BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0026.0087.p (898 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1600 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 1219 0.0 PA5015 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase... 1219 0.0 XF0669 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase... 1152 0.0 NMB1341 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 1137 0.0 NMA1554 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenas... 1136 0.0 >RSc1600 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Rso Ralstonia solanacearum Length = 896 Score = 1219 bits (3153), Expect = 0.0, Method: Compositional matrix adjust. Identities = 577/900 (64%), Positives = 720/900 (80%), Gaps = 8/900 (0%) Query: 1 MSAQIDQVL-AQAANDPDVIETQEWLDALEAVIEAEGPERAHYLMERMVDLARRRGAHIP 59 MSA +QVL A A+D D ET+EWL+AL+ VI AEGP+RA +L+++ ++ AR G P Sbjct: 1 MSAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSP 60 Query: 60 FSSNTAYVNTIPADQGEHCPGNLEIEERLRSWMRWNAMAMVVKANRVDGDLGGHLSSFAS 119 + T Y+NTIP + E PG+ EIE R+RS+ RWNAMAMV++AN+ D ++GGH+SSFAS Sbjct: 61 LHAETPYINTIPVENQERIPGDQEIEHRIRSFTRWNAMAMVLRANK-DTNVGGHISSFAS 119 Query: 120 LANMLGIGFNHFWHAPTEDHGGDLLYIQGHSSPGIYARAFLEGRLTEDQLIHFRREADGH 179 A + +G+NHFWHAP++ HGGD++++QGHS+PG+Y+RAFL GRL+EDQL FR+E DG Sbjct: 120 AATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFLLGRLSEDQLDSFRQEVDGK 179 Query: 180 GLSSYPHPKLMPEFWQFPTVSMGLGPLMAIYQARFLKYLHARGIAKT-DNRKVWAFCGDG 238 G+SSYPHP LMP+FWQFPTVSMGLGP+MAIYQARF KYL +R + + +NRKVWAF GDG Sbjct: 180 GISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDG 239 Query: 239 EMDEPESMGAIGMAGREKLNNLVIVVNCNLQRLDGPVRGNGKIIQELESDFRGAGWNVVK 298 E DEPES+GAIGMAGREKL+NLV V+NCNLQRLDGPVRGNGKIIQELES+FRGAGWNV+K Sbjct: 240 ETDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIK 299 Query: 299 VIWGSGWDELLAKDKEGILQKVMMETVDGEYQNYKAKDGAFVRKHFFGKHPKLLEMVSKM 358 VIWGS WD+LLA+D +G+L MME VDGEYQ +K+K GA+VR+ FF P+L MV+ Sbjct: 300 VIWGSRWDQLLARDTKGLLMSRMMECVDGEYQTFKSKSGAYVREFFFNT-PELKAMVADW 358 Query: 359 SDDDIWRLTRGGHDPHKIYAAFKVAQDSKDQPTVILAKSIKGYGFGKSGEARNTAHNTKK 418 SDDDIW L RGGHDPHKI+AAFK A + K QPTVILAK+IKGYG G++GEA N AH KK Sbjct: 359 SDDDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGYGMGEAGEAMNIAHQQKK 418 Query: 419 LDDEAIKAMRDRFQLPISDADLPSIPFFKPSEDTPEMQYLHERRKALGGYLPQRRPQADE 478 + +AI+ +RDRF +P++D L +P+ K E + E++Y+ R LGGYLP RR +AD Sbjct: 419 MPVDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKAD- 477 Query: 479 KLVVPELSAFQVMLEPTAEGREISTTAAYSRVLTALLRDSSLGQRVVPIMVDESRTFGME 538 L VP L+AF +L+ T EGRE+STT A+ R+L LL+D ++G+ VVPI+ DESRTFGME Sbjct: 478 ALQVPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGME 537 Query: 539 GLFRQIGIFSQVGQLYEPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNN 598 GLFRQ+GI++Q GQ Y P D DQ+M+Y+E + GQ+LQEGINEAG M WIAAATSYST+ Sbjct: 538 GLFRQVGIWNQEGQKYVPQDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHG 597 Query: 599 RIMIPFYTYYSMFGLQRIGDLAWAAGDMRARGFLIGGTAGRTTLNGEGLQHEDGHSHVFA 658 MIPFY YYSMFG+QRIGDL WAAGDMR+RGFL+GGTAGRTTLNGEGLQHEDGHSHV+ Sbjct: 598 VAMIPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVYH 657 Query: 659 SAIPNCVPYDPTFAHEVAVIIHDGLRRMVGNQEDVFYYITVMNENYAHPGIKPGQEEGII 718 +AIPNC+ YDPTF +E+AV++ DGLRRM QEDV+YY+TVMNENY HP + G E II Sbjct: 658 AAIPNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADII 717 Query: 719 KGLYLLNEGGKK-NKLRVQLLGSGTILREVIAAADLLRDDWKVDADVWSAPSFTLLARDG 777 KG+YL +G + N RVQLLGSGTI REVIAAA+LL+ DW V++D+W PSFT LAR+G Sbjct: 718 KGMYLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREG 777 Query: 778 QDSERWNMLHPAEAARKSHFEQSMEGTEGPIVVSTDYMRTYAEQVRAFVPKGRTYKVLGT 837 + RWN+LHP +A R+SH E+ ++G GP++ STDY+RT+AEQ+RAFVP R Y VLGT Sbjct: 778 NAAARWNLLHPTDAPRESHVEKMLKGVRGPVIASTDYVRTFAEQIRAFVP--RRYVVLGT 835 Query: 838 DGYGRSDTRAKLREFFEVDRHYVTVAALKSLADEGKIKPSVVAEAIAKYGINPEKPNPVT 897 DG+GRSDTR KLR FFEVDR++VTVA+LK+LADEG + VAEA+ KY ++P KPNP+T Sbjct: 836 DGFGRSDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEALKKYNLDPNKPNPMT 895 >PA5015 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Pae Pseudomonas aeruginosa Length = 882 Score = 1219 bits (3153), Expect = 0.0, Method: Compositional matrix adjust. Identities = 575/883 (65%), Positives = 708/883 (80%), Gaps = 4/883 (0%) Query: 14 NDPDVIETQEWLDALEAVIEAEGPERAHYLMERMVDLARRRGAHIPFSSNTAYVNTIPAD 73 D D +ETQEWLDALE+V++ EG +RAHYLM RM +LA R G +P++ T Y NTIP Sbjct: 2 