BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0028.0050.p (438 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 602 e-172 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 526 e-149 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 481 e-135 PA4126 [GEPR] COG0477 Permeases of the major facilitator superfa... 406 e-113 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 379 e-105 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 602 bits (1551), Expect = e-172, Method: Compositional matrix adjust. Identities = 301/438 (68%), Positives = 365/438 (83%), Gaps = 3/438 (0%) Query: 4 TPAQGVAAS---PGTDVSFEEATFSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDL 60 TP G +A P + FEEAT+ KV+WRL+P L LCYV +YLDRVNVGFAKLQML DL Sbjct: 5 TPPLGPSAGALPPQSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDL 64 Query: 61 KFSETVYGLGAGIFFIGYFIFEVPSNIILHKVGARLWIARIMITWGIISGAMIFVTTPEM 120 KFSETVYGLGAGIFFIGYF+FEVPSN+ILH+VGAR+WIARIMI+WG+IS AM+FVTTP M Sbjct: 65 KFSETVYGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAM 124 Query: 121 FYVMRFLLGVAEAGFFPGVILYLTYWYPSHRRGKITALFMTGIAISGVIGGPLSGWIMHA 180 FYVMRFLLG+AEAGFFPG+ILYLTYWYP+ RRG+ T FMT +A+SGVIGGP+SGW + Sbjct: 125 FYVMRFLLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKT 184 Query: 181 FPGVHGLTGWQWMFIIEAIPSLVLGVVVIFYLKDRIRDADWLSEDEKRLLESQIAQEQSE 240 F GV+GL GWQWMF+IE IPS+V+G+ V+ YL +RI A WL+++EK LL IA E+++ Sbjct: 185 FGGVYGLAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQ 244 Query: 241 KAEVSLGQMFADGKVWLSAIIYFCFVMGLYGVSFWLPTIIKTTGVTDPLNIGLLTAIPYA 300 K + + + A +VWL ++IYF FVMGLYGVSFWLPT+IK TGV DPL++GLLTAIPY Sbjct: 245 KEDAPIAAIMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYG 304 Query: 301 VAAVAMIMIGRSADQHRERRWHVAIPAFLGCVGLLFSTVYDHNTLLAMASLTLAAVGILT 360 A VAM+++ RSAD+ RERRWH+AIPA G +GL+ S V+ NT LAMA+LTL +GILT Sbjct: 305 AAVVAMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILT 364 Query: 361 TLPLFWSLPTAFLSGAAAAAGIALINSLGNLAGFVSPYLVGWLKDATQSTNTGMYVLAAS 420 TLPLFWSLPTAFL+G AAAGIALINSLGNLAGF+SPY VGWLKD T+ST++GMY+LAAS Sbjct: 365 TLPLFWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAAS 424 Query: 421 LLLGGLLTLAVPAKLVNK 438 ++LG LLTL+VPA+ VN+ Sbjct: 425 MVLGALLTLSVPARTVNR 442 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 526 bits (1356), Expect = e-149, Method: Compositional matrix adjust. Identities = 259/427 (60%), Positives = 325/427 (76%) Query: 12 SPGTDVSFEEATFSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSETVYGLGA 71 S T + E + K W LLPLL LCYV +YLDRVNVGFAKLQM DL+FS+TVYGLGA Sbjct: 10 SQPTQLQEENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGA 69 Query: 72 GIFFIGYFIFEVPSNIILHKVGARLWIARIMITWGIISGAMIFVTTPEMFYVMRFLLGVA 131 G+FFIGYF E+PSN+ILH+VGARLWIARIMITWGIIS M FVTTP FYVMRFLLGVA Sbjct: 70 GMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVA 129 Query: 132 EAGFFPGVILYLTYWYPSHRRGKITALFMTGIAISGVIGGPLSGWIMHAFPGVHGLTGWQ 191 EAGFFPG+ILY++YW+PSHRRG++ LF+ + +SG+IG PLSGWIM F G G GWQ Sbjct: 130 EAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYAGWQ 189 Query: 192 