BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0030.0198.p (320 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2442 [IM] COG0761 Penicillin tolerance protein Rso Ralstonia ... 480 e-135 NMB1831 [IM] COG0761 Penicillin tolerance protein Nme Neisseria ... 415 e-116 NMA0624 [IM] COG0761 Penicillin tolerance protein NmA Neisseria ... 415 e-116 PA4557 [IM] COG0761 Penicillin tolerance protein Pae Pseudomonas... 389 e-108 lytB [IM] COG0761 Penicillin tolerance protein Eco Escherichia c... 387 e-107 >RSc2442 [IM] COG0761 Penicillin tolerance protein Rso Ralstonia solanacearum Length = 324 Score = 480 bits (1236), Expect = e-135, Method: Compositional matrix adjust. Identities = 226/306 (73%), Positives = 269/306 (87%) Query: 5 ESEILLAQPRGFCAGVDRAIEIVERALTQFGAPIYVRHEIVHNAYVVADLRNKGAIFIEE 64 ++E+LLAQPRGFCAGVDRAIEIVERAL +FGAPIYVRHEIVHNAYVV+DLR+KGA+F++E Sbjct: 16 DAEVLLAQPRGFCAGVDRAIEIVERALQRFGAPIYVRHEIVHNAYVVSDLRSKGAVFVQE 75 Query: 65 LADVPAGNTVIFSAHGVSKAVQAEAQERGLTVFDATCPLVTKVHIEVAKMRREGREIIMI 124 L DVP G TVIFSAHGVS+AV+ A+ RGL VFDATCPLVTKVH+EV+KMR +G EIIMI Sbjct: 76 LDDVPVGGTVIFSAHGVSRAVRQAAEARGLRVFDATCPLVTKVHVEVSKMRTQGFEIIMI 135 Query: 125 GHEGHPEVEGTMGQTEAGMYLVETVDDVLKLQVTDPDLLAYVSQTTLSVDDTTDIIAALK 184 GH+GHPEVEGTMGQ + GM LVE+VDDV +L V DP LAYV+QTTLSVD+T +I+AA+K Sbjct: 136 GHKGHPEVEGTMGQADDGMLLVESVDDVARLAVKDPARLAYVTQTTLSVDETQEIVAAIK 195 Query: 185 QRFPTIAEPKKGDICYATTNRQEAVKFMAPQVDVVIVVGSPNSSNSNRLREVAEKKGVPA 244 RFP + EPKK DICYAT NRQ+AVKFMAPQV+VVIVVGSPNSSNSNRLRE+AEK GVPA Sbjct: 196 ARFPAVHEPKKQDICYATQNRQDAVKFMAPQVEVVIVVGSPNSSNSNRLRELAEKLGVPA 255 Query: 245 YMVDNAELIKQEWLDGKRRVGVTAGASAPEVLVQAVIDRIKEGSLRSVRILEGIEEHVTF 304 YMVD E ++ EWL GKRRVG+TAGASAPE L Q+++DR++ RSVR L+GI+E+++F Sbjct: 256 YMVDTPEQVRPEWLAGKRRVGLTAGASAPEELAQSIVDRLRALGARSVRPLDGIQENMSF 315 Query: 305 PMPKGL 310 P+P+GL Sbjct: 316 PLPRGL 321 >NMB1831 [IM] COG0761 Penicillin tolerance protein Nme Neisseria meningitidis MC58 Length = 322 Score = 415 bits (1066), Expect = e-116, Method: Compositional matrix adjust. Identities = 209/308 (67%), Positives = 243/308 (78%), Gaps = 1/308 (0%) Query: 4 QESEILLAQPRGFCAGVDRAIEIVERALTQFGAPIYVRHEIVHNAYVVADLRNKGAIFIE 63 E I+LA PRGFCAGVDRAI IVERAL +FGAPIYVRHE+VHN +VV +LR KGA+FIE Sbjct: 2 NEKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFIE 61 Query: 64 ELADVPAGNTVIFSAHGVSKAVQAEAQERGLTVFDATCPLVTKVHIEVAKMRREGREIIM 123 +LA+VP G T+++SAHGVSKAV+ EA ERG