BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0118.p (343 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMA0718 [H] COG0181 Porphobilinogen deaminase NmA Neisseria meni... 379 e-105 RSc2357 [H] COG0181 Porphobilinogen deaminase Rso Ralstonia sola... 379 e-105 NMB0539 [H] COG0181 Porphobilinogen deaminase Nme Neisseria meni... 377 e-104 PA5260 [H] COG0181 Porphobilinogen deaminase Pae Pseudomonas aer... 333 3e-91 VC0120 [H] COG0181 Porphobilinogen deaminase Vch Vibrio cholerae 327 3e-89 >NMA0718 [H] COG0181 Porphobilinogen deaminase NmA Neisseria meningitidis Z2491 Length = 311 Score = 379 bits (973), Expect = e-105, Method: Compositional matrix adjust. Identities = 191/303 (63%), Positives = 227/303 (74%) Query: 32 PSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVGGKGLF 91 P LVIASRES LAMWQA+H++ RL ALYP C + ILGMTTRGDQILD+TLSKVGGKGLF Sbjct: 3 PKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLF 62 Query: 92 VKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLDELPAG 151 VKELE A+ +GRAD AVHS+KDVPM+LP GF L AI ER +P DAFVSN YA L+E+P G Sbjct: 63 VKELEQALYDGRADLAVHSIKDVPMDLPEGFALAAIGERANPFDAFVSNQYARLEEMPEG 122 Query: 152 AVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRLGLESR 211 AVVGTSSLRR+A + ARYPHL+IKPLRGN+ TRL KLD G+Y AIILA AGL+RL L+ R Sbjct: 123 AVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLDNGEYDAIILAAAGLQRLKLDGR 182 Query: 212 IRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRTFGGSC 271 IR ++ SLPA GQGA+ IEI A R DL VL P+NH T+ VTAER L+R GGSC Sbjct: 183 IRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALARALGGSC 242 Query: 272 QIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQTQGAEAI 331 Q+PLAA+ T + +R LV PDG V A+A+ PA+ ALG+ +A L GA + Sbjct: 243 QVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGAREL 302 Query: 332 LAA 334 + A Sbjct: 303 IGA 305 >RSc2357 [H] COG0181 Porphobilinogen deaminase Rso Ralstonia solanacearum Length = 334 Score = 379 bits (972), Expect = e-105, Method: Compositional matrix adjust. Identities = 214/313 (68%), Positives = 242/313 (77%), Gaps = 6/313 (1%) Query: 32 PSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVGGKGLF 91 P+ LVIASRESRLAMWQAE+VR L YP C ++ILGMTTRGDQILDR+L+KVGGKGLF Sbjct: 19 PTKLVIASRESRLAMWQAEYVRAALQKYYPACDVSILGMTTRGDQILDRSLAKVGGKGLF 78 Query: 92 VKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLDELPAG 151 VKELEVA+AEGRAD AVHSLKDVPMELP GFVL AILEREDPRDAFVSNDYA L LPAG Sbjct: 79 VKELEVALAEGRADLAVHSLKDVPMELPPGFVLSAILEREDPRDAFVSNDYADLAALPAG 138 Query: 152 AVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRLGLESR 211 AVVGTSSLRR+A + AR+PHLVI+PLRGNLDTRL KLDRGDYAAIILA AGLKRLGL R Sbjct: 139 AVVGTSSLRREASLRARFPHLVIQPLRGNLDTRLSKLDRGDYAAIILAAAGLKRLGLSER 198 Query: 212 IRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRTFGGSC 271 IR+ IAPE SLPA GQGA+ IE +R D+Q LAP++H T AVTAER +SR GGSC Sbjct: 199 IRAVIAPETSLPAAGQGALGIESRVDRHDVQAWLAPLHHAPTALAVTAERAVSRQLGGSC 258 Query: 272 QIPLAAFA--TIAGDRMHMRALVATPDGKQ---VAAAEAEGPADAPAALGKQIADLLQTQ 326 Q+PLAAFA T AG + +RA VA+PDG++ A ALG ++A + Sbjct: 259 QVPLAAFAQWTDAGA-LRLRAFVASPDGRRKLAAEAEATPATPAEAEALGARVAQQMLDG 317 Query: 327 GAEAILAACRAEA 339 GA ILA A+A Sbjct: 318 GAHDILATLGADA 330 >NMB0539 [H] COG0181 Porphobilinogen deaminase Nme Neisseria meningitidis MC58 Length = 311 Score = 377 bits (969), Expect = e-104, Method: Compositional matrix adjust. Identities = 190/303 (62%), Positives = 226/303 (74%) Query: 32 PSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVGGKGLF 91 P LVIASRES LAMWQA+H++ RL ALYP C + ILGMTTRGDQILD+TLSKVGGKGLF Sbjct: 3 PKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLF 62 Query: 92 VKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLDELPAG 151 VKELE A+ +GRAD AVHS+KDVPM+LP GF L AI ER +P DAFVSN Y L+E+P G Sbjct: 63 VKELEQALYDGRADLAVHSIKDVPMDLPEGFALAAIGERANPFDAFVSNQYTRLEEMPEG 122 Query: 152 AVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRLGLESR 211 AVVGTSSLRR+A + ARYPHL+IKPLRGN+ TRL KLD G+Y AIILA AGL+RL L+ R Sbjct: 123 AVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLDNGEYDAIILAAAGLQRLKLDGR 182 Query: 212 IRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRTFGGSC 271 IR ++ SLPA GQGA+ IEI A R DL VL P+NH T+ VTAER L+R GGSC Sbjct: 183 IRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALARALGGSC 242 Query: 272 QIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQTQGAEAI 331 Q+PLAA+ T + +R LV PDG V A+A+ PA+ ALG+ +A L GA + Sbjct: 243 QVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGAREL 302 Query: 332 LAA 334 + A Sbjct: 303 IGA 305 >PA5260 [H] COG0181 Porphobilinogen deaminase Pae Pseudomonas aeruginosa Length = 313 Score = 333 bits (854), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 174/303 (57%), Positives = 219/303 (72%) Query: 37 IASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKVGGKGLFVKELE 96 IA+R+S LA+WQAE+V+ RL +P ++T+L MT+RGD++LD L+K+GGKGLFVKELE Sbjct: 8 IATRQSALALWQAEYVKARLEQAHPGLTVTLLPMTSRGDKLLDAPLAKIGGKGLFVKELE 67 Query: 97 VAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGLDELPAGAVVGT 156 A+ EG AD AVHS+KDVPM+ P G L I EREDPRDAFVSN YA L++LPAG+VVGT Sbjct: 68 TALLEGAADIAVHSMKDVPMDFPEGLGLYTICEREDPRDAFVSNTYASLEQLPAGSVVGT 127 Query: 157 SSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKRLGLESRIRSAI 216 SSLRRQA + AR P L I+ LRGN++TRL KLD G+Y AIILA AGL RLG ESRIRS+I Sbjct: 128 SSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFESRIRSSI 187 Query: 217 APEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSRTFGGSCQIPLA 276 + + SLPA GQGA+ IE +DL +L P++H T VTAER L++ G CQ+P+A Sbjct: 188 SVDDSLPAGGQGAVGIECRTADSDLHALLEPLHHTDTALRVTAERALNKRLNGGCQVPIA 247 Query: 277 AFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQTQGAEAILAACR 336 +A GD++ +R LV PDG Q+ AE P ALG ++A+ L QGAEAIL A Sbjct: 248 CYAIREGDQLWLRGLVGQPDGTQLLRAEGRAPLAEAEALGVRVAEDLLEQGAEAILEAVY 307 Query: 337 AEA 339 EA Sbjct: 308 GEA 310 >VC0120 [H] COG0181 Porphobilinogen deaminase Vch Vibrio cholerae Length = 317 Score = 327 bits (837), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 170/307 (55%), Positives = 214/307 (69%), Gaps = 3/307 (0%) Query: 26 VLKEFPPSSLVIASRESRLAMWQAEHVRDRLAALYPQCSITILGMTTRGDQILDRTLSKV 85 ++ E P + IA+R+S LA+WQA +V+D L A +P + ++ M TRGD ILD L+KV Sbjct: 6 IMTETP---IRIATRQSPLALWQANYVKDALMAAHPGLQVELVTMVTRGDVILDTPLAKV 62 Query: 86 GGKGLFVKELEVAMAEGRADFAVHSLKDVPMELPGGFVLGAILEREDPRDAFVSNDYAGL 145 GGKGLFVKELE+AM EGRAD AVHS+KDVP++ P G L I EREDPRDAFVSN YA + Sbjct: 63 GGKGLFVKELEIAMLEGRADLAVHSMKDVPVDFPDGLGLVTICEREDPRDAFVSNTYAKI 122 Query: 146 DELPAGAVVGTSSLRRQALIAARYPHLVIKPLRGNLDTRLGKLDRGDYAAIILAVAGLKR 205 ++LP+GA+VGT SLRRQ + A P LVIK LRGN+ TRL KLD G+Y AIILA AGLKR Sbjct: 123 EDLPSGAIVGTCSLRRQCQLKAARPDLVIKELRGNVGTRLSKLDAGEYDAIILAAAGLKR 182 Query: 206 LGLESRIRSAIAPEQSLPAPGQGAMAIEILAERTDLQRVLAPINHLATDRAVTAERTLSR 265 L LESRIRS I PEQSLPA GQGA+ IE ++ +LAP+NH T V ER ++ Sbjct: 183 LELESRIRSFIEPEQSLPAVGQGAVGIECRVNDQRVRALLAPLNHADTADRVRCERAMNL 242 Query: 266 TFGGSCQIPLAAFATIAGDRMHMRALVATPDGKQVAAAEAEGPADAPAALGKQIADLLQT 325 T G CQ+P+ ++A + GD + +RALV PDG Q+ E GP LG +A+ L + Sbjct: 243 TLQGGCQVPIGSYALLEGDTIWLRALVGEPDGSQIVRGEIRGPRTQAEQLGITLAEQLLS 302 Query: 326 QGAEAIL 332 QGA+ IL Sbjct: 303 QGAKEIL 309