BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0030.0042.p (611 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value DR1598 [R] COG0612 Predicted Zn-dependent peptidases Dra Deinoco... 490 e-138 CC3584 [R] COG0612 Predicted Zn-dependent peptidases Ccr Cauloba... 158 5e-38 VC0554 [R] COG0612 Predicted Zn-dependent peptidases Vch Vibrio ... 157 6e-38 CC2578 [R] COG0612 Predicted Zn-dependent peptidases Ccr Cauloba... 156 1e-37 all1021 [R] COG0612 Predicted Zn-dependent peptidases Nos Nostoc... 155 3e-37 >DR1598 [R] COG0612 Predicted Zn-dependent peptidases Dra Deinococcus radiodurans Length = 951 Score = 490 bits (1261), Expect = e-138, Method: Compositional matrix adjust. Identities = 264/609 (43%), Positives = 362/609 (59%), Gaps = 53/609 (8%) Query: 20 LPAGVSQGPSAEGITEYRFSNGFKLLLMPDASKPTVTVNMTYLVGSRQENYGETGMAHLL 79 LPAGV EGI EYR NG ++LL PD S+ T T+N TYLVGSR ENYGETGMAHLL Sbjct: 70 LPAGVRFVTEVEGIREYRLGNGLRVLLFPDTSQTTFTLNTTYLVGSRHENYGETGMAHLL 129 Query: 80 EHLMFKGTPQHGAIPQEFSKRGMSFNGSTSLDRTNYYEFFPAGDENLQWAIVMEADRMLN 139 EH++FKGTP G + ++ SKRG SFNG+TS DRTNY+E +NL+WAI MEADRM+N Sbjct: 130 EHMLFKGTPTSGNLMEQLSKRGASFNGTTSDDRTNYFETMTNSGDNLEWAIRMEADRMVN 189 Query: 140 SFIAQKDLDSEMTVVRNEFESGENSPGSVMVKRMQSIAFDWHNYGNSTIGNRSDIEHVKI 199 S ++ DL +EMTVVRNEFESGEN+P ++ K+++S+AFDWHNYGN+ IGNRSD+E+V I Sbjct: 190 SRVSADDLKTEMTVVRNEFESGENNPFGLLYKQVRSVAFDWHNYGNTAIGNRSDVENVPI 249 Query: 200 ENLQAFYRTYYQPDNAVLLVAGKFDPAKVLAWVDRSFGKMPKPARAV------------- 246 NL+AFY+TYYQPDNAV+ +AG FD + L + S+GK+ +P R + Sbjct: 250 GNLKAFYKTYYQPDNAVVTLAGNFDEGQALTLIADSYGKVRRPWRTLPRQYTEENPQDGE 309 Query: 247 --------------------------------VAADILADTPNGRLHKLLVETGKASAIM 274 V ++L+D P+GRL++ LV+TG+A+A Sbjct: 310 RSLTVRRVGDAQYLIVGYHIPSVRHPDAAALQVLGELLSDEPSGRLYQALVQTGQATAAG 369 Query: 275 QFQLSGYAPGLQIIGAVIKKGEPLEPVRKALTDAIESFATTPPTDAEMARVRVSNANGYE 334 G PGL A++ K + L+ + L +E+ A TP T+ E+ARVR +GYE Sbjct: 370 SITNPGSDPGLATYVAILGKDDDLQKAQATLLSTLENAAKTPFTEEEVARVRTRVLSGYE 429 Query: 335 RLLSDHQRIGISLSNVLALGDWRLLFAGRDQVDAMSAEQVAGAAAKYFRRDNRTVGLFIP 