BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0030.0061.p (552 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMB1388 [G] COG0166 Glucose-6-phosphate isomerase Nme Neisseria ... 661 0.0 NMA1604 [G] COG0166 Glucose-6-phosphate isomerase NmA Neisseria ... 654 0.0 jhp1093 [G] COG0166 Glucose-6-phosphate isomerase jHp Helicobact... 621 e-177 DR1742 [G] COG0166 Glucose-6-phosphate isomerase Dra Deinococcus... 617 e-176 HP1166 [G] COG0166 Glucose-6-phosphate isomerase Hpy Helicobacte... 616 e-176 >NMB1388 [G] COG0166 Glucose-6-phosphate isomerase Nme Neisseria meningitidis MC58 Length = 548 Score = 661 bits (1706), Expect = 0.0, Method: Compositional matrix adjust. Identities = 319/533 (59%), Positives = 389/533 (72%), Gaps = 1/533 (0%) Query: 11 AFQALLSHHAEVRDRHMRDLFAADPQRFDHMTVKAAGILFDYSKNRVDNTTLKLLFELAR 70 A+ L +H + + HMR++F DPQR + ++ G+ DYSKNR+++ T+ LLFELAR Sbjct: 9 AWSKLWNHFDDSKTLHMREMFEQDPQRAERYWLQVGGLTLDYSKNRINDETMSLLFELAR 68 Query: 71 ERGVERQRAAMFNGEKINFTEHRAVLHTALRAPRGQALQVDGQHIGADVHAVLDRIHGFT 130 E GV + MF+GEKIN TE+RAVLH ALR + VDG+ + V+ VL R+ F Sbjct: 69 EAGVPERMRQMFHGEKINTTENRAVLHVALRNRTNSPIVVDGEDVMPKVNRVLQRMGEFA 128 Query: 131 ERVREGQWLGLSGKPITDIVNIGIGGSHLGPQMACTALRTFAHPRLTMHFVSNVDGHDLH 190 VR G WLG + + ITD+VNIGIGGS LGP M CTAL+ F HPRL MHFVSNVDG L Sbjct: 129 HEVRSGSWLGYTNQVITDVVNIGIGGSDLGPLMMCTALKPFGHPRLNMHFVSNVDGSQLR 188 Query: 191 DALQRVDVETTLFIVASKTFTTQETMMNAGSARDWFLQRAGVDD-LAKHFVAVSTNTEAV 249 D L +V ETTLFI+ASKTFTTQET+ NA +AR+WFL AG ++ +AKHF AVSTN +AV Sbjct: 189 DVLSKVHPETTLFIIASKTFTTQETLTNALTAREWFLNHAGDEEAVAKHFAAVSTNQKAV 248 Query: 250 RAFGIDTDNMFPFWDWVGGRYSMWSSIGLSIALAIGFKNFSELLAGAHAMDKHFCEAPLK 309 FGIDT NMF FWDWVGGRYS+WS+IGL I L +G +NF E+L GAH MD+HF PL+ Sbjct: 249 AEFGIDTANMFEFWDWVGGRYSLWSAIGLPIMLYLGEENFIEMLNGAHLMDQHFINTPLE 308 Query: 310 QNMPIIQALIGIWNRNCFNSESLSIAPYHHDLRHFPAYLQQLEMESNGKRITRDGSAVGV 369 +N+P+I ALIGIW N + S IAPY L P ++QQL+MESNGK++T DG AVG Sbjct: 309 RNLPVILALIGIWYINYYGGGSHVIAPYDQHLHRLPKFIQQLDMESNGKQVTLDGKAVGH 368 Query: 370 ATCPFIWGDVGTNGQHAFFQLLHQGTDITPIDFIAVLHATHDLPGHHAVLLANCFAQSEA 429 T P IWG+ G NGQHAFFQLLHQGT ITPID IA L +LPGHH +LLAN FAQ+EA Sbjct: 369 ETSPIIWGETGINGQHAFFQLLHQGTHITPIDLIASLEKRSNLPGHHEILLANVFAQAEA 428 Query: 