VFDATCPLVTKVH EVA++ + EIIM Sbjct: 62 DLAEVPPGATLVYSAHGVSKAVRQEAAERGFRVFDATCPLVTKVHKEVARLDAQDCEIIM 121 Query: 124 IGHEGHPEVEGTMGQTEAG-MYLVETVDDVLKLQVTDPDLLAYVSQTTLSVDDTTDIIAA 182 IGH+GH EVEGTMGQ G M LVETV DV KL+V +PD LAYVSQTTLSVD+T DIIAA Sbjct: 122 IGHKGHVEVEGTMGQLAPGKMLLVETVGDVAKLEVRNPDKLAYVSQTTLSVDETKDIIAA 181 Query: 183 LKQRFPTIAEPKKGDICYATTNRQEAVKFMAPQVDVVIVVGSPNSSNSNRLREVAEKKGV 242 L RFP I P K DICYATTNRQ AVK +A Q D+VIVVGSPNSSNSNRLREVA +G+ Sbjct: 182 LNARFPNIRNPHKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAASRGI 241 Query: 243 PAYMVDNAELIKQEWLDGKRRVGVTAGASAPEVLVQAVIDRIKEGSLRSVRILEGIEEHV 302 AYMVDNA +++ W +GK +VGVTAGASAPEVLV+ V+ I+ +VR EG EE + Sbjct: 242 DAYMVDNAGYLQRAWFEGKNKVGVTAGASAPEVLVREVLATIRGWGHETVREGEGAEESI 301 Query: 303 TFPMPKGL 310 F +PK L Sbjct: 302 VFVLPKEL 309 >NMA0624 [IM] COG0761 Penicillin tolerance protein NmA Neisseria meningitidis Z2491 Length = 322 Score = 415 bits (1066), Expect = e-116, Method: Compositional matrix adjust. Identities = 209/308 (67%), Positives = 243/308 (78%), Gaps = 1/308 (0%) Query: 4 QESEILLAQPRGFCAGVDRAIEIVERALTQFGAPIYVRHEIVHNAYVVADLRNKGAIFIE 63 E I+LA PRGFCAGVDRAI IVERAL +FGAPIYVRHE+VHN +VV +LR KGA+FIE Sbjct: 2 NEKTIILANPRGFCAGVDRAISIVERALEEFGAPIYVRHEVVHNKFVVDNLREKGAVFIE 61 Query: 64 ELADVPAGNTVIFSAHGVSKAVQAEAQERGLTVFDATCPLVTKVHIEVAKMRREGREIIM 123 +LA+VP G T+++SAHGVSKAV+ EA ERG VFDATCPLVTKVH EVA++ + EIIM Sbjct: 62 DLAEVPPGATLVYSAHGVSKAVRQEAAERGFRVFDATCPLVTKVHKEVARLDAQDCEIIM 121 Query: 124 IGHEGHPEVEGTMGQTEAG-MYLVETVDDVLKLQVTDPDLLAYVSQTTLSVDDTTDIIAA 182 IGH+GH EVEGTMGQ G M LVETV DV KL+V +PD LAYVSQTTLSVD+T DIIAA Sbjct: 122 IGHKGHVEVEGTMGQLAPGKMLLVETVGDVAKLEVRNPDKLAYVSQTTLSVDETKDIIAA 181 Query: 183 LKQRFPTIAEPKKGDICYATTNRQEAVKFMAPQVDVVIVVGSPNSSNSNRLREVAEKKGV 242 L RFP I P K DICYATTNRQ AVK +A Q D+VIVVGSPNSSNSNRLREVA +G+ Sbjct: 182 LNARFPNIRNPHKEDICYATTNRQTAVKELAEQCDIVIVVGSPNSSNSNRLREVAASRGI 241 Query: 243 PAYMVDNAELIKQEWLDGKRRVGVTAGASAPEVLVQAVIDRIKEGSLRSVRILEGIEEHV 302 AYMVDNA +++ W +GK +VGVTAGASAPEVLV+ V+ I+ +VR EG EE + Sbjct: 242 DAYMVDNAGYLQRAWFEGKNKVGVTAGASAPEVLVREVLATIRGWGHETVREGEGAEESI 301 Query: 303 TFPMPKGL 310 F +PK L Sbjct: 302 VFVLPKEL 309 >PA4557 [IM] COG0761 Penicillin tolerance protein Pae Pseudomonas aeruginosa Length = 314 Score = 389 bits (999), Expect = e-108, Method: Compositional matrix adjust. Identities = 195/308 (63%), Positives = 240/308 (77%), Gaps = 4/308 (1%) Query: 7 