394 + L+ + +G+ LS +A GDWRL F GRD ++ ++ V AA Y + NRT+G FIP Sbjct: 430 QALTKPEAVGVGLSEAIAAGDWRLFFQGRDAIEKVTPADVQRVAATYLKSTNRTLGAFIP 489 Query: 395 EDQPQRSEIPVAPSLESALQSYRPRAAIATGEVFDTSPANLDLRTTQLRVGGLKLALLPK 454 QP R +P APS L+ ++ RAA + GE P L+ R + V G K+A+LPK Sbjct: 490 TAQPDRVAVPAAPSAADVLRDFKGRAAQSAGETIAPEPDALEARVLRETVAGAKVAMLPK 549 Query: 455 KTRGQTVSVRIKLDWGDEKTLFGKKTIAAMTDEMLSRGSMSMTREQLADEFARLK----- 509 KTRG+ + + + LD+G+ +T+ A +L+RGS S+TR+QL D K Sbjct: 550 KTRGERIELVLSLDFGNPETVRTGSDAADFVGPLLTRGSRSLTRQQLHDRLEAAKSQLDV 609 Query: 510 ---IAGGVYNFQTTRGNLDAALKLMADVLQHPRFEPAEFEQLRKQLLVSLESSRNDPTER 566 +G T R +L AL L+ VL+ P F A+F++L+K L E+ R DP Sbjct: 610 SAGASGATLTLSTDRQHLPEALGLLRQVLREPVFPQADFDELKKAALDGTEAGRGDPESV 669 Query: 567 ASEALSLHF 575 A AL F Sbjct: 670 AGLALGRAF 678 >CC3584 [R] COG0612 Predicted Zn-dependent peptidases Ccr Caulobacter vibrioides Length = 948 Score = 158 bits (399), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 165/622 (26%), Positives = 259/622 (41%), Gaps = 108/622 (17%) Query: 38 FSNGFKLLLMPDASKPTVTVNMTYLVGSRQENYGETGMAHLLEHLMFKGTPQHGAIPQEF 97 +NG K+ D S P V+V + Y VGS+ + G +G AHL EHLMFK T +P E Sbjct: 50 LANGMKVFTSRDTSTPNVSVQVWYGVGSKDDPQGRSGFAHLFEHLMFKATRN---MPNET 106 Query: 98 SKR-----GMSFNGSTSLDRTNYYEFFPAGD-ENLQWAIVMEADRMLNSFIAQKDLDSEM 151 R G N ST D TNYYE PA E L WA EADR+ + I + SE Sbjct: 107 VDRLTEDVGGFNNASTWDDFTNYYEVVPANHLERLIWA---EADRLKSLVIDEAVFASER 163 Query: 152 TVVRNEFESG--ENSPGSVMVKRMQSIAFDWHNYGNSTIGNRSDIEHVKIENLQAFYRTY 209 VV+ E + G + +F H Y IG+ +++ +++++AF+RTY Sbjct: 164 DVVKEELRQRVLADPYGRFFALSIPQQSFAVHPYQRPGIGSIEELDAATVDDVRAFHRTY 223 Query: 210 YQPDNAVLLVAGKFDPAKVLAWVDRSFGKMPKPARAV----------------------- 246 Y+PDNA L++ G FD K+ A +D+ FG + PA A+ Sbjct: 224 YRPDNAALIIVGNFDQTKLDAMIDKYFGSLTTPAGAIPKVTAVEPARTGPKTVNTYGPNV 283 Query: 247 -----------------------VAADILADTPNGRLHKLLVETGK-ASAIMQFQLSGYA 282 V IL + RL+ LV K A ++ + Sbjct: 284 PLPALAITWLAPAAADKDAPALAVLDAILTAGKSSRLYDSLVYDQKIAQSVFSSAPNNAQ 343 Query: 283 PGLQIIGAVIKKGEPLEPVRKALTDAIESFATTPPTDAEMARVRVSNANGYERLLSDHQR 