BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0026.0103.p (364 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PH0142 [V] COG1680 Beta-lactamase class C and other penicillin b... 89 2e-17 PAB0087 [V] COG1680 Beta-lactamase class C and other penicillin ... 83 8e-16 CC3086 [V] COG1680 Beta-lactamase class C and other penicillin b... 82 2e-15 XF1621 [V] COG1680 Beta-lactamase class C and other penicillin b... 80 5e-15 PAE3237 [V] COG1680 Beta-lactamase class C and other penicillin ... 80 9e-15 >PH0142 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Pho Pyrococcus horikoshii Length = 289 Score = 88.6 bits (218), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 111/230 (48%), Gaps = 24/230 (10%) Query: 37 LAFAPLEPTLTSYLVQYKLPALAAAVVQDGRIIAAGAVGTRKVGSGIAVTVNDRFHIGSD 96 + F LE + + + K+P ++ ++++DG +I A G R V + + T + IGS Sbjct: 4 MEFVELESFIVEKMSEKKVPGISISIIKDGEVIYAKGFGYRNVEAKLPSTPETIYGIGSI 63 Query: 97 TKAFTATLAGILVDRGAMAWTTTLGDAFPELAP-KMDPDFRRITISQLLSHTSGIPADNA 155 TK+FTA L + GA+ +L D + K+ P + +TI LL+H+SGIP+ Sbjct: 64 TKSFTALAIMKLAEEGAL----SLEDPVEKYVNIKLRPFGKPVTIHHLLTHSSGIPS--- 116 Query: 156 EFLELLAKSMFEEGNLDDLRYW---------TLQQWMSKPLPVQPGQRGQHFAYSNLGYT 206 L F EG + + R+ + M K +PG+R F Y N GY Sbjct: 117 ----LGYAEAFIEGMIGEDRWLPVASPDQIIAFAKDMEKWAVAKPGER---FFYLNTGYV 169 Query: 207 IAGAMIERVARKSWEELINESIFDPMELKSAGLGSQATLGRVDAALGHVL 256 + G +I +V+ +EE + + I +P+ +K + + D A+G+++ Sbjct: 170 LLGKIISKVSGVPYEEYVRKKILEPLGMKRSYFSKEEVEKDKDVAMGYIV 219 >PAB0087 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Pab Pyrococcus abyssi Length = 447 Score = 83.2 bits (204), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 112/240 (46%), Gaps = 28/240 (11%) Query: 42 LEPTLTSYLVQYKLPALAAAVVQDGRIIAAGAVGTRKVGSGIAVTVNDRFHIGSDTKAFT 101 LE + + + K+P ++ ++++DG ++ A G R V + + T + IGS TK+FT Sbjct: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65 Query: 102 ATLAGILVDRGAMAWTTTLGDAFPELAP-KMDPDFRRITISQLLSHTSGIPADNAEFLEL 160 A LV+ G + +L D + K+ P +T+ LL+H+SGIP+ + E Sbjct: 66 ALAIMKLVEEGGL----SLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLG--YAEA 119 Query: 161 LAKSMFEEGNLDDLRYW----------TLQQWMSKPLPVQPGQRGQHFAYSNLGYTIAGA 210 M N W + M K +PG+R F Y N GY + G Sbjct: 120 FIDGMVGGDN------WLPVSTPEETIAFARDMEKWAVAKPGER---FFYLNTGYVLLGK 170 Query: 211 MIERVARKSWEELINESIFDPMELKSAGLGSQATLGRVDAALGHVL--VGEDIAKPFMAG 268 +IE+V+ S+EE I + I +P+ + + + D A+G++L G + +PF G Sbjct: 171 IIEKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYG 230 >CC3086 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Ccr Caulobacter vibrioides Length = 536 Score = 82.4 bits (202), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 54/181 (29%), Positives = 88/181 (48%), Gaps = 11/181 (6%) Query: 56 PALAAAVVQDGRIIAAGAVGTRKVGSGIAVTVNDRFHIGSDTKAFTATLAGILVDRGAMA 115 P L VV++G+I A G + +G + F I S+TKA TA L +LV+ G + Sbjct: 53 PGLGITVVENGQITLAKGYGVKALGGQDRCDESTVFGIASNTKAMTAALLAMLVEEGRVE 112 Query: 116 WTTTLGDAFPELAPKMDPDFRRITISQLLSHTSGIPADNAEFLELLAKSMFEEGNLDDLR 175 W + P+ A K + +T+ LL H SG+ + + A + + L+ Sbjct: 113 WDAPVTQYLPDFAMKDPIVTKLLTVRDLLVHRSGLSLGAGDLMIWPAPTHTRAEIVAGLK 172 Query: 176 YWTLQQWMSKPLPVQPGQRGQHFAYSNLGYTIAGAMIERVARKSWEELINESIFDPMELK 235 + LP+ GQ +AY N+ Y +AGA+IE V ++WE++I IFDP+ + Sbjct: 173 H----------LPIG-GQFRGGYAYDNVLYVVAGAVIEAVTGQTWEQVIKARIFDPLGMS 221 Query: 236 S 236 + Sbjct: 222 N 222 >XF1621 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Xfa Xylella fastidiosa 9a5c Length = 455 Score = 80.5 bits (197), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 52/188 (27%), Positives = 96/188 (51%), Gaps = 15/188 (7%) Query: 54 KLPALAAAVVQDGRIIAAGAVGTRKVGSGIAVTVNDRFHIGSDTKAFTATLAGILVDRGA 113 K+P LA A+VQ G I++ G V + V + F + S +KAF + +AG+LV+ G Sbjct: 77 KVPGLAMAIVQGGHILSMRGYGVNDVSNPQPVNAHTVFRLASLSKAFASAMAGLLVNDGI 136 Query: 114 MAWTTTLGDAFPELAPKMDPDFRRITISQLLSHTSGIPADNAEFLELLAKSMFEEGNLDD 173 ++W + + D P ++T++ +LSH G+ + NA E+ E N D Sbjct: 137 LSWNSKIVDYVPGFHLSNPTATNKLTVADVLSHRVGL-SRNAYDGEI-------ESNAD- 187 Query: 174 LRYWTLQQWMSK-PLPVQPGQRGQHFAYSNLGYTIAGAMIERVARKSWEELINESIFDPM 232 Y++L + ++ PL PG+ ++Y N+ +++ G ++ + +E+ + IF P+ Sbjct: 188 --YYSLNRKLAYAPLICSPGEC---YSYQNVAFSLIGDVVFAASGDFYEQAVERRIFKPL 242 Query: 233 ELKSAGLG 240 + A LG Sbjct: 243 GMNDASLG 250 >PAE3237 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Pya Pyrobaculum aerophilum Length = 448 Score = 79.7 bits (195), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 104/234 (44%), Gaps = 40/234 (17%) Query: 54 KLPALAAAVVQDGRIIAAGAVGTRKVGSGIAVTVNDRFHIGSDTKAFTATLAGILVDRGA 113 KLP+++ AV++DG + A A+G R + G+ T + IGS TK+FTA LV+ G Sbjct: 16 KLPSVSYAVIKDGEVAYANALGFRDLERGLPATPATIYGIGSITKSFTALCILKLVEEGR 75 Query: 114 MAWTTTLGDAFPELAP-KMDPDFRRITISQLLSHTSGIPADNAEFLELLAKSMFEEGNLD 172 + +L D + P ++ +TI LL+HTSGIPA + E + + G Sbjct: 76 L----SLNDNVEKYIPIRLRSRGENVTIRHLLTHTSGIPALG--YAEAFIEGLVSRGG-- 127 Query: 173 DLRYWTLQQWM--SKPLPVQP----------GQRGQHFAYSNLGYTIAGAMIERVARKSW 220 W+ +KP + P + G+ F Y N GY + G +IE+V + Sbjct: 128 --------TWLPVAKPQDLLPFMESAEEWAVAKPGERFFYLNEGYVLLGLVIEKVTGAPY 179 Query: 221 EELINESIFDPMELKSAGLGSQATLGRVDAALGHVLVGEDIAKPFMAGPGDDNP 274 E + I P+ + L S+ V+ D+AKP+ P P Sbjct: 180 WECVRMKILTPLGMLRTYLASE-----------EVMKDGDVAKPYYPDPEKGTP 222