430 FMRGKQAEEVREDLKKLGVDDDEINFLLPHKTFNGNRPSNTLLLDALTPATLGALIALYE 489 FMRGK +EVR +LK G+D+ I L+PHKTF+GNRP+N +L+D + P +G+LIA+YE Sbjct: 429 FMRGKTPDEVRAELKAQGMDEVRIEELVPHKTFSGNRPTNLILMDKVNPRNMGSLIAMYE 488 Query: 490 HKTFVQGTIWGINSFDQWGVELGKVLAKTIQSELSGEAVPARHDCSTNALIAL 542 HKTFVQG IWGINSFDQWGVELGK LAKTI EL+GE P +HD ST LI L Sbjct: 489 HKTFVQGIIWGINSFDQWGVELGKQLAKTILGELTGETGPQKHDSSTERLINL 541 >NMA1604 [G] COG0166 Glucose-6-phosphate isomerase NmA Neisseria meningitidis Z2491 Length = 548 Score = 654 bits (1687), Expect = 0.0, Method: Compositional matrix adjust. Identities = 316/533 (59%), Positives = 387/533 (72%), Gaps = 1/533 (0%) Query: 11 AFQALLSHHAEVRDRHMRDLFAADPQRFDHMTVKAAGILFDYSKNRVDNTTLKLLFELAR 70 A+ L +H + + HMR++F DPQR + ++ G+ DYSKNR+++ T+ LLFELA Sbjct: 9 AWSKLWNHFDDSKTLHMREMFEQDPQRAERYWLQVGGLTLDYSKNRINDETMSLLFELAH 68 Query: 71 ERGVERQRAAMFNGEKINFTEHRAVLHTALRAPRGQALQVDGQHIGADVHAVLDRIHGFT 130 E GV + MF+G+KIN TE+RAVLH ALR + VDG+ + V+ VL R+ F Sbjct: 69 EAGVPERMRQMFHGKKINTTENRAVLHVALRNRTNSPIVVDGEDVMPKVNRVLQRMGEFA 128 Query: 131 ERVREGQWLGLSGKPITDIVNIGIGGSHLGPQMACTALRTFAHPRLTMHFVSNVDGHDLH 190 VR G WLG + + ITD+VNIGIGGS LGP M CTAL+ F HPRL MHFVSNVDG L Sbjct: 129 HEVRSGSWLGYTNQVITDVVNIGIGGSDLGPLMMCTALKPFGHPRLNMHFVSNVDGSQLR 188 Query: 191 DALQRVDVETTLFIVASKTFTTQETMMNAGSARDWFLQRAGVDD-LAKHFVAVSTNTEAV 249 D L +V ETTLFI+ASKTFTTQET+ NA +AR+WFL AG ++ +AKHF AVSTN +AV Sbjct: 189 DVLSKVHPETTLFIIASKTFTTQETLTNALTAREWFLNHAGDEEAVAKHFAAVSTNQKAV 248 Query: 250 RAFGIDTDNMFPFWDWVGGRYSMWSSIGLSIALAIGFKNFSELLAGAHAMDKHFCEAPLK 309 FGIDT NMF FWDWVGGRYS+WS+IGL I L +G +NF E+L GAH MD+HF PL+ Sbjct: 249 AEFGIDTANMFEFWDWVGGRYSLWSAIGLPIMLYLGEENFIEMLNGAHLMDQHFINTPLE 308 Query: 310 QNMPIIQALIGIWNRNCFNSESLSIAPYHHDLRHFPAYLQQLEMESNGKRITRDGSAVGV 369 +N+P+I ALIGIW N + S IAPY L P ++QQL+MESNGK++T DG AVG Sbjct: 309 RNLPVILALIGIWYINYYGGGSHVIAPYDQHLHRLPKFIQQLDMESNGKQVTLDGKAVGH 368 Query: 370 ATCPFIWGDVGTNGQHAFFQLLHQGTDITPIDFIAVLHATHDLPGHHAVLLANCFAQSEA 429 T P IWG+ G NGQHAFFQLLHQGT ITPID IA L +LPGHH +LLAN FAQ+EA Sbjct: 369 ETSPIIWGETGINGQHAFFQLLHQGTHITPIDLIASLEKRSNLPGHHEILLANVFAQAEA 428 Query: 430 FMRGKQAEEVREDLKKLGVDDDEINFLLPHKTFNGNRPSNTLLLDALTPATLGALIALYE 489 FMRGK +EVR +LK G+D+ I L+PHKTF+GNRP+N +L+D + P +G+LIA+YE Sbjct: 429 FMRGKTPDEVRAELKAQGMDEARIEELVPHKTFSGNRPTNLILMDKVNPRNMGSLIAMYE 488 Query: 490 HKTFVQGTIWGINSFDQWGVELGKVLAKTIQSELSGEAVPARHDCSTNALIAL 542 HKTFVQG IWGINSFDQWGVELGK LAKTI EL+GE +HD ST LI L Sbjct: 489 HKTFVQGIIWGINSFDQWGVELGKQLAKTILGELTGETGSQKHDSSTERLINL 541 >jhp1093 [G] COG0166 Glucose-6-phosphate isomerase jHp Helicobacter pylori J99 Length = 545 Score = 621 bits (1601), Expect = e-177, Method: Compositional matrix adjust. Identities = 298/540 (55%), Positives = 381/540 (70%), Gaps = 1/540 (0%) Query: 6 LTATAAFQALLSHHAEVRDRHMRDLFAADPQRFDHMTVKAAGILFDYSKNRVDNTTLKLL 65 LT + LL H+ E+++ HMRD F+ D +R V+ + DYSKNR+++TTLKLL Sbjct: 2 LTQLKTYPKLLKHYEEIKEVHMRDWFSKDKERASRYFVQLESLSLDYSKNRLNDTTLKLL 61 Query: 66 FELARERGVERQRAAMFNGEKINFTEHRAVLHTALRAPRGQALQVDGQHIGADVHAVLDR 125 FELA++ ++ + AMF GEKIN TE RAVLHTALR+ + +D + V +VL R Sbjct: 62 FELAKDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDAEILLDNMEVLKSVRSVLKR 121 Query: 126 IHGFTERVREGQWLGLSGKPITDIVNIGIGGSHLGPQMACTALRTFAHPRLTMHFVSNVD 185 + F++ VR G+ LG + + ITDIVNIGIGGS LG M CTAL+ + HPRL MHFVSNVD Sbjct: 122 MRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYGHPRLKMHFVSNVD 181 Query: 186 GHDLHDALQRVDVETTLFIVASKTFTTQETMMNAGSARDWFLQRAGVDD-LAKHFVAVST 244 G + D L++++ +TLFIVASKTF+TQET+ NA +AR WF++R+G + +AKHFVAVST Sbjct: 182 GTQILDVLEKINPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVST 241 Query: 245 NTEAVRAFGIDTDNMFPFWDWVGGRYSMWSSIGLSIALAIGFKNFSELLAGAHAMDKHFC 304 N EAV+ FGID NMF FWD+VGGRYS+WS+IGLSI + +G KNF+ LL GA+ MD+HF Sbjct: 242 NKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFR 301 Query: 305 EAPLKQNMPIIQALIGIWNRNCFNSESLSIAPYHHDLRHFPAYLQQLEMESNGKRITRDG 364 AP + N+P++ LIG+W N F S+S IAPY LRHFP ++QQL+MESNGKRI++ G Sbjct: 302 NAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKG 361 Query: 365 SAVGVATCPFIWGDVGTNGQHAFFQLLHQGTDITPIDFIAVLHATHDLPGHHAVLLANCF 424 + TCP +WGD+G N QHAFFQLLHQGT + PIDFIA L + GHH +L +N Sbjct: 362 EIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNVL 421 Query: 425 AQSEAFMRGKQAEEVREDLKKLGVDDDEINFLLPHKTFNGNRPSNTLLLDALTPATLGAL 484 AQ++AFM+GK EE +L G+D DE L H+ F GNRPSN LLL+ ++P+ +GAL Sbjct: 422 AQAQAFMKGKSYEEALGELLSKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGAL 481 Query: 485 IALYEHKTFVQGTIWGINSFDQWGVELGKVLAKTIQSELSGEAVPARHDCSTNALIALAK 544 +ALYEHK FVQG IW INSFDQWGVELGK LA I EL G A D ST LI L K Sbjct: 482 VALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTRHLIELYK 541 >DR1742 [G] COG0166 Glucose-6-phosphate isomerase Dra Deinococcus radiodurans Length = 541 Score = 617 bits (1592), Expect = e-176, Method: Compositional matrix adjust. Identities = 311/537 (57%), Positives = 384/537 (71%), Gaps = 10/537 (1%) Query: 6 LTATAAFQALLSHHAEVRDRHMRDLFAADPQRFDHMTVKAAGILFDYSKNRVDNTTLKLL 65 LT A+QAL H+ E++ H+R+LFAADP+R + M + AG+ DYSK+RV + TL+LL Sbjct: 4 LTDLPAWQALEDHYYELQGTHLRELFAADPERGEKMNAEGAGLYLDYSKHRVTDETLRLL 63 Query: 66 FELARERGVERQRAAMFNGEKINFTEHRAVLHTALRAPRGQALQVDGQHIGADVHAVLDR 125 ELA+ GVE +R AMF GEKIN TE RAVLHTALRAPR ++VDG+++ +VH VLDR Sbjct: 64 RELAQATGVEARRDAMFRGEKINVTEGRAVLHTALRAPRDAVIEVDGKNVVPEVHEVLDR 123 Query: 126 IHGFTERVREGQWLGLSGKPITDIVNIGIGGSHLGPQMACTALRTFAHPRLTMHFVSNVD 185 + F + VR G+WLG +GKPI +IVNIGIGGS LGP MA AL+ +A LT+ FVSNVD Sbjct: 124 MATFADAVRSGEWLGYTGKPIKNIVNIGIGGSDLGPVMAYEALKHYAQRDLTVRFVSNVD 183 Query: 186 GHDLHDALQRVDVETTLFIVASKTFTTQETMMNAGSARDWFLQRAGVD-DLAKHFVAVST 244 G DL + + +D E TLFIV+SKTFTTQETM NA SAR W L D + +HFVAVST Sbjct: 184 GTDLTEKTRDLDPEVTLFIVSSKTFTTQETMTNARSARKWLLGSLKDDAAVTRHFVAVST 243 Query: 245 NTEAVRAFGIDTDNMFPFWDWVGGRYSMWSSIGLSIALAIGFKNFSELLAGAHAMDKHFC 304 N E V+ FGIDT NMF FWDWVGGRYSM S+IGLS+ +A+G ++F E+LAG H MD+HF Sbjct: 244 NAEEVQKFGIDTANMFGFWDWVGGRYSMDSAIGLSLMVAVGPEHFREMLAGFHDMDEHFR 303 Query: 305 EAPLKQNMPIIQALIGIWNRNCFNSESLSIAPYHHDLRHFPAYLQQLEMESNGKRITRDG 364 AP +QN+P++ L+G+W + F +ESL++ PY L FPAYLQQL+MESNGK +T G Sbjct: 304 TAPAEQNLPMLMGLLGVWYGDFFGAESLAVLPYDQYLASFPAYLQQLDMESNGKHVTLGG 363 Query: 365 SAVGVATCPFIWGDVGTNGQHAFFQLLHQGTDITPIDFIAVLHATHDLPGHHAVLLANCF 424 V T P +WG GTNGQHAF+QL+HQGT + P DFI + LP HH +L+AN F Sbjct: 364 EPVDYQTGPIVWGQAGTNGQHAFYQLIHQGTKLIPCDFIGFCQTLNPLPPHHDLLMANVF 423 Query: 425 AQSEAFMRGKQAEEVREDLKKLGVDDDEINFLLPHKTFNGNRPSNTLLLDALTPATLGAL 484 AQ+EA GK E+V D GV + + PH+ F GNRP++T+L D LTP TLGAL Sbjct: 424 AQTEALAFGKTLEQVLAD----GVAPE----VAPHRVFEGNRPTSTILADRLTPRTLGAL 475 Query: 485 IALYEHKTFVQGTIWGINSFDQWGVELGKVLAKTIQSELSGEAVPA-RHDCSTNALI 540 IALYEHK FVQG +W INSFDQWGVELGKVLAK