342 PGL +GA++ G+ + AL + T AE+A + LL+D R Sbjct: 344 PGLFYVGAIMAGGKTVAQGEAALRAQVARVRDGLVTPAELAEAKAG-------LLADAVR 396 Query: 343 -----------IGISLSNVLALGDWRLLFAGRDQVDAMSAEQVAGAAAKYFRRDNRTVGL 391 IG +L GD + ++ A++A + A +Y D RTV Sbjct: 397 RREEIDGRGFAIGYALQTE---GDAAAANSSLAKLQAVTAADIQRVARQYLADDRRTVIN 453 Query: 392 FIPE-DQP--QRSEIPVAPSLES----------ALQSYRPRAAIATGEVFDTSPANLDLR 438 ++PE D+P ++ P P + S A ++ R + V P + Sbjct: 454 YLPEKDRPAGEKDATPPIPKVASVKYDGPITTLAPEAEREKPPAVAAPVPAVMPTPAE-- 511 Query: 439 TTQLRVGGLKLALLPKKTRGQTVSVRIKLDWGDEKTLFGKKTIAAMTDEMLSRGSMSMTR 498 + GL++ ++ K + ++ + + G G +++T E+L+ G+ + + Sbjct: 512 --KTLANGLRV-IVAKSSELPLITSTLTVKGGASSDPAGLAGTSSLTSELLTEGTATRSA 568 Query: 499 EQLADEFARL--KIAGG------VYNFQTTRGNLDAALKLMADVLQHPRFEPAEFEQLRK 550 Q+A E L +A G T N D A+ +MADV Q+P F+ E +++R Sbjct: 569 TQVARETEALGANLAAGSGWEAASLTLSVTANNADPAMAIMADVAQNPAFKTEELDRVRA 628 Query: 551 QLLVSLESSRNDPTERASEALS 572 + L L + P AS A S Sbjct: 629 ETLDGLSVAFQRPGSLASFATS 650 Score = 63.2 bits (152), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 47/209 (22%), Positives = 86/209 (41%), Gaps = 4/209 (1%) Query: 35 EYRFSNGFKLLLMPDASKPTVTVNMTYLVGSRQENYGETGMAHLLEHLMFKGTPQHGA-- 92 E +NG ++++ + P +T +T G+ + G G + L L+ +GT A Sbjct: 511 EKTLANGLRVIVAKSSELPLITSTLTVKGGASSDPAGLAGTSSLTSELLTEGTATRSATQ 570 Query: 93 IPQEFSKRGMSFNGSTSLDRTNYYEFFPAGDENLQWAIVMEADRMLNSFIAQKDLDSEMT 152 + +E G + + + + A + + AI+ AD N ++LD Sbjct: 571 VARETEALGANLAAGSGWEAASLTLSVTANNADPAMAIM--ADVAQNPAFKTEELDRVRA 628 Query: 153 VVRNEFESGENSPGSVMVKRMQSIAFDWHNYGNSTIGNRSDIEHVKIENLQAFYRTYYQP 212 + PGS+ + + YG+ G + +K E+L + Y++P Sbjct: 629 ETLDGLSVAFQRPGSLASFATSPVLYAGSAYGHVAGGTPGSLPKIKREDLAKTHAAYWRP 688 Query: 213 DNAVLLVAGKFDPAKVLAWVDRSFGKMPK 241 DNAVL+V G P A +++FG K Sbjct: 689 DNAVLVVTGNLSPEAGFALAEKAFGGWKK 717 >VC0554 [R] COG0612 Predicted Zn-dependent peptidases Vch Vibrio cholerae Length = 952 Score = 157 bits (398), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 94/257 (36%), Positives = 146/257 (56%), Gaps = 20/257 (7%) Query: 1 