BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0030.0032.p         (167 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

RSc0946 [H] COG0262 Dihydrofolate reductase Rso Ralstonia solana...   184   1e-46
BS_dfrA [H] COG0262 Dihydrofolate reductase Bsu Bacillus subtilis     156   2e-38
BH3450 [H] COG0262 Dihydrofolate reductase Bha Bacillus halodurans    146   2e-35
NMA2179 [H] COG0262 Dihydrofolate reductase NmA Neisseria mening...   145   4e-35
NMB0308 [H] COG0262 Dihydrofolate reductase Nme Neisseria mening...   144   7e-35

>RSc0946 [H] COG0262 Dihydrofolate reductase Rso Ralstonia solanacearum
          Length = 167

 Score =  184 bits (466), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 95/158 (60%), Positives = 113/158 (71%), Gaps = 2/158 (1%)

Query: 11  LCVIVATDSQNGIGINNTLPWHLPDDLAHFKRTTSGHPIIMGRKTFDSIGRPLPNRRNIV 70
           L +IVA      IG +NTLPW LP+DLAHFKRTT G PI+MGRKT++SIGRPLP RRNIV
Sbjct: 4   LTLIVARARNGVIGRDNTLPWRLPEDLAHFKRTTMGAPIVMGRKTYESIGRPLPGRRNIV 63

Query: 71  ITRNRDWSHAGVETVSSLQEAAALVAGVDA-FIIGGAQIYAESLPLATRLIVTEISKAFD 129
           +TR+   +  G E   SL++A  L  GV+  F+IGGAQ+YA++LP A RLIVTEI   F+
Sbjct: 64  VTRSAKLALPGCEIAHSLEDAQRLCIGVEQIFLIGGAQLYADALPSADRLIVTEIDADFE 123

Query: 130 CDAFFPAIDRELWRETARETHRAET-QGFDYAFVTYER 166
            DA FPA D  +W E ARETH A     FDYAFVTYER
Sbjct: 124 GDAHFPAPDPAVWHEVARETHHAAAPNDFDYAFVTYER 161


>BS_dfrA [H] COG0262 Dihydrofolate reductase Bsu Bacillus subtilis
          Length = 168

 Score =  156 bits (395), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 75/159 (47%), Positives = 102/159 (64%), Gaps = 2/159 (1%)

Query: 11  LCVIVATDSQNGIGINNTLPWHLPDDLAHFKRTTSGHPIIMGRKTFDSIGRPLPNRRNIV 70
           +  I A D+   IG +N LPWHLP+DLA+FK+ TSGH IIMGRKTF+SIGRPLPNR+NIV
Sbjct: 2   ISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNIV 61

Query: 71  ITRNRDWSHAGVETVSSLQEAAALVAG-VDAFIIGGAQIYAESLPLATRLIVTEISKAFD 129
           +T   D    G   VSSL++   + +G  + F+IGGAQ+Y +  P A RL +T+I   F+
Sbjct: 62  VTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEFE 121

Query: 130 CDAFFPAIDRELWRETARETH-RAETQGFDYAFVTYERR 167
            D  FP  D   W+  + E   + E   +DY F+ YE++
Sbjct: 122 GDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160


>BH3450 [H] COG0262 Dihydrofolate reductase Bha Bacillus halodurans
          Length = 163

 Score =  146 bits (368), Expect = 2e-35,   Method: Compositional matrix adjust.
 Identities = 72/159 (45%), Positives = 101/159 (63%), Gaps = 2/159 (1%)

Query: 11  LCVIVATDSQNGIGINNTLPWHLPDDLAHFKRTTSGHPIIMGRKTFDSIGRPLPNRRNIV 70
           +  IVA D    IG  N LPW LP DLAHFKR TSGH +IMGRKT++SIG+PLPNRRN+V
Sbjct: 2   ISFIVAMDKHRLIGKENDLPWRLPADLAHFKRVTSGHTVIMGRKTYESIGKPLPNRRNVV 61

Query: 71  ITRNRDWSHAGVETVSSLQEAAALVAGV-DAFIIGGAQIYAESLPLATRLIVTEISKAFD 129
           +TR++ ++  GV+ V S+ EA  L     + F+IGG++++    P A R+ VT I + FD
Sbjct: 62  VTRSQAYTAEGVDIVHSIDEAIRLTEHENETFVIGGSELFKAFWPHADRMYVTYIDEVFD 121

Query: 130 CDAFFPAIDRELWRETARETHRAETQG-FDYAFVTYERR 167
            D +FP ID + W   + E    + +  + + F  YER+
Sbjct: 122 GDTYFPEIDGQEWELVSVEAGTIDEKNVYPHEFRVYERQ 160


>NMA2179 [H] COG0262 Dihydrofolate reductase NmA Neisseria meningitidis
           Z2491
          Length = 162

 Score =  145 bits (366), Expect = 4e-35,   Method: Compositional matrix adjust.
 Identities = 80/158 (50%), Positives = 106/158 (67%), Gaps = 2/158 (1%)

Query: 11  LCVIVATDSQNGIGINNTLPWHLPDDLAHFKRTTSGHPIIMGRKTFDSIG-RPLPNRRNI 69
           + +I A      IG  N +PWH+P+D A FK  T G P+IMGRKT++S+  +PLP RRNI
Sbjct: 4   ITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRRNI 63

Query: 70  VITRNRDWSHAGVETVSSLQEAAALVAGVD-AFIIGGAQIYAESLPLATRLIVTEISKAF 128
           VI+R  D+  AG ET +SL+ A AL AG + A I+GGAQIY +++PLAT L +TE+  + 
Sbjct: 64  VISRQADYCAAGAETAASLEAALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123

Query: 129 DCDAFFPAIDRELWRETARETHRAETQGFDYAFVTYER 166
           + DAFFPAIDR  W+E  R   R  ++G  YAFV Y R
Sbjct: 124 EGDAFFPAIDRTHWKEAERTERRVSSKGTSYAFVHYLR 161


>NMB0308 [H] COG0262 Dihydrofolate reductase Nme Neisseria meningitidis MC58
          Length = 162

 Score =  144 bits (364), Expect = 7e-35,   Method: Compositional matrix adjust.
 Identities = 80/158 (50%), Positives = 106/158 (67%), Gaps = 2/158 (1%)

Query: 11  LCVIVATDSQNGIGINNTLPWHLPDDLAHFKRTTSGHPIIMGRKTFDSIG-RPLPNRRNI 69
           + +I A      IG  N +PWH+P+D A FK  T G P+IMGRKT++S+  +PLP RRNI
Sbjct: 4   ITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRRNI 63

Query: 70  VITRNRDWSHAGVETVSSLQEAAALVAGVD-AFIIGGAQIYAESLPLATRLIVTEISKAF 128
           VI+R  D+  AG ET +SL+ A AL AG + A I+GGAQIY +++PLAT L +TE+  + 
Sbjct: 64  VISRQADYCAAGAETAASLEAALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123

Query: 129 DCDAFFPAIDRELWRETARETHRAETQGFDYAFVTYER 166
           + DAFFPAIDR  W+E  R   R  ++G  YAFV Y R
Sbjct: 124 EGDAFFPAIDRTHWKEAERTERRVSSKGTRYAFVHYLR 161