLEDFFQKTLYSTEDLPLAECLATAG 458 Query: 478 IKFDDAGKDRK------------PS---LGLRVVRDGADAKVANVYEGGAGHRAGVSAGD 522 + R+ PS G R ++ + +V+ GG+ A + D Sbjct: 459 VGLTFLPLPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQD 518 Query: 523 KLVALDGLRVPPTGADGLLARYRENDVVALHVFR 556 K++ALDG T ARY N + +H FR Sbjct: 519 KIIALDGYAC--TDFTAQWARYHVNAKINIHFFR 550 >alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nos Nostoc sp. PCC 7120 Length = 543 Score = 381 bits (979), Expect = e-105, Method: Compositional matrix adjust. Identities = 210/561 (37%), Positives = 314/561 (55%), Gaps = 27/561 (4%) Query: 37 LPAWIPGSYMIREFARNIVQLRAEAGGKKVALRKLDKHTWKASPC-TGPLTLSYQVYAWD 95 +P W PGSY++RE+A+N+ A AG K + RK+ K+ W+ + +T+ Y+++A + Sbjct: 1 MPVWTPGSYLVREYAKNLQDFTAFAGDKILPWRKISKNHWQINKGDVSEVTVRYRIFANE 60 Query: 96 LSVRTAHLDQTHAFFNGTSVFLRVEGQEQSQHVVDIRRPAGDAYKRWRVATSLSELKAKR 155 LSVRT HLD TH +FNG ++F R+ G E V + P Y +WRV T L + + Sbjct: 61 LSVRTNHLDATHGYFNGAALFFRLPGWENLPICVTVIPP----YPQWRVTTPLPTIGEQS 116 Query: 156 YGFGTYVAADYDELIDHPVELGTFALATFTAHGVPHDVVITGQVPNLDLPRLSADLKKIC 215 T+ AAD+D L+D P E+G L F G PH++ I GQ N + +L D +KI Sbjct: 117 ---NTFYAADFDTLVDSPFEIGEHQLYHFEVLGKPHELAIWGQ-GNCQVQQLIRDTQKII 172 Query: 216 EAQIAFFEPKSKRAPMSRYVFMTMVVGDGYGGLEHRASTALVCARSDLPVKGKSELSDGY 275 + + F P RYVF+ + YGGLEH+ S +L+ R +S+ D Y Sbjct: 173 QIEAQMF----GGLPYERYVFLLHLFAQAYGGLEHKNSCSLIYQRFGF----RSQ--DKY 222 Query: 276 RTYLGLCSHEYFHSWNVKRIKPAVFAPYDLREEGYTSLLWLFEGFTSYYDDLFLVRTGLI 335 ++ L +HE+FH WNVKRI+P ++ +E YT LW EG TSYYD L +R G+ Sbjct: 223 ERFIQLLAHEFFHLWNVKRIRPQALEVFNYDQENYTPSLWFCEGTTSYYDLLIPLRAGIY 282 Query: 336 DEAAYLGMLAKTINGVLRGSGRRKQSVAESSFDAWVKYYRQDENAPNAIVSYYTKGSLVA 395 D YL +K I+ ++ GR+ Q ++ESSFDAW+K YR D N N+ VSYY KG +++ Sbjct: 283 DAKTYLNYWSKEISRLITTPGRKVQPLSESSFDAWIKLYRPDTNTGNSQVSYYLKGEMIS 342 Query: 396 LALDLTIRSETNGRKSLDDVMLALWQQYGRQFYSRNGGHGLGEEEAEALFEAVSGVKLKR 455 L LDL IR+ ++SLDDVM +WQ++G+ G E+ +A+ E+V+GV L Sbjct: 343 LLLDLLIRARYRNQRSLDDVMRQMWQKFGQ------AEIGYTPEQLQAVIESVAGVDLTD 396 Query: 456 FFDRYIRGTEDLPFAQLLPDMAIKFDDAGKDRKPSLGLRVVRDGADAKVANVYEGGAGHR 515 FF RYI GTE+LPF Q L + A ++ +P LG++V + + V G Sbjct: 397 FFARYIDGTEELPFNQYLEPFGLHL-VAEREEEPYLGVKVNTENGREMIKFVEAGSPAQM 455 Query: 516 AGVSAGDKLVALDGLRVPPTGADGLLARYRENDVVALHVFRRDELMSFSVKLKNDDAPQT 575 AG+ AGD+L+A+ G+++ L Y+ ND + + VF +DEL ++ VKL + Sbjct: 456 