WMFIIEAIPSLVLGVVVIFYLKDRIRDADWLSEDEKRLLESQIAQEQSEKAEVSLGQMFA 251 WMFI+E IPS+++G+++I+ LKDRI A WL++ EK +L++ I E + A L F Sbjct: 190 WMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYAHSRLRDAFL 249 Query: 252 DGKVWLSAIIYFCFVMGLYGVSFWLPTIIKTTGVTDPLNIGLLTAIPYAVAAVAMIMIGR 311 +VWL +IYFC + G Y + FWLPT+I+ +GV D L+IG LTAIP A AAV MI++ R Sbjct: 250 QPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSR 309 Query: 312 SADQHRERRWHVAIPAFLGCVGLLFSTVYDHNTLLAMASLTLAAVGILTTLPLFWSLPTA 371 SAD+ RERRWH+A+ A LG VG++ ST + N ++AM LT+ A+G L+T+PLFWSLPTA Sbjct: 310 SADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPTA 369 Query: 372 FLSGAAAAAGIALINSLGNLAGFVSPYLVGWLKDATQSTNTGMYVLAASLLLGGLLTLAV 431 FL G+AAAAGIA INS GNL GFV+PY++G+LKD TQST TGM +++ +L +G L + Sbjct: 370 FLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIGAALVFLI 429 Query: 432 PAKLVNK 438 PAK VN Sbjct: 430 PAKAVNH 436 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 481 bits (1239), Expect = e-135, Method: Compositional matrix adjust. Identities = 244/441 (55%), Positives = 323/441 (73%), Gaps = 8/441 (1%) Query: 5 PAQGVAASPGTDVSF------EEATFSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQ 58 P GV A ++ + E T+ KV +R++PLL +CY+ +YLDRVNVGFAKLQM + Sbjct: 12 PLPGVKAMKNSNTAITSPEVVENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSE 71 Query: 59 DLKFSETVYGLGAGIFFIGYFIFEVPSNIILHKVGARLWIARIMITWGIISGAMIFVTTP 118 +L FSE +YGLGAG+FFIGYF FE+PSNI+LHK+GARLWIARIMITWG++S FV T Sbjct: 72 ELGFSEAIYGLGAGLFFIGYFFFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTE 131 Query: 119 EMFYVMRFLLGVAEAGFFPGVILYLTYWYPSHRRGKITALFMTGIAISGVIGGPLSGWIM 178 FY++RFLLG AEAGF+PGVILYLTYW+PSHRRG + ALF G +G+ G PLSGWIM Sbjct: 132 WQFYILRFLLGAAEAGFYPGVILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIM 191 Query: 179 HAFPGVHGLTGWQWMFIIEAIPSLVLGVVVIFYLKDRIRDADWLSEDEKRLLESQI-AQE 237 F G GWQWMF++EAIP++VLGVV++ YL + ++ A WL+E+EK ++ I A Sbjct: 192 DQFHDTAGWQGWQWMFVLEAIPAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADS 251 Query: 238 QSEKAEVSLGQMFADGKVWLSAIIYFCFVMGLYGVSFWLPTIIKTTGVTDPLNIGLLTAI 297 + + A SL + + +W+ +IYFCFVMG +G++ W+PT+I+ +GVT + IGLL AI Sbjct: 252 KGKAASHSLMSLVKNPMLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAI 311 Query: 298 PYAVAAVAMIMIGRSADQHRERRWHVAIPAFLGCVGLLFSTVYDHNTLLAMASLTLAAVG 357 P+ A +AM++ RSAD +RERRWH+ +PA LG VG + + NT +++ L++AA G Sbjct: 312 PFICAIIAMVIFSRSADHYRERRWHLVVPALLGAVGFVVAASAT-NTTVSIIFLSMAAAG 370 Query: 358 ILTTLPLFWSLPTAFLSGAAAAAGIALINSLGNLAGFVSPYLVGWLKDATQSTNTGMYVL 417 +L PLFWSLPTA LSGAAAAAGIALINS+ NLAGF+SPY+VG ++DAT S+ GMYVL Sbjct: 371 VLACAPLFWSLPTAILSGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVL 430 Query: 418 AASLLLGGLLTLAVPAKLVNK 438 A L+LG + L +PA VN+ Sbjct: 431 AGFLILGAAIVLCIPASKVNR 451 >PA4126 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 434 Score = 406 bits (1043), Expect = e-113, Method: Compositional matrix adjust. Identities = 207/423 (48%), Positives = 291/423 (68%) Query: 15 TDVSFEEATFSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSETVYGLGAGIF 74 T + ++T +VTWRL+PLL +CYV ++LDR+N+GFAKLQM