LFLTVGGAHALAQTPPALPLPAGVS--------QGPSAEGITEYRFSNGFKLLLMPDASK 52 L L G + + + P LP GV+ G ++YR NG ++L PD S Sbjct: 12 LLLLAGCSSSDSSLPLFSSLPKGVTLVEEVKAEPGKVMIPYSKYRLDNGLTVILSPDDSD 71 Query: 53 PTVTVNMTYLVGSRQENYGETGMAHLLEHLMFKGTPQHGAIPQEF---SKRGMSFNGSTS 109 P V V++TY VGS +E G++G AH EH+MF+G+ +H Q F ++ G S NG+T+ Sbjct: 72 PLVHVDVTYHVGSAREEIGKSGFAHFFEHMMFQGS-KHVGDQQHFRLITEAGGSLNGTTN 130 Query: 110 LDRTNYYEFFPAGD-ENLQWAIVMEADRM--LNSFIAQKDLDSEMTVVRNE-FESGENSP 165 DRTNY+E PA E + W +EADRM L ++Q+ + + V+NE ++ +N P Sbjct: 131 RDRTNYFETVPANQLEKMLW---LEADRMGFLLDAVSQRKFEIQRDTVKNERAQNYDNRP 187 Query: 166 GSVMVKRM-QSIAFDWHNYGNSTIGNRSDIEHVKIENLQAFYRTYYQPDNAVLLVAGKFD 224 +M ++M +++ + H Y TIG SD++ V + +L+AF+ +Y P+NAVL + G D Sbjct: 188 YGLMWEKMGEALYPEGHPYSWQTIGYVSDLDRVDVNDLKAFFLRWYGPNNAVLTIGGDLD 247 Query: 225 PAKVLAWVDRSFGKMPK 241 + LAWV + FG +PK Sbjct: 248 VKQTLAWVQKYFGSIPK 264 >CC2578 [R] COG0612 Predicted Zn-dependent peptidases Ccr Caulobacter vibrioides Length = 927 Score = 156 bits (394), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 155/606 (25%), Positives = 263/606 (43%), Gaps = 92/606 (15%) Query: 34 TEYRFSNGFKLLLMPDASKPTVTVNMTYLVGSRQENYGETGMAHLLEHLMFKGTPQ-HGA 92 T ++ SNG +++ D P V VN+ Y VGS+ E G+TG AHL EHLMF G+ + Sbjct: 54 TTFKLSNGLTVIVHEDRKAPIVAVNIWYHVGSKNEPAGKTGFAHLFEHLMFNGSENFNDD 113 Query: 93 IPQEFSKRGMS-FNGSTSLDRTNYYEFFP-AGDENLQWAIVMEADRM--LNSFIAQKDLD 148 + K G + NG+T+ DRTNY++ P A + + W +E+DRM L + I + LD Sbjct: 114 WFKALEKLGATDMNGTTNRDRTNYFQNVPTAALDQVLW---LESDRMGWLLNAIDKAKLD 170 Query: 149 SEMTVVRNEFESGENSP-GSVMVKRMQSIAFDWHNYGNSTIGNRSDIEHVKIENLQAFYR 207 + VV+NE GEN P G +S H YG++ IG+ +D++ +++++ +++ Sbjct: 171 EQRGVVQNEKRQGENQPYGQAWNIITESTYPKDHPYGHTVIGSMADLDAASLDDVKTWFK 230 Query: 208 TYYQPDNAVLLVAGKFDPAKVLAWVDRSFGKM---PKPARAV------------------ 246 YY P NA L++AG A+ A V++ FG + P R Sbjct: 231 NYYGPANATLVLAGDISAAEAKAKVEKYFGDIASGPPVTRQKEWIAKRTGSQRAEMQDRV 290 Query: 247 -----------------------VAADILADTPNGRLHKLLVETGKASAIMQFQLSGYAP 283 + +D+L RL+K LV T +++ + +S Sbjct: 291 PQTRIYKVWNTPGFGAAETDYLDLLSDVLVSDKTSRLYKRLVFTDQSATAVGASVSPSEI 