BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0213.p (260 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1224 [R] COG2249 Putative NADPH-quinone reductase (modulator o... 409 e-114 mll7814 [R] COG2249 Putative NADPH-quinone reductase (modulator ... 328 1e-89 SMc03185 [R] COG2249 Putative NADPH-quinone reductase (modulator... 316 3e-86 PA4975 [R] COG2249 Putative NADPH-quinone reductase (modulator o... 162 5e-40 MA0326 [R] COG2249 Putative NADPH-quinone reductase (modulator o... 138 1e-32 >PA1224 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Pae Pseudomonas aeruginosa Length = 259 Score = 409 bits (1051), Expect = e-114, Method: Compositional matrix adjust. Identities = 192/257 (74%), Positives = 216/257 (84%) Query: 1 MNVLIVYAHPEPRSLNGSLKNFAVARLEASGHAVQVSDLYAMNWKTPLDVDDSLAPRNGE 60 MNVLIVYAHPEPRSLNG+LK+FAVARLEA+GHAVQVSDLYAM WK LD DSL E Sbjct: 1 MNVLIVYAHPEPRSLNGALKDFAVARLEAAGHAVQVSDLYAMGWKAVLDAGDSLEREASE 60 Query: 61 RFDASLASKHAFENGLQSADIAREQDKLRWADTVILQFPLWWYAMPAIMKGWVERVYAYG 120 RFD S S AFENG QS DIA EQDKLRWADT+ILQFPLWW++MPAI+KGW++RVYA G Sbjct: 61 RFDPSATSLRAFENGWQSVDIAGEQDKLRWADTLILQFPLWWFSMPAILKGWIDRVYACG 120 Query: 121 FAYGVGEHSDTHWGDRFGEGTLSGKRAMVIVTTGGWESHYTARGINGPIDDLLFPIHHGI 180 FAYGVGEHSD+HWGDR+GEG + GKRAM++VT GGWESHY ARGINGP+DDLLFPIHHGI Sbjct: 121 FAYGVGEHSDSHWGDRYGEGRMQGKRAMLVVTAGGWESHYAARGINGPMDDLLFPIHHGI 180 Query: 181 LYYPGFDVLPPFVVYRTGKTDAARYAGICEALGERLDTLESATPIAFRPQNAGDYAIPAL 240 L+YPGF+VLPPFVVYR+G+ DA R+A + E LG RLD L+ A PI FR QN GDY IPAL Sbjct: 181 LHYPGFEVLPPFVVYRSGRIDAERFAALSEQLGRRLDDLQRAAPIPFRRQNGGDYLIPAL 240 Query: 241 TLRDEIAPGVTGFGAHV 257 TLRDE+AP GF H+ Sbjct: 241 TLRDELAPQRAGFAMHL 257 >mll7814 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Mlo Mesorhizobium loti Length = 265 Score = 328 bits (840), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 157/261 (60%), Positives = 191/261 (73%), Gaps = 1/261 (0%) Query: 1 MNVLIVYAHPEPRSLNGSLKNFAVARLEASGHAVQVSDLYAMNWKTPLDVDDSLAPRNGE 60 M VL+V+AHPE RSL+G+L++ A+ LEA GH V+VSDLYA WK+ +D D + Sbjct: 1 MKVLLVFAHPESRSLSGALRDVAIRELEAQGHEVRVSDLYADGWKSEIDRADFPSLEPDA 60 Query: 61 RFDASLASKHAFENGLQSADIAREQDKLRWADTVILQFPLWWYAMPAIMKGWVERVYAYG 120 R ASK FE +AD+ E +KL WADT+ILQFPLWW+AMPAI+KGWV+RV+AYG Sbjct: 61 RLIPVAASKKGFEANTLTADVKAEIEKLLWADTLILQFPLWWFAMPAILKGWVDRVFAYG 120 Query: 121 FAYGVGEHSDTHWGDRFGEGTLSGKRAMVIVTTGGWESHYTARGINGPIDDLLFPIHHGI 180 FAYGVGEHSD WGDR+GEGTL GKRAM+IVT GGWE HYT RGINGPIDDLLFPI+HGI Sbjct: 121 FAYGVGEHSDRRWGDRYGEGTLVGKRAMLIVTAGGWEEHYTPRGINGPIDDLLFPINHGI 180 Query: 181 LYYPGFDVLPPFVVYRTGKTDAARYAGICEALGERLDTLESATPIAFRPQNAGDYAIPAL 240 LYYPG+DVLPPFVVY+ + D + + E L +R+ TL + PI +R QN GDY IP++ Sbjct: 181 LYYPGYDVLPPFVVYKVDRLDETGFEPVAERLRDRMRTLATTAPIPYRRQNGGDYLIPSM 240 Query: 241 TLRDEIA-PGVTGFGAHVRNA 260 LR E+ PG GF H A Sbjct: 241 NLRPELGDPGANGFALHSNQA 261 >SMc03185 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Sme Sinorhizobium meliloti Length = 270 Score = 316 bits (810), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 