BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0030.0185.p (330 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ZputA_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenas... 273 4e-73 ECs1260_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogen... 273 4e-73 putA_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase... 271 1e-72 YPO1851_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogen... 266 6e-71 BMEII0564_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrog... 264 2e-70 >ZputA_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase EcZ Escherichia coli O157:H7 EDL933 Length = 795 Score = 273 bits (698), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 172/353 (48%), Positives = 221/353 (62%), Gaps = 32/353 (9%) Query: 4 HVEQMKKGGK-----VYQLPLDERH-QYGTYVAPTVIEIDSIAQLKREVFGPVLHVLRYR 57 H++ M+ G+ V + D R Q GT+VAPT+IE+D A+L++EVFGPVLHV+RY Sbjct: 446 HIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVFGPVLHVVRYN 505 Query: 58 RDQLPQLIDTINASGYGLTLGVHSRIDETIAFVAERAHVGNIYVNRNIVGAVVGVQPFGG 117 R+QLP+LI+ INASGYGLTLGVH+RIDETIA V AHVGN+YVNRN+VGAVVGVQPFGG Sbjct: 506 RNQLPELIEQINASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVGAVVGVQPFGG 565 Query: 118 EGKSGTGPKAGGPLYLKRL--------------QRHADVKLFNDAAQAASQPLKSLLDWA 163 EG SGTGPKAGGPLYL RL ++ A+ + A +QPL +L +WA Sbjct: 566 EGLSGTGPKAGGPLYLYRLLANRPESALAVTLARQDAEYPVDAQLKAALTQPLNALREWA 625 Query: 164 ATHGHAKLAQLGATYVQESLLHRTLTLPGPTGERNTLSFAPRGKILCAAADVAALLNQVA 223 A +L L Y + + LPGPTGERNT + PR ++LC A D L Q+A Sbjct: 626 AN--RPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDEQDALTQLA 683 Query: 224 AVLATGNIAVVP--AAQGKLIPAGLPAEARQAIELSG--DVAALDLHLALVDGPVITQWR 279 AVLA G+ + P A +L+ A LP+ + I+L+ ++ A + G Q R Sbjct: 684 AVLAVGSQVLWPDDALHRQLVKA-LPSTVSERIQLAKAENITAQPFDAVIFHGDS-DQLR 741 Query: 280 GL---LAARDGALVPLVPTAE-DLPIDLWRLVAERALCVNTTAAGGNASLMTL 328 L +AARDGA+V + A + I L RL ER+L VNT AAGGNASLMT+ Sbjct: 742 ALCEAVAARDGAIVSVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTI 794 >ECs1260_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase Ecs Escherichia coli O157:H7 Length = 793 Score = 273 bits (698), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 172/353 (48%), Positives = 221/353 (62%), Gaps = 32/353 (9%) Query: 4 HVEQMKKGGK-----VYQLPLDERH-QYGTYVAPTVIEIDSIAQLKREVFGPVLHVLRYR 57 H++ M+ G+ V + D R Q GT+VAPT+IE+D A+L++EVFGPVLHV+RY Sbjct: 444 HIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVFGPVLHVVRYN 503 Query: 58 RDQLPQLIDTINASGYGLTLGVHSRIDETIAFVAERAHVGNIYVNRNIVGAVVGVQPFGG 117 R+QLP+LI+ INASGYGLTLGVH+RIDETIA V AHVGN+YVNRN+VGAVVGVQPFGG Sbjct: 