350 Query: 284 GLQ-IIGAVIKKGEPLEPVRKALTDAIESFATTPPTDAEMARVRVSN----ANGYERLLS 338 G Q I+ +K G V KA + + PT E+A+VR +N G ER+ Sbjct: 351 GGQFIVTLTVKPGGDPAAVEKAFDEEFQRLLRDGPTPEEVAKVRTNNLANVVRGAERIGG 410 Query: 339 DHQRIGISLSNVLALGDWRLLFAGRDQVDAMSAEQVAGAAAKYFRRDNRTVGLFIPEDQP 398 + + N + LGD ++V + A K+ + T+ + Sbjct: 411 FGGKSDLLAQNQVYLGDAGAYKHSLERVRNAKPADLVAAGRKWLTDGDFTLTV------- 463 Query: 399 QRSEIPVAPSLESALQSYRPRAAIATGEVFDTSPANLDLRTTQLRVG----GLKLALLPK 454 S +Y+ A A +V A +L G GLK+ L + Sbjct: 464 ------------SPFPNYKAATAGADRKVMPEVGAPKPPSFVKLHRGVLSNGLKVVLAER 511 Query: 455 KTRGQTVSVRIKLDWGDEKTLFGKKTIAA-----MTDEMLSRGSMSMTREQLADEFARLK 509 + Q V + D G GK +++ MT+ +R +++++RE LA A ++ Sbjct: 512 RDTPQ-VQFSMVFDAGQAAETGGKAGVSSLAVGMMTEGTTNRDNLTLSRE-LAQLGAEVR 569 Query: 510 IAGGV----YNFQTTRGNLDAALKLMADVLQHPRFEPAEFEQLRKQLLVSLESSRNDPTE 565 G+ + T LD AL L AD+L++P + P + + ++ + ++ ++ +P Sbjct: 570 TGNGLDTSTVSLNTLTTTLDPALALYADILRNPAYTPDDLTRRKRLSIAGIQQTKQNPNA 629 Query: 566 RASEAL 571 AS L Sbjct: 630 MASRIL 635 >all1021 [R] COG0612 Predicted Zn-dependent peptidases Nos Nostoc sp. PCC 7120 Length = 945 Score = 155 bits (391), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 166/629 (26%), Positives = 267/629 (42%), Gaps = 117/629 (18%) Query: 31 EGITEYRFSNGFKLLLMPDASKPTVTVNMTYLVGSRQENYGETGMAHLLEHLMFKGTP-- 88 E + + NG + + + P V+V + Y GSR E G G+AH LEH+MFKGT Sbjct: 61 ENVHKTVLDNGLTVFIKEVPTVPIVSVQVWYKFGSRHEESGVNGIAHQLEHMMFKGTKSR 120 Query: 89 --QHGAIPQEFSKRGMSFNGSTSLDRTNYYEFFPAGDENLQWAIVMEADRMLNSFIAQKD 146 Q G + FS G N TS D+T YY + L+ +V+EADRM N+ I Sbjct: 121 PIQFGRL---FSALGSDSNAFTSYDQTAYYG--TVERDKLKVLLVLEADRMQNALIDADK 175 Query: 147 LDSEMTVVRNEFESGENSPGSVMVKRMQSIAFDWHNYGNSTIGNRSDIEHVKIENLQAFY 206 L SE VV +E + ENSP + + + F H YG G ++D+E +E +Q +Y Sbjct: 176 LASEKRVVISELQGYENSPEYRLNRAVMQAVFPNHPYGLPVGGTKADVEKFPVEKVQEYY 235 Query: 207 RTYYQPDNAVLLVAGKFDPAKVLAWVDRSFGKMPK------------------------- 241 + +Y P+NAVL++ G + LA V FG +P+ Sbjct: 236 QDFYSPENAVLVIVGDCQAKETLATVKEIFGGIPQRQQPTANSQQSIINSQQPTANSPIV 295 Query: 242 ------------------------PARAVVAADILADTPNGRLHKLLVETGKASAIMQFQ 277 PA VV IL + N RL+K L+E+G AS + Sbjct: 296 LREPGAAGLLQVIYPLPPASHPDMPALEVVDY-ILTEGRNSRLYKALIESGLAS-----E 349 Query: 278 LSGYAPGLQIIG--AVIKKGEPLEPVRK---ALTDAIESFATTPPTDAEMARVR------ 326 + GLQ G ++ +P + + K L AI + A T E+AR + Sbjct: 350 VEASIGGLQQAGWYELLVTADPDQDIGKIDSVLNKAIANLARTDVKAEELARAKRQLEAA 409 Query: 327 --VSNANGYERLLSDHQRIGISLSN-VLALGDWRLLFAGRDQVDAMSAEQVAGAAAKYFR 383 +SN R ++D + L N +G++R + +++ V KY Sbjct: 410 IILSN-----RTITDQ---AMQLGNDETTVGNYRFTDYYLSAIRQVTSADVVRVVNKYLP 461 Query: 384 RDNRTVGLFIPEDQPQRSEIPVAPSLESALQSYRPRAAIATGEVFDTSPANLDLRT---- 439 + +R VG+F P E+ S + ++ +++ + EV P+ LD+ T Sbjct: 462 KSHRKVGIFQPTISTSTKEVGNKKSTQRTQENLAGDSSVTSSEVMKYLPS-LDITTDNIP 520 Query: 440 --TQLRV-------GGLKLALLPKKTRGQTVSVRIKLDWGDEKTLFGKKTIAAMTDEMLS 490 +Q R+ GL++ LLP K+ TV++ + G E G+ +A++ + L Sbjct: 521 QKSQTRLPQQFTLANGLQVFLLPDKST-PTVTLSGYVKAGTEFDPDGQAGLASLVADSL- 578 Query: 491 RGSMSMTREQLADEFAR-LKIAGGVYNFQTTRG-----------NLDAALKLMADVLQHP 538 MS T+ + A A+ L G +F R + ++ +AD L++ Sbjct: 579 ---MSGTKTKNASTLAQVLDDRGVTLDFAAYRNGMRIQADSLAEDFPVLIRTLADGLKNS 635 Query: 539 RFEPAEFEQLRKQLLVSLESSRNDPTERA 567 F E + +Q + SL+ +DP E A Sbjct: 636 TFPKKELDLNLQQAVTSLKMELDDPGEVA 664 Score = 69.7 bits (169), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 96/211 (45%), Gaps = 17/211 (8%) Query: 35 EYRFSNGFKLLLMPDASKPTVTVNMTYLVGSRQENYGETGMAHLLEHLMFKGTPQHGA-- 92 ++ +NG ++ L+PD S PTVT++ G+ + G+ G+A L+ + GT A Sbjct: 530 QFTLANGLQVFLLPDKSTPTVTLSGYVKAGTEFDPDGQAGLASLVADSLMSGTKTKNAST 589 Query: 93 IPQEFSKRGMS-----FNGSTSLDRTNYYEFFPAGDENLQWAIVMEADRMLNSFIAQKDL 147 + Q RG++ + + + E FP L AD + NS +K+L Sbjct: 590 LAQVLDDRGVTLDFAAYRNGMRIQADSLAEDFPVLIRTL-------ADGLKNSTFPKKEL 642 Query: 148 DSEMTVVRNEFESGENSPGSVMVKR-MQSIAFDWHNYGNSTIGNRSDIEHVKIENLQAFY 206 D + + + PG V + +QS+ H T + ++ +++ AF Sbjct: 643 DLNLQQAVTSLKMELDDPGEVARRIFLQSVYPKKHPL--HTFPTVESLRKIRRQDVIAFS 700 Query: 207 RTYYQPDNAVLLVAGKFDPAKVLAWVDRSFG 237 + YY+PD VL++ G F+P +V + + FG Sbjct: 701 QKYYRPDTTVLVLMGDFEPQQVRSLIQAEFG 731