QDLDPVETQEWLDALESVLDREGEDRAHYLMTRMGELASRSGTQLPYAITTPYRNTIPVT 61 Query: 74 QGEHCPGNLEIEERLRSWMRWNAMAMVVKANRVDGDLGGHLSSFASLANMLGIGFNHFWH 133 PG+L +E R+RS +RWNA+AMV++AN+ D DLGGH+S+FAS A + IGFN+F+ Sbjct: 62 HEARMPGDLFMERRIRSLVRWNALAMVMRANKHDPDLGGHISTFASSATLYDIGFNYFFQ 121 Query: 134 APTEDHGGDLLYIQGHSSPGIYARAFLEGRLTEDQLIHFRREADGHGLSSYPHPKLMPEF 193 APT++HGGDL++ QGH+SPG+YARAFLEGR++E+QL +FR+E DG+GLSSYPHP LMP+F Sbjct: 122 APTDEHGGDLVFFQGHASPGVYARAFLEGRISEEQLENFRQEVDGNGLSSYPHPWLMPDF 181 Query: 194 WQFPTVSMGLGPLMAIYQARFLKYLHARGIAKTDNRKVWAFCGDGEMDEPESMGAIGMAG 253 WQFPTVSMGLGP+ AIYQARF+KYL +RG +KVW F GDGE DEPES+GAI +AG Sbjct: 182 WQFPTVSMGLGPIQAIYQARFMKYLESRGFIPAGKQKVWCFMGDGECDEPESLGAISLAG 241 Query: 254 REKLNNLVIVVNCNLQRLDGPVRGNGKIIQELESDFRGAGWNVVKVIWGSGWDELLAKDK 313 REKL+NL+ V+NCNLQRLDGPVRGN KIIQELE FRGA WNV KVIWG WD L AKD Sbjct: 242 REKLDNLIFVINCNLQRLDGPVRGNAKIIQELEGVFRGAEWNVNKVIWGRFWDPLFAKDT 301 Query: 314 EGILQKVMMETVDGEYQNYKAKDGAFVRKHFFGKHPKLLEMVSKMSDDDIWRLTRGGHDP 373 G+LQ+ M E +DGEYQNYKAKDGA+VR+HFFG P+LLEMV +SD++IW+L RGGHDP Sbjct: 302 AGLLQQRMDEVIDGEYQNYKAKDGAYVREHFFGARPELLEMVKDLSDEEIWKLNRGGHDP 361 Query: 374 HKIYAAFKVAQDSKDQPTVILAKSIKGYGFGKSGEARNTAHNTKKLDDEAIKAMRDRFQL 433 +K+YAA+ A + K QPTVILAK+IKGYG G SGEA+N AHN KK+D ++++A RD+F + Sbjct: 362 YKVYAAYHQAVNHKGQPTVILAKTIKGYGTG-SGEAKNIAHNVKKVDVDSLRAFRDKFDI 420 Query: 434 PISDADLPSIPFFKPSEDTPEMQYLHERRKALGGYLPQRRPQADEKLVVPELSAFQVMLE 493 P+ DADL +PF+KP E + E +YL ERR ALGG++P RR Q + VP L + ML+ Sbjct: 421 PVKDADLEKLPFYKPEEGSAEAKYLAERRAALGGFMPVRR-QKSMSVPVPPLETLKAMLD 479 Query: 494 PTAEGREISTTAAYSRVLTALLRDSSLGQRVVPIMVDESRTFGMEGLFRQIGIFSQVGQL 553 + + REISTT A+ R+++ L++D LG R+VPI+ DE+RTFGMEG+FRQ+GI+S VGQL Sbjct: 480 GSGD-REISTTMAFVRIISQLVKDKELGPRIVPIVPDEARTFGMEGMFRQLGIYSSVGQL 538 Query: 554 YEPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFYTYYSMFGL 613 YEPVDKDQVM+YREDK GQIL+EGINEAG MSSWIAA TSYST+N+ M+PFY +YSMFG Sbjct: 539 YEPVDKDQVMFYREDKKGQILEEGINEAGAMSSWIAAGTSYSTHNQPMLPFYIFYSMFGF 598 Query: 614 QRIGDLAWAAGDMRARGFLIGGTAGRTTLNGEGLQHEDGHSHVFASAIPNCVPYDPTFAH 673 QRIGDLAWAAGD RA GFLIGGTAGRTTLNGEGLQHEDGHSH+ AS IPNC YDPT+A+ Sbjct: 599 QRIGDLAWAAGDSRAHGFLIGGTAGRTTLNGEGLQHEDGHSHLLASTIPNCRTYDPTYAY 658 Query: 674 EVAVIIHDGLRRMVGNQEDVFYYITVMNENYAHPGIKPGQEEGIIKGLYLLNEGGKKNKL 