EILLAQPRGFCAGVDRAIEIVERALTQFGAPIYVRHEIVHNAYVVADLRNKGAIFIEELA 66 +I LA PRGFCAGVDRAIEIV RAL FG PIYVRHE+VHN +VV +LR +GAIF+EEL Sbjct: 2 QIKLANPRGFCAGVDRAIEIVNRALDVFGPPIYVRHEVVHNKFVVDNLRQRGAIFVEELD 61 Query: 67 DVPAGNTVIFSAHGVSKAVQAEAQERGLTVFDATCPLVTKVHIEVAKMRREGREIIMIGH 126 VP VIFSAHGVS+AV+ EA+ RGL VFDATCPLVTKVH+EV + R+G E ++IGH Sbjct: 62 QVPNNVIVIFSAHGVSQAVRKEAEGRGLKVFDATCPLVTKVHMEVVRYSRDGHECVLIGH 121 Query: 127 EGHPEVEGTMGQTEA----GMYLVETVDDVLKLQVTDPDLLAYVSQTTLSVDDTTDIIAA 182 EGHPEVEGTMGQ +A +YLVE DV L+V P+ L YV+QTTLS+DDT+ +I A Sbjct: 122 EGHPEVEGTMGQYDASNGGAIYLVEDEADVAALEVRKPEALHYVTQTTLSMDDTSKVIDA 181 Query: 183 LKQRFPTIAEPKKGDICYATTNRQEAVKFMAPQVDVVIVVGSPNSSNSNRLREVAEKKGV 242 L+ +FP I P+K DICYAT NRQ+AVK +A Q D+V+VVGSPNSSNSNRLRE+AE+ G Sbjct: 182 LRAKFPQIQGPRKNDICYATQNRQDAVKELADQCDMVLVVGSPNSSNSNRLRELAERMGT 241 Query: 243 PAYMVDNAELIKQEWLDGKRRVGVTAGASAPEVLVQAVIDRIKEGSLRSVRILEGIEEHV 302 PAY++D AE +++ W DG RR+G+TAGASAPEVLV+ VI +++E + LEG EE++ Sbjct: 242 PAYLIDGAEDMQRGWFDGVRRIGITAGASAPEVLVRGVIAQLREWGASEEQELEGREENI 301 Query: 303 TFPMPKGL 310 TF MPK L Sbjct: 302 TFSMPKEL 309 >lytB [IM] COG0761 Penicillin tolerance protein Eco Escherichia coli K12 Length = 316 Score = 387 bits (995), Expect = e-107, Method: Compositional matrix adjust. Identities = 191/307 (62%), Positives = 243/307 (79%), Gaps = 3/307 (0%) Query: 7 EILLAQPRGFCAGVDRAIEIVERALTQFGAPIYVRHEIVHNAYVVADLRNKGAIFIEELA 66 +ILLA PRGFCAGVDRAI IVE AL +GAPIYVRHE+VHN YVV LR +GAIFIE+++ Sbjct: 2 QILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRERGAIFIEQIS 61 Query: 67 DVPAGNTVIFSAHGVSKAVQAEAQERGLTVFDATCPLVTKVHIEVAKMRREGREIIMIGH 126 +VP G +IFSAHGVS+AV+ EA+ R LTVFDATCPLVTKVH+EVA+ R G E I+IGH Sbjct: 62 EVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGH 121 Query: 127 EGHPEVEGTMGQT---EAGMYLVETVDDVLKLQVTDPDLLAYVSQTTLSVDDTTDIIAAL 183 GHPEVEGTMGQ E GMYLVE+ DDV KL V + + L++++QTTLSVDDT+D+I AL Sbjct: 122 AGHPEVEGTMGQYSNPEGGMYLVESPDDVWKLTVKNEEKLSFMTQTTLSVDDTSDVIDAL 181 Query: 184 KQRFPTIAEPKKGDICYATTNRQEAVKFMAPQVDVVIVVGSPNSSNSNRLREVAEKKGVP 243 ++RFP I P+K DICYATTNRQEAV+ +A Q +VV+VVGS NSSNSNRL E+A++ G Sbjct: 182 RKRFPKIVGPRKDDICYATTNRQEAVRALAEQAEVVLVVGSKNSSNSNRLAELAQRMGKR 241 Query: 244 AYMVDNAELIKQEWLDGKRRVGVTAGASAPEVLVQAVIDRIKEGSLRSVRILEGIEEHVT 303 A+++D+A+ I++EW+ + VGVTAGASAP++LVQ V+ R+++ LEG EE++ Sbjct: 242 AFLIDDAKDIQEEWVKEVKCVGVTAGASAPDILVQNVVARLQQLGGGEAIPLEGREENIV 301 Query: 304 FPMPKGL 310 F +PK L Sbjct: 302 FEVPKEL 308