BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0115.p (313 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2507 [GER] COG0697 Permeases of the drug/metabolite transport... 153 5e-37 VCA0090 [GER] COG0697 Permeases of the drug/metabolite transport... 140 3e-33 AGc3767 [GER] COG0697 Permeases of the drug/metabolite transport... 118 1e-26 BH0396 [GER] COG0697 Permeases of the drug/metabolite transporte... 110 3e-24 mlr1585 [GER] COG0697 Permeases of the drug/metabolite transport... 103 5e-22 >RSc2507 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 310 Score = 153 bits (386), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 119/321 (37%), Positives = 170/321 (52%), Gaps = 27/321 (8%) Query: 1 MKPADLLRLLALSAIWGASFLFMRLAVPEMGALNTAFFRVLFGAAGLLLLLAI------L 54 M+ +D + LL L+A+WG SFLFMR+A P G + RV +A LL +LA+ L Sbjct: 1 MRRSDAIELLILAALWGGSFLFMRVAAPPFGPVALIALRVAIASAFLLPVLAMRGGLGAL 60 Query: 55 RVKWRFQGKLHATMLLGAINSGLPFVLFSLAAKVLPAGYSAILNGTAPLMGVVIGALFFG 114 R W + +G +NS +PF L + A L AG++++LN APL ++ + G Sbjct: 61 RPHWPH------LLAVGVLNSAVPFCLLAYAELTLTAGFTSVLNAAAPLFAAIVAFAWLG 114 Query: 115 DTLTSRKVGGVILGLAGVAVLTRTGPVDFDTATVLGALACLLATSCYGLASFLTKRWITD 174 + +++ +V G+ +G GV VL L A L AT YGLA KR++T Sbjct: 115 ERMSAWRVLGLAIGFVGVIVLVGGSSALDARQGGLAVAAALGATVLYGLAGSYAKRYLT- 173 Query: 175 RGGLDSKLVACGSQLGAVALLLPFFAVMAVLEDGPAAPLHAGIGT-WFALLALGFVCSAL 233 G+ VA GSQ+ A +L P + P H G+ W ++ LG C+ + Sbjct: 174 --GVPPLAVATGSQIAAAVVLAPLAVWLW--------PAHTPTGSVWLHVIGLGIACTGI 223 Query: 234 AYILFFRLIADIGPVKSLTVTFLIPLFGVLWGWLFLQEQLSWAYAAGGALIGMALLL--- 290 AYILFFRLIA +GP ++++VTFL+P+FGVLWG LFL EQL+ AG A+I + L Sbjct: 224 AYILFFRLIAHVGPTRAVSVTFLVPVFGVLWGILFLGEQLTLNMVAGCAVILLGTSLSTG 283 Query: 291 VLMPARAGAGGNKQKIDGKPS 311 VL + A G D K S Sbjct: 284 VLASGKRAAAGTGSGADDKAS 304 >VCA0090 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Vch Vibrio cholerae Length = 297 Score = 140 bits (354), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 97/261 (37%), Positives = 142/261 (54%), Gaps = 11/261 (4%) Query: 13 SAIWGASFLFMRLAVPEMGALNTAFFRVLFGAAGLLLLLAILRVKWRFQGKLHATMLLGA 72 +AIWG SFLFMR+A G RV F A L L+ +LR + ++LG Sbjct: 13 AAIWGGSFLFMRIAAHSFGPAYLIEARVGFAALSLFLVAQLLRRSLPIRQHWPHFLILGL 72 Query: 73 INSGLPFVLFSLAAKVLPAGYSAILNGTAPLMGVVIGALFFGDTLTSRKVGGVILGLAGV 132 IN+ +PF+LF+ AA L +ILN TAP+ G VIG L+ G L+ + V G++LG++GV Sbjct: 73 INTAVPFLLFAYAALTLNVSTLSILNSTAPIWGAVIGFLWHGTPLSRKAVAGLLLGVSGV 132 Query: 133 AVLTRTGPVDFDTATVLGALACLLATSCYGLASFLTKRWITDRGGLDSKLVACGSQLGAV 192 AV+ V L + LA + YGLA+ TK+ L + A GS A Sbjct: 133 AVIVGWDMVAIGHHAALPMVCAALAAASYGLATNYTKQ----APQLSAFENAHGSMWAAC 188 Query: 193 ALLLPFFAVMAVLEDGPAAPLHAGIGTWFALLALGFVCSALAYILFFRLIADIGPVKSLT 252 + P + L + P++ W A++ LG +C+ LAY+++FRL+ IG +L+ Sbjct: 189 LWVAPLMWFVP-LRETPSSL------EWGAVILLGVICTGLAYLIYFRLVKAIGAASTLS 241 Query: 253 VTFLIPLFGVLWGWLFLQEQL 273 VTFLIP+FG+LWG+ L E + Sbjct: 242 VTFLIPVFGILWGYWILDEPI 262 >AGc3767 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 329 Score = 118 bits (296), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 97/291 (33%), Positives = 147/291 (50%), Gaps = 11/291 (3%) Query: 1 MKPADLLRLLALSAIWGASFLFMRLAVPEMGALNTAFFRVLFGAAGLLLLLAILRVKW-R 59 M + L+ALS +WG SF F+ +AV E+ + RV A LL++ I+ ++ R