733 E+AVII +G R+M+ Q+D+FYYITVMNENY P + G EEGIIKG+YLL E K+ Sbjct: 659 ELAVIIREGSRQMIEEQQDIFYYITVMNENYVQPAMPKGAEEGIIKGMYLLEEDKKEAAH 718 Query: 734 RVQLLGSGTILREVIAAADLLRDDWKVDADVWSAPSFTLLARDGQDSERWNMLHPAEAAR 793 VQLLGSGTILREV AA LLR+D+ + ADVWS PSF L RDG ERWN LHP + + Sbjct: 719 HVQLLGSGTILREVEEAAKLLRNDFGIGADVWSVPSFNELRRDGLAVERWNRLHPGQKPK 778 Query: 794 KSHFEQSMEGTEGPIVVSTDYMRTYAEQVRAFVPKGRTYKVLGTDGYGRSDTRAKLREFF 853 +S+ E+ + G GP++ STDYM+ YAEQ+R +VP + YKVLGTDG+GRSD+R KLR FF Sbjct: 779 QSYVEECLGGRRGPVIASTDYMKLYAEQIRQWVPS-KEYKVLGTDGFGRSDSRKKLRNFF 837 Query: 854 EVDRHYVTVAALKSLADEGKIKPSVVAEAIAKYGINPEKPNPV 896 EVDRH+V +AAL++LAD G I+P VVAEAIAKYGI+PEK NP+ Sbjct: 838 EVDRHWVVLAALEALADRGDIEPKVVAEAIAKYGIDPEKRNPL 880 >XF0669 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Xfa Xylella fastidiosa 9a5c Length = 985 Score = 1152 bits (2980), Expect = 0.0, Method: Compositional matrix adjust. Identities = 545/888 (61%), Positives = 683/888 (76%), Gaps = 8/888 (0%) Query: 14 NDPDVIETQEWLDALEAVIEAEGPERAHYLMERMVDLARRRGAHIPFSSNTAYVNTIPAD 73 NDP+ +ETQEWL++++AVI+ GPERAH L+E + + R G ++PFS T YVNTIP Sbjct: 99 NDPNPLETQEWLESIKAVIDIAGPERAHQLLEGVAEQIHRTGTNLPFSPITEYVNTIPTA 158 Query: 74 QGEHCPGNLEIEERLRSWMRWNAMAMVVKANRVDGDLGGHLSSFASLANMLGIGFNHFWH 133 PG+ +E +RS +RWNAMA VV+ANR GDLGGH++SFAS A + +GFNHFW Sbjct: 159 DEAKNPGDPALERSIRSIIRWNAMATVVRANRKPGDLGGHIASFASSATLYDVGFNHFWR 218 Query: 134 APTEDHGGDLLYIQGHSSPGIYARAFLEGRLTEDQLIHFRREADGHGLSSYPHPKLMPEF 193 AP+ H GDLLYIQGHSSPGIYARAFLEGR++E QL HFR E DG G+SSYPHP LMP+F Sbjct: 219 APSPQHPGDLLYIQGHSSPGIYARAFLEGRISESQLDHFRMEVDGKGISSYPHPWLMPQF 278 Query: 194 WQFPTVSMGLGPLMAIYQARFLKYLHARGIAKTDNRKVWAFCGDGEMDEPESMGAIGMAG 253 WQ PTVSMGLGPL AIYQA+F+KYL RG+ +RKVW F GDGE DEPE++GAI +AG Sbjct: 279 WQTPTVSMGLGPLSAIYQAQFMKYLEHRGLIAPSDRKVWCFIGDGESDEPETLGAIALAG 338 Query: 254 REKLNNLVIVVNCNLQRLDGPVRGNGKIIQELESDFRGAGWNVVKVIWGSGWDELLAKDK 313 RE L+NL+ VVNCNLQRLDGPVRGNGKIIQELE FRG GWNV+K++WG+ WD LLA+D Sbjct: 339 REGLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGVFRGGGWNVIKLLWGAHWDPLLAQDT 398 Query: 314 EGILQKVMMETVDGEYQNYKAKDGAFVRKHFFGKHPKLLEMVSKMSDDDIWRLTRGGHDP 373 +G+L+K+MMETVDGEYQN KA G + RKHFF K+P+ MV+ +SD+DIWRL