AGIDAGDELLAIAGIKITAHQLSDRLKDYQANDTIQVTVFHQDELRTYPVKLGTPRPTKY 515 Query: 576 ALTSEAKPAAAVRKR-KSWLG 595 L + P A ++ +WLG Sbjct: 516 QLLAIQNPNATQQENFAAWLG 536 >slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ domain Syn Synechocystis Length = 584 Score = 332 bits (852), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 204/600 (34%), Positives = 300/600 (50%), Gaps = 34/600 (5%) Query: 5 IHYSITSNDCAAHVFDITLRVDAPAADGQVFSLPAWIPGSYMIREFARNIVQLRAE--AG 62 +HY + H F + L + A P W PGSY++RE+ R++ +A+ + Sbjct: 8 LHYQVAMPTPQTHYFTVDLHIQGFTASVLELKFPVWTPGSYLVREYERHLQDFQAQGLSN 67 Query: 63 GKKVALRKLDKHTWKASPC--TGPLTLSYQVYAWDLSVRTAHLDQTHAFFNGTSVFLRVE 120 G+ + +KL K W A C + +SY++YA +L+VRT HLD +H FF G ++F + Sbjct: 68 GEYLEHQKLGKAHW-AIACGEEENIAISYRIYADELTVRTNHLDYSHGFFTGAALFFYLP 126 Query: 121 GQEQSQHVVDIRRPAGDAYKRWRVATSL-SELKAKRYGFGTYVAADYDELIDHPVELGTF 179 G + + P W +AT+L + G T+ A D+D L+D PVE+G Sbjct: 127 GHTHRPLALTVVPPE----PAWAIATALPCKATDSTTGAKTFYAQDFDTLVDSPVEVGIH 182 Query: 180 ALATFTAHGVPHDVVITGQVPNLDLPRLSADLKKICEAQIAFFEPKSKRAPMSRYVFMTM 239 F G H V+ G+ NL+ +L D +KI + F P Y F+ Sbjct: 183 RDYAFETQGKEHHFVVWGE-SNLNGEQLVRDTEKIIAVEAGLF----GNLPYDHYWFILH 237 Query: 240 VVGDGYGGLEHRASTALVCARSDLPVKGKSELSDGYRTYLGLCSHEYFHSWNVKRIKPAV 299 GYGGLEH+ S L R K Y+ +L L +HE+FH WN+KRI+P Sbjct: 238 TSNQGYGGLEHKDSCVLNYDRFGFRDPEK------YQRFLQLVAHEFFHLWNIKRIRPIA 291 Query: 300 FAPYDLREEGYTSLLWLFEGFTSYYDDLFLVRTGLIDEAAYLGMLAKTINGVLRGSGRRK 359 +D +E YT LW EG TSYYD L +R + D YL L K I L+ GR Sbjct: 292 LEKFDYDQENYTPSLWFSEGTTSYYDLLIPLRAEIYDRQTYLKNLGKEITRYLKTLGRLV 351 Query: 360 QSVAESSFDAWVKYYRQDENAPNAIVSYYTKGSLVALALDLTIRSETNGRKSLDDVMLAL 419 Q +AESSFDAW+K YR+D N+ N+ +SYY KG LV L LDL IR ++S DDV+ A+ Sbjct: 352 QPLAESSFDAWIKLYRRDANSDNSQMSYYLKGELVTLMLDLLIRERHQNQRSFDDVLRAM 411 Query: 420 WQQYGRQFYSRNGGHGLGEEEAEALFEAVSGVKLKRFFDRYIRGTEDLPFAQLLPDMAIK 479 WQ++GR+ G E+ +A+ V+ L FF Y+ T +LP L + Sbjct: 412 WQEFGRE------EIGFTPEQLQAVISRVADTDLTEFFHTYLHTTAELPLNDYLQPFGLV 465 Query: 480 FDDAGKDRKPSLGLRVVRDGADAKVANVYEGGAGHRAGVSAGDKLVALDGLRVPPTGADG 539 +D P LG++V + K+ V AG+S D L+A++G+RV GA+ Sbjct: 466 IKPMQEDLTPYLGIKVKSEAGQEKITFVAAHSPAAMAGISPQDLLLAINGVRV---GAEQ 522 Query: 540 L---LARYRENDVVALHVFRRDELMSFSVKLKNDDAPQTALTSEAKPA-AAVRKRKSWLG 595 L L Y+ ND++ L VF +D L + V L + A + + A P+ + ++ WLG Sbjct: 523 LSLRLKDYQANDMIQLTVFHQDLLRTVDVVLASPQANRYEVVPIADPSDSQLQNLAGWLG 582