BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0025.0093.p (486 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2119 [FR] COG0402 Cytosine deaminase and related metal-depend... 293 7e-79 PA0142 [FR] COG0402 Cytosine deaminase and related metal-depende... 161 3e-39 MTH1505 [FR] COG0402 Cytosine deaminase and related metal-depend... 105 2e-22 SP1356 [FR] COG0402 Cytosine deaminase and related metal-depende... 103 1e-21 MK0366 [FR] COG0402 Cytosine deaminase and related metal-depende... 102 1e-21 >RSc2119 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Rso Ralstonia solanacearum Length = 474 Score = 293 bits (750), Expect = 7e-79, Method: Compositional matrix adjust. Identities = 137/168 (81%), Positives = 150/168 (89%) Query: 1 MSVGQSKGGLPPDRVVEDENDILRDTQRLIETYHDHSRHAMQRIVVAPCSPFSVSRDLMR 60 MSVG+S+GGLPPDRVVE E ILR+TQRLIET+HD RHAM RIVVAPCSPFSVSRDLMR Sbjct: 173 MSVGRSQGGLPPDRVVEGEPAILRETQRLIETWHDADRHAMLRIVVAPCSPFSVSRDLMR 232 Query: 61 EAANMARSYKVSLHTHLAENVNDIAYSREKFNMTPAEYAEDCGWVGHDVWHAHCVQLDDH 120 E+A +ARSY VS+HTHLAEN +DIAYSRE+F MTPAEYAED GWVGHDVWHAHCV+LD H Sbjct: 233 ESARLARSYGVSMHTHLAENDSDIAYSRERFGMTPAEYAEDLGWVGHDVWHAHCVKLDAH 292 Query: 121 GIDLFARTGTGVAHCPCSNMRLASGIAPIRKMIAAGVPVGLGVDXIAA 168 GI+LFARTGTGVAHCPCSNMRLASGIAP+R M AG PVGLGVD A+ Sbjct: 293 GIELFARTGTGVAHCPCSNMRLASGIAPVRAMRDAGAPVGLGVDGSAS 340 Score = 219 bits (557), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 102/161 (63%), Positives = 127/161 (78%), Gaps = 8/161 (4%) Query: 191 LLIKNATVVVTMNDTREEIKNGALFIRNNIIEQVGQTADLP--------QTADEIIDASN 242 L+ ++A V+VTM+ R EI +GAL R +IE VG TADLP + +++ + Sbjct: 12 LIARHADVLVTMDAQRREIADGALVARCGVIEWVGATADLPVPYRDAIGRPNVRVLELRD 71 Query: 243 HVVLPGLINTHHHMYQSLTRVIPAAQDGELFNWLTNLYPIWAGLTPEMIKVSTLTAMAEL 302 HVV PGL+NTHHHM QSLTR +PAAQD ELF WLT+LYP+WAGLTPEM++VSTLTAMAEL Sbjct: 72 HVVTPGLVNTHHHMAQSLTRALPAAQDAELFGWLTHLYPVWAGLTPEMVRVSTLTAMAEL 131 Query: 303 ILSGCTTSSDHLYIYPNKTRLDDSLEAAQEIGMRFHGARGA 343 +LSGCTTSSDHLY+YPN RLDD++EAA++IGMRFH ARG+ Sbjct: 132 MLSGCTTSSDHLYLYPNGCRLDDAIEAARQIGMRFHAARGS 172 Score = 194 bits (493), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 99/140 (70%), Positives = 110/140 (78%) Query: 347 AKVGLGVDGSASNDGAHMLGEVRQAMLLQRVGFGPDAMTARQALEIATLGGAKVLNRDDI 406 A VGLGVDGSASNDGAHMLGE RQAMLL RVGFGP AM AR+ALEIATLGGA VLNRDDI Sbjct: 329 APVGLGVDGSASNDGAHMLGEARQAMLLARVGFGPAAMGAREALEIATLGGACVLNRDDI 388 Query: 407 GALKPGMSADVAMFKLDQIGFAGALHDPVAALVFCTPANVSYSIINGRVIVREGQCTTID 466 GAL PGMSAD F Q+GFAGA HDPVAALVFC P+ VS+S+INGRV+V + T++ Sbjct: 389 GALAPGMSADFVSFDRRQVGFAGADHDPVAALVFCAPSGVSHSVINGRVVVDNRRLVTLE 448 Query: 467 LGSVIERHNALAFELADAAN 486 LG+ + H LA ELA A Sbjct: 449 LGAHLSVHRKLALELAQTAR 468 >PA0142 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Pae