RGGHDP Sbjct: 399 QGVLRKLMMETVDGEYQNCKAFGGEYTRKHFFDKYPETAAMVAHLSDNDIWRLNRGGHDP 458 Query: 374 HKIYAAFKVAQDSKDQPTVILAKSIKGYGFGKSGEARNTAHNTKKLDDEAIKAMRDRFQL 433 HKIYAA+ A +++ PTVILAK++KGYG G +GE+ N H TKKLD +AIK RDRF + Sbjct: 459 HKIYAAYHRAVNTQGMPTVILAKTVKGYGMGTAGESLNPTHQTKKLDHDAIKHFRDRFNI 518 Query: 434 PISDADLPS---IPFFKPSEDTPEMQYLHERRKALGGYLPQRRPQADEKLVVPELSAFQV 490 PISD L + IPF+ P D+PE++Y+ RR+ALGG+LPQRR ++ + +VP L ++ Sbjct: 519 PISDQQLDAADHIPFYHPGPDSPEIKYMLARREALGGFLPQRRTKSSKSFIVPGLDKYER 578 Query: 491 MLEPTAEGREISTTAAYSRVLTALLRDSSLGQRVVPIMVDESRTFGMEGLFRQIGIFSQV 550 +L + E R STT A+ + L LRD +LG +VPI+ DE+RTFGMEGLFRQIGI++ Sbjct: 579 LLTSSGE-RTYSTTMAFVQSLNITLRDKALGPHIVPIVADEARTFGMEGLFRQIGIYAPF 637 Query: 551 GQLYEPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFYTYYSM 610 GQ Y+PVD DQ+MYYRED++GQ+LQ+GI E G ++SW+AA TSYS ++ M+PFY YYSM Sbjct: 638 GQKYKPVDADQLMYYREDESGQVLQQGITEPGAIASWMAAGTSYSVSDVPMLPFYIYYSM 697 Query: 611 FGLQRIGDLAWAAGDMRARGFLIGGTAGRTTLNGEGLQHEDGHSHVFASAIPNCVPYDPT 670 FG QRIGD+AW A DMR RGFL+GGTAGRTTLNGEGLQHEDGHSH+ A AIPN YDPT Sbjct: 698 FGFQRIGDIAWQAADMRTRGFLLGGTAGRTTLNGEGLQHEDGHSHLMAGAIPNVRSYDPT 757 Query: 671 FAHEVAVIIHDGLRRMVGNQEDVFYYITVMNENYAHPGIKPGQEEGIIKGLYLLNEGG-- 728 F +EV VI+ G++ M+ +Q D +YY+T+MNENYAHP + G E+GIIKG+YLL + G Sbjct: 758 FGYEVTVILQHGMKAMMQDQIDEYYYLTLMNENYAHPDMPAGAEQGIIKGMYLLKDAGKP 817 Query: 729 KKNKLRVQLLGSGTILREVIAAADLLRDDWKVDADVWSAPSFTLLARDGQDSERWNMLHP 788 KK +LRVQLLGSG ILRE IAAA+LL D+ + AD+WS PSF+ L +DG D+ERWN LHP Sbjct: 818 KKGELRVQLLGSGAILREAIAAAELLHQDFGITADLWSCPSFSELRKDGFDTERWNRLHP 877 Query: 789 AEAARKSHFEQSMEGTEGPIVVSTDYMRTYAEQVRAFVPKGRTYKVLGTDGYGRSDTRAK 848 R + Q +E +GP + +TDY+R +A+Q+RAFVP Y VLGTDG+GRSDTR+ Sbjct: 878 DSEPRTPYVTQQLENRQGPAIAATDYVRLFADQIRAFVPM--HYTVLGTDGFGRSDTRSN 935 Query: 849 LREFFEVDRHYVTVAALKSLADEGKIKPSVVAEAIAKYGINPEKPNPV 896 LR FFEVDR+++ AA+ +LA EGK+ VA AI +Y INPEKPNPV Sbjct: 936 LRRFFEVDRYFIAHAAIAALAKEGKMTGKDVARAIEQYNINPEKPNPV 983 >NMB1341 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component Nme Neisseria meningitidis MC58 Length = 887 Score = 1137 bits (2941), Expect = 0.0, Method: Compositional matrix adjust. Identities = 547/886 (61%), Positives = 683/886 (77%), Gaps = 9/886 (1%) Query: 9 LAQAANDPDVIETQEWLDALEAVIEAEGPERAHYLMERMVDLARRRGAHIPFSSNTAYVN 68 ++ +D D IETQEWLDAL +V+E EG ERA YL+E +V R +G +P + T Y+N Sbjct: 1 MSTQLHDVDPIETQEWLDALSSVLEYEGGERAQYLLENLVKYCRDKGVRMPHGTTTPYLN 60 Query: 69 TIPADQGEHCPGNLEIEERLRSWMRWNAMAMVVKANRVDGDLGGHLSSFASLANMLGIGF 128 T+ + + PG+ IE R+R+++RWNA A+V++A + D +LGGH++SF S A M +GF Sbjct: 61 TVSVENEKGIPGDQNIEHRIRAFVRWNAAAIVLRAGKKDLELGGHIASFQSAATMYEVGF 120 Query: 129 NHFWHAPTEDHGGDLLYIQGHSSPGIYARAFLEGRLTEDQLIHFRREADGHGLSSYPHPK 188 NHFW A E GDL++ QGH +PGIYARAF+EGRLTEDQL +FR+E DGHGL SYPHP Sbjct: 121 NHFWKAKGEGEEGDLVFFQGHVAPGIYARAFVEGRLTEDQLNNFRQEVDGHGLPSYPHPH 180 Query: 189 LMPEFWQFPTVSMGLGPLMAIYQARFLKYLHARGIAKTDNRKVWAFCGDGEMDEPESMGA 248 L+P+FWQFPTVSMGLGP+MAIYQARFLKYL +RG+AKT RKVW FCGDGEMDEPES GA Sbjct: 181 LLPDFWQFPTVSMGLGPIMAIYQARFLKYLESRGLAKTKGRKVWCFCGDGEMDEPESQGA 240 Query: 249 IGMAGREKLNNLVIVVNCNLQRLDGPVRGNGKIIQELESDFRGAGWNVVKVIWGSGWDEL 308 I +A RE L+NL+ V+NCNLQRLDGPVRGNGKIIQELE +F GAGWNVVKVIWG WD L Sbjct: 241 IALAAREGLDNLIFVINCNLQRLDGPVRGNGKIIQELEGNFAGAGWNVVKVIWGRRWDRL 300 Query: 309 LAKDKEGILQKVMMETVDGEYQNYKAKDGAFVRKHFFGKHPKLLEMVSKMSDDDIWRLTR 368 LAKDK+GIL++ M E +DG+YQ YK+KDGA+VR+HFF P+L +V+ M+D+ +W L R Sbjct: 301 LAKDKDGILRQRMEECLDGDYQTYKSKDGAYVREHFFNT-PELKALVADMTDEQLWALNR 359 Query: 369 GGHDPHKIYAAFKVAQDSKD-QPTVILAKSIKGYGFGKSGEARNTAHNTKKLDDEAIKAM 427 GGHDP K+Y A+ A + D +PTVILAK+IKGYG G SGE +N AH KK+D ++K Sbjct: 360 GGHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEGQNVAHQAKKMDKASLKQF 419 Query: 428 RDRFQLPISDADLPS--IPFFKPSEDTPEMQYLHERRKALGGYLPQRRPQADEKLVVPEL 485 RDRF +P++D + S +P+ + DT E +YLH RR ALGGYLPQR+P E L VPEL Sbjct: 420 RDRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKP-TQEVLEVPEL 478 Query: 486 SAFQVMLEPTAEGREISTTAAYSRVLTALLRDSSLGQRVVPIMVDESRTFGMEGLFRQIG 545 SAF L+ + E RE STT A+ R+L+ LL+D +G+RVVPI+ DESRTFGMEG+FRQ G Sbjct: 479 SAFDAQLKSSGE-REFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQYG 537 Query: 546 IFSQVGQLYEPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFY 605 I++ GQ Y P DKDQ+M+Y+E GQILQEGINE G M+ WIAAATSY+ +N MIPFY Sbjct: 538 IWNPKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIAAATSYANSNFAMIPFY 597 Query: 606 