504 RNQLPELIEQINASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVGAVVGVQPFGG 563 Query: 118 EGKSGTGPKAGGPLYLKRL--------------QRHADVKLFNDAAQAASQPLKSLLDWA 163 EG SGTGPKAGGPLYL RL ++ A+ + A +QPL +L +WA Sbjct: 564 EGLSGTGPKAGGPLYLYRLLANRPESALAVTLARQDAEYPVDAQLKAALTQPLNALREWA 623 Query: 164 ATHGHAKLAQLGATYVQESLLHRTLTLPGPTGERNTLSFAPRGKILCAAADVAALLNQVA 223 A +L L Y + + LPGPTGERNT + PR ++LC A D L Q+A Sbjct: 624 AN--RPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDEQDALTQLA 681 Query: 224 AVLATGNIAVVP--AAQGKLIPAGLPAEARQAIELSG--DVAALDLHLALVDGPVITQWR 279 AVLA G+ + P A +L+ A LP+ + I+L+ ++ A + G Q R Sbjct: 682 AVLAVGSQVLWPDDALHRQLVKA-LPSTVSERIQLAKAENITAQPFDAVIFHGDS-DQLR 739 Query: 280 GL---LAARDGALVPLVPTAE-DLPIDLWRLVAERALCVNTTAAGGNASLMTL 328 L +AARDGA+V + A + I L RL ER+L VNT AAGGNASLMT+ Sbjct: 740 ALCEAVAARDGAIVSVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTI 792 >putA_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase Eco Escherichia coli K12 Length = 795 Score = 271 bits (694), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 174/353 (49%), Positives = 220/353 (62%), Gaps = 32/353 (9%) Query: 4 HVEQMKKGGK-----VYQLPLDERH-QYGTYVAPTVIEIDSIAQLKREVFGPVLHVLRYR 57 H++ M+ G+ V + D R Q GT+VAPT+IE+D A+L++EVFGPVLHV+RY Sbjct: 446 HIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVFGPVLHVVRYN 505 Query: 58 RDQLPQLIDTINASGYGLTLGVHSRIDETIAFVAERAHVGNIYVNRNIVGAVVGVQPFGG 117 R+QLP+LI+ INASGYGLTLGVH+RIDETIA V AHVGN+YVNRN+VGAVVGVQPFGG Sbjct: 506 RNQLPELIEQINASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVGAVVGVQPFGG 565 Query: 118 EGKSGTGPKAGGPLYLKRLQRH------------ADVKLFNDA--AQAASQPLKSLLDWA 163 EG SGTGPKAGGPLYL RL + D K DA A +QPL +L +WA Sbjct: 566 EGLSGTGPKAGGPLYLYRLLANRPESALAVTLARQDAKYPVDAQLKAALTQPLNALREWA 625 Query: 164 ATHGHAKLAQLGATYVQESLLHRTLTLPGPTGERNTLSFAPRGKILCAAADVAALLNQVA 223 A +L L Y + + LPGPTGERNT + PR ++LC A D L Q+A Sbjct: 626 AN--RPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDEQDALTQLA 683 Query: 224 AVLATGNIAVVP--AAQGKLIPAGLPAEARQAIELSG--DVAALDLHLALVDGPVITQWR 279 AVLA G+ + P A +L+ A LP+ + I+L+ ++ A + G Q R Sbjct: 684 AVLAVGSQVLWPDDALHRQLVKA-LPSAVSERIQLAKAENITAQPFDAVIFHGDS-DQLR 741 Query: 280 GL---LAARDGALVPLVPTAE-DLPIDLWRLVAERALCVNTTAAGGNASLMTL 328 L +AARDG +V + A + I L RL ER+L VNT AAGGNASLMT+ Sbjct: 742 ALCEAVAARDGTIVSVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTI 794 >YPO1851_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase Ype Yersinia pestis Length = 795 Score = 266 bits (679), Expect = 6e-71, Method: Compositional matrix adjust. Identities = 169/352 (48%), Positives = 215/352 (61%), Gaps = 28/352 (7%) Query: 4 HVEQMK-KGGKVYQL----PLDERH-QYGTYVAPTVIEIDSIAQLKREVFGPVLHVLRYR 57 H++ M+ KG KVYQ LDE+ Q GT++ PT+IE+DS +L++EVFGPVLHV+R++ Sbjct: 444 HIQAMRAKGRKVYQAARTNSLDEKEWQRGTFIKPTLIELDSFDELQKEVFGPVLHVVRFQ 503 Query: 58 RDQLPQLIDTINASGYGLTLGVHSRIDETIAFVAERAHVGNIYVNRNIVGAVVGVQPFGG 117 R L +L+D INASGYGLTLG+H+RIDETIA V E+A VGN+YVNRN+VGAVVGVQPFGG Sbjct: 504 RQHLNELVDQINASGYGLTLGIHTRIDETIARVTEKAKVGNLYVNRNMVGAVVGVQPFGG 563 Query: 118 EGKSGTGPKAGGPLYLKR-LQRHADVKLFNDAAQ---------AASQPL----KSLLDWA 163 EG SGTGPKAGGPLYL R L D L N A A + L ++ WA Sbjct: 564 EGLSGTGPKAGGPLYLYRLLSSRPDDALANTLAHQDGEQQQNVAGREALLTAHRAFTQWA 623 Query: 164 ATHGHAKLAQLGATYVQESLLHRTLTLPGPTGERNTLSFAPRGKILCAAADVAALLNQVA 223 H LA L Y + LPGPTGERNT + PR ++LC A + L Q+A Sbjct: 624 TEQQHDSLATLCQRYASLAQGGTVRLLPGPTGERNTYALLPRERVLCLADTESDTLTQLA 683 Query: 224 AVLATGNIAVVPA--AQGKLIPAGLPAEARQAIELSGDVAALDLHL-ALVDGPVITQWRG 280 AVLATG+ + P Q L+P LP E + I L+ D ++ A++ Q R Sbjct: 684 AVLATGSQVLWPENDVQKALLPQ-LPTEVQSRITLTHDWQTANITFDAVIYHGDADQLRT 742 Query: 281 L---LAARDGALVPLVPTAE-DLPIDLWRLVAERALCVNTTAAGGNASLMTL 328 L +A DG +V + A + I L RL+ E +L VNT AAGGNASLMT+ Sbjct: 743 LCEQVAQIDGPIVSVQGFARGETNILLERLLIEHSLSVNTAAAGGNASLMTI 794 >BMEII0564_2 [C] COG4230 Delta 1-pyrroline-5-carboxylate dehydrogenase Bme Brucella melitensis Length = 772 Score = 264 bits (675), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 169/347 (48%), Positives = 203/347 (58%), Gaps = 34/347 (9%) Query: 4 HVEQMKK-GGKVYQLPLDERHQYGTYVAPTVIEIDSIAQLKREVFGPVLHVLRYRRDQLP 62 H++ M+ G KV QLPL Q GT+VAPT+IEI+S+ LKREVFGPVLHV+RY+RD + Sbjct: 437 HIQAMRDLGRKVEQLPLGPETQNGTFVAPTIIEIESLRDLKREVFGPVLHVVRYKRDDME 496 Query: 63 QLIDTINASGYGLTLGVHSRIDETIAFVAERAHVGNIYVNRNIVGAVVGVQPFGGEGKSG 122 LID IN++GYGLT G+H+R+DETIA VA+R VGNIY+NRNI+GAVVGVQPFGG G SG Sbjct: 497 SLIDDINSTGYGLTFGLHTRLDETIANVADRIRVGNIYINRNIIGAVVGVQPFGGRGLSG 556 Query: 123 TGPKAGGPLYLKRL-------QRHADVKLFNDAAQAASQPLKSLLDWAATHGHAKLAQLG 175 TGPKAGGPLYL RL RHA V DAA LK W G LAQ Sbjct: 557 TGPKAGGPLYLGRLVETAPIPPRHASV--HTDAA------LKDFARWLGNRGMNDLAQAA 608 Query: 176 ATYVQESLLHRTLTLPGPTGERNTLSFAPRGKILCAAADVAALLNQVAAVLATGNIAVVP 235 S L L LPGP GERN + PRG++L L Q+ AVLATGN AV+ Sbjct: 609 RDTGSASALGLELELPGPVGERNLYALHPRGRVLLVPQTEIGLYRQLTAVLATGNTAVID 668 Query: 236 AAQG-KLIPAGLPAEARQAIELSGDVAA-LDLHLALVDGPV--ITQWRGLLAARDGALVP 291 A G + + LP +GD A AL++G I + +AA G P Sbjct: 669 EACGLRAVLKDLPETVAARAIWTGDWQADAPFAGALIEGDSARIKEVNSRIAALPG---P 725 Query: 292 LVPTAEDLPIDL----------WRLVAERALCVNTTAAGGNASLMTL 328 LV T P DL W L+ E + +NTTAAGGNASLM + Sbjct: 726 LVLTQAASPEDLAANQDAYCLNW-LLEEVSTSINTTAAGGNASLMAI 771