Pseudomonas aeruginosa Length = 449 Score = 161 bits (408), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 74/168 (44%), Positives = 106/168 (63%) Query: 1 MSVGQSKGGLPPDRVVEDENDILRDTQRLIETYHDHSRHAMQRIVVAPCSPFSVSRDLMR 60 MS+G+ GGLPP + V++ IL D++RLI YH A +I +APCSPFSV+ ++MR Sbjct: 157 MSLGEKDGGLPPQQTVQEAETILADSERLIARYHQRGDGARVQIALAPCSPFSVTPEIMR 216 Query: 61 EAANMARSYKVSLHTHLAENVNDIAYSREKFNMTPAEYAEDCGWVGHDVWHAHCVQLDDH 120 +A +A + V LHTHLAE +++ + ++F + +Y + GW+G W AH + + Sbjct: 217 ASAEVAARHDVRLHTHLAETLDEEDFCLQRFGLRTVDYLDSVGWLGPRTWLAHGIHFNAE 276 Query: 121 GIDLFARTGTGVAHCPCSNMRLASGIAPIRKMIAAGVPVGLGVDXIAA 168 I GTG+ HCP SNMRLASGI P ++ AAG P+GLGVD A+ Sbjct: 277 EIRRLGEAGTGICHCPSSNMRLASGICPTVELEAAGAPIGLGVDGSAS 324 Score = 127 bits (318), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 66/159 (41%), Positives = 93/159 (58%), Gaps = 5/159 (3%) Query: 187 MTKTLLIKNATVVVTMNDTREEIKNGALFIRNNIIEQVGQTADLPQTADEIIDASNHVVL 246 M++T I+N + T N + G + I+E +G Q DAS HVVL Sbjct: 1 MSRTW-IRNPLAIFTANGL--DAAGGLVVEDGRIVELLGAGQQPAQPCASQFDASRHVVL 57 Query: 247 PGLINTHHHMYQSLTRVIPAAQDGELFNWLTNLYPIWAGLTPEMIKVSTLTAMAELILSG 306 PGL+NTHHH YQ+LTR + LF WL LYP+WA LTPE ++++T A+AEL+LSG Sbjct: 58 PGLVNTHHHFYQTLTRAWAPVVNQPLFPWLKTLYPVWARLTPEKLELATKVALAELLLSG 117 Query: 307 CTTSSDHLYIYPN--KTRLDDSLEAAQEIGMRFHGARGA 343 CTT++DH Y++P + +D +E+GMR RG+ Sbjct: 118 CTTAADHHYLFPGGLEQAIDVQAGVVEELGMRAMLTRGS 156 Score = 119 bits (299), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 63/138 (45%), Positives = 89/138 (64%), Gaps = 1/138 (0%) Query: 344 AXKAKVGLGVDGSASNDGAHMLGEVRQAMLLQRVGFGPDAMTARQALEIATLGGAKVLNR 403 A A +GLGVDGSASND ++M+ E RQA+ LQR+ +G + +T AL AT G A++L R Sbjct: 310 AAGAPIGLGVDGSASNDASNMILEARQALYLQRLRYGAERITPELALGWATRGSARLLGR 369 Query: 404 DDIGALKPGMSADVAMFKLDQIGFAGALHDPVAALVFCTPANVSYSIINGRVIVREGQCT 463 DIG L PG AD+A+FKLD++ F+G+ HDP++AL+ C ++ G V +G Sbjct: 370 SDIGELAPGKQADLALFKLDELRFSGS-HDPLSALLLCAADRADRVMVGGAWRVVDGAVE 428 Query: 464 TIDLGSVIERHNALAFEL 481 +DL ++I RH A A L Sbjct: 429 GLDLAALIARHRAAASAL 446 >MTH1505 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Mth Methanothermobacter thermautotrophicus Length = 427 Score = 105 bits (263), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 52/146 (35%), Positives = 87/146 (59%), Gaps = 1/146 (0%) Query: 23 LRDTQRLIETYHDHSRHAMQRIVVAPCSPFSVSRDLMREAANMARSYKVSLHTHLAENVN 82 LR+++R+I+ H + + R+ + P SP++ S +L++E A +A + +H H++E N Sbjct: 158 LRESRRIIKECHGMADDRI-RVALGPHSPYTCSEELLKETAALADKNDLMIHIHVSETEN 216 Query: 83 DIAYSREKFNMTPAEYAEDCGWVGHDVWHAHCVQLDDHGIDLFARTGTGVAHCPCSNMRL 142 +++ MTP EY ++ G +G AHCV L D ID+ A V+H P SNM+L Sbjct: 217 EVSEVSRSHGMTPVEYLDEVGVLGPRTVAAHCVWLKDWEIDVLAERDVKVSHNPSSNMKL 276 Query: 143 ASGIAPIRKMIAAGVPVGLGVDXIAA 168 