TYYSMFGLQRIGDLAWAAGDMRARGFLIGGTAGRTTLNGEGLQHEDGHSHVFASAIPNCV 665 YYSMFG QRIGDLAWAAGDM ARGFL+GGTAGRTTLNGEGLQHEDGHSH+ A IPNCV Sbjct: 598 IYYSMFGFQRIGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQHEDGHSHIQADLIPNCV 657 Query: 666 PYDPTFAHEVAVIIHDGLRRMVGNQEDVFYYITVMNENYAHPGIKPGQEEGIIKGLYLLN 725 YDPTF +EVAVI+ DGLRRM N EDVFYYIT+MNENY HP + G E+ I+KG+YLL Sbjct: 658 SYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEGAEQDILKGMYLLK 717 Query: 726 EGGKKNKLRVQLLGSGTILREVIAAADLLRDDWKVDADVWSAPSFTLLARDGQDSERWNM 785 GGK +K +VQL+GSGTIL+EVIA A+LL+ D+ V+AD+WS PSF LL RD + ER+N Sbjct: 718 AGGKGDK-KVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERFNR 776 Query: 786 LHPAEAARKSHFEQSMEGTEGPIVVSTDYMRTYAEQVRAFVPKGRTYKVLGTDGYGRSDT 845 LHP EA + ++G +GP++ +TDY+R+YA+++RA++P Y VLGTDG+GRSD+ Sbjct: 777 LHPLEAEKVPFVTSQLQGHDGPVIAATDYIRSYADRIRAYIPN--DYHVLGTDGFGRSDS 834 Query: 846 RAKLREFFEVDRHYVTVAALKSLADEGKIKPSVVAEAIAKYGINPE 891 RA LR FFEVDR+ V VAAL +LA++GK+ V +AI KYGI + Sbjct: 835 RANLRRFFEVDRYNVAVAALAALAEQGKVSKETVQQAIEKYGIKAD 880 >NMA1554 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component NmA Neisseria meningitidis Z2491 Length = 887 Score = 1136 bits (2938), Expect = 0.0, Method: Compositional matrix adjust. Identities = 546/886 (61%), Positives = 682/886 (76%), Gaps = 9/886 (1%) Query: 9 LAQAANDPDVIETQEWLDALEAVIEAEGPERAHYLMERMVDLARRRGAHIPFSSNTAYVN 68 ++ +D D IETQEWLDAL +V+E EG ERA YL+E +V R +G +P + T Y+N Sbjct: 1 MSTQLHDVDPIETQEWLDALSSVLEYEGGERAQYLLENLVKYCRDKGVRMPHGTTTPYLN 60 Query: 69 TIPADQGEHCPGNLEIEERLRSWMRWNAMAMVVKANRVDGDLGGHLSSFASLANMLGIGF 128 T+ + + PG+ IE R+R+++RWNA A+V++A + D +LGGH++SF S A M +GF Sbjct: 61 TVSVENEKGIPGDQNIEHRIRAFVRWNAAAIVLRAGKKDLELGGHIASFQSAATMYEVGF 120 Query: 129 NHFWHAPTEDHGGDLLYIQGHSSPGIYARAFLEGRLTEDQLIHFRREADGHGLSSYPHPK 188 NHFW A E GDL++ QGH +PGIYARAF+EGRLTEDQL +FR E DGHGL SYPHP Sbjct: 121 NHFWKAKGEGEEGDLVFFQGHVAPGIYARAFVEGRLTEDQLNNFRLEVDGHGLPSYPHPH 180 Query: 189 LMPEFWQFPTVSMGLGPLMAIYQARFLKYLHARGIAKTDNRKVWAFCGDGEMDEPESMGA 248 L+P+FWQFPTVSMGLGP+MAIYQARFLKYL +RG+AKT RKVW FCGDGEMDEPES GA Sbjct: 181 LLPDFWQFPTVSMGLGPIMAIYQARFLKYLESRGLAKTKGRKVWCFCGDGEMDEPESQGA 240 Query: 249 IGMAGREKLNNLVIVVNCNLQRLDGPVRGNGKIIQELESDFRGAGWNVVKVIWGSGWDEL 308 I +A RE