DL FS+TVYGLGAG+F Sbjct: 10 TTLPLSDSTHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAGLF 69 Query: 75 FIGYFIFEVPSNIILHKVGARLWIARIMITWGIISGAMIFVTTPEMFYVMRFLLGVAEAG 134 FI Y +F +PSN++L ++G R WIA +M+ WG +S AM+ V T FY++RFLLGVAEAG Sbjct: 70 FIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAEAG 129 Query: 135 FFPGVILYLTYWYPSHRRGKITALFMTGIAISGVIGGPLSGWIMHAFPGVHGLTGWQWMF 194 FFPG+++YL W+P+ RRG+ITALF + ++GVIGGPLSGWI+ F GL GWQWMF Sbjct: 130 FFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQWMF 189 Query: 195 IIEAIPSLVLGVVVIFYLKDRIRDADWLSEDEKRLLESQIAQEQSEKAEVSLGQMFADGK 254 +IE +P ++LGVVV L + WLS+++K LL ++A E+ K S +F++ + Sbjct: 190 LIEGLPVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQRKTITSFSGIFSNPQ 249 Query: 255 VWLSAIIYFCFVMGLYGVSFWLPTIIKTTGVTDPLNIGLLTAIPYAVAAVAMIMIGRSAD 314 VWL IYF ++ + ++FW+P++I G+ IG+L+A+PY MI IGRS+D Sbjct: 250 VWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRSSD 309 Query: 315 QHRERRWHVAIPAFLGCVGLLFSTVYDHNTLLAMASLTLAAVGILTTLPLFWSLPTAFLS 374 + RERRWH+ IP + GL + + + L M L +A +G LP+FW LP AFLS Sbjct: 310 RLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAFLS 369 Query: 375 GAAAAAGIALINSLGNLAGFVSPYLVGWLKDATQSTNTGMYVLAASLLLGGLLTLAVPAK 434 A AAGIALI+S G++A F++PYL+GW++D TQS + +Y+LA + LG L L PA Sbjct: 370 SATLAAGIALISSFGSIAAFLAPYLIGWMRDTTQSASLALYLLAILIALGAGLVLRTPAA 429 Query: 435 LVN 437 +VN Sbjct: 430 VVN 432 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 379 bits (974), Expect = e-105, Method: Compositional matrix adjust. Identities = 197/405 (48%), Positives = 260/405 (64%), Gaps = 4/405 (0%) Query: 11 ASPGTDVSFEEAT--FSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSETVYG 68 A P S E +T +S V R+LP L CY+ +YLDR+N+GFAKLQM DL S+ YG Sbjct: 5 AIPAQAHSGERSTSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAAYG 64 Query: 69 LGAGIFFIGYFIFEVPSNIILHKVGARLWIARIMITWGIISGAMIFVTTPEMFYVMRFLL 128 LGAGIFF GY +FEVPSN++L K+GAR ++RI+I WGI+S +M+FVT FY +RFLL Sbjct: 65 LGAGIFFFGYMLFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRFLL 124 Query: 129 GVAEAGFFPGVILYLTYWYPSHRRGKITALFMTGIAISGVIGGPLSGWIMHAFPGVHGLT 188 GV EAGF PG+I YLT WYP R + A+ + + GVIGGP S WIM F G GL Sbjct: 125 GVFEAGFAPGMIYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGGLA 184 Query: 189 GWQWMFIIEAIPSLVLGVVVIFYLKDRIRDADWLSEDEKRLLESQIAQEQSEKAEVSLGQ 248 GWQWMF+ E IPS++LG+ YL D+ DA WL++ +K ++ IA+ +A S G+ Sbjct: 185 GWQWMFLAEGIPSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIARAAPGQAS-SFGK 243 Query: 249 MFADGKVWLSAIIYFCFVMGLYGVSFWLPTIIKTTGVTDPLNIGLLTAIPYAVAAVAMIM 308 + K+++ A YFC + G+Y V FWLP+I+K+ G++D IGL +AIP VAM Sbjct: 244 ALTEPKLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIVAMYA 303 Query: 309 IGRSADQHRERRWHVAIPAFLGCVGLLFSTVYDHNTLLAMASLTLAAVGILTTLPLFWSL 368 +GR +D+ ER H AI A LG GLL Y + A+ S+TLA+ I + +FW++ Sbjct: 304 LGRRSDRRGERHLHSAITAVLGA-GLLAWAAYATSFPAALISITLASAAIFASYSVFWAI 362 Query: 369 PTAFLSGAAAAAGIALINSLGNLAGFVSPYLVGWLKDATQSTNTG 413 P L G AAA GIALINS+G GF SP L+GW K+AT S G Sbjct: 363 PQQHLKGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407