ASG++P+ +++ GV V LG D A+ Sbjct: 277 ASGVSPVARLLQRGVNVSLGTDGAAS 302 Score = 65.5 bits (158), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 45/129 (34%), Positives = 67/129 (51%), Gaps = 10/129 (7%) Query: 209 IKNGALFIRNNIIEQVGQTADLPQTADEIIDASNHVVLPGLINTHHHMYQSLTRVIPAAQ 268 I+ G++ I +N I V T P AD +ID + +++PGL+NTH H+ +L R I A Sbjct: 19 IRRGSVLIEDNRIADVSNTLS-PGDADTVIDGTGKLLIPGLVNTHTHLSMTLFRGI--AD 75 Query: 269 DGELFNWLTN-LYPIWAGLTPEMIKVSTLTAMAELILSGCTTSSDHLYIYPNKTRLDDSL 327 D L WL + ++P A L + L E+I SG TTS + +Y Y +D Sbjct: 76 DLPLDRWLNDHIWPAEARLNGDYCYAGALLGCIEMIRSG-TTSFNDMYFY-----MDHVA 129 Query: 328 EAAQEIGMR 336 A +E G+R Sbjct: 130 RAVEEAGLR 138 Score = 63.2 bits (152), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 40/128 (31%), Positives = 64/128 (50%), Gaps = 2/128 (1%) Query: 340 ARGAAXKAKVGLGVDGSASNDGAHMLGEVRQAMLLQRVGF-GPDAMTARQALEIATLGGA 398 AR V LG DG+ASN+ M E++ A LLQ+V P A+ A +ATL GA Sbjct: 284 ARLLQRGVNVSLGTDGAASNNNLDMFQEMKTASLLQKVNLEDPTALPAMDVFSMATLNGA 343 Query: 399 KVLNRDDIGALKPGMSADVAMFKLDQIGFAGALHDPVAALVFCTPANVSYSIINGRVIVR 458 + L D G + PG AD+ + + + P + + A+V I +GR+++R Sbjct: 344 RALGID-AGLIAPGKLADIVILNTRRPHLTPWRNPPSHTVYSASGADVDTVICDGRILLR 402 Query: 459 EGQCTTID 466 +G+ ++ Sbjct: 403 DGELEVLE 410 >SP1356 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Spn Streptococcus pneumoniae TIGR4 Length = 419 Score = 103 bits (256), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 47/126 (37%), Positives = 77/126 (61%) Query: 43 RIVVAPCSPFSVSRDLMREAANMARSYKVSLHTHLAENVNDIAYSREKFNMTPAEYAEDC 102 +++VAP SP+S SRDL+ + MA+ + LH H+AE + +++ P + E+ Sbjct: 182 KVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAETKEESGIILKRYGKRPLAFLEEL 241 Query: 103 GWVGHDVWHAHCVQLDDHGIDLFARTGTGVAHCPCSNMRLASGIAPIRKMIAAGVPVGLG 162 G++ H AH V+L++ I+ A + +AH P SN++LASGIAPI ++ AGV VG+ Sbjct: 242 GYLDHPSVFAHGVELNEREIERLASSQVAIAHNPISNLKLASGIAPIIQLQKAGVAVGIA 301 Query: 163 VDXIAA 168 D +A+ Sbjct: 302 TDSVAS 307 >MK0366 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases Mka Methanopyrus kandleri AV19 Length = 431 Score = 102 bits (255), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 51/156 (32%), Positives = 88/156 (56%), Gaps = 10/156 (6%) Query: 46 VAPCSPFSVSRDLMREAANMARSYKVSLHTHLAENVNDIAYSREKFNMTPAEYAEDCGWV 105 + P +P++ S +L++E +A + V + H+AE +++ + K P EY ++ G + Sbjct: 182 LGPHAPYTCSEELLKEVRRLADEWGVKIQIHVAETEDEVKEVKRKHGKRPVEYLDEIGLL 241 Query: 106 GHDVWHAHCVQLDDHGIDLFARTGTGVAHCPCSNMRLASGIAPIRKMIAAGVPVGLGVDX 165 G DV AHCV LDD I++ ++ G V+H P SNM+LASGI+P+ +M+ GV V +G D Sbjct: 242 GDDVIAAHCVWLDDKEIEILSKRGVIVSHNPISNMKLASGISPVPEMLERGVNVTIGTDG 301 Query: 166 IAAG----------VPVGINTQHQTQPSESQMTKTL 191 A+ V ++ ++ PS ++M + L Sbjct: 302 CASNNNLDMLEEIKVAALLHKVNKMDPSATEMLEIL 337