L+NL+ V+NCNLQRLDGPVRGNGKIIQELE +F GAGWNVVKVIWG WD L Sbjct: 241 IALAAREGLDNLIFVINCNLQRLDGPVRGNGKIIQELEGNFAGAGWNVVKVIWGRRWDRL 300 Query: 309 LAKDKEGILQKVMMETVDGEYQNYKAKDGAFVRKHFFGKHPKLLEMVSKMSDDDIWRLTR 368 LAKDK+GIL++ M E +DG+YQ YK+KDGA+VR+HFF P+L +V+ M+D+ +W L R Sbjct: 301 LAKDKDGILRQRMEECLDGDYQTYKSKDGAYVREHFFNT-PELKTLVADMTDEQLWALNR 359 Query: 369 GGHDPHKIYAAFKVAQDSKD-QPTVILAKSIKGYGFGKSGEARNTAHNTKKLDDEAIKAM 427 GGHDP K+Y A+ A + D +PTVILAK+IKGYG G SGE +N AH KK+D ++K Sbjct: 360 GGHDPQKVYNAYDRAANHADGKPTVILAKTIKGYGMGASGEGQNVAHQAKKMDKASLKQF 419 Query: 428 RDRFQLPISDADLPS--IPFFKPSEDTPEMQYLHERRKALGGYLPQRRPQADEKLVVPEL 485 RDRF +P++D + S +P+ + DT E +YLH RR ALGGYLPQR+P E L VPEL Sbjct: 420 RDRFDIPVTDEQIESGDLPYLTFAPDTEEYKYLHARRDALGGYLPQRKP-TQEVLEVPEL 478 Query: 486 SAFQVMLEPTAEGREISTTAAYSRVLTALLRDSSLGQRVVPIMVDESRTFGMEGLFRQIG 545 SAF L+ + E RE STT A+ R+L+ LL+D +G+RVVPI+ DESRTFGMEG+FRQ G Sbjct: 479 SAFDAQLKSSGE-REFSTTMAFVRILSTLLKDKKIGKRVVPIVPDESRTFGMEGMFRQYG 537 Query: 546 IFSQVGQLYEPVDKDQVMYYREDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFY 605 I++ GQ Y P DKDQ+M+Y+E GQILQEGINE G M+ WIAAATSY+ +N MIPFY Sbjct: 538 IWNPKGQQYTPQDKDQLMFYKESVDGQILQEGINEPGAMADWIAAATSYANSNFAMIPFY 597 Query: 606 TYYSMFGLQRIGDLAWAAGDMRARGFLIGGTAGRTTLNGEGLQHEDGHSHVFASAIPNCV 665 YYSMFG QR+GDLAWAAGDM ARGFL+GGTAGRTTLNGEGLQHEDGHSH+ A IPNCV Sbjct: 598 IYYSMFGFQRVGDLAWAAGDMHARGFLLGGTAGRTTLNGEGLQHEDGHSHIQADLIPNCV 657 Query: 666 PYDPTFAHEVAVIIHDGLRRMVGNQEDVFYYITVMNENYAHPGIKPGQEEGIIKGLYLLN 725 YDPTF +EVAVI+ DGLRRM N EDVFYYIT+MNENY HP + G E+ I+KG+YLL Sbjct: 658 SYDPTFQYEVAVIVQDGLRRMYANNEDVFYYITLMNENYTHPDMPEGAEQDILKGMYLLK 717 Query: 726 EGGKKNKLRVQLLGSGTILREVIAAADLLRDDWKVDADVWSAPSFTLLARDGQDSERWNM 785 GGK +K +VQL+GSGTIL+EVIA A+LL+ D+ V+AD+WS PSF LL RD + ER+N Sbjct: 718 AGGKGDK-KVQLMGSGTILQEVIAGAELLKADFGVEADIWSCPSFNLLHRDAVEVERFNR 776 Query: 786 LHPAEAARKSHFEQSMEGTEGPIVVSTDYMRTYAEQVRAFVPKGRTYKVLGTDGYGRSDT 845 LHP EA + ++G +GP++ +TDY+R+YA+++RA++P Y VLGTDG+GRSD+ Sbjct: 777 LHPLEAEKVPFVTSQLQGHDGPVIAATDYIRSYADRIRAYIPN--DYHVLGTDGFGRSDS 834 Query: 846 RAKLREFFEVDRHYVTVAALKSLADEGKIKPSVVAEAIAKYGINPE 891 RA LR FFEVDR+ V VAAL +LA++GK+ V +AI KYGI + Sbjct: 835 RANLRRFFEVDRYNVAVAALAALAEQGKVSKETVQQAIEKYGIKAD 880