Sbjct: 27 MDAREWAMLIALSLLWGGSFFFIGVAVKELPPVTIVTLRVSLAAVALLVVCRIMGLRLPR 86 Query: 60 FQGKLHATMLLGAINSGLPFVLFSLAAKVLPAGYSAILNGTAPLMGVVIGALFFGDT-LT 118 A +G +N+ +PF L + +G ++ILN T PL V++ D +T Sbjct: 87 EWAVWRAFFGMGLLNNIIPFCLIVWGQTQIASGLASILNATTPLFTVIVAHFLTADEKMT 146 Query: 119 SRKVGGVILGLAGVAVLTRTGPVDFDTATVL-GALACLLATSCYGLASFLTKRWITDRGG 177 K+ GV++G GVA T GP F ++ L G +A L A Y A +R+ G Sbjct: 147 GNKLAGVLIGFVGVA--TMIGPAAFGGSSGLWGQIAILGAAISYSFAGIFGRRF--KAMG 202 Query: 178 LDSKLVACGSQLGAVALLLPFFAVMAVLEDGPAAPLHAGIGTWFALLALGFVCSALAYIL 237 + + A G + +L+P A+L D P G+GTW AL+ + + +ALAY++ Sbjct: 203 VPPLMTATGQISSSTLMLIP----AALLIDKPWTLAMPGLGTWGALIGIALLSTALAYLI 258 Query: 238 FFRLIADIGPVKSLTVTFLIPLFGVLWGWLFLQEQLSWAYAAGGALIGMAL 288 FFR++A G VTFLIP+ +L G L L EQL + AG A+I L Sbjct: 259 FFRILASAGATNLALVTFLIPVSAILLGSLILGEQLEIKHFAGMAMIAAGL 309 >BH0396 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 305 Score = 110 bits (276), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 93/304 (30%), Positives = 151/304 (49%), Gaps = 10/304 (3%) Query: 9 LLALSAIWGASFLFMRLAVPEMGALNTAFFRVLFGAAGLLLLLAILRVKWRFQGKLHATM 68 LL+LS IWG SF+F+ + +G T R GA LL +L + R + A M Sbjct: 7 LLSLSLIWGFSFVFIEHLLGIVGVWGTVVVRCFAGAIILLPILLMRRKLFYRPAPWKALM 66 Query: 69 LLGAINSGLPFVLFSLAAKVLPAGYSAILNGTAPLMGVVIGALFFGDTLTSRKVGGVILG 128 ++G N+GLP+ L +L+ + + +A+LN PL +IG L + + L+ ++ GG++LG Sbjct: 67 IVGIFNAGLPWGLIALSQTEIYSSTAAVLNALTPLFTGLIGFLLYSNALSRQQWGGIVLG 126 Query: 129 LAGVAVLTRTGPVDFDTATVLGALACLLATSCYGLASFLTKRWITDRGGLDSKLVACGSQ 188 +GV VLT +G +LAT CYG AS KR + D D L+ S Sbjct: 127 FSGVVVLTGFQLQLLAPEHFVGVGTMILATICYGFASQYVKRHLHDT---DVVLITTFSL 183 Query: 189 L--GAVALL-LPFFAVMAVLEDGPAAPLHAGIGTWFALLALGFVCSALAYILFFRLIADI 245 L G V L+ + + V+ PL + +++ LG + S +A++L++ L+ Sbjct: 184 LFGGLVGLIGMWITDSLHVVR----VPLTIDWLSLISIIGLGCLGSGMAHLLYYDLMKKG 239 Query: 246 GPVKSLTVTFLIPLFGVLWGWLFLQEQLSWAYAAGGALIGMALLLVLMPARAGAGGNKQK 305 GP + TVT+LIP+ ++WG LFL E ++ G +I M + + N+ Sbjct: 240 GPEFATTVTYLIPMTAIIWGKLFLDELITKNIVIGMLMILMGVYFTSRKRNVCSKANEDS 299 Query: 306 IDGK 309 G+ Sbjct: 300 NKGE 303 >mlr1585 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 305 Score = 103 bits (257), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 98/294 (33%), Positives = 148/294 (50%), Gaps = 12/294 (4%) Query: 1 MKPADLLRLLALSAIWGASFLFMRLAVPEMGALNTAFFRVLFGAAGLLLLLAILRVKWRF 60 M D +LL L AIWG SF F R+AV E+ L FRV A L + L + +R Sbjct: 13 MTLTDWGQLLLLGAIWGGSFFFARIAVAELHPLVLVLFRVAIAAIALQIYLGLRGPSFRL 72 Query: 61 QGKLHATM--LLGAINSGLPFVLFSLAAKVLPAGYSAILNGTAPLMGVVI-GALFFGDTL 117 HA + LL N+ +PF L L AG +++LN T P +++ AL + L Sbjct: 73 AFP-HAGLFFLLAFTNNVVPFSLIFAGQTELGAGVASVLNATTPFWTLILANALTSDEKL 131 Query: 118 TSRKVGGVILGLAGVAVLTRTGPVDFDTATVLGALACLLATSCYGLASFLTKRWITDRGG 177 + K+ G+ LG+AG AV+ G + V A + A+ YG+A + +R+ G Sbjct: 132 SWNKLAGIGLGVAGTAVMIGPGLLAGLGGPVWAKFALIGASLSYGVALMVARRF----KG 187 Query: 178 LDSKLVACGSQLGAVALLLPFFAVMAVLEDGPAAPLHAGIGTWFALLALGFVCSALAYIL 237 + S ++A G + +++P + +L GPA A W A+LAL + +A AYIL Sbjct: 188 VPSPVIATGQLTASTIIMIP----IVLLTHGPADLFSASPSVWAAVLALALLSTAFAYIL 243 Query: 238 FFRLIADIGPVKSLTVTFLIPLFGVLWGWLFLQEQLSWAYAAGGALIGMALLLV 291 +F L+A G + VT ++P +L G+LFL E+L G LIG+ LL + Sbjct: 244 YFNLVASAGATNASLVTLIVPASAMLLGFLFLGERLELFEIGGVVLIGLGLLTI 297