I EL E P +HD STNALI Sbjct: 476 IALYEHKVFVQGAVWDINSFDQWGVELGKVLAKKIDGELQSEGEPELQHDSSTNALI 532 >HP1166 [G] COG0166 Glucose-6-phosphate isomerase Hpy Helicobacter pylori 26695 Length = 545 Score = 616 bits (1589), Expect = e-176, Method: Compositional matrix adjust. Identities = 297/540 (55%), Positives = 380/540 (70%), Gaps = 1/540 (0%) Query: 6 LTATAAFQALLSHHAEVRDRHMRDLFAADPQRFDHMTVKAAGILFDYSKNRVDNTTLKLL 65 LT + LL H+ E+++ HMRD F D +R ++ + DYSKNR+++TTLKLL Sbjct: 2 LTQLKTYPKLLKHYEEIKEVHMRDWFFKDKERASRYFLQFESLSLDYSKNRLNDTTLKLL 61 Query: 66 FELARERGVERQRAAMFNGEKINFTEHRAVLHTALRAPRGQALQVDGQHIGADVHAVLDR 125 FELA + ++ + AMF GEKIN TE RAVLHTALR+ + +D + + +VL R Sbjct: 62 FELANDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSIRSVLKR 121 Query: 126 IHGFTERVREGQWLGLSGKPITDIVNIGIGGSHLGPQMACTALRTFAHPRLTMHFVSNVD 185 + F++ VR G+ LG + + ITDIVNIGIGGS LG M CTAL+ +AHPRL MHFVSNVD Sbjct: 122 MRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYAHPRLKMHFVSNVD 181 Query: 186 GHDLHDALQRVDVETTLFIVASKTFTTQETMMNAGSARDWFLQRAGVDD-LAKHFVAVST 244 G + D L++++ +TLFIVASKTF+TQET+ NA +AR WF++R+G + +AKHFVAVST Sbjct: 182 GTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVST 241 Query: 245 NTEAVRAFGIDTDNMFPFWDWVGGRYSMWSSIGLSIALAIGFKNFSELLAGAHAMDKHFC 304 N EAV+ FGID NMF FWD+VGGRYS+WS+IGLSI + +G KNF+ LL GA+ MD+HF Sbjct: 242 NKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFR 301 Query: 305 EAPLKQNMPIIQALIGIWNRNCFNSESLSIAPYHHDLRHFPAYLQQLEMESNGKRITRDG 364 AP + N+P++ LIG+W N F S+S IAPY LRHFP ++QQL+MESNGKRI++ G Sbjct: 302 NAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKG 361 Query: 365 SAVGVATCPFIWGDVGTNGQHAFFQLLHQGTDITPIDFIAVLHATHDLPGHHAVLLANCF 424 + TCP +WGD+G N QHAFFQLLHQGT + PIDFIA L + GHH +L +N Sbjct: 362 EIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNVL 421 Query: 425 AQSEAFMRGKQAEEVREDLKKLGVDDDEINFLLPHKTFNGNRPSNTLLLDALTPATLGAL 484 AQ++AFM+GK EE +L G+D DE L H+ F GNRPSN LLL+ ++P+ +GAL Sbjct: 422 AQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGAL 481 Query: 485 IALYEHKTFVQGTIWGINSFDQWGVELGKVLAKTIQSELSGEAVPARHDCSTNALIALAK 544 +ALYEHK FVQG IW INSFDQWGVELGK LA I EL G A D ST LI L K Sbjct: 482 VALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKHLIELYK 541