151/261 (57%), Positives = 191/261 (73%), Gaps = 3/261 (1%) Query: 1 MNVLIVYAHPEPRSLNGSLKNFAVARLEASGHAVQVSDLYAMNWKTPL-DVDDSLAPRNG 59 M +L+V+AHPE RSLNG+L++ A+ L A GH V+VSDLYA WK+ + D L P + Sbjct: 1 MKILLVFAHPESRSLNGALRDVAIEELTAQGHEVRVSDLYADGWKSEVGHADFPLLPPDA 60 Query: 60 ERFDASLASKHAFENGLQSADIAREQDKLRWADTVILQFPLWWYAMPAIMKGWVERVYAY 119 R ASK AFE G + D+ E +KL WAD +ILQFPLWW++MPAI+KGWV+RV+AY Sbjct: 61 -RLVPVAASKTAFEAGALTEDVKAEIEKLLWADVLILQFPLWWFSMPAILKGWVDRVFAY 119 Query: 120 GFAYGVGEHSDTHWGDRFGEGTLSGKRAMVIVTTGGWESHYTARGINGPIDDLLFPIHHG 179 GFAYGVGEHSD WGDR+GEG+L+GKRAM+IVT GGWE HY+ARG+NGPIDDLLFPI+HG Sbjct: 120 GFAYGVGEHSDKRWGDRYGEGSLAGKRAMLIVTAGGWEEHYSARGVNGPIDDLLFPINHG 179 Query: 180 ILYYPGFDVLPPFVVYRTGKTDAARYAGICEALGERLDTLESATPIAFRPQNAGDYAIPA 239 ILYYPG+DVLPPFV YR + D A + + E L ER+ T+ + +PI +R QN GDY IP+ Sbjct: 180 ILYYPGYDVLPPFVAYRADRLDEAGFTEVAEGLRERMRTIGTVSPIPYRQQNGGDYLIPS 239 Query: 240 LTLRDEIA-PGVTGFGAHVRN 259 + LR + P F H+ Sbjct: 240 MQLRPGLGDPAAPSFALHLNE 260 >PA4975 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Pae Pseudomonas aeruginosa Length = 234 Score = 162 bits (411), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 91/228 (39%), Positives = 124/228 (54%), Gaps = 10/228 (4%) Query: 1 MNVLIVYAHPEPRSLNGSLKNFAVARLEASGHAVQVSDLYAMNWKTPLDVDDSLAPRNGE 60 MNVLIV+AH EP+S +L + A L GHAVQVSDLYAMNW D + + Sbjct: 1 MNVLIVHAHNEPQSFTRALCDQACETLAGQGHAVQVSDLYAMNWNPVASAADFAERADPD 60 Query: 61 RFDASLASKHAFENGLQSADIAREQDKLRWADTVILQFPLWWYAMPAIMKGWVERVYAYG 120 +L + + + +ADI E DKL WAD +IL FP++W+++PAI+KGW +RV G Sbjct: 61 YLVYALEQRESVKRQSLAADIQAELDKLLWADLLILNFPIYWFSVPAILKGWFDRVLVSG 120 Query: 121 FAYGVGEHSDTHWGDRF-GEGTLSGKRAMVIVTTGGWESHYTARGINGPIDDLLFPIHHG 179 YG G RF +G L+GK+A+V +T GG + + I+GP++D+L PI G Sbjct: 121 VCYG---------GKRFYDQGGLAGKKALVSLTLGGRQHMFGEGAIHGPLEDMLRPILRG 171 Query: 180 ILYYPGFDVLPPFVVYRTGKTDAARYAGICEALGERLDTLESATPIAF 227 L Y G VL PFV + A RL+ LE P+ F Sbjct: 172 TLAYVGMQVLEPFVAWHVPYISEEARGNFLRAYRARLENLEQDVPLRF 219 >MA0326 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) Mac Methanosarcina acetivorans str.C2A Length = 213 Score = 138 bits (348), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 80/219 (36%), Positives = 119/219 (54%), Gaps = 6/219 (2%) Query: 1 MNVLIVYAHPEPRSLNGSLKNFAVARLEASGHAVQVSDLYAMNWKTPLDVDDSLAPRNGE 60 M VL +YAH EP+S N +LK+ A+A L+ GH V++SDLYAMN+ L D + + Sbjct: 1 MKVLYIYAHQEPKSFNAALKDTALAALKEKGHEVELSDLYAMNFNPVLTEKDFTDRKKPD 60 Query: 61 RFDASLASKHAFENGLQSADIAREQDKLRWADTVILQFPLWWYAMPAIMKGWVERVYAYG 120 F L + A + G + DI E +K++WAD +I QFP+++ +MPAI+KGW++RV A G Sbjct: 61 VFKPFLEAIQASKTGAFAPDILAEMEKVKWADFLIFQFPIYFTSMPAILKGWIDRVLAPG 120 Query: 121 FAYGVGEHSDTHWGDRFGEGTLSGKRAMVIVTTGGWESHYTARGINGPIDDLLFPIHHGI 180 F + +S + G L GK M+ TTG E Y+ G +G ++ L + H + Sbjct: 121 FGFNPLTNS------AYETGLLKGKTTMITTTTGASEEWYSEGGEHGDLNRHLESVTHCV 174 Query: 181 LYYPGFDVLPPFVVYRTGKTDAARYAGICEALGERLDTL 219 Y G VLP ++Y R A E +R+ L Sbjct: 175 FEYMGMKVLPSHIIYEVSSLTKERGAEELEKYRKRISEL 213